                         SEQUENCE LISTING



<110>  Ghosh, Malabika 

      Tang, Y. Tom 

      Wang, Jian-Rui 

      Wang, Zhiwei 

      Zhao, Qing 

      Xu, Chongjun 

      Mulero, Julio J

      Boyle, Bryan J.



<120>  METHODS AND MATERIALS RELATING TO NOVEL POLYPEPTIDES AND POLYNUCLEOTIDES



<130>  HYS-B1/PCT



<140>  Not Yet Assigned

<141>  2002-12-03



<150>  US 09/488,725

<151>  2000-01-21



<150>  US 09/552,317

<151>  2000-04-25



<150>  PCT/US00/35017

<151>  2000-12-22



<150>  US 09/620,312

<151>  2000-07-19



<150>  PCT/US00/34263

<151>  2000-12-26



<150>  US 09/496,914

<151>  2000-02-03



<150>  US 09/560,875

<151>  2000-04-27



<150>  PCT/US01/03800 

<151>  2001-02-05



<150>  US 09/598,075

<151>  2000-06-20



<150>  PCT/US01/04098

<151>  2001-02-05



<150>  US 09/540,217

<151>  2000-03-31



<150>  US 09/649,167

<151>  2000-08-23



<150>  PCT/US01/08631

<151>  2001-03-30



<150>  US09/728,952

<151>  2000-11-30



<150>  US 60/306,971

<151>  2001-07-21



<150>  US 60/341,362

<151>  2001-12-17



<150>  US 09/649/167

<151>  2000-08-23



<150>  US 60/379,875

<151>  2002-05-10



<150>  US 60/379,834

<151>  2002-05-10



<150>  US 09/687,535

<151>  2000-10-13



<150>  US 60/384,450

<151>  2002-05-31



<150>  US 60/384,665

<151>  2002-05-31



<150>  US 60/389,715

<151>  2002-06-17



<150>  US 60/365,384

<151>  2002-03-14



<150>  US 60/393,722

<151>  2002-07-02



<150>  US 60/390,531

<151>  2002-06-21



<150>  US 60/391,326

<151>  2002-06-24



<160>  653   



<170>  PatentIn version 3.1



<210>  1

<211>  480

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(480)

<223>  n = A, T, G, or C



<400>  1
agggggaaan annaacctga agcctgagaa catcagtcat nccangatga agatacccca     60

ccaaacccaa aaaaagagat ctctcgagga tccgaattcg cggccgcgtc gacgtcagta    120

ccatgaaagt gtaaactgtt gtaaactatt gtaaggatgt actatgtaca tcaatgtaaa    180

ctattgtaac aatgtactac aactaggata aaattaggat ttctattccc agtaattttc    240

aattaggtca tgtgacaatt aagtcttaat cactctttct tagacaaaca cttgaaggat    300

ctactgtcta aattgctgaa ctcaggctat tttgaaagta tcccagttcc caaaaatgcc    360

aaggaaaagg aagtaccact ggaggaagaa atgctaatac aatcagagaa aaaaacacaa    420

ttatcgaaga ctgaatctgt caaagagtca gagtctctaa tggaatttgc ccagccagaa    480


<210>  2

<211>  2454

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(2454)

<223>  n = A,T, G, or C



<400>  2
gttttgatac ttatagagga ctcccttcaa tttccaatgg aaattatagc cagctgcagt     60

tccaagctag agagtattct ggagcacctt attcccaaag gatctcagca atcaccacag    120

tatctgttgc ttggaaggta ctcagtggga agataggaga aggtgcagag ggcaactgta    180

aatgtgtcat aagtgaaggg gcctgggctg tttgccctac ccagccctgt ggcaaggcta    240

aaccagacaa acacttgaag gatctactgt ctaaattgct gaactcaggc tattttgaaa    300

gtatcccagt tcccaaaaat gccaaggaaa aggaagtacc actggaggaa gaaatgctaa    360

tacaatcaga gaaaaaaaca caattatcga agactgaatc tgtcaaagag tcagagtctc    420

taatggaatt tgcccagcca gagatacaac cacaagagtt tcttaacaga cgctatatga    480

cagaagtaga ttattcaaac aaacaaggcg aagagcaacc ttgggaagca gattatgcta    540

gaaaaccaaa tctcccaaaa cgttgggata tgcttactga accagatggt caagagaaga    600

aacaggagtc ctttaagtcc tgggaggctt ctggtaagca ccaggaggta tccaagcctg    660

cagtttcctt agaacagagg aaacaagaca cctcaaaact caggtctact ctgccggaag    720

agcagaagaa gcaggagatc tccaaatcca agccatctcc tagccagtgg aagcaagata    780

cacctaaatc caaagcaggg tatgttcaag aggaacataa gaaacaggag acaccaaagc    840

tgtggccagt tcagctgcag aaagaacaag atccaaagaa gcaaactcca aagtcttgga    900

caccttccat gcagagcgaa cagaacacca ccaagtcatg gaccactccc atgtgtgaag    960

aacaggattc aaaacagcca gagactccaa aatcctggga aaacaatgtt gagagtcaaa   1020

aacactcttt aacatcacag tcacagattt ctccaaagtc ctggggagta gctacagcaa   1080

gcctcatacc aaatgaccag ctgctgccca ggaagttgaa cacagaaccc aaagatgtgc   1140

ctaagcctgt gcatcagcct gaggtttcct tccgttanaa nnccccttcc gaaggatcca   1200

gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac ttgtaacttt   1260

atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac gtcacaaccg   1320

ccttcagcta ctccagggta gccccgtagg catctaaagg aacaaaatct gtccagtcaa   1380

agtgattttc tttcaaggag ccgttacagg tatttaacgt taatgcacct ctgcctccac   1440

gaaaagaaca agaaataaaa gaatcccctt attcacctgg ctacaatcaa agttttacca   1500

cagcaagtac acaaacacca ccccagtgcc aactgccatc tatacatgta gaacaaactg   1560

tccattctca agagactgca aattatcatc ctgatggaac tattcaagta agcaatggta   1620

gccttgcctt ttacccagca cagacgaatg tatttcccag acctactcag ccatttgtca   1680

atagccgggg atctgttaga ggatgtactc gtggtgggag attaataacc aattcctatc   1740

ggtcccctgg tggttataaa ggttttgata cttatagagg actcccttca atttccaatg   1800

gaaattatag ccagctgcag ttccaagcta gagagtattc tggagcacct tattcccaaa   1860

gggataattt ccagcagtgt tataagcgag gagggacatc tggtggtcca cgagcaaatt   1920

cgagagcagg gtggagtgat tcttctcagg tgagcagccc agaaagagac aacgaaacct   1980

ttaacagtgg tgactctgga caaggagact cccgtagcat gacccctgtg gatgtgccag   2040

tgacaaatcc agcagccacc atactgccag tacacgtcta ccctctgcct cagcagatgc   2100

gagttgcctt ctcagcagcc agaacctcta atctggcccc tggaacttta gaccaaccta   2160

ttgtgtttga tcttcttctg aacaacttag gagaaacttt tgatcttcag cttggtagat   2220

ttaattgccc agtgaatggc acttacgttt tcatttttca catgctaaag ctggcagtga   2280

atgtgccact gtatgtcaac ctcatgaaga atgaagaggt cttggtatca gcctatgcca   2340

atgatggtgc tccagaccat gaaactgcta gcaatcatgc aattcttcag ctcttccagg   2400

gagaccagat atggttacgt ctgcacaggg gagcaattta tggaagtagc tgga         2454


<210>  3

<211>  2382

<212>  DNA

<213>  Homo sapiens



<400>  3
atgaaaggaa ttaaggtgag gcagctagag aaaactaagg agcatcccca aaccaaggac     60

agaacaggcc ccatgcacgc cagcgcgcac cccctcaagt ctccggggga gcctgagcga    120

agagcacctc tcccgagcgg ccacggagag ccctgcaggc accgaccccc acccttccca    180

cagccgcccc gggtacgcag aagccgcttc tgcaaggccc cgggggaggc tgacctgcgg    240

aaaacgcacc gaccgcggcc ctcgggagcc ccgccccgcc ccggggatgc caagccgccc    300

ctccacctcg cagcggcgcc ggccgcccag acctgcccac cctcgccggg ccgcgccccg    360

ccccggcccg ctccgccctc ggccgccccg ccaccgcctc cttccggtgc tccttcccgg    420

ctgcagctgg ccgccagcgc ttgtcgggtg ttagttccgg gcccagcttg ggctggtggt    480

aggtcgggag agggcgcggt ctcccagcct ttgcgcagat tgcggggcac caggtggggc    540

cgaggcgacg ccgaacgccg gcaggccgga aaccgcgcag ccccgctgga cctcgctgat    600

tgccggcggc accggtggtt tcgcgacctt gaacagctac taaaagcgca aaagaaggcc    660

cagagaaggg agcacatgct aaaacttgag gctgagaaga aaaagcttcg aactatactt    720

caagttcagt atgtattgca gaacttgaca caggagcacg tacaaaaaga cttcaaaggg    780

ggtttgaatg gtgcagtgta tttgccttca aaagaacttg actacctcat taagttttca    840

aaactgacct gccctgaaag aaatgaaagt ctgagtgttg aagaccagat ggagcagtca    900

tccttgtact tttgggacct tttggaaggt agtgagaaag cagtggtagg aacgacatac    960

aaacacttga aggatctact gtctaaattg ctgaactcag gctattttga aagtatccca   1020

gttcccaaaa atgccaagga aaaggaagta ccactggagg aagaaatgct aatacaatca   1080

gagaaaaaaa cacaattatc gaagactgaa tctgtcaaag agtcagagtc tctaatggaa   1140

tttgcccagc cagagataca accacaagag tttcttaaca gacgctatat gacagaagta   1200

gattattcaa acaaacaagg cgaagagcaa ccttgggaag cagattatgc tagaaaacca   1260

aatctcccaa aacgttggga tatgcttact gaaccagatg gtcaagagaa gaaacaggag   1320

tcctttaagt cctgggaggc ttctggtaag caccaggagg tatccaagcc tgcagtttcc   1380

ttagaacaga ggaaacaaga cacctcaaaa ctcaggtcta ctctgccgga agagcagaag   1440

aagcaggaga tctccaaatc caagccatct cctagccagt ggaagcaaga tacacctaaa   1500

tccaaagcag ggtatgttca agaggaacaa aagaaacagg agacaccaaa gctgtggcca   1560

gttcagctgc agaaagaaca agatccaaag aagcaaactc caaagtcttg gacaccttcc   1620

atgcagagcg aacagaacac caccaagtca tggaccactc ccatgtgtga agaacaggat   1680

tcaaaacagc cagagactcc aaaatcctgg gaaaacaatg ttgagagtca aaaacactct   1740

ttaacatcac agtcacagat ttctccaaag tcctggggag tagctacagc aagcctcata   1800

ccaaatgacc agctgctgcc caggaagttg aacacagaac ccaaagatgt gcctaagcct   1860

gtgcatcagc ctgtaggttc ttcctctacc cttccgaagg atccagtatt gaggaaagaa   1920

aaactgcagg atctgatgac tcagattcaa ggaacttgta actttatgca agagtctgtt   1980

cttgactttg acaaaccttc aagtgcaatt ccaacgtcac aaccgccttc agctactcca   2040

ggtagccccg tagcatctaa agaacaaaat ctgtccagtc aaagtgattt tcttcaagag   2100

ccgttacagg ctacttcttc tccagttact tgtagctcaa atgcttgctt ggttactacc   2160

gatcaggctt cttctggatc tgaaacagag tttatgacct cagagactcc tgaggcagca   2220

attcccccag gcaagcaacc gtcttcacta gcttctccaa atcctcccat ggcaaagggc   2280

tctgaacagg gcttccagtc acctccagca agtagtagtt cagtaaccat taacacagca   2340

ccctttcaag ccatgcagac agtgagtatg aaacatgaat ga                      2382


<210>  4

<211>  2913

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (511)..(2913)

<223>  



<400>  4
atgaatatgg acatcaatga ttggtacttc gctactcatc atggtgatat tagcggttct     60

agacatatcc tggatttggg actactaaaa gcgcaaaaga aggcccagag aagggagcac    120

atgctaaaac ttgaggctga gaagaaaaag cttcgaacta tacttcaagt tcagtatgta    180

ttgcagaact tgacacagga gcacgtacaa aaagacttca aagggggttt gaatggtgca    240

gtgtatttgc cttcaaaaga acttgactac ctcattaagt tttcaaaact gacctgccct    300

gaaagaaatg aaagtctgag tgttgaagac cagatggagc agtcatcctt gtacttttgg    360

gaccttttgg aaggtagtga gaaagcagtg gtaggaacga catacaaaca cttgaaggat    420

ctactgtcta aattgctgaa ctcaggctat tttgaaagta tcccagttcc caaaaatgcc    480

aaggaaaagg aagtaccact ggaggaagaa atg cta ata caa tca gag aaa aaa     534
                                 Met Leu Ile Gln Ser Glu Lys Lys        
                                 1               5                      

aca caa tta tcg aag act gaa tct gtc aaa gag tca gag tct cta atg      582
Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu Ser Glu Ser Leu Met         
    10                  15                  20                          

gaa ttt gcc cag cca gag ata caa cca caa gag ttt ctt aac aga cgc      630
Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu Phe Leu Asn Arg Arg         
25                  30                  35                  40          

tat atg aca gaa gta gat tat tca aac aaa caa ggc gaa gag caa cct      678
Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln Gly Glu Glu Gln Pro         
                45                  50                  55              

tgg gaa gca gat tat gct aga aaa cca aat ctc cca aaa cgt tgg gat      726
Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu Pro Lys Arg Trp Asp         
            60                  65                  70                  

atg ctt act gaa cca gat ggt caa gag aag aaa cag gag tcc ttt aag      774
Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys Gln Glu Ser Phe Lys         
        75                  80                  85                      

tcc tgg gag gct tct ggt aag cac cag gag gta tcc aag cct gca gtt      822
Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val Ser Lys Pro Ala Val         
    90                  95                  100                         

tcc tta gaa cag agg aaa caa gac acc tca aaa ctc agg tct act ctg      870
Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys Leu Arg Ser Thr Leu         
105                 110                 115                 120         

ccg gaa gag cag aag aag cag gag atc tcc aaa tcc aag cca tct cct      918
Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys Ser Lys Pro Ser Pro         
                125                 130                 135             

agc cag tgg aag caa gat aca cct aaa tcc aaa gca ggg tat gtt caa      966
Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys Ala Gly Tyr Val Gln         
            140                 145                 150                 

gag gaa caa aag aaa cag gag aca cca aag ctg tgg cca gtt cag ctg     1014
Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu Trp Pro Val Gln Leu         
        155                 160                 165                     

cag aaa gaa caa gat cca aag aag caa act cca aag tct tgg aca cct     1062
Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro Lys Ser Trp Thr Pro         
    170                 175                 180                         

tcc atg cag agc gaa cag aac acc acc aag tca tgg acc act ccc atg     1110
Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser Trp Thr Thr Pro Met         
185                 190                 195                 200         

tgt gaa gaa cag gat tca aaa cag cca gag act cca aaa tcc tgg gaa     1158
Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr Pro Lys Ser Trp Glu         
                205                 210                 215             

aac aat gtt gag agt caa aaa cac tct tta aca tca cag tca cag att     1206
Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr Ser Gln Ser Gln Ile         
            220                 225                 230                 

tct cca aag tcc tgg gga gta gct aca gca agc ctc ata cca aat gac     1254
Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser Leu Ile Pro Asn Asp         
        235                 240                 245                     

cag ctg ctg ccc agg aag ttg aac aca gaa ccc aaa gat gtg cct aag     1302
Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro Lys Asp Val Pro Lys         
    250                 255                 260                         

cct gtg cat cag cct gta ggt tct tcc tct acc ctt ccg aag gat cca     1350
Pro Val His Gln Pro Val Gly Ser Ser Ser Thr Leu Pro Lys Asp Pro         
265                 270                 275                 280         

gta ttg agg aaa gaa aaa ctg cag gat ctg atg act cag att caa gga     1398
Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met Thr Gln Ile Gln Gly         
                285                 290                 295             

act tgt aac ttt atg caa gag tct gtt ctt gac ttt gac aaa cct tca     1446
Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp Phe Asp Lys Pro Ser         
            300                 305                 310                 

agt gca att cca acg tca caa ccg cct tca gct act cca ggt agc ccc     1494
Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala Thr Pro Gly Ser Pro         
        315                 320                 325                     

gta gca tct aaa gaa caa aat ctg tcc agt caa agt gat ttt ctt caa     1542
Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln Ser Asp Phe Leu Gln         
    330                 335                 340                         

gag ccg tta cag gct act tct tct cca gtt act tgt agc tca aat gct     1590
Glu Pro Leu Gln Ala Thr Ser Ser Pro Val Thr Cys Ser Ser Asn Ala         
345                 350                 355                 360         

tgc ttg gtt act acc gat cag gct tct tct gga tct gaa aca gag ttt     1638
Cys Leu Val Thr Thr Asp Gln Ala Ser Ser Gly Ser Glu Thr Glu Phe         
                365                 370                 375             

atg acc tca gag act cct gag gca gca att ccc cca ggc aag caa ccg     1686
Met Thr Ser Glu Thr Pro Glu Ala Ala Ile Pro Pro Gly Lys Gln Pro         
            380                 385                 390                 

tct tca cta gct tct cca aat cct ccc atg gca aag ggc tct gaa cag     1734
Ser Ser Leu Ala Ser Pro Asn Pro Pro Met Ala Lys Gly Ser Glu Gln         
        395                 400                 405                     

ggc ttc cag tca cct cca gca agt agt agt tca gta acc att aac aca     1782
Gly Phe Gln Ser Pro Pro Ala Ser Ser Ser Ser Val Thr Ile Asn Thr         
    410                 415                 420                         

gca ccc ttt caa gcc atg cag aca gta ttt aac gtt aat gca cct ctg     1830
Ala Pro Phe Gln Ala Met Gln Thr Val Phe Asn Val Asn Ala Pro Leu         
425                 430                 435                 440         

cct cca cga aaa gaa caa gaa ata aaa gaa tcc cct tat tca cct ggc     1878
Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro Tyr Ser Pro Gly         
                445                 450                 455             

tac aat caa agt ttt acc aca gca agt aca caa aca cca ccc cag tgc     1926
Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln Thr Pro Pro Gln Cys         
            460                 465                 470                 

caa ctg cca tct ata cat gta gaa caa act gtc cat tct caa gag act     1974
Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His Ser Gln Glu Thr         
        475                 480                 485                     

gca aat tat cat cct gat gga act att caa gta agc aat ggt agc ctt     2022
Ala Asn Tyr His Pro Asp Gly Thr Ile Gln Val Ser Asn Gly Ser Leu         
    490                 495                 500                         

gcc ttt tac cca gca cag acg aat gtg ttt ccc aga cct act cag cca     2070
Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe Pro Arg Pro Thr Gln Pro         
505                 510                 515                 520         

ttt gtc aat agc cgg gga tct gtt aga gga tgt act cgt ggt ggg aga     2118
Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys Thr Arg Gly Gly Arg         
                525                 530                 535             

tta ata acc aat tcc tat cgg tcc cct ggt ggt tat aaa ggt ttt gat     2166
Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly Gly Tyr Lys Gly Phe Asp         
            540                 545                 550                 

act tat aga gga ctc cct tca att tcc aat gga aat tat agc cag ctg     2214
Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn Tyr Ser Gln Leu         
        555                 560                 565                     

cag ttc caa gct aga gag tat tct gga gca cct tat tcc caa agg tgt     2262
Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr Ser Gln Arg Cys         
    570                 575                 580                         

ttg gaa aca tct gag cct ctt tgg ttg ctg ggg aag gcc agg ata att     2310
Leu Glu Thr Ser Glu Pro Leu Trp Leu Leu Gly Lys Ala Arg Ile Ile         
585                 590                 595                 600         

tcc agc agt gtt ata agc gag gag gga cat ctg gtg gtc cac gag caa     2358
Ser Ser Ser Val Ile Ser Glu Glu Gly His Leu Val Val His Glu Gln         
                605                 610                 615             

att cga gag gtg agc agc cca gaa aga gac aac gaa acc ttt aac agt     2406
Ile Arg Glu Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn Ser         
            620                 625                 630                 

ggt gac tct gga caa gga gac tcc cgt agc atg acc cct gtg gat gtg     2454
Gly Asp Ser Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp Val         
        635                 640                 645                     

cca gtg aca aat cca gca gcc acc ata ctg cca gta cac gtc tac cct     2502
Pro Val Thr Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr Pro         
    650                 655                 660                         

ctg cct cag cag atg cga gtt gcc ttc tca gca gcc aga acc tct aat     2550
Leu Pro Gln Gln Met Arg Val Ala Phe Ser Ala Ala Arg Thr Ser Asn         
665                 670                 675                 680         

ctg gcc cct gga act tta gac caa cct att gtg ttt gat ctt ctt ctg     2598
Leu Ala Pro Gly Thr Leu Asp Gln Pro Ile Val Phe Asp Leu Leu Leu         
                685                 690                 695             

aac aac tta gga gaa act ttt gat ctt cag ctt ggt aga ttt aat tgc     2646
Asn Asn Leu Gly Glu Thr Phe Asp Leu Gln Leu Gly Arg Phe Asn Cys         
            700                 705                 710                 

cca gtg aat ggc act tac gtt ttc att ttt cac atg cta aag ctg gca     2694
Pro Val Asn Gly Thr Tyr Val Phe Ile Phe His Met Leu Lys Leu Ala         
        715                 720                 725                     

gtg aat gtg cca ctg tat gtc aac ctc atg aag aat gaa gag gtc ttg     2742
Val Asn Val Pro Leu Tyr Val Asn Leu Met Lys Asn Glu Glu Val Leu         
    730                 735                 740                         

gta tca gcc tat gcc aat gat ggt gct cca gac cat gaa act gct agc     2790
Val Ser Ala Tyr Ala Asn Asp Gly Ala Pro Asp His Glu Thr Ala Ser         
745                 750                 755                 760         

aat cat gca att ctt cag ctc ttc cag gga gac cag ata tgg tta cgt     2838
Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln Ile Trp Leu Arg         
                765                 770                 775             

ctg cac agg gga gca att tat gga agt agc tgg aaa tat tct acg ttt     2886
Leu His Arg Gly Ala Ile Tyr Gly Ser Ser Trp Lys Tyr Ser Thr Phe         
            780                 785                 790                 

tca ggc tat ctt ctt tat caa gat tga                                 2913
Ser Gly Tyr Leu Leu Tyr Gln Asp                                         
        795                 800                                         


<210>  5

<211>  800

<212>  PRT

<213>  Homo sapiens



<400>  5

Met Leu Ile Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser 
1               5                   10                  15      


Val Lys Glu Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln 
            20                  25                  30          


Pro Gln Glu Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser 
        35                  40                  45              


Asn Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys 
    50                  55                  60                  


Pro Asn Leu Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln 
65                  70                  75                  80  


Glu Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His 
                85                  90                  95      


Gln Glu Val Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp 
            100                 105                 110         


Thr Ser Lys Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu 
        115                 120                 125             


Ile Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro 
    130                 135                 140                 


Lys Ser Lys Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr 
145                 150                 155                 160 


Pro Lys Leu Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys 
                165                 170                 175     


Gln Thr Pro Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr 
            180                 185                 190         


Thr Lys Ser Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln 
        195                 200                 205             


Pro Glu Thr Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His 
    210                 215                 220                 


Ser Leu Thr Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala 
225                 230                 235                 240 


Thr Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn 
                245                 250                 255     


Thr Glu Pro Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser 
            260                 265                 270         


Ser Ser Thr Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln 
        275                 280                 285             


Asp Leu Met Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser 
    290                 295                 300                 


Val Leu Asp Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro 
305                 310                 315                 320 


Pro Ser Ala Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu 
                325                 330                 335     


Ser Ser Gln Ser Asp Phe Leu Gln Glu Pro Leu Gln Ala Thr Ser Ser 
            340                 345                 350         


Pro Val Thr Cys Ser Ser Asn Ala Cys Leu Val Thr Thr Asp Gln Ala 
        355                 360                 365             


Ser Ser Gly Ser Glu Thr Glu Phe Met Thr Ser Glu Thr Pro Glu Ala 
    370                 375                 380                 


Ala Ile Pro Pro Gly Lys Gln Pro Ser Ser Leu Ala Ser Pro Asn Pro 
385                 390                 395                 400 


Pro Met Ala Lys Gly Ser Glu Gln Gly Phe Gln Ser Pro Pro Ala Ser 
                405                 410                 415     


Ser Ser Ser Val Thr Ile Asn Thr Ala Pro Phe Gln Ala Met Gln Thr 
            420                 425                 430         


Val Phe Asn Val Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile 
        435                 440                 445             


Lys Glu Ser Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala 
    450                 455                 460                 


Ser Thr Gln Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu 
465                 470                 475                 480 


Gln Thr Val His Ser Gln Glu Thr Ala Asn Tyr His Pro Asp Gly Thr 
                485                 490                 495     


Ile Gln Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn 
            500                 505                 510         


Val Phe Pro Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val 
        515                 520                 525             


Arg Gly Cys Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser 
    530                 535                 540                 


Pro Gly Gly Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile 
545                 550                 555                 560 


Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser 
                565                 570                 575     


Gly Ala Pro Tyr Ser Gln Arg Cys Leu Glu Thr Ser Glu Pro Leu Trp 
            580                 585                 590         


Leu Leu Gly Lys Ala Arg Ile Ile Ser Ser Ser Val Ile Ser Glu Glu 
        595                 600                 605             


Gly His Leu Val Val His Glu Gln Ile Arg Glu Val Ser Ser Pro Glu 
    610                 615                 620                 


Arg Asp Asn Glu Thr Phe Asn Ser Gly Asp Ser Gly Gln Gly Asp Ser 
625                 630                 635                 640 


Arg Ser Met Thr Pro Val Asp Val Pro Val Thr Asn Pro Ala Ala Thr 
                645                 650                 655     


Ile Leu Pro Val His Val Tyr Pro Leu Pro Gln Gln Met Arg Val Ala 
            660                 665                 670         


Phe Ser Ala Ala Arg Thr Ser Asn Leu Ala Pro Gly Thr Leu Asp Gln 
        675                 680                 685             


Pro Ile Val Phe Asp Leu Leu Leu Asn Asn Leu Gly Glu Thr Phe Asp 
    690                 695                 700                 


Leu Gln Leu Gly Arg Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe 
705                 710                 715                 720 


Ile Phe His Met Leu Lys Leu Ala Val Asn Val Pro Leu Tyr Val Asn 
                725                 730                 735     


Leu Met Lys Asn Glu Glu Val Leu Val Ser Ala Tyr Ala Asn Asp Gly 
            740                 745                 750         


Ala Pro Asp His Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe 
        755                 760                 765             


Gln Gly Asp Gln Ile Trp Leu Arg Leu His Arg Gly Ala Ile Tyr Gly 
    770                 775                 780                 


Ser Ser Trp Lys Tyr Ser Thr Phe Ser Gly Tyr Leu Leu Tyr Gln Asp 
785                 790                 795                 800 


<210>  6

<211>  2403

<212>  DNA

<213>  Homo sapiens



<400>  6
atgctaatac aatcagagaa aaaaacacaa ttatcgaaga ctgaatctgt caaagagtca     60

gagtctctaa tggaatttgc ccagccagag atacaaccac aagagtttct taacagacgc    120

tatatgacag aagtagatta ttcaaacaaa caaggcgaag agcaaccttg ggaagcagat    180

tatgctagaa aaccaaatct cccaaaacgt tgggatatgc ttactgaacc agatggtcaa    240

gagaagaaac aggagtcctt taagtcctgg gaggcttctg gtaagcacca ggaggtatcc    300

aagcctgcag tttccttaga acagaggaaa caagacacct caaaactcag gtctactctg    360

ccggaagagc agaagaagca ggagatctcc aaatccaagc catctcctag ccagtggaag    420

caagatacac ctaaatccaa agcagggtat gttcaagagg aacaaaagaa acaggagaca    480

ccaaagctgt ggccagttca gctgcagaaa gaacaagatc caaagaagca aactccaaag    540

tcttggacac cttccatgca gagcgaacag aacaccacca agtcatggac cactcccatg    600

tgtgaagaac aggattcaaa acagccagag actccaaaat cctgggaaaa caatgttgag    660

agtcaaaaac actctttaac atcacagtca cagatttctc caaagtcctg gggagtagct    720

acagcaagcc tcataccaaa tgaccagctg ctgcccagga agttgaacac agaacccaaa    780

gatgtgccta agcctgtgca tcagcctgta ggttcttcct ctacccttcc gaaggatcca    840

gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac ttgtaacttt    900

atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac gtcacaaccg    960

ccttcagcta ctccaggtag ccccgtagca tctaaagaac aaaatctgtc cagtcaaagt   1020

gattttcttc aagagccgtt acaggctact tcttctccag ttacttgtag ctcaaatgct   1080

tgcttggtta ctaccgatca ggcttcttct ggatctgaaa cagagtttat gacctcagag   1140

actcctgagg cagcaattcc cccaggcaag caaccgtctt cactagcttc tccaaatcct   1200

cccatggcaa agggctctga acagggcttc cagtcacctc cagcaagtag tagttcagta   1260

accattaaca cagcaccctt tcaagccatg cagacagtat ttaacgttaa tgcacctctg   1320

cctccacgaa aagaacaaga aataaaagaa tccccttatt cacctggcta caatcaaagt   1380

tttaccacag caagtacaca aacaccaccc cagtgccaac tgccatctat acatgtagaa   1440

caaactgtcc attctcaaga gactgcaaat tatcatcctg atggaactat tcaagtaagc   1500

aatggtagcc ttgcctttta cccagcacag acgaatgtgt ttcccagacc tactcagcca   1560

tttgtcaata gccggggatc tgttagagga tgtactcgtg gtgggagatt aataaccaat   1620

tcctatcggt cccctggtgg ttataaaggt tttgatactt atagaggact cccttcaatt   1680

tccaatggaa attatagcca gctgcagttc caagctagag agtattctgg agcaccttat   1740

tcccaaaggt gtttggaaac atctgagcct ctttggttgc tggggaaggc caggataatt   1800

tccagcagtg ttataagcga ggagggacat ctggtggtcc acgagcaaat tcgagaggtg   1860

agcagcccag aaagagacaa cgaaaccttt aacagtggtg actctggaca aggagactcc   1920

cgtagcatga cccctgtgga tgtgccagtg acaaatccag cagccaccat actgccagta   1980

cacgtctacc ctctgcctca gcagatgcga gttgccttct cagcagccag aacctctaat   2040

ctggcccctg gaactttaga ccaacctatt gtgtttgatc ttcttctgaa caacttagga   2100

gaaacttttg atcttcagct tggtagattt aattgcccag tgaatggcac ttacgttttc   2160

atttttcaca tgctaaagct ggcagtgaat gtgccactgt atgtcaacct catgaagaat   2220

gaagaggtct tggtatcagc ctatgccaat gatggtgctc cagaccatga aactgctagc   2280

aatcatgcaa ttcttcagct cttccaggga gaccagatat ggttacgtct gcacagggga   2340

gcaatttatg gaagtagctg gaaatattct acgttttcag gctatcttct ttatcaagat   2400

tga                                                                 2403


<210>  7

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  7

Pro Ile Val Phe Asp Leu Leu Leu Asn Asn Leu Gly Glu Thr Phe Asp 
1               5                   10                  15      


Leu Gln Leu Gly Arg Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe 
            20                  25                  30          


Ile Phe His Met 
        35      


<210>  8

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  8

Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln 
1               5                   10                  15      


Ile Trp Leu Arg Leu His 
            20          


<210>  9

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  9

Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln 
1               5                   10                  15      


Ile Trp Leu Arg 
            20  


<210>  10

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  10

Lys Tyr Ser Thr Phe Ser Gly Tyr Leu Leu Tyr 
1               5                   10      


<210>  11

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  11

Ser Thr Phe Ser Gly Tyr Leu Leu Tyr Gln 
1               5                   10  


<210>  12

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  12

Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe Ile Phe His Met Leu 
1               5                   10                  15      


Lys Leu Ala Val 
            20  


<210>  13

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  13

Pro Gly Thr Leu Asp Gln Pro Ile Val Phe Asp Leu Leu Leu Asn Asn 
1               5                   10                  15      


Leu Gly Glu Thr Phe Asp Leu Gln Leu Gly Arg 
            20                  25          


<210>  14

<211>  2643

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (511)..(2643)

<223>  



<400>  14
atgaatatgg acatcaatga ttggtacttc gctactcatc atggtgatat tagcggttct     60

agacatatcc tggatttggg actactaaaa gcgcaaaaga aggcccagag aagggagcac    120

atgctaaaac ttgaggctga gaagaaaaag cttcgaacta tacttcaagt tcagtatgta    180

ttgcagaact tgacacagga gcacgtacaa aaagacttca aagggggttt gaatggtgca    240

gtgtatttgc cttcaaaaga acttgactac ctcattaagt tttcaaaact gacctgccct    300

gaaagaaatg aaagtctgag tgttgaagac cagatggagc agtcatcctt gtacttttgg    360

gaccttttgg aaggtagtga gaaagcagtg gtaggaacga catacaaaca cttgaaggat    420

ctactgtcta aattgctgaa ctcaggctat tttgaaagta tcccagttcc caaaaatgcc    480

aaggaaaagg aagtaccact ggaggaagaa atg cta ata caa tca gag aaa aaa     534
                                 Met Leu Ile Gln Ser Glu Lys Lys        
                                 1               5                      

aca caa tta tcg aag act gaa tct gtc aaa gag tca gag tct cta atg      582
Thr Gln Leu Ser Lys Thr Glu Ser Val Lys Glu Ser Glu Ser Leu Met         
    10                  15                  20                          

gaa ttt gcc cag cca gag ata caa cca caa gag ttt ctt aac aga cgc      630
Glu Phe Ala Gln Pro Glu Ile Gln Pro Gln Glu Phe Leu Asn Arg Arg         
25                  30                  35                  40          

tat atg aca gaa gta gat tat tca aac aaa caa ggc gaa gag caa cct      678
Tyr Met Thr Glu Val Asp Tyr Ser Asn Lys Gln Gly Glu Glu Gln Pro         
                45                  50                  55              

tgg gaa gca gat tat gct aga aaa cca aat ctc cca aaa cgt tgg gat      726
Trp Glu Ala Asp Tyr Ala Arg Lys Pro Asn Leu Pro Lys Arg Trp Asp         
            60                  65                  70                  

atg ctt act gaa cca gat ggt caa gag aag aaa cag gag tcc ttt aag      774
Met Leu Thr Glu Pro Asp Gly Gln Glu Lys Lys Gln Glu Ser Phe Lys         
        75                  80                  85                      

tcc tgg gag gct tct ggt aag cac cag gag gta tcc aag cct gca gtt      822
Ser Trp Glu Ala Ser Gly Lys His Gln Glu Val Ser Lys Pro Ala Val         
    90                  95                  100                         

tcc tta gaa cag agg aaa caa gac acc tca aaa ctc agg tct act ctg      870
Ser Leu Glu Gln Arg Lys Gln Asp Thr Ser Lys Leu Arg Ser Thr Leu         
105                 110                 115                 120         

ccg gaa gag cag aag aag cag gag atc tcc aaa tcc aag cca tct cct      918
Pro Glu Glu Gln Lys Lys Gln Glu Ile Ser Lys Ser Lys Pro Ser Pro         
                125                 130                 135             

agc cag tgg aag caa gat aca cct aaa tcc aaa gca ggg tat gtt caa      966
Ser Gln Trp Lys Gln Asp Thr Pro Lys Ser Lys Ala Gly Tyr Val Gln         
            140                 145                 150                 

gag gaa caa aag aaa cag gag aca cca aag ctg tgg cca gtt cag ctg     1014
Glu Glu Gln Lys Lys Gln Glu Thr Pro Lys Leu Trp Pro Val Gln Leu         
        155                 160                 165                     

cag aaa gaa caa gat cca aag aag caa act cca aag tct tgg aca cct     1062
Gln Lys Glu Gln Asp Pro Lys Lys Gln Thr Pro Lys Ser Trp Thr Pro         
    170                 175                 180                         

tcc atg cag agc gaa cag aac acc acc aag tca tgg acc act ccc atg     1110
Ser Met Gln Ser Glu Gln Asn Thr Thr Lys Ser Trp Thr Thr Pro Met         
185                 190                 195                 200         

tgt gaa gaa cag gat tca aaa cag cca gag act cca aaa tcc tgg gaa     1158
Cys Glu Glu Gln Asp Ser Lys Gln Pro Glu Thr Pro Lys Ser Trp Glu         
                205                 210                 215             

aac aat gtt gag agt caa aaa cac tct tta aca tca cag tca cag att     1206
Asn Asn Val Glu Ser Gln Lys His Ser Leu Thr Ser Gln Ser Gln Ile         
            220                 225                 230                 

tct cca aag tcc tgg gga gta gct aca gca agc ctc ata cca aat gac     1254
Ser Pro Lys Ser Trp Gly Val Ala Thr Ala Ser Leu Ile Pro Asn Asp         
        235                 240                 245                     

cag ctg ctg ccc agg aag ttg aac aca gaa ccc aaa gat gtg cct aag     1302
Gln Leu Leu Pro Arg Lys Leu Asn Thr Glu Pro Lys Asp Val Pro Lys         
    250                 255                 260                         

cct gtg cat cag cct gta ggt tct tcc tct acc ctt ccg aag gat cca     1350
Pro Val His Gln Pro Val Gly Ser Ser Ser Thr Leu Pro Lys Asp Pro         
265                 270                 275                 280         

gta ttg agg aaa gaa aaa ctg cag gat ctg atg act cag att caa gga     1398
Val Leu Arg Lys Glu Lys Leu Gln Asp Leu Met Thr Gln Ile Gln Gly         
                285                 290                 295             

act tgt aac ttt atg caa gag tct gtt ctt gac ttt gac aaa cct tca     1446
Thr Cys Asn Phe Met Gln Glu Ser Val Leu Asp Phe Asp Lys Pro Ser         
            300                 305                 310                 

agt gca att cca acg tca caa ccg cct tca gct act cca ggt agc ccc     1494
Ser Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala Thr Pro Gly Ser Pro         
        315                 320                 325                     

gta gca tct aaa gaa caa aat ctg tcc agt caa agt gat ttt ctt caa     1542
Val Ala Ser Lys Glu Gln Asn Leu Ser Ser Gln Ser Asp Phe Leu Gln         
    330                 335                 340                         

gag ccg tta cag gta ttt aac gtt aat gca cct ctg cct cca cga aaa     1590
Glu Pro Leu Gln Val Phe Asn Val Asn Ala Pro Leu Pro Pro Arg Lys         
345                 350                 355                 360         

gaa caa gaa ata aaa gaa tcc cct tat tca cct ggc tac aat caa agt     1638
Glu Gln Glu Ile Lys Glu Ser Pro Tyr Ser Pro Gly Tyr Asn Gln Ser         
                365                 370                 375             

ttt acc aca gca agt aca caa aca cca ccc cag tgc caa ctg cca tct     1686
Phe Thr Thr Ala Ser Thr Gln Thr Pro Pro Gln Cys Gln Leu Pro Ser         
            380                 385                 390                 

ata cat gta gaa caa act gtc cat tct caa gag act gca gca aat tat     1734
Ile His Val Glu Gln Thr Val His Ser Gln Glu Thr Ala Ala Asn Tyr         
        395                 400                 405                     

cat cct gat gga act att caa gta agc aat ggt agc ctt gcc ttt tac     1782
His Pro Asp Gly Thr Ile Gln Val Ser Asn Gly Ser Leu Ala Phe Tyr         
    410                 415                 420                         

cca gca cag acg aat gtg ttt ccc aga cct act cag cca ttt gtc aat     1830
Pro Ala Gln Thr Asn Val Phe Pro Arg Pro Thr Gln Pro Phe Val Asn         
425                 430                 435                 440         

agc cgg gga tct gtt aga gga tgt act cgt ggt ggg aga tta ata acc     1878
Ser Arg Gly Ser Val Arg Gly Cys Thr Arg Gly Gly Arg Leu Ile Thr         
                445                 450                 455             

aat tcc tat cgg tcc cct ggt ggt tat aaa ggt ttt gat act tat aga     1926
Asn Ser Tyr Arg Ser Pro Gly Gly Tyr Lys Gly Phe Asp Thr Tyr Arg         
            460                 465                 470                 

gga ctc cct tca att tcc aat gga aat tat agc cag ctg cag ttc caa     1974
Gly Leu Pro Ser Ile Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe Gln         
        475                 480                 485                     

gct aga gag tat tct gga gca cct tat tcc caa agg gat aat ttc cag     2022
Ala Arg Glu Tyr Ser Gly Ala Pro Tyr Ser Gln Arg Asp Asn Phe Gln         
    490                 495                 500                         

cag tgt tat aag cga gga ggg aca tct ggt ggt cca cga gca aat tcg     2070
Gln Cys Tyr Lys Arg Gly Gly Thr Ser Gly Gly Pro Arg Ala Asn Ser         
505                 510                 515                 520         

aga gca ggg tgg agt gat tct tct cag gtg agc agc cca gaa aga gac     2118
Arg Ala Gly Trp Ser Asp Ser Ser Gln Val Ser Ser Pro Glu Arg Asp         
                525                 530                 535             

aac gaa acc ttt aac agt ggt gac tct gga caa gga gac tcc cgt agc     2166
Asn Glu Thr Phe Asn Ser Gly Asp Ser Gly Gln Gly Asp Ser Arg Ser         
            540                 545                 550                 

atg acc cct gtg gat gtg cca gtg aca aat cca gca gcc acc ata ctg     2214
Met Thr Pro Val Asp Val Pro Val Thr Asn Pro Ala Ala Thr Ile Leu         
        555                 560                 565                     

cca gta cac gtc tac cct ctg cct cag cag atg cga gtt gcc ttc tca     2262
Pro Val His Val Tyr Pro Leu Pro Gln Gln Met Arg Val Ala Phe Ser         
    570                 575                 580                         

gca gcc aga acc tct aat ctg gcc cct gga act tta gac caa cct tat     2310
Ala Ala Arg Thr Ser Asn Leu Ala Pro Gly Thr Leu Asp Gln Pro Tyr         
585                 590                 595                 600         

ggt gtt gat ctt ctt ctg aac aac tta gga gaa act ttt gat ctt cag     2358
Gly Val Asp Leu Leu Leu Asn Asn Leu Gly Glu Thr Phe Asp Leu Gln         
                605                 610                 615             

ctt ggt aga ttt aat tgc cca gtg aat ggc act tac gtt ttc att ttt     2406
Leu Gly Arg Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe Ile Phe         
            620                 625                 630                 

cac atg cta aag ctg gca gtg aat gtg cca ctg tat gtc aac ctc atg     2454
His Met Leu Lys Leu Ala Val Asn Val Pro Leu Tyr Val Asn Leu Met         
        635                 640                 645                     

aag aat gaa gag gtc ttg gta tca gcc tat gcc aat gat ggt gct cca     2502
Lys Asn Glu Glu Val Leu Val Ser Ala Tyr Ala Asn Asp Gly Ala Pro         
    650                 655                 660                         

gac cat gaa act gct agc aat cat gca att ctt cag ctc ttc cag gga     2550
Asp His Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly         
665                 670                 675                 680         

gac cag ata tgg tta cgt ctg cac agg gga gca att tat gga agt agc     2598
Asp Gln Ile Trp Leu Arg Leu His Arg Gly Ala Ile Tyr Gly Ser Ser         
                685                 690                 695             

tgg aaa tat tct acg ttt tca ggc tat ctt ctt tat caa gat tga         2643
Trp Lys Tyr Ser Thr Phe Ser Gly Tyr Leu Leu Tyr Gln Asp                 
            700                 705                 710                 


<210>  15

<211>  710

<212>  PRT

<213>  Homo sapiens



<400>  15

Met Leu Ile Gln Ser Glu Lys Lys Thr Gln Leu Ser Lys Thr Glu Ser 
1               5                   10                  15      


Val Lys Glu Ser Glu Ser Leu Met Glu Phe Ala Gln Pro Glu Ile Gln 
            20                  25                  30          


Pro Gln Glu Phe Leu Asn Arg Arg Tyr Met Thr Glu Val Asp Tyr Ser 
        35                  40                  45              


Asn Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala Asp Tyr Ala Arg Lys 
    50                  55                  60                  


Pro Asn Leu Pro Lys Arg Trp Asp Met Leu Thr Glu Pro Asp Gly Gln 
65                  70                  75                  80  


Glu Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu Ala Ser Gly Lys His 
                85                  90                  95      


Gln Glu Val Ser Lys Pro Ala Val Ser Leu Glu Gln Arg Lys Gln Asp 
            100                 105                 110         


Thr Ser Lys Leu Arg Ser Thr Leu Pro Glu Glu Gln Lys Lys Gln Glu 
        115                 120                 125             


Ile Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp Lys Gln Asp Thr Pro 
    130                 135                 140                 


Lys Ser Lys Ala Gly Tyr Val Gln Glu Glu Gln Lys Lys Gln Glu Thr 
145                 150                 155                 160 


Pro Lys Leu Trp Pro Val Gln Leu Gln Lys Glu Gln Asp Pro Lys Lys 
                165                 170                 175     


Gln Thr Pro Lys Ser Trp Thr Pro Ser Met Gln Ser Glu Gln Asn Thr 
            180                 185                 190         


Thr Lys Ser Trp Thr Thr Pro Met Cys Glu Glu Gln Asp Ser Lys Gln 
        195                 200                 205             


Pro Glu Thr Pro Lys Ser Trp Glu Asn Asn Val Glu Ser Gln Lys His 
    210                 215                 220                 


Ser Leu Thr Ser Gln Ser Gln Ile Ser Pro Lys Ser Trp Gly Val Ala 
225                 230                 235                 240 


Thr Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu Pro Arg Lys Leu Asn 
                245                 250                 255     


Thr Glu Pro Lys Asp Val Pro Lys Pro Val His Gln Pro Val Gly Ser 
            260                 265                 270         


Ser Ser Thr Leu Pro Lys Asp Pro Val Leu Arg Lys Glu Lys Leu Gln 
        275                 280                 285             


Asp Leu Met Thr Gln Ile Gln Gly Thr Cys Asn Phe Met Gln Glu Ser 
    290                 295                 300                 


Val Leu Asp Phe Asp Lys Pro Ser Ser Ala Ile Pro Thr Ser Gln Pro 
305                 310                 315                 320 


Pro Ser Ala Thr Pro Gly Ser Pro Val Ala Ser Lys Glu Gln Asn Leu 
                325                 330                 335     


Ser Ser Gln Ser Asp Phe Leu Gln Glu Pro Leu Gln Val Phe Asn Val 
            340                 345                 350         


Asn Ala Pro Leu Pro Pro Arg Lys Glu Gln Glu Ile Lys Glu Ser Pro 
        355                 360                 365             


Tyr Ser Pro Gly Tyr Asn Gln Ser Phe Thr Thr Ala Ser Thr Gln Thr 
    370                 375                 380                 


Pro Pro Gln Cys Gln Leu Pro Ser Ile His Val Glu Gln Thr Val His 
385                 390                 395                 400 


Ser Gln Glu Thr Ala Ala Asn Tyr His Pro Asp Gly Thr Ile Gln Val 
                405                 410                 415     


Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala Gln Thr Asn Val Phe Pro 
            420                 425                 430         


Arg Pro Thr Gln Pro Phe Val Asn Ser Arg Gly Ser Val Arg Gly Cys 
        435                 440                 445             


Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser Tyr Arg Ser Pro Gly Gly 
    450                 455                 460                 


Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly 
465                 470                 475                 480 


Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro 
                485                 490                 495     


Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys Tyr Lys Arg Gly Gly Thr 
            500                 505                 510         


Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala Gly Trp Ser Asp Ser Ser 
        515                 520                 525             


Gln Val Ser Ser Pro Glu Arg Asp Asn Glu Thr Phe Asn Ser Gly Asp 
    530                 535                 540                 


Ser Gly Gln Gly Asp Ser Arg Ser Met Thr Pro Val Asp Val Pro Val 
545                 550                 555                 560 


Thr Asn Pro Ala Ala Thr Ile Leu Pro Val His Val Tyr Pro Leu Pro 
                565                 570                 575     


Gln Gln Met Arg Val Ala Phe Ser Ala Ala Arg Thr Ser Asn Leu Ala 
            580                 585                 590         


Pro Gly Thr Leu Asp Gln Pro Tyr Gly Val Asp Leu Leu Leu Asn Asn 
        595                 600                 605             


Leu Gly Glu Thr Phe Asp Leu Gln Leu Gly Arg Phe Asn Cys Pro Val 
    610                 615                 620                 


Asn Gly Thr Tyr Val Phe Ile Phe His Met Leu Lys Leu Ala Val Asn 
625                 630                 635                 640 


Val Pro Leu Tyr Val Asn Leu Met Lys Asn Glu Glu Val Leu Val Ser 
                645                 650                 655     


Ala Tyr Ala Asn Asp Gly Ala Pro Asp His Glu Thr Ala Ser Asn His 
            660                 665                 670         


Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln Ile Trp Leu Arg Leu His 
        675                 680                 685             


Arg Gly Ala Ile Tyr Gly Ser Ser Trp Lys Tyr Ser Thr Phe Ser Gly 
    690                 695                 700                 


Tyr Leu Leu Tyr Gln Asp 
705                 710 


<210>  16

<211>  2133

<212>  DNA

<213>  Homo sapiens



<400>  16
atgctaatac aatcagagaa aaaaacacaa ttatcgaaga ctgaatctgt caaagagtca     60

gagtctctaa tggaatttgc ccagccagag atacaaccac aagagtttct taacagacgc    120

tatatgacag aagtagatta ttcaaacaaa caaggcgaag agcaaccttg ggaagcagat    180

tatgctagaa aaccaaatct cccaaaacgt tgggatatgc ttactgaacc agatggtcaa    240

gagaagaaac aggagtcctt taagtcctgg gaggcttctg gtaagcacca ggaggtatcc    300

aagcctgcag tttccttaga acagaggaaa caagacacct caaaactcag gtctactctg    360

ccggaagagc agaagaagca ggagatctcc aaatccaagc catctcctag ccagtggaag    420

caagatacac ctaaatccaa agcagggtat gttcaagagg aacaaaagaa acaggagaca    480

ccaaagctgt ggccagttca gctgcagaaa gaacaagatc caaagaagca aactccaaag    540

tcttggacac cttccatgca gagcgaacag aacaccacca agtcatggac cactcccatg    600

tgtgaagaac aggattcaaa acagccagag actccaaaat cctgggaaaa caatgttgag    660

agtcaaaaac actctttaac atcacagtca cagatttctc caaagtcctg gggagtagct    720

acagcaagcc tcataccaaa tgaccagctg ctgcccagga agttgaacac agaacccaaa    780

gatgtgccta agcctgtgca tcagcctgta ggttcttcct ctacccttcc gaaggatcca    840

gtattgagga aagaaaaact gcaggatctg atgactcaga ttcaaggaac ttgtaacttt    900

atgcaagagt ctgttcttga ctttgacaaa ccttcaagtg caattccaac gtcacaaccg    960

ccttcagcta ctccaggtag ccccgtagca tctaaagaac aaaatctgtc cagtcaaagt   1020

gattttcttc aagagccgtt acaggtattt aacgttaatg cacctctgcc tccacgaaaa   1080

gaacaagaaa taaaagaatc cccttattca cctggctaca atcaaagttt taccacagca   1140

agtacacaaa caccacccca gtgccaactg ccatctatac atgtagaaca aactgtccat   1200

tctcaagaga ctgcagcaaa ttatcatcct gatggaacta ttcaagtaag caatggtagc   1260

cttgcctttt acccagcaca gacgaatgtg tttcccagac ctactcagcc atttgtcaat   1320

agccggggat ctgttagagg atgtactcgt ggtgggagat taataaccaa ttcctatcgg   1380

tcccctggtg gttataaagg ttttgatact tatagaggac tcccttcaat ttccaatgga   1440

aattatagcc agctgcagtt ccaagctaga gagtattctg gagcacctta ttcccaaagg   1500

gataatttcc agcagtgtta taagcgagga gggacatctg gtggtccacg agcaaattcg   1560

agagcagggt ggagtgattc ttctcaggtg agcagcccag aaagagacaa cgaaaccttt   1620

aacagtggtg actctggaca aggagactcc cgtagcatga cccctgtgga tgtgccagtg   1680

acaaatccag cagccaccat actgccagta cacgtctacc ctctgcctca gcagatgcga   1740

gttgccttct cagcagccag aacctctaat ctggcccctg gaactttaga ccaaccttat   1800

ggtgttgatc ttcttctgaa caacttagga gaaacttttg atcttcagct tggtagattt   1860

aattgcccag tgaatggcac ttacgttttc atttttcaca tgctaaagct ggcagtgaat   1920

gtgccactgt atgtcaacct catgaagaat gaagaggtct tggtatcagc ctatgccaat   1980

gatggtgctc cagaccatga aactgctagc aatcatgcaa ttcttcagct cttccaggga   2040

gaccagatat ggttacgtct gcacagggga gcaatttatg gaagtagctg gaaatattct   2100

acgttttcag gctatcttct ttatcaagat tga                                2133


<210>  17

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  17

Pro Tyr Gly Val Asp Leu Leu Leu Asn Asn Leu Gly Glu Thr Phe Asp 
1               5                   10                  15      


Leu Gln Leu Gly Arg Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe 
            20                  25                  30          


Ile Phe His Met 
        35      


<210>  18

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  18

Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln 
1               5                   10                  15      


Ile Trp Leu Arg Leu His 
            20          


<210>  19

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  19

Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln 
1               5                   10                  15      


Ile Trp Leu Arg 
            20  


<210>  20

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  20

Lys Tyr Ser Thr Phe Ser Gly Tyr Leu Leu Tyr 
1               5                   10      


<210>  21

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  21

Ser Thr Phe Ser Gly Tyr Leu Leu Tyr Gln 
1               5                   10  


<210>  22

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  22

Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe Ile Phe His Met Leu 
1               5                   10                  15      


Lys Leu Ala Val 
            20  


<210>  23

<211>  815

<212>  PRT

<213>  Homo sapiens



<400>  23

Phe Asp Thr Tyr Arg Gly Leu Pro Ser Ile Ser Asn Gly Asn Tyr Ser 
1               5                   10                  15      


Gln Leu Gln Phe Gln Ala Arg Glu Tyr Ser Gly Ala Pro Tyr Ser Gln 
            20                  25                  30          


Arg Ile Ser Ala Ile Thr Thr Val Ser Val Ala Trp Lys Val Leu Ser 
        35                  40                  45              


Gly Lys Ile Gly Glu Gly Ala Glu Gly Asn Cys Lys Cys Val Ile Ser 
    50                  55                  60                  


Glu Gly Ala Trp Ala Val Cys Pro Thr Gln Pro Cys Gly Lys Ala Lys 
65                  70                  75                  80  


Pro Asp Lys His Leu Lys Asp Leu Leu Ser Lys Leu Leu Asn Ser Gly 
                85                  90                  95      


Tyr Phe Glu Ser Ile Pro Val Pro Lys Asn Ala Lys Glu Lys Glu Val 
            100                 105                 110         


Pro Leu Glu Glu Glu Met Leu Ile Gln Ser Glu Lys Lys Thr Gln Leu 
        115                 120                 125             


Ser Lys Thr Glu Ser Val Lys Glu Ser Glu Ser Leu Met Glu Phe Ala 
    130                 135                 140                 


Gln Pro Glu Ile Gln Pro Gln Glu Phe Leu Asn Arg Arg Tyr Met Thr 
145                 150                 155                 160 


Glu Val Asp Tyr Ser Asn Lys Gln Gly Glu Glu Gln Pro Trp Glu Ala 
                165                 170                 175     


Asp Tyr Ala Arg Lys Pro Asn Leu Pro Lys Arg Trp Asp Met Leu Thr 
            180                 185                 190         


Glu Pro Asp Gly Gln Glu Lys Lys Gln Glu Ser Phe Lys Ser Trp Glu 
        195                 200                 205             


Ala Ser Gly Lys His Gln Glu Val Ser Lys Pro Ala Val Ser Leu Glu 
    210                 215                 220                 


Gln Arg Lys Gln Asp Thr Ser Lys Leu Arg Ser Thr Leu Pro Glu Glu 
225                 230                 235                 240 


Gln Lys Lys Gln Glu Ile Ser Lys Ser Lys Pro Ser Pro Ser Gln Trp 
                245                 250                 255     


Lys Gln Asp Thr Pro Lys Ser Lys Ala Gly Tyr Val Gln Glu Glu His 
            260                 265                 270         


Lys Lys Gln Glu Thr Pro Lys Leu Trp Pro Val Gln Leu Gln Lys Glu 
        275                 280                 285             


Gln Asp Pro Lys Lys Gln Thr Pro Lys Ser Trp Thr Pro Ser Met Gln 
    290                 295                 300                 


Ser Glu Gln Asn Thr Thr Lys Ser Trp Thr Thr Pro Met Cys Glu Glu 
305                 310                 315                 320 


Gln Asp Ser Lys Gln Pro Glu Thr Pro Lys Ser Trp Glu Asn Asn Val 
                325                 330                 335     


Glu Ser Gln Lys His Ser Leu Thr Ser Gln Ser Gln Ile Ser Pro Lys 
            340                 345                 350         


Ser Trp Gly Val Ala Thr Ala Ser Leu Ile Pro Asn Asp Gln Leu Leu 
        355                 360                 365             


Pro Arg Lys Leu Asn Thr Glu Pro Lys Asp Val Pro Ile Ala Cys Ala 
    370                 375                 380                 


Ser Ala Gly Phe Leu Pro Leu Gln Pro Pro Phe Arg Arg Ile His Val 
385                 390                 395                 400 


Leu Arg Lys Glu Lys Leu Gln Asp Leu Met Thr Gln Ile Gln Gly Thr 
                405                 410                 415     


Cys Asn Phe Met Gln Glu Ser Val Leu Asp Phe Asp Lys Pro Ser Ser 
            420                 425                 430         


Ala Ile Pro Thr Ser Gln Pro Pro Ser Ala Thr Pro Gly Pro Arg Arg 
        435                 440                 445             


His Leu Lys Glu Gln Asn Leu Ser Val Lys Val Ile Phe Phe Gln Gly 
    450                 455                 460                 


Ala Val Thr Val Phe Asn Val Asn Ala Pro Leu Pro Pro Arg Lys Glu 
465                 470                 475                 480 


Gln Glu Ile Lys Glu Ser Pro Tyr Ser Pro Gly Tyr Asn Gln Ser Phe 
                485                 490                 495     


Thr Thr Ala Ser Thr Gln Thr Pro Pro Gln Cys Gln Leu Pro Ser Ile 
            500                 505                 510         


His Val Glu Gln Thr Val His Ser Gln Glu Thr Ala Asn Tyr His Pro 
        515                 520                 525             


Asp Gly Thr Ile Gln Val Ser Asn Gly Ser Leu Ala Phe Tyr Pro Ala 
    530                 535                 540                 


Gln Thr Asn Val Phe Pro Arg Pro Thr Gln Pro Phe Val Asn Ser Arg 
545                 550                 555                 560 


Gly Ser Val Arg Gly Cys Thr Arg Gly Gly Arg Leu Ile Thr Asn Ser 
                565                 570                 575     


Tyr Arg Ser Pro Gly Gly Tyr Lys Gly Phe Asp Thr Tyr Arg Gly Leu 
            580                 585                 590         


Pro Ser Ile Ser Asn Gly Asn Tyr Ser Gln Leu Gln Phe Gln Ala Arg 
        595                 600                 605             


Glu Tyr Ser Gly Ala Pro Tyr Ser Gln Arg Asp Asn Phe Gln Gln Cys 
    610                 615                 620                 


Tyr Lys Arg Gly Gly Thr Ser Gly Gly Pro Arg Ala Asn Ser Arg Ala 
625                 630                 635                 640 


Gly Trp Ser Asp Ser Ser Gln Val Ser Ser Pro Glu Arg Asp Asn Glu 
                645                 650                 655     


Thr Phe Asn Ser Gly Asp Ser Gly Gln Gly Asp Ser Arg Ser Met Thr 
            660                 665                 670         


Pro Val Asp Val Pro Val Thr Asn Pro Ala Ala Thr Ile Leu Pro Val 
        675                 680                 685             


His Val Tyr Pro Leu Pro Gln Gln Met Arg Val Ala Phe Ser Ala Ala 
    690                 695                 700                 


Arg Thr Ser Asn Leu Ala Pro Gly Thr Leu Asp Gln Pro Ile Val Phe 
705                 710                 715                 720 


Asp Leu Leu Leu Asn Asn Leu Gly Glu Thr Phe Asp Leu Gln Leu Gly 
                725                 730                 735     


Arg Phe Asn Cys Pro Val Asn Gly Thr Tyr Val Phe Ile Phe His Met 
            740                 745                 750         


Leu Lys Leu Ala Val Asn Val Pro Leu Tyr Val Asn Leu Met Lys Asn 
        755                 760                 765             


Glu Glu Val Leu Val Ser Ala Tyr Ala Asn Asp Gly Ala Pro Asp His 
    770                 775                 780                 


Glu Thr Ala Ser Asn His Ala Ile Leu Gln Leu Phe Gln Gly Asp Gln 
785                 790                 795                 800 


Ile Trp Leu Arg Leu His Arg Gly Ala Ile Tyr Gly Ser Ser Trp 
                805                 810                 815 


<210>  24

<211>  185

<212>  PRT

<213>  Homo sapiens



<400>  24

Gly Ala Ser Pro Asn Gln Gly Gln Asn Arg Pro His Ala Arg Gln Arg 
1               5                   10                  15      


Ala Pro Pro Gln Gly Pro Pro Gly Glu Pro Glu Arg Arg Ala Pro Leu 
            20                  25                  30          


Pro Ser Gly His Gly Glu Pro Cys Arg His Arg Pro Pro Pro Phe Pro 
        35                  40                  45              


Gln Pro Pro Ala Gly Thr Gln Lys Pro Leu Leu Gln Gly Pro Gly Gly 
    50                  55                  60                  


Gly Pro Ala Glu Asn Ala Pro Thr Ala Ala Leu Gly Ser Pro Ala Pro 
65                  70                  75                  80  


Pro Arg Gly Cys Gln Ala Ala Pro Pro Pro Arg Ser Gly Ala Gly Arg 
                85                  90                  95      


Pro Asp Leu Pro Thr Leu Ala Gly Pro Arg Pro Ala Pro Ala Pro Pro 
            100                 105                 110         


Pro Ser Ala Ala Pro Pro Pro Pro Pro Ser Gly Ala Pro Ser Arg Pro 
        115                 120                 125             


Ala Ala Gly Arg Gln Arg Leu Ser Gly Val Ser Ser Gly Pro Ser Leu 
    130                 135                 140                 


Gly Trp Trp Val Gly Arg Gly Arg Gly Leu Pro Ala Phe Ala Gln Ile 
145                 150                 155                 160 


Ala Gly His Gln Val Gly Pro Arg Arg Arg Arg Thr Pro Ala Gly Arg 
                165                 170                 175     


Lys Pro Arg Ser Pro Ala Gly Pro Arg 
            180                 185 


<210>  25

<211>  475

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(475)

<223>  n = A, T, G, or C



<400>  25
ntttgaacgc cctgcggtac cggtccggaa ttcccgggtc gacccacgcg tccggcctcc     60

cagggccccc tgggttccct ggtataggga aacccggagt ggcaggactt catggccccc    120

cagggaagcc tggtgccctt ggtcctcaag gccagcctgg ccttccagga cccccaggcc    180

ctccaggacc tccaggaccc ccagctgtga tgccccctac accaccaccc cagggagagt    240

atctgccaaa tatggggctg ggaattgatg gcgtgaaacc cccccatgcc tacggggcta    300

agaaaggcaa gaatggaggg ccagcctatg agatgcctgc atttaccgcc gagctaaccg    360

cacctttccc accggtgggg gccccagtga agtttaacaa actgctgtat aacggcagac    420

agaactacaa cccgcagaca ggcatcttca cctgtgaggt ccctggtgtc tacta         475


<210>  26

<211>  3443

<212>  DNA

<213>  Homo sapiens



<400>  26
gcacgagtaa ggacagaaaa gtgaaatgca gtatggtgaa gaggataccc tgaatatgta     60

tgaagacatg ctgttgtgag acggagttgt gaaacagagg ccacagaagc tgttgtgaag    120

gcagagcagc atctgctgaa gagacagaaa ccagccccag aggtgtcaca ggaaggcacc    180

agcaaggaca ttggtctttg atttgattca gcagtcctgt caagtataaa tgtgatggct    240

gtgctgcctg gccctctgca gctgctggga gtgctgctta ccatttccct gagttccatc    300

aggctcattc aggctggtgc ctactatggg atcaagccgc tgccacctca aattcctcct    360

cagatgccac cacaaattcc acaataccag cccctgggtc agcaagtacc tcacatgcct    420

ttggccaaag atggccttgc catgggcaag gagatgcccc acttgcagta tggcaaagag    480

tatccacacc taccccaata tatgaaggaa attcaaccgg cgccaagaat gggcaaggaa    540

gccgttccca agaaaggcaa agaaatacca ttagccagtt tacgagggga acaaggtccc    600

cgtggagagc ctggcccaag aggaccacct gggccccctg gtttaccagg tcatgggata    660

cctggaatta aaggaaaacc agggccacag ggatatccag gagttggaaa gccaggtatg    720

cctggaatgc cagggaagcc aggagccatg ggcatgcctg gggcaaaagg agaaattgga    780

cagaaagggg aaattgggcc tatggggatc ccatgaccac aaggacctcc agggcctcat    840

ggacttcctg gcattgggaa gccaggtggg ccagggttac cagggcaacc aggaccaaag    900

ggtgatcgag gacccaaagg actaccagga cctcaaggcc ttcggggtcc taaaggagac    960

aagggcttcg ggatgccagg tgcgccaggt gtaaaggggc ctccagggat gcacggccct   1020

cccggccctg ttggactgcc aggagtgggc aaaccaggag tgacaggctt ccctgggccc   1080

ccagggcccc ctggggaaag ccaggggctc caggagaacc tgggccacaa ggccctattg   1140

gggtaccggg ggttcaagga cctcctggga tacccggaat tggaaagcca ggccaggatg   1200

gggatcccag gccagccagg atttccaggt ggcaaagggg agcaaggact gccagggcta   1260

ccaggacccc caggccttcc agggattggg aaaccaggct tcccaggacc caaaggtgac   1320

cggggcatgg gaggtgttcc tggggctctt ggaccaagag gggagaaagg accaataggt   1380

gccccaggaa tagggggtcc tccaggagag ccaggcctgc ctggaatccc aggtcctatg   1440

ggccctccag gtgctattgg ttttcctgga cccaaaggag aaggtgggat tgtagggcca   1500

caggggccac caggtcccaa gggtgagcca gggcttcaag gcttcccagg aaagccaggt   1560

ttccttggtg aagtagggcc tcctggcatg aggggtttcc caggtcccat aggccccaag   1620

ggggaacatg ggcaaaaagg tgtaccagga ctccctggtg ttccagggct tctcggacct   1680

aagggagaac caggaatccc aggggatcag ggtttacagg gccccccagg tatcccaggg   1740

attgggggcc ctagtggccc cattggacca cctgggattc caggccccaa aggggagcct   1800

ggcctcccag ggccccctgg gttccctggt atagggaaac ccggagtggc aggacttcat   1860

ggccccccag ggaagcctgg tgcccttggt cctcaaggcc agcctggcct tccaggaccc   1920

ccaggccctc caggacctcc aggaccccca gctgtgatgc cccctacacc accaccccag   1980

ggagagtatc tgccagatat ggggctggga attgatggcg tgaaaccccc ccatgcctac   2040

ggggctaaga aaggcaagaa tggagggcca gcctatgaga tgcctgcatt taccgccgag   2100

ctaaccgcac ctttcccacc ggtgggggcc ccagtgaagt ttaacaaact gctgtataac   2160

ggcagacaga actacaaccc gcagacaggc atcttcacct gtgaggtccc tggtgtctac   2220

tactttgcat accacgttca ctgcaagggg ggcaacgtgt gggttgctct attcaagaac   2280

aacgagcccg tgatgtacac gtacgacgag tacaaaaagg gcttcctgga ccaggcatct   2340

gggagtgcag tgctgctgct caggcccgga gaccgggtgt tcctccagat gccctcagaa   2400

caggctgcag gactgtatgc cgggcagtat gtccactcct ccttttcagg atatttattg   2460

tatcccatgt aaaaacaaaa aaacaaaaaa caaagaaaag aaagagattt tatagaagaa   2520

aatgacacac caaaaaatcc aaatgaaaaa cataattgct tcaaaacact tacacagttg   2580

gaaagttata tgtaagtgaa aatttggacc attgtgtaca aataaaaact aagatgcatg   2640

tttaatactc cacacagcag cctgtaattg cgaatgatgg gatagagtta tgtatcaagt   2700

actgacactt ggttgtaccc actggaatca tattagctgt tttatgttat atgcttccac   2760

agtaacctgc ttattcagat cagtcaaaat atatcagtat gaaagatcat agctaatgaa   2820

aggcactcac tcatattgtt tactttaaaa tatttataaa tatgccttaa agaaatacaa   2880

atgataacaa ttacataccg tatttacttg cttaatttcc tctgtatttg tgtagatact   2940

ttgacatgga atatatggtg gggagacccg tagtgttacc gccccagtgg gagggggccc   3000

tggggaccct ggtaatgctt tagtcaaagg gatatctctc ttgtatcaga ggctgtgtct   3060

tttagtaaca ggagtcctcg tcagaattgc gtgtctgttg tctctaaaag aatgggtgaa   3120

ccaatcggcc tttgtgaatt tattcagtgc cttctctgta ccaagcactg ggtaaggcac   3180

ttttgtggag cattagacag taaccctcaa ggagctagag aaccggatgg gagacatgag   3240

cggtaattaa ctcacttgtt ccccagagtt tctatttgtt ttgattttct ttttctgtga   3300

cttattttcc tattttcttt cctccatgta attttcacta tggcccaact aatataaaca   3360

cctggaaatt acaaggaaaa aaaattcttc ctctaataac tttccaaatt tgtggaatat   3420

ttatttggaa tagcaggtat cag                                           3443


<210>  27

<211>  2487

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (235)..(2469)

<223>  



<400>  27
gcacgagtaa ggacagaaaa gtgaaatgca gtatggtgaa gaggataccc tgaatatgta     60

tgaagacatg ctgttgtgag acggagttgt gaaacagagg ccacagaagc tgttgtgaag    120

gcagagcagc atctgctgaa gagacagaaa ccagccccag aggtgtcaca ggaaggcacc    180

agcaaggaca ttggtctttg atttgattca gcagtcctgt caagtataaa tgtg atg      237
                                                            Met         
                                                            1           

gct gtg ctg cct ggc cct ctg cag ctg ctg gga gtg ctg ctt acc att      285
Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr Ile         
            5                   10                  15                  

tcc ctg agt tcc atc agg ctc att cag gct ggt gcc tac tat ggg atc      333
Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly Ile         
        20                  25                  30                      

aag ccg ctg cca cct caa att cct cct cag atg cca cca caa att cca      381
Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile Pro         
    35                  40                  45                          

caa tac cag ccc ctg ggt cag caa gta cct cac atg cct ttg gcc aaa      429
Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala Lys         
50                  55                  60                  65          

gat ggc ctc gcc atg ggc aag gag atg ccc cac ttg cag tat ggc aaa      477
Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly Lys         
                70                  75                  80              

gag tat cca cac cta ccc caa tat atg aag gaa att caa ccg gcg cca      525
Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala Pro         
            85                  90                  95                  

aga atg ggc aag gaa gcc gtt ccc aag aaa ggc aaa gaa ata cca tta      573
Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro Leu         
        100                 105                 110                     

gcc agt tta cga ggg gaa caa ggt ccc cgt gga gag cct ggc cca aga      621
Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro Arg         
    115                 120                 125                         

gga cca cct ggg ccc cct ggt tta cca ggt cat ggg ata cct gga att      669
Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly Ile         
130                 135                 140                 145         

aaa gga aaa cca ggg cca cag gga tat cca gga gtt gga aag cca ggt      717
Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro Gly         
                150                 155                 160             

atg cct gga atg cca ggg aag cca gga gcc atg ggc atg cct ggg gca      765
Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly Ala         
            165                 170                 175                 

aaa gga gaa att gga cag aaa ggg gaa att ggg cct atg ggg atc cca      813
Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile Pro         
        180                 185                 190                     

gga cca caa gga cct cca ggg cct cat gga ctt cct ggc att ggg aag      861
Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly Lys         
    195                 200                 205                         

cca ggt ggg cca ggg tta cca ggg caa cca gga cca aag ggt gat cga      909
Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg         
210                 215                 220                 225         

gga ccc aaa gga cta cca gga cct caa ggc ctt cgg ggt cct aaa gga      957
Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys Gly         
                230                 235                 240             

gac aag ggc ttc ggg atg cca ggt gcg cca ggt gta aag ggg cct cca     1005
Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro Pro         
            245                 250                 255                 

ggg atg cac ggc cct ccc ggc cct gtt gga ctg cca gga gtg ggc aaa     1053
Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly Lys         
        260                 265                 270                     

cca gga gtg aca ggc ttc cct ggg ccc cag ggc ccc ctg gga aag cca     1101
Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys Pro         
    275                 280                 285                         

ggg gct cca gga gaa cct ggg cca caa ggc cct att ggg gta ccg ggg     1149
Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro Gly         
290                 295                 300                 305         

gtt caa gga cct cct ggg ata ccc gga att gga aag cca ggc cag gat     1197
Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln Asp         
                310                 315                 320             

ggg atc cca ggc cag cca gga ttt cca ggt ggc aaa ggg gag caa gga     1245
Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly         
            325                 330                 335                 

ctg cca ggg cta cca gga ccc cca ggc ctt cca ggg att ggg aaa cca     1293
Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys Pro         
        340                 345                 350                     

ggc ttc cca gga ccc aaa ggt gac cgg ggc atg gga ggt gtt cct ggg     1341
Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro Gly         
    355                 360                 365                         

gct ctt gga cca aga ggg gag aaa gga cca ata ggt gcc cca gga ata     1389
Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly Ile         
370                 375                 380                 385         

ggg ggt cct cca gga gag cca ggc ctg cct gga atc cca ggt cct atg     1437
Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met         
                390                 395                 400             

ggc cct cca ggt gct att ggt ttt cct gga ccc aaa gga gaa ggt ggg     1485
Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly Gly         
            405                 410                 415                 

att gta ggg cca cag ggg cca cca ggt ccc aag ggt gag cca ggg ctt     1533
Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Leu         
        420                 425                 430                     

caa ggc ttc cca gga aag cca ggt ttc ctt ggt gaa gta ggg cct cct     1581
Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro         
    435                 440                 445                         

ggc atg agg ggt ttc cca ggt ccc ata ggc ccc aag ggg gaa cat ggg     1629
Gly Met Arg Gly Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu His Gly         
450                 455                 460                 465         

caa aaa ggt gta cca gga ctc cct ggt gtt cca ggg ctt ctc gga cct     1677
Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly Pro         
                470                 475                 480             

aag gga gaa cca gga atc cca ggg gat cag ggt tta cag ggc ccc cca     1725
Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro Pro         
            485                 490                 495                 

ggt atc cca ggg att ggg ggc cct agt ggc ccc att gga cca cct ggg     1773
Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly         
        500                 505                 510                     

att cca ggc ccc aaa ggg gag cct ggc ctc cca ggg ccc cct ggg ttc     1821
Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Phe         
    515                 520                 525                         

cct ggt ata ggg aaa ccc gga gtg gca gga ctt cat ggc ccc cca ggg     1869
Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro Gly         
530                 535                 540                 545         

aag cct ggt gcc ctt ggt cct caa ggc cag cct ggc ctt cca gga ccc     1917
Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro         
                550                 555                 560             

cca ggc cct cca gga cct cca gga ccc cca gct gtg atg ccc cct aca     1965
Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr         
            565                 570                 575                 

cca cca ccc cag gga gag tat ctg cca gat atg ggg ctg gga att gat     2013
Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile Asp         
        580                 585                 590                     

ggc gtg aaa ccc ccc cat gcc tac ggg gct aag aaa ggc aag aat gga     2061
Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn Gly         
    595                 600                 605                         

ggg cca gcc tat gag atg cct gca ttt acc gcc gag cta acc gca cct     2109
Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala Pro         
610                 615                 620                 625         

ttc cca ccg gtg ggg gcc cca gtg aag ttt aac aaa ctg ctg tat aac     2157
Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr Asn         
                630                 635                 640             

ggc aga cag aac tac aac ccg cag aca ggc atc ttc acc tgt gag gtc     2205
Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu Val         
            645                 650                 655                 

cct ggt gtc tac tac ttt gca tac cac gtt cac tgc aag ggg ggc aac     2253
Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly Asn         
        660                 665                 670                     

gtg tgg gtt gct cta ttc aag aac aac gag ccc gtg atg tac acg tac     2301
Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr Tyr         
    675                 680                 685                         

gac gag tac aaa aag ggc ttc ctg gac cag gca tct ggg agt gca gtg     2349
Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala Val         
690                 695                 700                 705         

ctg ctg ctc agg ccc gga gac cgg gtg ttc ctc cag atg ccc tca gaa     2397
Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser Glu         
                710                 715                 720             

cag gct gca gga ctg tat gcc ggg cag tat gtc cac tcc tcc ttt tca     2445
Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe Ser         
            725                 730                 735                 

gga tat tta ttg tat ccc atg taa aaacaaaaaa aaaaaaaa                 2487
Gly Tyr Leu Leu Tyr Pro Met                                             
        740                                                             


<210>  28

<211>  744

<212>  PRT

<213>  Homo sapiens



<400>  28

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly 
            20                  25                  30          


Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile 
        35                  40                  45              


Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro His Met Pro Leu Ala 
    50                  55                  60                  


Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly 
65                  70                  75                  80  


Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala 
                85                  90                  95      


Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro 
            100                 105                 110         


Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro 
        115                 120                 125             


Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly 
    130                 135                 140                 


Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro 
145                 150                 155                 160 


Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
                165                 170                 175     


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile 
            180                 185                 190         


Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly Leu Pro Gly Ile Gly 
        195                 200                 205             


Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp 
    210                 215                 220                 


Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
225                 230                 235                 240 


Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro 
                245                 250                 255     


Pro Gly Met His Gly Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            260                 265                 270         


Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys 
        275                 280                 285             


Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
    290                 295                 300                 


Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln 
305                 310                 315                 320 


Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln 
                325                 330                 335     


Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys 
            340                 345                 350         


Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
        355                 360                 365             


Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly 
    370                 375                 380                 


Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro 
385                 390                 395                 400 


Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
                405                 410                 415     


Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly 
            420                 425                 430         


Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro 
        435                 440                 445             


Pro Gly Met Arg Gly Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu His 
    450                 455                 460                 


Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro 
                485                 490                 495     


Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            500                 505                 510         


Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
        515                 520                 525             


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro 
    530                 535                 540                 


Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
545                 550                 555                 560 


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro 
                565                 570                 575     


Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile 
            580                 585                 590         


Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala Lys Lys Gly Lys Asn 
        595                 600                 605             


Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr Ala Glu Leu Thr Ala 
    610                 615                 620                 


Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr 
625                 630                 635                 640 


Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu 
                645                 650                 655     


Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His Cys Lys Gly Gly 
            660                 665                 670         


Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu Pro Val Met Tyr Thr 
        675                 680                 685             


Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala 
    690                 695                 700                 


Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe Leu Gln Met Pro Ser 
705                 710                 715                 720 


Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr Val His Ser Ser Phe 
                725                 730                 735     


Ser Gly Tyr Leu Leu Tyr Pro Met 
            740                 


<210>  29

<211>  2235

<212>  DNA

<213>  Homo sapiens



<400>  29
atggctgtgc tgcctggccc tctgcagctg ctgggagtgc tgcttaccat ttccctgagt     60

tccatcaggc tcattcaggc tggtgcctac tatgggatca agccgctgcc acctcaaatt    120

cctcctcaga tgccaccaca aattccacaa taccagcccc tgggtcagca agtacctcac    180

atgcctttgg ccaaagatgg cctcgccatg ggcaaggaga tgccccactt gcagtatggc    240

aaagagtatc cacacctacc ccaatatatg aaggaaattc aaccggcgcc aagaatgggc    300

aaggaagccg ttcccaagaa aggcaaagaa ataccattag ccagtttacg aggggaacaa    360

ggtccccgtg gagagcctgg cccaagagga ccacctgggc cccctggttt accaggtcat    420

gggatacctg gaattaaagg aaaaccaggg ccacagggat atccaggagt tggaaagcca    480

ggtatgcctg gaatgccagg gaagccagga gccatgggca tgcctggggc aaaaggagaa    540

attggacaga aaggggaaat tgggcctatg gggatcccag gaccacaagg acctccaggg    600

cctcatggac ttcctggcat tgggaagcca ggtgggccag ggttaccagg gcaaccagga    660

ccaaagggtg atcgaggacc caaaggacta ccaggacctc aaggccttcg gggtcctaaa    720

ggagacaagg gcttcgggat gccaggtgcg ccaggtgtaa aggggcctcc agggatgcac    780

ggccctcccg gccctgttgg actgccagga gtgggcaaac caggagtgac aggcttccct    840

gggccccagg gccccctggg aaagccaggg gctccaggag aacctgggcc acaaggccct    900

attggggtac cgggggttca aggacctcct gggatacccg gaattggaaa gccaggccag    960

gatgggatcc caggccagcc aggatttcca ggtggcaaag gggagcaagg actgccaggg   1020

ctaccaggac ccccaggcct tccagggatt gggaaaccag gcttcccagg acccaaaggt   1080

gaccggggca tgggaggtgt tcctggggct cttggaccaa gaggggagaa aggaccaata   1140

ggtgccccag gaataggggg tcctccagga gagccaggcc tgcctggaat cccaggtcct   1200

atgggccctc caggtgctat tggttttcct ggacccaaag gagaaggtgg gattgtaggg   1260

ccacaggggc caccaggtcc caagggtgag ccagggcttc aaggcttccc aggaaagcca   1320

ggtttccttg gtgaagtagg gcctcctggc atgaggggtt tcccaggtcc cataggcccc   1380

aagggggaac atgggcaaaa aggtgtacca ggactccctg gtgttccagg gcttctcgga   1440

cctaagggag aaccaggaat cccaggggat cagggtttac agggcccccc aggtatccca   1500

gggattgggg gccctagtgg ccccattgga ccacctggga ttccaggccc caaaggggag   1560

cctggcctcc cagggccccc tgggttccct ggtataggga aacccggagt ggcaggactt   1620

catggccccc cagggaagcc tggtgccctt ggtcctcaag gccagcctgg ccttccagga   1680

cccccaggcc ctccaggacc tccaggaccc ccagctgtga tgccccctac accaccaccc   1740

cagggagagt atctgccaga tatggggctg ggaattgatg gcgtgaaacc cccccatgcc   1800

tacggggcta agaaaggcaa gaatggaggg ccagcctatg agatgcctgc atttaccgcc   1860

gagctaaccg cacctttccc accggtgggg gccccagtga agtttaacaa actgctgtat   1920

aacggcagac agaactacaa cccgcagaca ggcatcttca cctgtgaggt ccctggtgtc   1980

tactactttg cataccacgt tcactgcaag gggggcaacg tgtgggttgc tctattcaag   2040

aacaacgagc ccgtgatgta cacgtacgac gagtacaaaa agggcttcct ggaccaggca   2100

tctgggagtg cagtgctgct gctcaggccc ggagaccggg tgttcctcca gatgccctca   2160

gaacaggctg caggactgta tgccgggcag tatgtccact cctccttttc aggatattta   2220

ttgtatccca tgtaa                                                    2235


<210>  30

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  30

Met Ala Val Leu Pro Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr 
1               5                   10                  15      


Ile Ser Leu Ser Ser Ile Arg Leu Ile Gln Ala 
            20                  25          


<210>  31

<211>  717

<212>  PRT

<213>  Homo sapiens



<400>  31

Gly Ala Tyr Tyr Gly Ile Lys Pro Leu Pro Pro Gln Ile Pro Pro Gln 
1               5                   10                  15      


Met Pro Pro Gln Ile Pro Gln Tyr Gln Pro Leu Gly Gln Gln Val Pro 
            20                  25                  30          


His Met Pro Leu Ala Lys Asp Gly Leu Ala Met Gly Lys Glu Met Pro 
        35                  40                  45              


His Leu Gln Tyr Gly Lys Glu Tyr Pro His Leu Pro Gln Tyr Met Lys 
    50                  55                  60                  


Glu Ile Gln Pro Ala Pro Arg Met Gly Lys Glu Ala Val Pro Lys Lys 
65                  70                  75                  80  


Gly Lys Glu Ile Pro Leu Ala Ser Leu Arg Gly Glu Gln Gly Pro Arg 
                85                  90                  95      


Gly Glu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Leu Pro Gly 
            100                 105                 110         


His Gly Ile Pro Gly Ile Lys Gly Lys Pro Gly Pro Gln Gly Tyr Pro 
        115                 120                 125             


Gly Val Gly Lys Pro Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala 
    130                 135                 140                 


Met Gly Met Pro Gly Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile 
145                 150                 155                 160 


Gly Pro Met Gly Ile Pro Gly Pro Gln Gly Pro Pro Gly Pro His Gly 
                165                 170                 175     


Leu Pro Gly Ile Gly Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro 
            180                 185                 190         


Gly Pro Lys Gly Asp Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly 
        195                 200                 205             


Leu Arg Gly Pro Lys Gly Asp Lys Gly Phe Gly Met Pro Gly Ala Pro 
    210                 215                 220                 


Gly Val Lys Gly Pro Pro Gly Met His Gly Pro Pro Gly Pro Val Gly 
225                 230                 235                 240 


Leu Pro Gly Val Gly Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln 
                245                 250                 255     


Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly 
            260                 265                 270         


Pro Ile Gly Val Pro Gly Val Gln Gly Pro Pro Gly Ile Pro Gly Ile 
        275                 280                 285             


Gly Lys Pro Gly Gln Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly 
    290                 295                 300                 


Gly Lys Gly Glu Gln Gly Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu 
305                 310                 315                 320 


Pro Gly Ile Gly Lys Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly 
                325                 330                 335     


Met Gly Gly Val Pro Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro 
            340                 345                 350         


Ile Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro 
        355                 360                 365             


Gly Ile Pro Gly Pro Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly 
    370                 375                 380                 


Pro Lys Gly Glu Gly Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro 
385                 390                 395                 400 


Lys Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu 
                405                 410                 415     


Gly Glu Val Gly Pro Pro Gly Met Arg Gly Phe Pro Gly Pro Ile Gly 
            420                 425                 430         


Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val 
        435                 440                 445             


Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln 
    450                 455                 460                 


Gly Leu Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly 
465                 470                 475                 480 


Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu 
                485                 490                 495     


Pro Gly Pro Pro Gly Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly 
            500                 505                 510         


Leu His Gly Pro Pro Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln 
        515                 520                 525             


Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
    530                 535                 540                 


Ala Val Met Pro Pro Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro Asp 
545                 550                 555                 560 


Met Gly Leu Gly Ile Asp Gly Val Lys Pro Pro His Ala Tyr Gly Ala 
                565                 570                 575     


Lys Lys Gly Lys Asn Gly Gly Pro Ala Tyr Glu Met Pro Ala Phe Thr 
            580                 585                 590         


Ala Glu Leu Thr Ala Pro Phe Pro Pro Val Gly Ala Pro Val Lys Phe 
        595                 600                 605             


Asn Lys Leu Leu Tyr Asn Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly 
    610                 615                 620                 


Ile Phe Thr Cys Glu Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val 
625                 630                 635                 640 


His Cys Lys Gly Gly Asn Val Trp Val Ala Leu Phe Lys Asn Asn Glu 
                645                 650                 655     


Pro Val Met Tyr Thr Tyr Asp Glu Tyr Lys Lys Gly Phe Leu Asp Gln 
            660                 665                 670         


Ala Ser Gly Ser Ala Val Leu Leu Leu Arg Pro Gly Asp Arg Val Phe 
        675                 680                 685             


Leu Gln Met Pro Ser Glu Gln Ala Ala Gly Leu Tyr Ala Gly Gln Tyr 
    690                 695                 700                 


Val His Ser Ser Phe Ser Gly Tyr Leu Leu Tyr Pro Met 
705                 710                 715         


<210>  32

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  32

Pro Val Lys Phe Asn Lys Leu Leu Tyr Asn Gly Arg Gln Asn Tyr Asn 
1               5                   10                  15      


Pro Gln Thr Gly Ile Phe Thr Cys Glu Val Pro Gly Val Tyr Tyr Phe 
            20                  25                  30          


Ala Tyr His Val 
        35      


<210>  33

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  33

Phe Thr Cys Glu Val Pro Gly Val Tyr Tyr Phe Ala Tyr His Val His 
1               5                   10                  15      


Cys Lys Gly Gly 
            20  


<210>  34

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  34

Phe Pro Pro Val Gly Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr Asn 
1               5                   10                  15      


Gly Arg Gln Asn Tyr Asn Pro Gln Thr Gly Ile 
            20                  25          


<210>  35

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  35

Asp Gln Ala Ser Gly Ser Ala Val Leu Leu Leu Arg Pro Gly Asp Arg 
1               5                   10                  15      


Val Phe Leu Gln Met Pro 
            20          


<210>  36

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  36

Asp Gln Ala Ser Gly Ser Ala Val Leu Leu Leu Arg Pro Gly Asp Arg 
1               5                   10                  15      


Val Phe Leu Gln 
            20  


<210>  37

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  37

Pro Gly Pro His Gly Leu Pro Gly Ile Gly Lys Pro Gly Gly Pro Gly 
1               5                   10                  15      


Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg 
            20                  25          


<210>  38

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  38

Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly Gly 
1               5                   10                  15      


Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  39

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  39

Gly Pro Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly 
1               5                   10                  15      


Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro 
            20                  25          


<210>  40

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  40

Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met Gly 
1               5                   10                  15      


Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys 
            20                  25          


<210>  41

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  41

Gly Val Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly Ile Pro Gly 
1               5                   10                  15      


Asp Gln Gly Leu Gln Gly Pro Pro Gly Ile Pro 
            20                  25          


<210>  42

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  42

Gly Lys Pro Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly 
1               5                   10                  15      


Met Pro Gly Ala Lys Gly Glu Ile Gly Gln Lys 
            20                  25          


<210>  43

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  43

Val His Ser Ser Phe Ser Gly Tyr Leu Leu Tyr 
1               5                   10      


<210>  44

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  44

Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly 
1               5                   10                  15      


Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg 
            20                  25          


<210>  45

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  45

Gly Lys Pro Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly 
1               5                   10                  15      


Met Pro Gly Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu 
            20                  25                  


<210>  46

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  46

Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly 
1               5                   10                  15      


Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro 
            20                  25          


<210>  47

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  47

Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly 
1               5                   10                  15      


Ile Pro Gly Pro Met Gly Pro Pro Gly Ala Ile 
            20                  25          


<210>  48

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  48

Gly Lys Pro Gly Gln Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly 
1               5                   10                  15      


Gly Lys Gly Glu Gln Gly Leu Pro Gly Leu Pro 
            20                  25          


<210>  49

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  49

Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro Gly 
1               5                   10                  15      


Met Arg Gly Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu 
            20                  25                  


<210>  50

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  50

Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Phe Pro Gly Ile Gly Lys Pro Gly 
            20                  25          


<210>  51

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  51

Gly Met Pro Gly Ala Pro Gly Val Lys Gly Pro Pro Gly Met His Gly 
1               5                   10                  15      


Pro Pro Gly Pro Val Gly Leu Pro Gly Val Gly 
            20                  25          


<210>  52

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  52

Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly 
1               5                   10                  15      


Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro 
            20                  25          


<210>  53

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  53

Gly Pro Pro Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            20                  25          


<210>  54

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  54

Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Pro Gly Leu Pro Gly Pro Pro Gly Phe Pro 
            20                  25          


<210>  55

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  55

Gly Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro Gly Ala Ile Gly 
1               5                   10                  15      


Phe Pro Gly Pro Lys Gly Glu Gly Gly Ile Val 
            20                  25          


<210>  56

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  56

Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
            20                  25          


<210>  57

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  57

Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met Gly 
1               5                   10                  15      


Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  58

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  58

Gly Pro Ile Gly Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro Gly 
1               5                   10                  15      


Leu Pro Gly Val Pro Gly Leu Leu Gly Pro Lys Gly Glu 
            20                  25                  


<210>  59

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  59

Pro Gly Ile Gly Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly 
1               5                   10                  15      


Pro Lys Gly Asp Arg Gly Pro Lys Gly Leu Pro 
            20                  25          


<210>  60

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  60

Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly 
1               5                   10                  15      


Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro 
            20                  25          


<210>  61

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  61

Gly Pro Pro Gly Met Arg Gly Phe Pro Gly Pro Ile Gly Pro Lys Gly 
1               5                   10                  15      


Glu His Gly Gln Lys Gly Val Pro Gly Leu Pro 
            20                  25          


<210>  62

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  62

Ser Ser Phe Ser Gly Tyr Leu Leu Tyr Pro 
1               5                   10  


<210>  63

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  63

Gly Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly 
1               5                   10                  15      


Asp Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln 
            20                  25          


<210>  64

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  64

Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro Gly 
1               5                   10                  15      


Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly Gly Ile 
            20                  25                  


<210>  65

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  65

Pro Gly Ile Gly Lys Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly 
1               5                   10                  15      


Met Gly Gly Val Pro Gly Ala Leu Gly Pro Arg Gly Glu 
            20                  25                  


<210>  66

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  66

Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Leu Gln Gly 
1               5                   10                  15      


Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val 
            20                  25          


<210>  67

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  67

Pro Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro Gly Met Pro Gly 
1               5                   10                  15      


Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro 
            20                  25          


<210>  68

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  68

Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly 
1               5                   10                  15      


Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro 
            20                  25          


<210>  69

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  69

Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly Ile Gly Gly 
1               5                   10                  15      


Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro 
            20                  25          


<210>  70

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  70

Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro Gly Met Arg Gly 
1               5                   10                  15      


Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu His Gly Gln 
            20                  25                  


<210>  71

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  71

Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro Gly Val Gln Gly 
1               5                   10                  15      


Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly 
            20                  25          


<210>  72

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  72

Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Pro Gly Ala Ile Gly Phe Pro 
            20                  25          


<210>  73

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  73

Gly Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly 
1               5                   10                  15      


Val Pro Gly Val Gln Gly Pro Pro Gly Ile Pro 
            20                  25          


<210>  74

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  74

Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly Pro Lys Gly 
1               5                   10                  15      


Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys 
            20                  25          


<210>  75

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  75

Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly Pro Lys Gly 
1               5                   10                  15      


Glu Pro Gly Ile Pro Gly Asp Gln Gly Leu Gln 
            20                  25          


<210>  76

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  76

Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro Gly Met Arg Gly 
1               5                   10                  15      


Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu His 
            20                  25          


<210>  77

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  77

Gly Phe Pro Gly Pro Ile Gly Pro Lys Gly Glu His Gly Gln Lys Gly 
1               5                   10                  15      


Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu 
            20                  25          


<210>  78

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  78

Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln Asp Gly 
1               5                   10                  15      


Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys 
            20                  25          


<210>  79

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  79

Pro Gly Pro Pro Gly Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly 
1               5                   10                  15      


Leu His Gly Pro Pro Gly Lys Pro Gly Ala Leu 
            20                  25          


<210>  80

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  80

Gly Gln Asp Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly 
1               5                   10                  15      


Glu Gln Gly Leu Pro Gly Leu Pro Gly Pro Pro 
            20                  25          


<210>  81

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  81

Gly Pro Ile Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro 
            20                  25          


<210>  82

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  82

Gly Pro Met Gly Pro Pro Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Gly Gly Ile Val Gly Pro Gln Gly Pro Pro 
            20                  25          


<210>  83

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  83

Gly Pro Ile Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro Gly Ala 
            20                  25                  


<210>  84

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  84

Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly 
1               5                   10                  15      


Pro Ile Gly Val Pro Gly Val Gln Gly Pro Pro 
            20                  25          


<210>  85

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  85

Pro Gly Val Gly Lys Pro Gly Met Pro Gly Met Pro Gly Lys Pro Gly 
1               5                   10                  15      


Ala Met Gly Met Pro Gly Ala Lys Gly Glu Ile 
            20                  25          


<210>  86

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  86

Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
1               5                   10                  15      


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile 
            20                  25          


<210>  87

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  87

Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly 
1               5                   10                  15      


Glu Val Gly Pro Pro Gly Met Arg Gly Phe Pro 
            20                  25          


<210>  88

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  88

Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Val Met Pro Pro Thr Pro Pro Pro 
            20                  25          


<210>  89

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  89

Gly Leu Pro Gly Val Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly 
1               5                   10                  15      


Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro Pro 
            20                  25          


<210>  90

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  90

Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln Gly 
1               5                   10                  15      


Leu Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly 
            20                  25          


<210>  91

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  91

Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly Leu Pro Gly Leu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Leu Pro Gly Ile Gly Lys Pro Gly 
            20                  25          


<210>  92

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  92

Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro Gly 
1               5                   10                  15      


Met Arg Gly Phe Pro Gly Pro Ile Gly Pro Lys 
            20                  25          


<210>  93

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  93

Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr 
            20                  25          


<210>  94

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  94

Gly Ile Pro Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly 
1               5                   10                  15      


Leu Pro Gly Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile 
            20                  25                  


<210>  95

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  95

Pro Gly Ile Gly Lys Pro Gly Gln Asp Gly Ile Pro Gly Gln Pro Gly 
1               5                   10                  15      


Phe Pro Gly Gly Lys Gly Glu Gln Gly Leu Pro 
            20                  25          


<210>  96

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  96

Gly Leu His Gly Pro Pro Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly 
1               5                   10                  15      


Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro 
            20                  25          


<210>  97

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  97

Gln Gly Tyr Pro Gly Val Gly Lys Pro Gly Met Pro Gly Met Pro Gly 
1               5                   10                  15      


Lys Pro Gly Ala Met Gly Met Pro Gly Ala Lys Gly Glu 
            20                  25                  


<210>  98

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  98

Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly Leu Leu Gly 
1               5                   10                  15      


Pro Lys Gly Glu Pro Gly Ile Pro Gly Asp Gln 
            20                  25          


<210>  99

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  99

Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly 
1               5                   10                  15      


Phe Pro Gly Ile Gly Lys Pro Gly Val Ala Gly 
            20                  25          


<210>  100

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  100

Gly Met Pro Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly 
1               5                   10                  15      


Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro 
            20                  25                  


<210>  101

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  101

Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met 
            20                  25          


<210>  102

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  102

Gly Val Ala Gly Leu His Gly Pro Pro Gly Lys Pro Gly Ala Leu Gly 
1               5                   10                  15      


Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro Pro 
            20                  25          


<210>  103

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  103

Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys Pro Gly Phe Pro Gly 
1               5                   10                  15      


Pro Lys Gly Asp Arg Gly Met Gly Gly Val Pro 
            20                  25          


<210>  104

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  104

Gly Pro Pro Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro 
            20                  25                  


<210>  105

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  105

Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly Leu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly 
            20                  25          


<210>  106

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  106

Gly Lys Pro Gly Phe Pro Gly Pro Lys Gly Asp Arg Gly Met Gly Gly 
1               5                   10                  15      


Val Pro Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro 
            20                  25                  


<210>  107

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  107

Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr Pro Pro Pro 
1               5                   10                  15  


<210>  108

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  108

Pro Gly Val Gly Lys Pro Gly Met Pro Gly Met Pro Gly Lys Pro Gly 
1               5                   10                  15      


Ala Met Gly Met Pro Gly Ala Lys Gly Glu Ile Gly Gln 
            20                  25                  


<210>  109

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  109

Gly Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro Gly Leu Pro Gly 
1               5                   10                  15      


Val Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro 
            20                  25          


<210>  110

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  110

Gly Pro Gln Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu Pro Gly 
1               5                   10                  15      


Pro Gln Gly Pro Ile Gly Val Pro Gly Val Gln 
            20                  25          


<210>  111

<211>  33

<212>  PRT

<213>  Homo sapiens



<400>  111

Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro 
1               5                   10                  15      


Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr Pro Pro Pro Gln 
            20                  25                  30          


Gly 
    


<210>  112

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  112

Gly Met Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly Ala Lys Gly 
1               5                   10                  15      


Glu Ile Gly Gln Lys Gly Glu Ile Gly Pro Met 
            20                  25          


<210>  113

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  113

Gly Val Pro Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly Pro Ile Gly 
1               5                   10                  15      


Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro 
            20                  25          


<210>  114

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  114

Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly Pro Lys Gly Leu Pro Gly 
1               5                   10                  15      


Pro Gln Gly Leu Arg Gly Pro Lys Gly Asp Lys 
            20                  25          


<210>  115

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  115

Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Phe Pro Gly Ile Gly 
            20                  25          


<210>  116

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  116

Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro Gly Lys Pro Gly 
1               5                   10                  15      


Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro 
            20                  25          


<210>  117

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  117

Gly Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro Gly 
1               5                   10                  15      


Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly 
            20                  25          


<210>  118

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  118

Pro Gly Pro Val Gly Leu Pro Gly Val Gly Lys Pro Gly Val Thr Gly 
1               5                   10                  15      


Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys Pro 
            20                  25          


<210>  119

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  119

Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro Ile Gly Val Pro Gly 
1               5                   10                  15      


Val Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly 
            20                  25          


<210>  120

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  120

Pro Gly Val Gly Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly 
1               5                   10                  15      


Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu Pro 
            20                  25          


<210>  121

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  121

Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro Pro Gly Ile Pro Gly 
1               5                   10                  15      


Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Ile 
            20                  25                  


<210>  122

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  122

Gly Glu Gly Gly Ile Val Gly Pro Gln Gly Pro Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Pro Gly Leu Gln Gly Phe Pro Gly Lys Pro 
            20                  25          


<210>  123

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  123

Gly Leu Gln Gly Pro Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly 
1               5                   10                  15      


Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  124

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  124

Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Ala Val Met Pro Pro Thr 
            20                  


<210>  125

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  125

Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly 
1               5                   10                  15      


Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro 
            20                  25          


<210>  126

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  126

Gly Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro Pro Gly Ile Pro Gly 
1               5                   10                  15      


Ile Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro 
            20                  25          


<210>  127

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  127

Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly Lys Pro Gly Phe Leu Gly 
1               5                   10                  15      


Glu Val Gly Pro Pro Gly Met Arg Gly Phe Pro Gly Pro 
            20                  25                  


<210>  128

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  128

Pro Pro Gly Lys Pro Gly Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu 
1               5                   10                  15      


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met 
            20                  25                  30          


Pro Pro Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro 
        35                  40                  


<210>  129

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  129

Met Pro Gly Ala Pro Gly Val Lys Gly Pro Pro Gly Met His Gly Pro 
1               5                   10                  15      


Pro Gly Pro Val Gly Leu Pro Gly Val Gly Lys Pro Gly Val Thr Gly 
            20                  25                  30          


Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys Pro Gly 
        35                  40                  


<210>  130

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  130

Pro Gln Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro 
1               5                   10                  15      


Gln Gly Pro Ile Gly Val Pro Gly Val Gln Gly Pro Pro Gly Ile Pro 
            20                  25                  30          


Gly Ile Gly Lys Pro Gly Gln Asp Gly Ile Pro Gly 
        35                  40                  


<210>  131

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  131

Gly Pro Pro Gly Ile Pro Gly Ile Gly Gly Pro Ser Gly Pro Ile Gly 
1               5                   10                  15      


Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly Leu 
            20                  25                  


<210>  132

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  132

Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr 
1               5                   10                  15      


Pro Pro 
        


<210>  133

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  133

Gly Glu Val Gly Pro Pro Gly Met Arg Gly Phe Pro Gly Pro Ile Gly 
1               5                   10                  15      


Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro 
            20                  25          


<210>  134

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  134

Gly Glu His Gly Gln Lys Gly Val Pro Gly Leu Pro Gly Val Pro Gly 
1               5                   10                  15      


Leu Leu Gly Pro Lys Gly Glu Pro Gly Ile Pro 
            20                  25          


<210>  135

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  135

Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
1               5                   10                  15  


<210>  136

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  136

Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala 
1               5                   10                  15      


Val Met Pro Pro Thr Pro Pro Pro Gln Gly Glu 
            20                  25          


<210>  137

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  137

Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro 
1               5                   10                  15      


Pro Thr Pro Pro Pro Gln Gly Glu Tyr Leu Pro 
            20                  25          


<210>  138

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  138

Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly 
1               5                   10                  15      


Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro 
            20                  25                  


<210>  139

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  139

Gly Met Pro Gly Ala Lys Gly Glu Ile Gly Gln Lys Gly Glu Ile Gly 
1               5                   10                  15      


Pro Met Gly Ile Pro Gly Pro Gln Gly Pro Pro 
            20                  25          


<210>  140

<211>  35

<212>  PRT

<213>  Homo sapiens



<400>  140

Pro Gly Ile Gly Lys Pro Gly Gly Pro Gly Leu Pro Gly Gln Pro Gly 
1               5                   10                  15      


Pro Lys Gly Asp Arg Gly Pro Lys Gly Leu Pro Gly Pro Gln Gly Leu 
            20                  25                  30          


Arg Gly Pro 
        35  


<210>  141

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  141

Gly Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly 
1               5                   10                  15      


Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln 
            20                  25          


<210>  142

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  142

Gly Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro Gly Leu Pro Gly 
1               5                   10                  15      


Val Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly Ile 
            20                  25                  


<210>  143

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  143

Gly Gln Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly Leu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys Pro 
            20                  25                  


<210>  144

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  144

Gly Ala Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly Gly Ile Val Gly 
1               5                   10                  15      


Pro Gln Gly Pro Pro Gly Pro Lys Gly Glu Pro 
            20                  25          


<210>  145

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  145

Pro Lys Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly Ile 
1               5                   10                  15      


Gly Lys Pro Gly Val Ala Gly Leu His Gly Pro Pro Gly Lys Pro Gly 
            20                  25                  30          


Ala Leu Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly 
        35                  40                  


<210>  146

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  146

Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu Pro Gly Leu Pro Gly 
1               5                   10                  15      


Ile Pro Gly Pro Met Gly Pro Pro Gly Ala Ile Gly Phe 
            20                  25                  


<210>  147

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  147

Gly Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly Pro Lys Gly 
1               5                   10                  15      


Leu Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys Gly Asp 
            20                  25                  


<210>  148

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  148

Gly Met Gly Gly Val Pro Gly Ala Leu Gly Pro Arg Gly Glu Lys Gly 
1               5                   10                  15      


Pro Ile Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly Glu 
            20                  25                  


<210>  149

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  149

Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys Gly Glu Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Phe Pro Gly Ile Gly Lys Pro 
            20                  25                  


<210>  150

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  150

Pro Gly Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr Pro Pro 
1               5                   10                  15  


<210>  151

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  151

Gly Lys Pro Gly Val Thr Gly Phe Pro Gly Pro Gln Gly Pro Leu Gly 
1               5                   10                  15      


Lys Pro Gly Ala Pro Gly Glu Pro Gly Pro Gln Gly Pro 
            20                  25                  


<210>  152

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  152

Gly Lys Pro Gly Ala Met Gly Met Pro Gly Ala Lys Gly Glu Ile Gly 
1               5                   10                  15      


Gln Lys Gly Glu Ile Gly Pro Met Gly Ile Pro 
            20                  25          


<210>  153

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  153

Gly Phe Leu Gly Glu Val Gly Pro Pro Gly Met Arg Gly Phe Pro Gly 
1               5                   10                  15      


Pro Ile Gly Pro Lys Gly Glu His Gly Gln Lys Gly Val 
            20                  25                  


<210>  154

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  154

Ser Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro Arg Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Leu Pro Gly His Gly 
            20                  25          


<210>  155

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  155

Gly Pro Lys Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly Lys Pro Gly 
1               5                   10                  15      


Phe Leu Gly Glu Val Gly Pro Pro Gly Met Arg 
            20                  25          


<210>  156

<211>  754

<212>  PRT

<213>  Homo sapiens



<400>  156

Phe Asp Ser Ala Val Leu Ser Ser Ile Asn Val Met Ala Val Leu Pro 
1               5                   10                  15      


Gly Pro Leu Gln Leu Leu Gly Val Leu Leu Thr Ile Ser Leu Ser Ser 
            20                  25                  30          


Ile Arg Leu Ile Gln Ala Gly Ala Tyr Tyr Gly Ile Lys Pro Leu Pro 
        35                  40                  45              


Pro Gln Ile Pro Pro Gln Met Pro Pro Gln Ile Pro Gln Tyr Gln Pro 
    50                  55                  60                  


Leu Gly Gln Gln Val Pro His Met Pro Leu Ala Lys Asp Gly Leu Ala 
65                  70                  75                  80  


Met Gly Lys Glu Met Pro His Leu Gln Tyr Gly Lys Glu Tyr Pro His 
                85                  90                  95      


Leu Pro Gln Tyr Met Lys Glu Ile Gln Pro Ala Pro Arg Met Gly Lys 
            100                 105                 110         


Glu Ala Val Pro Lys Lys Gly Lys Glu Ile Pro Leu Ala Ser Leu Arg 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly Pro Arg Gly Pro Pro Gly 
    130                 135                 140                 


Pro Pro Gly Leu Pro Gly His Gly Ile Pro Gly Ile Lys Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Gln Gly Tyr Pro Gly Val Gly Lys Pro Gly Met Pro Gly Met 
                165                 170                 175     


Pro Gly Lys Pro Gly Ala Met Gly Met Pro Gly Ala Lys Gly Glu Ile 
            180                 185                 190         


Gly Gln Lys Gly Glu Ile Gly Pro Met Gly Ile Pro Pro Gln Gly Pro 
        195                 200                 205             


Pro Gly Pro His Gly Leu Pro Gly Ile Gly Lys Pro Gly Gly Pro Gly 
    210                 215                 220                 


Leu Pro Gly Gln Pro Gly Pro Lys Gly Asp Arg Gly Pro Lys Gly Leu 
225                 230                 235                 240 


Pro Gly Pro Gln Gly Leu Arg Gly Pro Lys Gly Asp Lys Gly Phe Gly 
                245                 250                 255     


Met Pro Gly Ala Pro Gly Val Lys Gly Pro Pro Gly Met His Gly Pro 
            260                 265                 270         


Pro Gly Pro Val Gly Leu Pro Gly Val Gly Lys Pro Gly Val Thr Gly 
        275                 280                 285             


Phe Pro Gly Pro Gln Gly Pro Leu Gly Lys Pro Gly Ala Pro Gly Glu 
    290                 295                 300                 


Pro Gly Pro Gln Gly Pro Ile Gly Val Pro Gly Val Gln Gly Pro Pro 
305                 310                 315                 320 


Gly Ile Pro Gly Ile Gly Lys Pro Gly Gln Asp Gly Ile Pro Gly Gln 
                325                 330                 335     


Pro Gly Phe Pro Gly Gly Lys Gly Glu Gln Gly Leu Pro Gly Leu Pro 
            340                 345                 350         


Gly Pro Pro Gly Leu Pro Gly Ile Gly Lys Pro Gly Phe Pro Gly Pro 
        355                 360                 365             


Lys Gly Asp Arg Gly Met Gly Gly Val Pro Gly Ala Leu Gly Pro Arg 
    370                 375                 380                 


Gly Glu Lys Gly Pro Ile Gly Ala Pro Gly Ile Gly Gly Pro Pro Gly 
385                 390                 395                 400 


Glu Pro Gly Leu Pro Gly Ile Pro Gly Pro Met Gly Pro Pro Gly Ala 
                405                 410                 415     


Ile Gly Phe Pro Gly Pro Lys Gly Glu Gly Gly Ile Val Gly Pro Gln 
            420                 425                 430         


Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Leu Gln Gly Phe Pro Gly 
        435                 440                 445             


Lys Pro Gly Phe Leu Gly Glu Val Gly Pro Pro Gly Met Arg Gly Phe 
    450                 455                 460                 


Pro Gly Pro Ile Gly Pro Lys Gly Glu His Gly Gln Lys Gly Val Pro 
465                 470                 475                 480 


Gly Leu Pro Gly Val Pro Gly Leu Leu Gly Pro Lys Gly Glu Pro Gly 
                485                 490                 495     


Ile Pro Gly Asp Gln Gly Leu Gln Gly Pro Pro Gly Ile Pro Gly Ile 
            500                 505                 510         


Gly Gly Pro Ser Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Pro Lys 
        515                 520                 525             


Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly Ile Gly Lys 
    530                 535                 540                 


Pro Gly Val Ala Gly Leu His Gly Pro Pro Gly Lys Pro Gly Ala Leu 
545                 550                 555                 560 


Gly Pro Gln Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Pro Pro Gly Pro Pro Ala Val Met Pro Pro Thr Pro Pro Pro Gln Gly 
            580                 585                 590         


Glu Tyr Leu Pro Asp Met Gly Leu Gly Ile Asp Gly Val Lys Pro Pro 
        595                 600                 605             


His Ala Tyr Gly Ala Lys Lys Gly Lys Asn Gly Gly Pro Ala Tyr Glu 
    610                 615                 620                 


Met Pro Ala Phe Thr Ala Glu Leu Thr Ala Pro Phe Pro Pro Val Gly 
625                 630                 635                 640 


Ala Pro Val Lys Phe Asn Lys Leu Leu Tyr Asn Gly Arg Gln Asn Tyr 
                645                 650                 655     


Asn Pro Gln Thr Gly Ile Phe Thr Cys Glu Val Pro Gly Val Tyr Tyr 
            660                 665                 670         


Phe Ala Tyr His Val His Cys Lys Gly Gly Asn Val Trp Val Ala Leu 
        675                 680                 685             


Phe Lys Asn Asn Glu Pro Val Met Tyr Thr Tyr Asp Glu Tyr Lys Lys 
    690                 695                 700                 


Gly Phe Leu Asp Gln Ala Ser Gly Ser Ala Val Leu Leu Leu Arg Pro 
705                 710                 715                 720 


Gly Asp Arg Val Phe Leu Gln Met Pro Ser Glu Gln Ala Ala Gly Leu 
                725                 730                 735     


Tyr Ala Gly Gln Tyr Val His Ser Ser Phe Ser Gly Tyr Leu Leu Tyr 
            740                 745                 750         


Pro Met 
        


<210>  157

<211>  443

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(443)

<223>  n = A, T, G, or C



<400>  157
cgcaccggnn nnccggttga cccacgcgtc cgcgctccct ctctctgcca ccgctcaaag     60

cctgggataa cgcttttgaa agcgaatcag gaaattactt aggaatcgga agccccaaag    120

aattatgaat aatcctcgct gccaaaggga aggggatttt gagcaaaagc tccacatctg    180

cgcacactag agttcaaaga ctccagctgt tggaaggtct tgtgagcaat gtttgagagg    240

taagactgga ccgctaggtc ttgccggtga gaaaggggac caaggaaaga ctgggaagaa    300

aggacccata tgaccatagg gagagaaagg agaagtaggt ccaattggtc ctcctggacc    360

caagggagac agaggagaac aaggggaccc cgggctgcct ggggttttgc cgatgtggaa    420

gcatcctggc tcaaatccgg ctc                                            443


<210>  158

<211>  1397

<212>  DNA

<213>  Homo sapiens



<400>  158
ctcagagcgg tggaattcga acgcttttga aagcgaatca ggaaattact tatcaatctg     60

aagccccata taattatgaa taatcctcgc tgccaaaggg aaggggattt tgagcaaaag    120

ctccacatct gcgcacacta gagttcaaag actccagctg ttggaaggtc ttgtgagcaa    180

gagccaaaga tgtttgtctt gctctatgtt acaagttttg ccatttgtgc cagtggacaa    240

ccccggggta atcagttgaa aggagagaac tactccccca ggtatatctg cagcattcct    300

ggcttgcctg gacctccagg gccccctgga gcaaatggtt cccctgggcc ccatggtcgc    360

atcggccttc caggaagaga tggtagagac ggcaggaaag gagagaaagg tgaaaaggga    420

actgcaggtt tgagaggtaa gactggaccg ctaggtcttg ccggtgagaa aggggaccaa    480

ggagagactg ggaagaaagg acccatagga ccagagggag agaaaggaga agtaggtcca    540

attggtcctc ctggaccaaa gggagacaga ggagaacaag gggacccggg gctgcctgga    600

gtttgcagat gtggaagcat cgtgctcaaa tccgcctttt ctgttggcat cacaaccagc    660

tacccagaag aaagactacc tattatattt aacaaggtcc tcttcaacga gggagagcac    720

tacaaccctg ccacagggaa gttcatctgt gctttcccag ggatctatta cttttcttat    780

gatatcacat tggctaataa gcatctggca atcggactgg tacacaatgg gcaataccgg    840

ataaagacct tcgacgccaa cacaggaaac catgatgtgg cttcggggtc cacagtcatc    900

tatctgcagc cagaagatga agtctggctg gagattttct tcacagacca gaatggcctc    960

ttctcagacc caggttgggc agacagctta ttctccgggt ttctcttata cgttgacaca   1020

gattacctag attccatatc agaagatgat gaattgtgat caggaccaag atccctgtgg   1080

taaacactct gattgaatct ggggttccag aaggtggaac aagcaggaat gggatccaaa   1140

gagactccca ctcagattct aaagcattta aagacaattc tagcagaatt tatcaaaaca   1200

agatgaaaca cagaaaagtt gaaaccacaa caaaatgaat tctattaaag aatagcccca   1260

gatataaatt ctcttgaaag caatgttcat aaatatttaa gcaaattaaa gacaatgtta   1320

acaaattttc tattaaatgc cctgagtgat aaaaccagtt ggcaataata ttgccttatt   1380

aaatcttcaa aaaataa                                                  1397


<210>  159

<211>  1297

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (80)..(949)

<223>  



<400>  159
cgcccggaat tcccgggtcg aggcacgcgt tcgatttaga atcctgcagc accccaccat     60

ctaagagcaa gagccaaag atg ttt gtc ttg ctc tat gtt aca agt ttt gcc     112
                     Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala        
                     1               5                   10             

att tgt gcc agt gga caa ccc cgg ggt aat cag ttg aaa gga gag aac      160
Ile Cys Ala Ser Gly Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn         
            15                  20                  25                  

tac tcc ccc agg tat atc tgc agc att cct ggc ttg cct gga cct cca      208
Tyr Ser Pro Arg Tyr Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro         
        30                  35                  40                      

ggg ccc cct gga gca aat ggt tcc cct ggg ccc cat ggt cgc atc ggc      256
Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly         
    45                  50                  55                          

ctt cca gga aga gat ggt aga gac ggc agg aaa gga gag aaa ggt gaa      304
Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu         
60                  65                  70                  75          

aag gga act gca ggt ttg aga ggt aag act gga ccg cta ggt ctt gcc      352
Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala         
                80                  85                  90              

ggt gag aaa ggg gac caa gga gag act ggg aag aaa gga ccc ata gga      400
Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly         
            95                  100                 105                 

cca gag gga gag aaa gga gaa gta ggt cca att ggt cct cct gga cca      448
Pro Glu Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro         
        110                 115                 120                     

aag gga gac aga gga gaa caa ggg gac ccg ggg ctg cct gga gtt tgc      496
Lys Gly Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys         
    125                 130                 135                         

aga tgt gga agc atc gtg ctc aaa tcc gcc ttt tct gtt ggc atc aca      544
Arg Cys Gly Ser Ile Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr         
140                 145                 150                 155         

acc agc tac cca gaa gaa aga cta cct att ata ttt aac aag gtc ctc      592
Thr Ser Tyr Pro Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu         
                160                 165                 170             

ttc aac gag gga gag cac tac aac cct gcc aca ggg aag ttc atc tgt      640
Phe Asn Glu Gly Glu His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys         
            175                 180                 185                 

gct ttc cca ggg atc tat tac ttt tct tat gat atc aca ttg gct aat      688
Ala Phe Pro Gly Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn         
        190                 195                 200                     

aag cat ctg gca atc gga ctg gta cac aat ggg caa tac cgg ata aag      736
Lys His Leu Ala Ile Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys         
    205                 210                 215                         

acc ttc gac gcc aac aca gga aac cat gat gtg gct tcg ggg tcc aca      784
Thr Phe Asp Ala Asn Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr         
220                 225                 230                 235         

gtc atc tat ctg cag cca gaa gat gaa gtc tgg ctg gag att ttc ttc      832
Val Ile Tyr Leu Gln Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe         
                240                 245                 250             

aca gac cag aat ggc ctc ttc tca gac cca ggt tgg gca gac agc tta      880
Thr Asp Gln Asn Gly Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu         
            255                 260                 265                 

ttc tcc ggg ttt ctc tta tac gtt gac aca gat tac cta gat tcc ata      928
Phe Ser Gly Phe Leu Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile         
        270                 275                 280                     

tca gaa gat gat gaa ttg tga tcaggaccaa gatccctgtg gtaaacactc         979
Ser Glu Asp Asp Glu Leu                                                 
    285                                                                 

tgattgaatc tggggttcca gaaggtggaa caagcaggaa tgggatccaa agagactccc   1039

actcagattc taaagcattt aaagacaatt ctagcagaat ttatcaaaac aagatgaaac   1099

acagaaaagt tgaaaccaca acaaaatgaa ttctattaaa gaatagcccc agatataaat   1159

tctcttgaaa gcaatgttca taaatattta agcaaattaa agacaatgtt aacaaatttt   1219

ctattaaatg ccctgagtga taaaaccagt tggcaataat attgccttat taaatcttca   1279

aaaaataaaa aaaaaaaa                                                 1297


<210>  160

<211>  289

<212>  PRT

<213>  Homo sapiens



<400>  160

Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
1               5                   10                  15      


Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
            20                  25                  30          


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
        35                  40                  45              


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
    50                  55                  60                  


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
65                  70                  75                  80  


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
                85                  90                  95      


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
            100                 105                 110         


Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly 
        115                 120                 125             


Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile 
    130                 135                 140                 


Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu 
145                 150                 155                 160 


Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu 
                165                 170                 175     


His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile 
            180                 185                 190         


Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile 
        195                 200                 205             


Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn 
    210                 215                 220                 


Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly 
                245                 250                 255     


Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu 
            260                 265                 270         


Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu 
        275                 280                 285             


Leu 
    


<210>  161

<211>  870

<212>  DNA

<213>  Homo sapiens



<400>  161
atgtttgtct tgctctatgt tacaagtttt gccatttgtg ccagtggaca accccggggt     60

aatcagttga aaggagagaa ctactccccc aggtatatct gcagcattcc tggcttgcct    120

ggacctccag ggccccctgg agcaaatggt tcccctgggc cccatggtcg catcggcctt    180

ccaggaagag atggtagaga cggcaggaaa ggagagaaag gtgaaaaggg aactgcaggt    240

ttgagaggta agactggacc gctaggtctt gccggtgaga aaggggacca aggagagact    300

gggaagaaag gacccatagg accagaggga gagaaaggag aagtaggtcc aattggtcct    360

cctggaccaa agggagacag aggagaacaa ggggacccgg ggctgcctgg agtttgcaga    420

tgtggaagca tcgtgctcaa atccgccttt tctgttggca tcacaaccag ctacccagaa    480

gaaagactac ctattatatt taacaaggtc ctcttcaacg agggagagca ctacaaccct    540

gccacaggga agttcatctg tgctttccca gggatctatt acttttctta tgatatcaca    600

ttggctaata agcatctggc aatcggactg gtacacaatg ggcaataccg gataaagacc    660

ttcgacgcca acacaggaaa ccatgatgtg gcttcggggt ccacagtcat ctatctgcag    720

ccagaagatg aagtctggct ggagattttc ttcacagacc agaatggcct cttctcagac    780

ccaggttggg cagacagctt attctccggg tttctcttat acgttgacac agattaccta    840

gattccatat cagaagatga tgaattgtga                                     870


<210>  162

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  162

Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
1               5                   10                  15      


<210>  163

<211>  273

<212>  PRT

<213>  Homo sapiens



<400>  163

Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
1               5                   10                  15      


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
            20                  25                  30          


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
        35                  40                  45              


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
    50                  55                  60                  


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
65                  70                  75                  80  


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
                85                  90                  95      


Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly 
            100                 105                 110         


Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile 
        115                 120                 125             


Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu 
    130                 135                 140                 


Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu 
145                 150                 155                 160 


His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile 
                165                 170                 175     


Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile 
            180                 185                 190         


Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn 
        195                 200                 205             


Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln 
    210                 215                 220                 


Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly 
225                 230                 235                 240 


Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu 
                245                 250                 255     


Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu 
            260                 265                 270         


Leu 
    


<210>  164

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  164

Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu His Tyr Asn 
1               5                   10                  15      


Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile Tyr Tyr Phe 
            20                  25                  30          


Ser Tyr Asp Ile 
        35      


<210>  165

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  165

Tyr Pro Glu Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn 
1               5                   10                  15      


Glu Gly Glu His Tyr Asn Pro Ala Thr Gly Lys 
            20                  25          


<210>  166

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  166

Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln Pro Glu Asp Glu 
1               5                   10                  15      


Val Trp Leu Glu 
            20  


<210>  167

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  167

Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln Pro Glu Asp Glu 
1               5                   10                  15      


Val Trp Leu Glu Ile Phe 
            20          


<210>  168

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  168

Phe Ile Cys Ala Phe Pro Gly Ile Tyr Tyr Phe Ser Tyr Asp Ile Thr 
1               5                   10                  15      


Leu Ala Asn Lys 
            20  


<210>  169

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  169

Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys 
            20                  25          


<210>  170

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  170

Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala Asn Gly 
1               5                   10                  15      


Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro 
            20                  25          


<210>  171

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  171

Gly Pro Pro Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly 
1               5                   10                  15      


Arg Ile Gly Leu Pro Gly Arg Asp Gly Arg Asp 
            20                  25          


<210>  172

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  172

Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu 
            20                  25                  


<210>  173

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  173

Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp Gln Gly Glu Thr Gly 
1               5                   10                  15      


Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys Gly Glu 
            20                  25                  


<210>  174

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  174

Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly 
1               5                   10                  15      


Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
            20                  25          


<210>  175

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  175

Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys Gly Glu Val Gly 
1               5                   10                  15      


Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly Glu 
            20                  25                  


<210>  176

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  176

Ala Asp Ser Leu Phe Ser Gly Phe Leu Leu Tyr 
1               5                   10      


<210>  177

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  177

Gly Pro Pro Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys 
            20                  25          


<210>  178

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  178

Gly Ala Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu 
            20                  25                  


<210>  179

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  179

Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly 
1               5                   10                  15      


Glu Lys Gly Thr Ala Gly Leu Arg Gly Lys Thr 
            20                  25          


<210>  180

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  180

Gly Glu Lys Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly 
1               5                   10                  15      


Asp Arg Gly Glu Gln Gly Asp Pro Gly Leu Pro 
            20                  25          


<210>  181

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  181

Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr 
            20                  25                  


<210>  182

<211>  305

<212>  PRT

<213>  Homo sapiens



<400>  182

Ser Ser Lys Thr Pro Ala Val Gly Arg Ser Cys Glu Gln Glu Pro Lys 
1               5                   10                  15      


Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly 
            20                  25                  30          


Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr 
        35                  40                  45              


Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala 
    50                  55                  60                  


Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp 
65                  70                  75                  80  


Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly 
                85                  90                  95      


Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp 
            100                 105                 110         


Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys 
        115                 120                 125             


Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly 
    130                 135                 140                 


Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile 
145                 150                 155                 160 


Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu 
                165                 170                 175     


Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu 
            180                 185                 190         


His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile 
        195                 200                 205             


Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile 
    210                 215                 220                 


Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn 
225                 230                 235                 240 


Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln 
                245                 250                 255     


Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly 
            260                 265                 270         


Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu 
        275                 280                 285             


Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu 
    290                 295                 300                 


Leu 
305 


<210>  183

<211>  414

<212>  DNA

<213>  Homo sapiens



<400>  183
aggaaggctg attttattta gccgtttctt ttttcttggt ttgcacagta tctgggtcca     60

gcctgcagcc ctagggtcca gttcagagtc tgtcatctga accatgagga tctggtggtt    120

tctgcttgcc attgaaatct gcacagggaa cataaactca caggacacct gcaggcaagg    180

gcaccctggc atccctggga accccggtca caatggtctg cctggaagag atggacgaga    240

cggagcgaag ggtgacaaag gcgatgcagg agaaccagga cgtcctggca gcccggggaa    300

ggatgggacg agtggagaga agggagaacg aggagcagat ggaaaagttg aagcaaaagg    360

catcaaaggt gatcaaggct caagaggatc ccagaaaaca tggccccaag gggc          414


<210>  184

<211>  792

<212>  DNA

<213>  Homo sapiens



<400>  184
aggaaggctg attttattta gccgtttctt ttttcttggt ttgcacagta tctgggtcca     60

gcctgcagcc ctagggtcca gttcagagtc tgtcatctga accatgagga tctggtggtt    120

tctgcttgcc attgaaatct gcacagggaa cataaactca caggacacct gcaggcaagg    180

gcaccctggc atccctggga accccggtca caatggtctg cctggaagag atggacgaga    240

cggagcgaag ggtgacaaag gcgatgcagg agaaccagga cgtcctggca gcccggggaa    300

ggatgggacg agtggagaga agggagaacg aggagcagat ggaaaagttg aagcaaaagg    360

catcaaaggt gatcaaggct caatgaggat ccccaggaaa acatggcccc aaggggcttg    420

cagggcccat gggagagaaa ggcctccgag gagagactgg gcctcagggg cagaagggga    480

ataagggtga cgtgggtccc actggtcctg aggggccaag gggcaacatt gggcctttgg    540

gcccaactgg tttaccgggc cccatgggcc ctattggaaa gcctggtccc aagggagaag    600

ctggacccac ggggccccag ggtgagccag gagtccgggg aataagaggc tggaaaggag    660

atcgaggaga gaaagggaaa atcggtgaga ctctagtctt gccaaaaagt gctttcactg    720

tggggctcac ggtgctgagc aagtttcctt cttcagatgt gcccattaaa tttgataaga    780

tccacatcac tg                                                        792


<210>  185

<211>  951

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (18)..(884)

<223>  



<400>  185
agtctgtcat ctgaacc atg agg atc tgg tgg ctt ctg ctt gcc att gaa        50
                   Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu          
                   1               5                   10               

atc tgc aca ggg aac ata aac tca cag gac acc tgc agg caa ggg cac       98
Ile Cys Thr Gly Asn Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His         
            15                  20                  25                  

cct ggc atc cct ggg aac ccc ggt cac aat ggt ctg cct gga aga gat      146
Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp         
        30                  35                  40                      

gga cga gac gga gcg aag ggt gac aaa ggc gat gca gga gaa cca gga      194
Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly         
    45                  50                  55                          

cgt cct ggc agc ccg ggg aag gat ggg acg agt gga gag aag gga gaa      242
Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu         
60                  65                  70                  75          

cga gga gca gat gga aaa gtt gaa gca aaa ggc atc aaa ggt gat caa      290
Arg Gly Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln         
                80                  85                  90              

ggc tca aga gga tcc cca gga aaa cat ggc ccc aag ggg ctt gca ggg      338
Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly         
            95                  100                 105                 

ccc atg gga gag aag ggc ctc cga gga gag act ggg cct cag ggg cag      386
Pro Met Gly Glu Lys Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln         
        110                 115                 120                     

aag ggg aat aag ggt gac gtg ggt ccc act ggt cct gag ggg cca agg      434
Lys Gly Asn Lys Gly Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg         
    125                 130                 135                         

ggc aac att ggg cct ttg ggc cca act ggt tta ccg ggc ccc atg ggc      482
Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly         
140                 145                 150                 155         

cct att gga aag cct ggt ccc aaa gga gaa gct gga ccc acg ggg ccc      530
Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro         
                160                 165                 170             

cag gat atg ccc att aaa ttt gat aag atc ctg tat aac gaa ttc aac      578
Gln Asp Met Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn         
            175                 180                 185                 

cat tat gat aca gca gcg ggg aaa ttc acg tgc cac att gct ggg gtc      626
His Tyr Asp Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val         
        190                 195                 200                     

tat tac ttc acc tac cac atc act gtt ttc tcc agg aat gtt cag gtg      674
Tyr Tyr Phe Thr Tyr His Ile Thr Val Phe Ser Arg Asn Val Gln Val         
    205                 210                 215                         

tct ttg gtc aaa aat gga gta aaa ata ctg cac acc aaa gat gct tac      722
Ser Leu Val Lys Asn Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr         
220                 225                 230                 235         

atg agc tct gag gac cag gcc tct ggc ggc att gtc ctg cag ctg aag      770
Met Ser Ser Glu Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys         
                240                 245                 250             

ctc ggg gat gag gtg tgg ctg cag gtg aca gga gga gag agg ttc aat      818
Leu Gly Asp Glu Val Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn         
            255                 260                 265                 

ggc ttg ttt gct gat gag gac gat gac aca act ttc aca ggg ttc ctt      866
Gly Leu Phe Ala Asp Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu         
        270                 275                 280                     

ctg ttc agc agc ccg tga cagaggagag tttaaaaatc cgccacacca             914
Leu Phe Ser Ser Pro                                                     
    285                                                                 

tccatcagaa tcagcttggg atgaacttat tcagatg                             951


<210>  186

<211>  288

<212>  PRT

<213>  Homo sapiens



<400>  186

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Asp Met Pro Ile 
                165                 170                 175     


Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala 
            180                 185                 190         


Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr 
        195                 200                 205             


His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn 
    210                 215                 220                 


Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp 
225                 230                 235                 240 


Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val 
                245                 250                 255     


Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp 
            260                 265                 270         


Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
        275                 280                 285             


<210>  187

<211>  867

<212>  DNA

<213>  Homo sapiens



<400>  187
atgaggatct ggtggcttct gcttgccatt gaaatctgca cagggaacat aaactcacag     60

gacacctgca ggcaagggca ccctggcatc cctgggaacc ccggtcacaa tggtctgcct    120

ggaagagatg gacgagacgg agcgaagggt gacaaaggcg atgcaggaga accaggacgt    180

cctggcagcc cggggaagga tgggacgagt ggagagaagg gagaacgagg agcagatgga    240

aaagttgaag caaaaggcat caaaggtgat caaggctcaa gaggatcccc aggaaaacat    300

ggccccaagg ggcttgcagg gcccatggga gagaagggcc tccgaggaga gactgggcct    360

caggggcaga aggggaataa gggtgacgtg ggtcccactg gtcctgaggg gccaaggggc    420

aacattgggc ctttgggccc aactggttta ccgggcccca tgggccctat tggaaagcct    480

ggtcccaaag gagaagctgg acccacgggg ccccaggata tgcccattaa atttgataag    540

atcctgtata acgaattcaa ccattatgat acagcagcgg ggaaattcac gtgccacatt    600

gctggggtct attacttcac ctaccacatc actgttttct ccaggaatgt tcaggtgtct    660

ttggtcaaaa atggagtaaa aatactgcac accaaagatg cttacatgag ctctgaggac    720

caggcctctg gcggcattgt cctgcagctg aagctcgggg atgaggtgtg gctgcaggtg    780

acaggaggag agaggttcaa tggcttgttt gctgatgagg acgatgacac aactttcaca    840

gggttccttc tgttcagcag cccgtga                                        867


<210>  188

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  188

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser 
            


<210>  189

<211>  269

<212>  PRT

<213>  Homo sapiens



<400>  189

Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly 
1               5                   10                  15      


His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp 
            20                  25                  30          


Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp 
        35                  40                  45              


Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly Lys Val Glu 
    50                  55                  60                  


Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys 
65                  70                  75                  80  


His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg 
                85                  90                  95      


Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly Asp Val Gly 
            100                 105                 110         


Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro 
        115                 120                 125             


Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys 
    130                 135                 140                 


Gly Glu Ala Gly Pro Thr Gly Pro Gln Asp Met Pro Ile Lys Phe Asp 
145                 150                 155                 160 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
                165                 170                 175     


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
            180                 185                 190         


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
        195                 200                 205             


Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser 
    210                 215                 220                 


Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln 
225                 230                 235                 240 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
                245                 250                 255     


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
            260                 265                 


<210>  190

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  190

Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp 
1               5                   10                  15      


Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe 
            20                  25                  30          


Thr Tyr His Ile 
        35      


<210>  191

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  191

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln Val Thr 
            20          


<210>  192

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  192

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln 
            20  


<210>  193

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  193

Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
1               5                   10                  15      


Val Phe Ser Arg 
            20  


<210>  194

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  194

Thr Gly Pro Gln Asp Met Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn 
1               5                   10                  15      


Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
            20                  25          


<210>  195

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  195

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala 
            20                  25          


<210>  196

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  196

Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Ala Gly Pro Thr Gly Pro Gln Asp Met Pro 
            20                  25          


<210>  197

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  197

Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu 
            20                  25                  


<210>  198

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  198

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu 
            20                  25                  


<210>  199

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  199

Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly 
1               5                   10                  15      


Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu 
            20                  25                  


<210>  200

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  200

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys 
            20                  25          


<210>  201

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  201

Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly 
1               5                   10                  15      


Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
            20                  25          


<210>  202

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  202

Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
1               5                   10                  15      


Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro 
            20                  25          


<210>  203

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  203

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp 
            20                  25                  


<210>  204

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  204

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg 
            20                  25          


<210>  205

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  205

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu 
            20                  25                  


<210>  206

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  206

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala 
            20                  25                  


<210>  207

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  207

Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly 
1               5                   10                  15      


Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro 
            20                  25                  


<210>  208

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  208

Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe 
1               5                   10      


<210>  209

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  209

Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser 
1               5                   10  


<210>  210

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  210

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys 
            20                  25          


<210>  211

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  211

Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly 
1               5                   10                  15      


Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys 
            20                  25          


<210>  212

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  212

Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys 
            20                  25          


<210>  213

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  213

Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  214

<211>  1176

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(1176)

<223>  n = A, T, G, or C



<220>

<221>  CDS

<222>  (18)..(920)

<223>  



<400>  214
agtctgtcat ctgaacc atg agg atc tgg tgg ctt ctg ctt gcc att gaa        50
                   Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu          
                   1               5                   10               

atc tgc aca ggg aac ata aac tca cag gac acc tgc agg caa ggg cac       98
Ile Cys Thr Gly Asn Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His         
            15                  20                  25                  

cct ggc atc cct ggg aac ccc ggt cac aat ggt ctg cct gga aga gat      146
Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp         
        30                  35                  40                      

gga cga gac gga gcg aag ggt gac aaa ggc gat gca gga gaa cca gga      194
Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly         
    45                  50                  55                          

cgt cct ggc agc ccg ggg aag gat ggg acg agt gga gag aag gga gaa      242
Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu         
60                  65                  70                  75          

cga gga gca gat gga aaa gtt gaa gca aaa ggc atc aaa ggt gat caa      290
Arg Gly Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln         
                80                  85                  90              

ggc tca aga gga tcc cca gga aaa cat ggc ccc aag ggg ctt gca ggg      338
Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly         
            95                  100                 105                 

ccc atg gga gag aag ggc ctc cga gga gag act ggg cct cag ggg cag      386
Pro Met Gly Glu Lys Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln         
        110                 115                 120                     

aag ggg aat aag ggt gac gtg ggt ccc act ggt cct gag ggg cca agg      434
Lys Gly Asn Lys Gly Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg         
    125                 130                 135                         

ggc aac att ggg cct ttg ggc cca act ggt tta ccg ggc ccc atg ggc      482
Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly         
140                 145                 150                 155         

cct att gga aag cct ggt ccc aag gga gaa gct gga ccc acg ggg ccc      530
Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro         
                160                 165                 170             

cag ggt gag cca gga gtc cgg gga ata aga ggc tgg aaa gga gat cga      578
Gln Gly Glu Pro Gly Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg         
            175                 180                 185                 

gga gag aaa ggg aaa atc ggt gag act cta gtc ttg cca aaa agt gct      626
Gly Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala         
        190                 195                 200                     

ttc act gtg ggg ctc acg gtg ctg agc aag ttt cct tct tca gat gtg      674
Phe Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val         
    205                 210                 215                         

ccc att aaa ttt gat aag atc cac atc act gtt ttc tcc agg aat gtt      722
Pro Ile Lys Phe Asp Lys Ile His Ile Thr Val Phe Ser Arg Asn Val         
220                 225                 230                 235         

cag gtg tct ttg gtc aaa aac gga gta aaa ata ctg cac acc aga gat      770
Gln Val Ser Leu Val Lys Asn Gly Val Lys Ile Leu His Thr Arg Asp         
                240                 245                 250             

gct tac gtg agc tct gag gac cag gcc tct ggc agc att gtc ctg cag      818
Ala Tyr Val Ser Ser Glu Asp Gln Ala Ser Gly Ser Ile Val Leu Gln         
            255                 260                 265                 

ctg aag ctc ggg gat gag atg tgg tgt gtg att cat cgt gtg gca aaa      866
Leu Lys Leu Gly Asp Glu Met Trp Cys Val Ile His Arg Val Ala Lys         
        270                 275                 280                     

tgt ctc tcc atc tgt gat cct ttt aca gtg gcg tct tgt gtg cgc tct      914
Cys Leu Ser Ile Cys Asp Pro Phe Thr Val Ala Ser Cys Val Arg Ser         
    285                 290                 295                         

cga tga gggcaaggtc acctctgctt tgaggggccg ggtttagtgg tctcctaccc       970
Arg                                                                     
300                                                                     

agagtgtcgg gtccgggaac tgcttctgca tgagcccctt gctccacgtg aatctgaata   1030

gttcgttctg gcagtggcgg tgaattcgtc ctgccaggac ccgccctctg catacactca   1090

ggcgcacccc tgctaaagcc ctttaacttc agcgctacaa gtccttgctt aanaagccta   1150

tcccttgngc gntcacaggc cggatt                                        1176


<210>  215

<211>  300

<212>  PRT

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(1176)

<223>  n = A, T, G, or C

<400>  215

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu Val 
225                 230                 235                 240 


Lys Asn Gly Val Lys Ile Leu His Thr Arg Asp Ala Tyr Val Ser Ser 
                245                 250                 255     


Glu Asp Gln Ala Ser Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp 
            260                 265                 270         


Glu Met Trp Cys Val Ile His Arg Val Ala Lys Cys Leu Ser Ile Cys 
        275                 280                 285             


Asp Pro Phe Thr Val Ala Ser Cys Val Arg Ser Arg 
    290                 295                 300 


<210>  216

<211>  903

<212>  DNA

<213>  Homo sapiens



<400>  216
atgaggatct ggtggcttct gcttgccatt gaaatctgca cagggaacat aaactcacag     60

gacacctgca ggcaagggca ccctggcatc cctgggaacc ccggtcacaa tggtctgcct    120

ggaagagatg gacgagacgg agcgaagggt gacaaaggcg atgcaggaga accaggacgt    180

cctggcagcc cggggaagga tgggacgagt ggagagaagg gagaacgagg agcagatgga    240

aaagttgaag caaaaggcat caaaggtgat caaggctcaa gaggatcccc aggaaaacat    300

ggccccaagg ggcttgcagg gcccatggga gagaagggcc tccgaggaga gactgggcct    360

caggggcaga aggggaataa gggtgacgtg ggtcccactg gtcctgaggg gccaaggggc    420

aacattgggc ctttgggccc aactggttta ccgggcccca tgggccctat tggaaagcct    480

ggtcccaagg gagaagctgg acccacgggg ccccagggtg agccaggagt ccggggaata    540

agaggctgga aaggagatcg aggagagaaa gggaaaatcg gtgagactct agtcttgcca    600

aaaagtgctt tcactgtggg gctcacggtg ctgagcaagt ttccttcttc agatgtgccc    660

attaaatttg ataagatcca catcactgtt ttctccagga atgttcaggt gtctttggtc    720

aaaaacggag taaaaatact gcacaccaga gatgcttacg tgagctctga ggaccaggcc    780

tctggcagca ttgtcctgca gctgaagctc ggggatgaga tgtggtgtgt gattcatcgt    840

gtggcaaaat gtctctccat ctgtgatcct tttacagtgg cgtcttgtgt gcgctctcga    900

tga                                                                  903


<210>  217

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  217

Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly 
1               5                   10                  15      


His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp 
            20                  25                  30          


Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp 
        35                  40                  45              


Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly Lys Val Glu 
    50                  55                  60                  


Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys 
65                  70                  75                  80  


His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg 
                85                  90                  95      


Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly Asp Val Gly 
            100                 105                 110         


Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro 
        115                 120                 125             


Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys 
    130                 135                 140                 


Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly Val Arg Gly 
145                 150                 155                 160 


Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu 
                165                 170                 175     


Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu Thr Val Leu 
            180                 185                 190         


Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp Lys Ile His 
        195                 200                 205             


Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly 
    210                 215                 220                 


Val Lys Ile Leu His Thr Arg Asp Ala Tyr Val Ser Ser Glu Asp Gln 
225                 230                 235                 240 


Ala Ser Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Met Trp 
                245                 250                 255     


Cys Val Ile His Arg Val Ala Lys Cys Leu Ser Ile Cys Asp Pro Phe 
            260                 265                 270         


Thr Val Ala Ser Cys Val Arg Ser Arg 
        275                 280     


<210>  218

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  218

Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro 
            20                  25          


<210>  219

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  219

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala 
            20                  25          


<210>  220

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  220

Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu 
            20                  25                  


<210>  221

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  221

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu 
            20                  25                  


<210>  222

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  222

Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly 
1               5                   10                  15      


Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu 
            20                  25                  


<210>  223

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  223

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys 
            20                  25          


<210>  224

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  224

Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly 
1               5                   10                  15      


Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
            20                  25          


<210>  225

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  225

Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
1               5                   10                  15      


Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro 
            20                  25          


<210>  226

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  226

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp 
            20                  25                  


<210>  227

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  227

Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly 
1               5                   10                  15      


Glu Pro Gly Val Arg Gly Ile Arg Gly Trp Lys 
            20                  25          


<210>  228

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  228

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg 
            20                  25          


<210>  229

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  229

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu 
            20                  25                  


<210>  230

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  230

Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
1               5                   10                  15      


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu 
            20                  25                  


<210>  231

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  231

Asp Gln Ala Ser Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Met Trp Cys Val 
            20  


<210>  232

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  232

Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly 
1               5                   10                  15      


Pro Gln Gly Glu Pro Gly Val Arg Gly Ile Arg 
            20                  25          


<210>  233

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  233

Asp Gln Ala Ser Gly Ser Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Met Trp Cys Val Ile His 
            20          


<210>  234

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  234

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala 
            20                  25                  


<210>  235

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  235

Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly 
1               5                   10                  15      


Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro 
            20                  25                  


<210>  236

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  236

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys 
            20                  25          


<210>  237

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  237

Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly 
1               5                   10                  15      


Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys 
            20                  25          


<210>  238

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  238

Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys 
            20                  25          


<210>  239

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  239

Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  240

<211>  1026

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (25)..(1026)

<223>  



<400>  240
tcagttcagt ctgtcatctg aacc atg agg atc tgg tgg ctt ctg ctt gcc        51
                           Met Arg Ile Trp Trp Leu Leu Leu Ala          
                           1               5                            

att gaa atc tgc aca ggg aac ata aac tca cag gac acc tgc agg caa       99
Ile Glu Ile Cys Thr Gly Asn Ile Asn Ser Gln Asp Thr Cys Arg Gln         
10                  15                  20                  25          

ggg cac cct ggc atc cct ggg aac ccc ggt cac aat ggt ctg cct gga      147
Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly         
                30                  35                  40              

aga gat gga cga gac gga gcg aag ggt gac aaa ggc gat gca gga gaa      195
Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu         
            45                  50                  55                  

cca gga cgt cct ggc agc ccg ggg aag gat ggg acg agt gga gag aag      243
Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys         
        60                  65                  70                      

gga gaa cga gga gca gat gga aaa gtt gaa gca aaa ggc atc aaa ggt      291
Gly Glu Arg Gly Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys Gly         
    75                  80                  85                          

gat caa ggc tca aga gga tcc cca gga aaa cat ggc ccc aag ggg ctt      339
Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly Leu         
90                  95                  100                 105         

gca ggg ccc atg gga gag aag ggc ctc cga gga gag act ggg cct cag      387
Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu Thr Gly Pro Gln         
                110                 115                 120             

ggg cag aag ggg aat aag ggt gac gtg ggt ccc act ggt cct gag ggg      435
Gly Gln Lys Gly Asn Lys Gly Asp Val Gly Pro Thr Gly Pro Glu Gly         
            125                 130                 135                 

cca agg ggc aac att ggg cct ttg ggc cca act ggt tta ccg ggc ccc      483
Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly Pro         
        140                 145                 150                     

atg ggc cct att gga aag cct ggt ccc aaa gga gaa gct gga ccc acg      531
Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr         
    155                 160                 165                         

ggg ccc cag ggt gag cca gga gtc cag gga ata aga ggc tgg aaa gga      579
Gly Pro Gln Gly Glu Pro Gly Val Gln Gly Ile Arg Gly Trp Lys Gly         
170                 175                 180                 185         

gat cga gga gag aaa ggg aaa atc ggt gag act cta gtc ttg cca aaa      627
Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys         
                190                 195                 200             

agt gct ttc act gtg ggg ctc acg gtg ctg agc aag ttt cct tct tca      675
Ser Ala Phe Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser         
            205                 210                 215                 

gat agg ccc att aaa ttt gat aag atc ctg tat aac gaa ttc aac cat      723
Asp Arg Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His         
        220                 225                 230                     

tat gat aca gca gcg ggg aaa ttc acg tgc cac att gct ggg gtc tat      771
Tyr Asp Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr         
    235                 240                 245                         

tac ttc acc tac cac atc act gtt ttc tcc aga aat gtt cag gtg tct      819
Tyr Phe Thr Tyr His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser         
250                 255                 260                 265         

ttg gtc aaa aat gga gta aaa ata ctg cac acc aaa gat gct tac atg      867
Leu Val Lys Asn Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met         
                270                 275                 280             

agc tct gag gac cag gcc tct ggc ggc att gtc ctg cag ctg aag ctc      915
Ser Ser Glu Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu         
            285                 290                 295                 

ggg gat gag gtg tgg ctg cag gtg aca gga gga gag agg ttc aat ggc      963
Gly Asp Glu Val Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly         
        300                 305                 310                     

ttg ttt gct gat gag gac gat gac aca act ttc aca ggg ttc ctt ctg     1011
Leu Phe Ala Asp Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu         
    315                 320                 325                         

ttc agc agc ccg tga                                                 1026
Phe Ser Ser Pro                                                         
330                                                                     


<210>  241

<211>  333

<212>  PRT

<213>  Homo sapiens



<400>  241

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Gln Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Arg Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
225                 230                 235                 240 


Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
                245                 250                 255     


Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys 
            260                 265                 270         


Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser 
        275                 280                 285             


Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln 
    290                 295                 300                 


Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp 
305                 310                 315                 320 


Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
                325                 330             


<210>  242

<211>  1002

<212>  DNA

<213>  Homo sapiens



<400>  242
atgaggatct ggtggcttct gcttgccatt gaaatctgca cagggaacat aaactcacag     60

gacacctgca ggcaagggca ccctggcatc cctgggaacc ccggtcacaa tggtctgcct    120

ggaagagatg gacgagacgg agcgaagggt gacaaaggcg atgcaggaga accaggacgt    180

cctggcagcc cggggaagga tgggacgagt ggagagaagg gagaacgagg agcagatgga    240

aaagttgaag caaaaggcat caaaggtgat caaggctcaa gaggatcccc aggaaaacat    300

ggccccaagg ggcttgcagg gcccatggga gagaagggcc tccgaggaga gactgggcct    360

caggggcaga aggggaataa gggtgacgtg ggtcccactg gtcctgaggg gccaaggggc    420

aacattgggc ctttgggccc aactggttta ccgggcccca tgggccctat tggaaagcct    480

ggtcccaaag gagaagctgg acccacgggg ccccagggtg agccaggagt ccagggaata    540

agaggctgga aaggagatcg aggagagaaa gggaaaatcg gtgagactct agtcttgcca    600

aaaagtgctt tcactgtggg gctcacggtg ctgagcaagt ttccttcttc agataggccc    660

attaaatttg ataagatcct gtataacgaa ttcaaccatt atgatacagc agcggggaaa    720

ttcacgtgcc acattgctgg ggtctattac ttcacctacc acatcactgt tttctccaga    780

aatgttcagg tgtctttggt caaaaatgga gtaaaaatac tgcacaccaa agatgcttac    840

atgagctctg aggaccaggc ctctggcggc attgtcctgc agctgaagct cggggatgag    900

gtgtggctgc aggtgacagg aggagagagg ttcaatggct tgtttgctga tgaggacgat    960

gacacaactt tcacagggtt ccttctgttc agcagcccgt ga                      1002


<210>  243

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  243

Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly 
1               5                   10                  15      


His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp 
            20                  25                  30          


Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp 
        35                  40                  45              


Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly Lys Val Glu 
    50                  55                  60                  


Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys 
65                  70                  75                  80  


His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg 
                85                  90                  95      


Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly Asp Val Gly 
            100                 105                 110         


Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro 
        115                 120                 125             


Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys 
    130                 135                 140                 


Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly Val Gln Gly 
145                 150                 155                 160 


Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu 
                165                 170                 175     


Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu Thr Val Leu 
            180                 185                 190         


Ser Lys Phe Pro Ser Ser Asp Arg Pro Ile Lys Phe Asp Lys Ile Leu 
        195                 200                 205             


Tyr Asn Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys Phe Thr Cys 
    210                 215                 220                 


His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr Val Phe Ser 
225                 230                 235                 240 


Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys Ile Leu His 
                245                 250                 255     


Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser Gly Gly Ile 
            260                 265                 270         


Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln Val Thr Gly 
        275                 280                 285             


Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp Asp Thr Thr 
    290                 295                 300                 


Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
305                 310                 


<210>  244

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  244

Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn Glu Phe Asn His Tyr Asp 
1               5                   10                  15      


Thr Ala Ala Gly Lys Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe 
            20                  25                  30          


Thr Tyr His Ile 
        35      


<210>  245

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  245

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln Val Thr 
            20          


<210>  246

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  246

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln 
            20  


<210>  247

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  247

Phe Thr Cys His Ile Ala Gly Val Tyr Tyr Phe Thr Tyr His Ile Thr 
1               5                   10                  15      


Val Phe Ser Arg 
            20  


<210>  248

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  248

Phe Pro Ser Ser Asp Arg Pro Ile Lys Phe Asp Lys Ile Leu Tyr Asn 
1               5                   10                  15      


Glu Phe Asn His Tyr Asp Thr Ala Ala Gly Lys 
            20                  25          


<210>  249

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  249

Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro 
            20                  25          


<210>  250

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  250

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala 
            20                  25          


<210>  251

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  251

Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu 
            20                  25                  


<210>  252

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  252

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu 
            20                  25                  


<210>  253

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  253

Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly 
1               5                   10                  15      


Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu 
            20                  25                  


<210>  254

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  254

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys 
            20                  25          


<210>  255

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  255

Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly 
1               5                   10                  15      


Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
            20                  25          


<210>  256

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  256

Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly 
1               5                   10                  15      


Glu Pro Gly Val Gln Gly Ile Arg Gly Trp Lys 
            20                  25          


<210>  257

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  257

Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
1               5                   10                  15      


Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro 
            20                  25          


<210>  258

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  258

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp 
            20                  25                  


<210>  259

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  259

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg 
            20                  25          


<210>  260

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  260

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu 
            20                  25                  


<210>  261

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  261

Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
1               5                   10                  15      


Val Gln Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu 
            20                  25                  


<210>  262

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  262

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala 
            20                  25                  


<210>  263

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  263

Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly 
1               5                   10                  15      


Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro 
            20                  25                  


<210>  264

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  264

Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe 
1               5                   10      


<210>  265

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  265

Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly 
1               5                   10                  15      


Pro Gln Gly Glu Pro Gly Val Gln Gly Ile Arg 
            20                  25          


<210>  266

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  266

Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser 
1               5                   10  


<210>  267

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  267

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys 
            20                  25          


<210>  268

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  268

Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly 
1               5                   10                  15      


Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys 
            20                  25          


<210>  269

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  269

Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys 
            20                  25          


<210>  270

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  270

Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  271

<211>  945

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (25)..(945)

<223>  



<400>  271
tcagttcagt ctgtcatctg aacc atg agg atc tgg tgg ctt ctg ctt gcc        51
                           Met Arg Ile Trp Trp Leu Leu Leu Ala          
                           1               5                            

att gaa atc tgc aca ggg aac ata aac tca cag gac acc tgc agg caa       99
Ile Glu Ile Cys Thr Gly Asn Ile Asn Ser Gln Asp Thr Cys Arg Gln         
10                  15                  20                  25          

ggg cac cct ggc atc cct ggg aac ccc ggt cac aat ggt ctg cct gga      147
Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly         
                30                  35                  40              

aga gat gga cga gac gga gcg aag ggt gac aaa ggc gat gca gga gaa      195
Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu         
            45                  50                  55                  

cca gga cgt cct ggc agc ccg ggg aag gat ggg acg agt gga gag aag      243
Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys         
        60                  65                  70                      

gga gaa cga gga gca gat gga aaa gtt gaa gca aaa ggc atc aaa ggt      291
Gly Glu Arg Gly Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys Gly         
    75                  80                  85                          

gat caa ggc tca aga gga tcc cca gga aaa cat ggc ccc aag ggg ctt      339
Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly Leu         
90                  95                  100                 105         

gca ggg ccc atg gga gag aag ggc ctc cga gga gag act ggg cct cag      387
Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu Thr Gly Pro Gln         
                110                 115                 120             

ggg cag aag ggg aat aag ggt gac gtg ggt ccc act ggt cct gag ggg      435
Gly Gln Lys Gly Asn Lys Gly Asp Val Gly Pro Thr Gly Pro Glu Gly         
            125                 130                 135                 

cca agg ggc aac att ggg cct ttg ggc cca act ggt tta ccg ggc ccc      483
Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly Pro         
        140                 145                 150                     

atg ggc cct att gga aag cct ggt ccc aaa gga gaa gct gga ccc acg      531
Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr         
    155                 160                 165                         

ggg ccc cag ggt gag cca gga gtc cag gga ata aga ggc tgg aaa gga      579
Gly Pro Gln Gly Glu Pro Gly Val Gln Gly Ile Arg Gly Trp Lys Gly         
170                 175                 180                 185         

gat cga gga gag aaa ggg aaa atc ggt gag act cta gtc ttg cca aaa      627
Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu Thr Leu Val Leu Pro Lys         
                190                 195                 200             

agt gct ttc act gtg ggg ctc acg gtg ctg agc aag ttt cct tct tca      675
Ser Ala Phe Thr Val Gly Leu Thr Val Leu Ser Lys Phe Pro Ser Ser         
            205                 210                 215                 

gat agg ccc att aaa ttt gat aag atc cac atc act gtt ttc tcc aga      723
Asp Arg Pro Ile Lys Phe Asp Lys Ile His Ile Thr Val Phe Ser Arg         
        220                 225                 230                     

aat gtt cag gtg tct ttg gtc aaa aat gga gta aaa ata ctg cac acc      771
Asn Val Gln Val Ser Leu Val Lys Asn Gly Val Lys Ile Leu His Thr         
    235                 240                 245                         

aaa gat gct tac atg agc tct gag gac cag gcc tct ggc ggc att gtc      819
Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln Ala Ser Gly Gly Ile Val         
250                 255                 260                 265         

ctg cag ctg aag ctc ggg gat gag gtg tgg ctg cag gtg aca gga gga      867
Leu Gln Leu Lys Leu Gly Asp Glu Val Trp Leu Gln Val Thr Gly Gly         
                270                 275                 280             

gag agg ttc aat ggc ttg ttt gct gat gag gac gat gac aca act ttc      915
Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu Asp Asp Asp Thr Thr Phe         
            285                 290                 295                 

aca ggg ttc ctt ctg ttc agc agc ccg tga                              945
Thr Gly Phe Leu Leu Phe Ser Ser Pro                                     
        300                 305                                         


<210>  272

<211>  306

<212>  PRT

<213>  Homo sapiens



<400>  272

Met Arg Ile Trp Trp Leu Leu Leu Ala Ile Glu Ile Cys Thr Gly Asn 
1               5                   10                  15      


Ile Asn Ser Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly 
            20                  25                  30          


Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala 
        35                  40                  45              


Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
    50                  55                  60                  


Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly 
65                  70                  75                  80  


Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser 
                85                  90                  95      


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
            100                 105                 110         


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
        115                 120                 125             


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
    130                 135                 140                 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
145                 150                 155                 160 


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
                165                 170                 175     


Val Gln Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
            180                 185                 190         


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
        195                 200                 205             


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Arg Pro Ile Lys Phe Asp 
    210                 215                 220                 


Lys Ile His Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu Val 
225                 230                 235                 240 


Lys Asn Gly Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser 
                245                 250                 255     


Glu Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp 
            260                 265                 270         


Glu Val Trp Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe 
        275                 280                 285             


Ala Asp Glu Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser 
    290                 295                 300                 


Ser Pro 
305     


<210>  273

<211>  921

<212>  DNA

<213>  Homo sapiens



<400>  273
atgaggatct ggtggcttct gcttgccatt gaaatctgca cagggaacat aaactcacag     60

gacacctgca ggcaagggca ccctggcatc cctgggaacc ccggtcacaa tggtctgcct    120

ggaagagatg gacgagacgg agcgaagggt gacaaaggcg atgcaggaga accaggacgt    180

cctggcagcc cggggaagga tgggacgagt ggagagaagg gagaacgagg agcagatgga    240

aaagttgaag caaaaggcat caaaggtgat caaggctcaa gaggatcccc aggaaaacat    300

ggccccaagg ggcttgcagg gcccatggga gagaagggcc tccgaggaga gactgggcct    360

caggggcaga aggggaataa gggtgacgtg ggtcccactg gtcctgaggg gccaaggggc    420

aacattgggc ctttgggccc aactggttta ccgggcccca tgggccctat tggaaagcct    480

ggtcccaaag gagaagctgg acccacgggg ccccagggtg agccaggagt ccagggaata    540

agaggctgga aaggagatcg aggagagaaa gggaaaatcg gtgagactct agtcttgcca    600

aaaagtgctt tcactgtggg gctcacggtg ctgagcaagt ttccttcttc agataggccc    660

attaaatttg ataagatcca catcactgtt ttctccagaa atgttcaggt gtctttggtc    720

aaaaatggag taaaaatact gcacaccaaa gatgcttaca tgagctctga ggaccaggcc    780

tctggcggca ttgtcctgca gctgaagctc ggggatgagg tgtggctgca ggtgacagga    840

ggagagaggt tcaatggctt gtttgctgat gaggacgatg acacaacttt cacagggttc    900

cttctgttca gcagcccgtg a                                              921


<210>  274

<211>  287

<212>  PRT

<213>  Homo sapiens



<400>  274

Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly 
1               5                   10                  15      


His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp 
            20                  25                  30          


Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly Lys Asp 
        35                  40                  45              


Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp Gly Lys Val Glu 
    50                  55                  60                  


Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys 
65                  70                  75                  80  


His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg 
                85                  90                  95      


Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly Asp Val Gly 
            100                 105                 110         


Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro 
        115                 120                 125             


Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys 
    130                 135                 140                 


Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly Val Gln Gly 
145                 150                 155                 160 


Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys Ile Gly Glu 
                165                 170                 175     


Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu Thr Val Leu 
            180                 185                 190         


Ser Lys Phe Pro Ser Ser Asp Arg Pro Ile Lys Phe Asp Lys Ile His 
        195                 200                 205             


Ile Thr Val Phe Ser Arg Asn Val Gln Val Ser Leu Val Lys Asn Gly 
    210                 215                 220                 


Val Lys Ile Leu His Thr Lys Asp Ala Tyr Met Ser Ser Glu Asp Gln 
225                 230                 235                 240 


Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu Val Trp 
                245                 250                 255     


Leu Gln Val Thr Gly Gly Glu Arg Phe Asn Gly Leu Phe Ala Asp Glu 
            260                 265                 270         


Asp Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser Ser Pro 
        275                 280                 285         


<210>  275

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  275

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln Val Thr 
            20          


<210>  276

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  276

Asp Gln Ala Ser Gly Gly Ile Val Leu Gln Leu Lys Leu Gly Asp Glu 
1               5                   10                  15      


Val Trp Leu Gln 
            20  


<210>  277

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  277

Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly 
1               5                   10                  15      


Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro 
            20                  25          


<210>  278

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  278

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala 
            20                  25          


<210>  279

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  279

Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu 
            20                  25                  


<210>  280

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  280

Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly 
1               5                   10                  15      


Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu 
            20                  25                  


<210>  281

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  281

Gly Asp Gln Gly Ser Arg Gly Ser Pro Gly Lys His Gly Pro Lys Gly 
1               5                   10                  15      


Leu Ala Gly Pro Met Gly Glu Lys Gly Leu Arg Gly Glu 
            20                  25                  


<210>  282

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  282

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys 
            20                  25          


<210>  283

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  283

Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly 
1               5                   10                  15      


Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro 
            20                  25          


<210>  284

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  284

Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly 
1               5                   10                  15      


Glu Pro Gly Val Gln Gly Ile Arg Gly Trp Lys 
            20                  25          


<210>  285

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  285

Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
1               5                   10                  15      


Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro 
            20                  25          


<210>  286

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  286

Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly Leu Pro Gly 
1               5                   10                  15      


Arg Asp Gly Arg Asp Gly Ala Lys Gly Asp Lys Gly Asp 
            20                  25                  


<210>  287

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  287

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg 
            20                  25          


<210>  288

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  288

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu 
            20                  25                  


<210>  289

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  289

Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
1               5                   10                  15      


Val Gln Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu 
            20                  25                  


<210>  290

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  290

Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser Pro Gly 
1               5                   10                  15      


Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala 
            20                  25                  


<210>  291

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  291

Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly 
1               5                   10                  15      


Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro Gly Pro 
            20                  25                  


<210>  292

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  292

Asp Asp Thr Thr Phe Thr Gly Phe Leu Leu Phe 
1               5                   10      


<210>  293

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  293

Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly 
1               5                   10                  15      


Pro Gln Gly Glu Pro Gly Val Gln Gly Ile Arg 
            20                  25          


<210>  294

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  294

Thr Thr Phe Thr Gly Phe Leu Leu Phe Ser 
1               5                   10  


<210>  295

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  295

Gly Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys 
            20                  25          


<210>  296

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  296

Gly Ser Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly 
1               5                   10                  15      


Ala Asp Gly Lys Val Glu Ala Lys Gly Ile Lys 
            20                  25          


<210>  297

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  297

Cys Arg Gln Gly His Pro Gly Ile Pro Gly Asn Pro Gly His Asn Gly 
1               5                   10                  15      


Leu Pro Gly Arg Asp Gly Arg Asp Gly Ala Lys 
            20                  25          


<210>  298

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  298

Gly Pro Arg Gly Asn Ile Gly Pro Leu Gly Pro Thr Gly Leu Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Ile Gly Lys Pro Gly Pro Lys Gly Glu 
            20                  25                  


<210>  299

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  299

Ala Ser Phe Leu Leu Gln Met Cys Pro Gly Pro Val Gln Ser Leu Ser 
1               5                   10                  15      


Ser Glu Pro Gly Ser Gly Gly Phe Cys Leu Pro Leu Lys Ser Ala Gln 
            20                  25                  30          


Gly Thr Thr Pro Gln Asp Thr Cys Arg Gln Gly His Pro Gly Ile Pro 
        35                  40                  45              


Gly Asn Pro Gly His Asn Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
    50                  55                  60                  


Ala Lys Gly Asp Lys Gly Asp Ala Gly Glu Pro Gly Arg Pro Gly Ser 
65                  70                  75                  80  


Pro Gly Lys Asp Gly Thr Ser Gly Glu Lys Gly Glu Arg Gly Ala Asp 
                85                  90                  95      


Gly Lys Val Glu Ala Lys Gly Ile Lys Gly Asp Gln Gly Ser Gly Ser 
            100                 105                 110         


Pro Gly Lys His Gly Pro Lys Gly Leu Ala Gly Pro Met Gly Glu Lys 
        115                 120                 125             


Gly Leu Arg Gly Glu Thr Gly Pro Gln Gly Gln Lys Gly Asn Lys Gly 
    130                 135                 140                 


Asp Val Gly Pro Thr Gly Pro Glu Gly Pro Arg Gly Asn Ile Gly Pro 
145                 150                 155                 160 


Leu Gly Pro Thr Gly Leu Pro Gly Pro Met Gly Pro Ile Gly Lys Pro 
                165                 170                 175     


Gly Pro Lys Gly Glu Ala Gly Pro Thr Gly Pro Gln Gly Glu Pro Gly 
            180                 185                 190         


Val Arg Gly Ile Arg Gly Trp Lys Gly Asp Arg Gly Glu Lys Gly Lys 
        195                 200                 205             


Ile Gly Glu Thr Leu Val Leu Pro Lys Ser Ala Phe Thr Val Gly Leu 
    210                 215                 220                 


Thr Val Leu Ser Lys Phe Pro Ser Ser Asp Val Pro Ile Lys Phe Asp 
225                 230                 235                 240 


Lys Ile His Ile Thr 
                245 


<210>  300

<211>  422

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(422)

<223>  n = A, T, G, or C



<400>  300
ttgggannat ctgattacgt cccgcttggc accagggtga atgaagtcct atatagatca     60

caatttttta tattcaaatc tacgacattg aattagggct tctatatata tgatactttg    120

gtgtactgtg atcttgctgc ttttatccat atgtcagctt tggttcttgt gagtttacct    180

gcttattatg atacttggag tccattcata gtgtggggaa gaatgatttt tgccctgcag    240

gagaaggtct aattgaaata atgctgcttg tccccaaaga aattgtttgc cttgtactct    300

tgttaacctt agagctagac ctgggaatga ttcaacttca agccttaacc tggaattttc    360

tggatttgag ggaattccca agcctatgat ctttttcaca ttttcttttt cttatatgaa    420

at                                                                   422


<210>  301

<211>  1848

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (199)..(1215)

<223>  



<400>  301
ttctaagaaa tgctatttct gcttaagtgc tgctggattt ggaaatcatt ttcatgacta     60

aatatttgtc tgcctggtga gagcccagcg tagggctgtg ctgtccgtag atactcaata    120

ctgattaatg gatggccgtg catgtctgtg tgggagtcgt gtgcttagga tctgctcagc    180

tctccgaaag caacagaa atg gtg tgg gga aga aga aaa tca cag gat tgt      231
                    Met Val Trp Gly Arg Arg Lys Ser Gln Asp Cys         
                    1               5                   10              

gat cca acc atg atc acg gct ttc tgg att gga ctt cat ctt ctg gag      279
Asp Pro Thr Met Ile Thr Ala Phe Trp Ile Gly Leu His Leu Leu Glu         
            15                  20                  25                  

ggt cca caa ggt cca gtg ctg gca gca aac ctc acc att ttg tcc tcc      327
Gly Pro Gln Gly Pro Val Leu Ala Ala Asn Leu Thr Ile Leu Ser Ser         
        30                  35                  40                      

aaa agg aag gtg act ttt aag aag caa tcc aga aga ggt ccc cgc cca      375
Lys Arg Lys Val Thr Phe Lys Lys Gln Ser Arg Arg Gly Pro Arg Pro         
    45                  50                  55                          

acc ttc aaa att ctg tcc aaa agc aga caa gag gat cgc ccc gcg ctg      423
Thr Phe Lys Ile Leu Ser Lys Ser Arg Gln Glu Asp Arg Pro Ala Leu         
60                  65                  70                  75          

agc cgg ctg gtg ggc agc agg agg cgc ctg atc gcc gcc ggg gcg ctg      471
Ser Arg Leu Val Gly Ser Arg Arg Arg Leu Ile Ala Ala Gly Ala Leu         
                80                  85                  90              

ggg gtg gtg atg gtg ctg ctg ctg gtg atc ctc atc ccg gtg ctg atg      519
Gly Val Val Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met         
            95                  100                 105                 

ctg ggc acc tgc cgc atg gtc tgc gac ccc tac ggg ggc acc aag gcg      567
Leu Gly Thr Cys Arg Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala         
        110                 115                 120                     

ccc agc acc gct gcc acg ccc gac cgc ggc ctc atg cag tcc ctg ccc      615
Pro Ser Thr Ala Ala Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro         
    125                 130                 135                         

acc ttc atc cag ggc ccc aaa ggc gag gcc ggc agg ccc ggg aag gcg      663
Thr Phe Ile Gln Gly Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala         
140                 145                 150                 155         

ggt ccg cgc ggg ccc ccc gga gag ccc ggg cca ccc ggc ccc atg ggg      711
Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly         
                160                 165                 170             

ccc ccg ggc gag aag ggc gag ccg ggc cgc caa ggc ctg ccg ggc ccg      759
Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro         
            175                 180                 185                 

ccc ggg gcg ccc ggc ctg aac gcg gcc ggg gcc atc agc gcc gcc acc      807
Pro Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr         
        190                 195                 200                     

tac agc acg ggg ccc aag atc gcc ttc tac gcc ggc ctc aag cgg cag      855
Tyr Ser Thr Gly Pro Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln         
    205                 210                 215                         

cat gaa ggc tac gag gtg ctc aag ttc gac gac gtg gtc acc aac ctc      903
His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu         
220                 225                 230                 235         

gga aac cac tac gac ccc acc acc ggc aag ttc acc tgc tcc atc ccg      951
Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro         
                240                 245                 250             

ggc atc tac ttc ttc acc tac cac gtc ctg atg cgc gga ggg gac ggc      999
Gly Ile Tyr Phe Phe Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly         
            255                 260                 265                 

acc agc atg tgg gct gat ctc tgc aaa aac aac cag gtg cgt gct agt     1047
Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser         
        270                 275                 280                     

gca att gcc caa gat gct gat cag aat tac gac tat gcc agt aac agt     1095
Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser         
    285                 290                 295                         

gtg gtt ctt cat ttg gag ccg gga gat gaa gtc tat atc aaa tta gat     1143
Val Val Leu His Leu Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp         
300                 305                 310                 315         

ggc ggg aaa gcc cat gga gga aac aac aac aaa tac agc acg ttt tct     1191
Gly Gly Lys Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser         
                320                 325                 330             

gga ttt att att tat gct gac tga taatgcagaa actaagctta ttattctgag    1245
Gly Phe Ile Ile Tyr Ala Asp                                             
            335                                                         

tttgaacact ggattcgtat ggctaacgtc agtgaatcaa ggatcccagg ggatgccaat   1305

ggcagggcac ctcagttgtg tatatgtggg gaaatcaaat gctacctgac tcacatctgt   1365

atcactcaga aacattatgt aaaaaatatc aaagcaagat aagcagatgt gtgatccact   1425

accgccaaag caaatactcc ttatcgttag tgtccatgtg aatgaagtcc tatatagatc   1485

acaaattttt atagacaaat ctaagacatt gaattatttc ttctatatat atgatacttt   1545

ggtgtactgt gatcttgctg cttttatcca tatgtcagct ttggttcttg tgagtttacc   1605

tgcttattat gatacttgga gtccattcat agtgtgggga agaatgattt ttgccctgca   1665

ggagaaggtc taattgaaat aatgctgctt gtccccaaag aaattgtttg ccttgtactc   1725

ttgttaacct tagagctaga cctgggaatg attcaacttc aagccttaac ctggaatttt   1785

ctggatttga gggaattccc aagcctatga tctttttcac attttctttt tcttatatga   1845

aat                                                                 1848


<210>  302

<211>  338

<212>  PRT

<213>  Homo sapiens



<400>  302

Met Val Trp Gly Arg Arg Lys Ser Gln Asp Cys Asp Pro Thr Met Ile 
1               5                   10                  15      


Thr Ala Phe Trp Ile Gly Leu His Leu Leu Glu Gly Pro Gln Gly Pro 
            20                  25                  30          


Val Leu Ala Ala Asn Leu Thr Ile Leu Ser Ser Lys Arg Lys Val Thr 
        35                  40                  45              


Phe Lys Lys Gln Ser Arg Arg Gly Pro Arg Pro Thr Phe Lys Ile Leu 
    50                  55                  60                  


Ser Lys Ser Arg Gln Glu Asp Arg Pro Ala Leu Ser Arg Leu Val Gly 
65                  70                  75                  80  


Ser Arg Arg Arg Leu Ile Ala Ala Gly Ala Leu Gly Val Val Met Val 
                85                  90                  95      


Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr Cys Arg 
            100                 105                 110         


Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala 
        115                 120                 125             


Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly 
    130                 135                 140                 


Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro 
145                 150                 155                 160 


Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys 
                165                 170                 175     


Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly 
            180                 185                 190         


Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Gly Pro 
        195                 200                 205             


Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu 
    210                 215                 220                 


Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp 
225                 230                 235                 240 


Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe 
                245                 250                 255     


Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala 
            260                 265                 270         


Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp 
        275                 280                 285             


Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu 
    290                 295                 300                 


Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His 
305                 310                 315                 320 


Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr 
                325                 330                 335     


Ala Asp 
        


<210>  303

<211>  1017

<212>  DNA

<213>  Homo sapiens



<400>  303
atggtgtggg gaagaagaaa atcacaggat tgtgatccaa ccatgatcac ggctttctgg     60

attggacttc atcttctgga gggtccacaa ggtccagtgc tggcagcaaa cctcaccatt    120

ttgtcctcca aaaggaaggt gacttttaag aagcaatcca gaagaggtcc ccgcccaacc    180

ttcaaaattc tgtccaaaag cagacaagag gatcgccccg cgctgagccg gctggtgggc    240

agcaggaggc gcctgatcgc cgccggggcg ctgggggtgg tgatggtgct gctgctggtg    300

atcctcatcc cggtgctgat gctgggcacc tgccgcatgg tctgcgaccc ctacgggggc    360

accaaggcgc ccagcaccgc tgccacgccc gaccgcggcc tcatgcagtc cctgcccacc    420

ttcatccagg gccccaaagg cgaggccggc aggcccggga aggcgggtcc gcgcgggccc    480

cccggagagc ccgggccacc cggccccatg gggcccccgg gcgagaaggg cgagccgggc    540

cgccaaggcc tgccgggccc gcccggggcg cccggcctga acgcggccgg ggccatcagc    600

gccgccacct acagcacggg gcccaagatc gccttctacg ccggcctcaa gcggcagcat    660

gaaggctacg aggtgctcaa gttcgacgac gtggtcacca acctcggaaa ccactacgac    720

cccaccaccg gcaagttcac ctgctccatc ccgggcatct acttcttcac ctaccacgtc    780

ctgatgcgcg gaggggacgg caccagcatg tgggctgatc tctgcaaaaa caaccaggtg    840

cgtgctagtg caattgccca agatgctgat cagaattacg actatgccag taacagtgtg    900

gttcttcatt tggagccggg agatgaagtc tatatcaaat tagatggcgg gaaagcccat    960

ggaggaaaca acaacaaata cagcacgttt tctggattta ttatttatgc tgactga      1017


<210>  304

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  304

Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp 
1               5                   10                  15      


Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe 
            20                  25                  30          


Thr Tyr His Val 
        35      


<210>  305

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  305

Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His Val Leu 
1               5                   10                  15      


Met Arg Gly Gly 
            20  


<210>  306

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  306

Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly Asp Glu 
1               5                   10                  15      


Val Tyr Ile Lys Leu Asp 
            20          


<210>  307

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  307

Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly 
1               5                   10                  15      


Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro 
            20                  25          


<210>  308

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  308

Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly Asp Glu 
1               5                   10                  15      


Val Tyr Ile Lys 
            20  


<210>  309

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  309

Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro 
            20                  25          


<210>  310

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  310

Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys 
            20                  25          


<210>  311

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  311

Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
1               5                   10                  15      


Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro 
            20                  25          


<210>  312

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  312

Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu 
            20                  25                  


<210>  313

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  313

Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro 
            20                  25          


<210>  314

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  314

Gln His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn 
1               5                   10                  15      


Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys 
            20                  25          


<210>  315

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  315

Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn 
            20                  25          


<210>  316

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  316

Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly 
1               5                   10                  15      


Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln 
            20                  25          


<210>  317

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  317

Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu 
            20                  25                  


<210>  318

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  318

Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu 
            20                  25                  


<210>  319

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  319

Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro 
1               5                   10                  15      


Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro 
            20                  25                  30          


Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser 
        35                  40                  


<210>  320

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  320

Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro 
            20                  25          


<210>  321

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  321

Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile 
            20                  25                  


<210>  322

<211>  1528

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (161)..(895)

<223>  



<400>  322
gtcctccaaa aggaaggtga cttttaagaa gcaatccaga agaggtcccc gcccaacctt     60

caaaattctg tccaaaagca gacaagagga tcgccccgcg ctgagccggc tggtgggcag    120

caggaggcgc ctgatcgccg ccggggcgct gggggtggtg atg gtg ctg ctg ctg      175
                                            Met Val Leu Leu Leu         
                                            1               5           

gtg atc ctc atc ccg gtg ctg atg ctg ggc acc tgc cgc atg gtc tgc      223
Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr Cys Arg Met Val Cys         
                10                  15                  20              

gac ccc tac ggg ggc acc aag gcg ccc agc acc gct gcc acg ccc gac      271
Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp         
            25                  30                  35                  

cgc ggc ctc atg cag tcc ctg ccc acc ttc atc cag ggc ccc aaa ggc      319
Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Lys Gly         
        40                  45                  50                      

gag gcc ggc agg ccc ggg aag gcg ggt ccg cgc ggg ccc ccc gga gag      367
Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu         
    55                  60                  65                          

ccc ggg cca ccc ggc ccc atg ggg ccc ccg ggc gag aag ggc gag ccg      415
Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro         
70                  75                  80                  85          

ggc cgc caa ggc ctg ccg ggc ccg ccc ggg gcg ccc ggc ctg aac gcg      463
Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn Ala         
                90                  95                  100             

gcc ggg gcc atc agc gcc gcc acc tac agc acg ggg ccc aag atc gcc      511
Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Gly Pro Lys Ile Ala         
            105                 110                 115                 

ttc tac gcc ggc ctc aag cgg cag cat gaa ggc tac gag gtg ctc aag      559
Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val Leu Lys         
        120                 125                 130                     

ttc gac gac gtg gtc acc aac ctc gga aac cac tac gac ccc acc acc      607
Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr         
    135                 140                 145                         

ggc aag ttc acc tgc tcc atc ccg ggc atc tac ttc ttc acc tac cac      655
Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His         
150                 155                 160                 165         

gtc ctg atg cgc gga ggg gac ggc acc agc atg tgg gct gat ctc tgc      703
Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys         
                170                 175                 180             

aaa aac aac cag gtg cgt gct agt gca att gcc caa gat gct gat cag      751
Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln         
            185                 190                 195                 

aat tac gac tat gcc agt aac agt gtg gtt ctt cat ttg gag ccg gga      799
Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly         
        200                 205                 210                     

gat gaa gtc tat atc aaa tta gat ggc ggg aaa gcc cat gga gga aac      847
Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn         
    215                 220                 225                         

aac aac aaa tac agc acg ttt tct gga ttt att att tat gct gac tga      895
Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala Asp             
230                 235                 240                             

taatgcagaa actaagctta ttattctgag tttgaacact ggattcgtat ggctaacgtc    955

agtgaatcaa ggatcccagg ggatgccaat ggcagggcac ctcagttgtg tatatgtggg   1015

gaaatcaaat gctacctgac tcacatctgt atcactcaga aacattatgt aaaaaatatc   1075

aaagcaagat aagcagatgt gtgatccact accgccaaag caaatactcc ttatcgttag   1135

tgtccatgtg aatgaagtcc tatatagatc acaaattttt atagacaaat ctaagacatt   1195

gaattatttc ttctatatat atgatacttt ggtgtactgt gatcttgctg cttttatcca   1255

tatgtcagct ttggttcttg tgagtttacc tgcttattat gatacttgga gtccattcat   1315

agtgtgggga agaatgattt ttgccctgca ggagaaggtc taattgaaat aatgctgctt   1375

gtccccaaag aaattgtttg ccttgtactc ttgttaacct tagagctaga cctgggaatg   1435

attcaacttc aagccttaac ctggaatttt ctggatttga gggaattccc aagcctatga   1495

tctttttcac attttctttt tcttatatga aat                                1528


<210>  323

<211>  244

<212>  PRT

<213>  Homo sapiens



<400>  323

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr 
1               5                   10                  15      


Cys Arg Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr 
            20                  25                  30          


Ala Ala Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile 
        35                  40                  45              


Gln Gly Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg 
    50                  55                  60                  


Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
65                  70                  75                  80  


Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala 
                85                  90                  95      


Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr 
            100                 105                 110         


Gly Pro Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly 
        115                 120                 125             


Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His 
    130                 135                 140                 


Tyr Asp Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr 
145                 150                 155                 160 


Phe Phe Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met 
                165                 170                 175     


Trp Ala Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala 
            180                 185                 190         


Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu 
        195                 200                 205             


His Leu Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys 
    210                 215                 220                 


Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile 
225                 230                 235                 240 


Ile Tyr Ala Asp 
                


<210>  324

<211>  735

<212>  DNA

<213>  Homo sapiens



<400>  324
atggtgctgc tgctggtgat cctcatcccg gtgctgatgc tgggcacctg ccgcatggtc     60

tgcgacccct acgggggcac caaggcgccc agcaccgctg ccacgcccga ccgcggcctc    120

atgcagtccc tgcccacctt catccagggc cccaaaggcg aggccggcag gcccgggaag    180

gcgggtccgc gcgggccccc cggagagccc gggccacccg gccccatggg gcccccgggc    240

gagaagggcg agccgggccg ccaaggcctg ccgggcccgc ccggggcgcc cggcctgaac    300

gcggccgggg ccatcagcgc cgccacctac agcacggggc ccaagatcgc cttctacgcc    360

ggcctcaagc ggcagcatga aggctacgag gtgctcaagt tcgacgacgt ggtcaccaac    420

ctcggaaacc actacgaccc caccaccggc aagttcacct gctccatccc gggcatctac    480

ttcttcacct accacgtcct gatgcgcgga ggggacggca ccagcatgtg ggctgatctc    540

tgcaaaaaca accaggtgcg tgctagtgca attgcccaag atgctgatca gaattacgac    600

tatgccagta acagtgtggt tcttcatttg gagccgggag atgaagtcta tatcaaatta    660

gatggcggga aagcccatgg aggaaacaac aacaaataca gcacgttttc tggatttatt    720

atttatgctg actga                                                     735


<210>  325

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  325

Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr 
1               5                   10                  15      


Cys Arg Met 
            


<210>  326

<211>  225

<212>  PRT

<213>  Homo sapiens



<400>  326

Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr 
1               5                   10                  15      


Pro Asp Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro 
        35                  40                  45              


Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly 
    50                  55                  60                  


Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu 
65                  70                  75                  80  


Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Gly Pro Lys 
                85                  90                  95      


Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val 
            100                 105                 110         


Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro 
        115                 120                 125             


Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr 
    130                 135                 140                 


Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp 
145                 150                 155                 160 


Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala 
                165                 170                 175     


Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu 
            180                 185                 190         


Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly 
        195                 200                 205             


Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala 
    210                 215                 220                 


Asp 
225 


<210>  327

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  327

Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp 
1               5                   10                  15      


Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe 
            20                  25                  30          


Thr Tyr His Val 
        35      


<210>  328

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  328

Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His Val Leu 
1               5                   10                  15      


Met Arg Gly Gly 
            20  


<210>  329

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  329

Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly Asp Glu 
1               5                   10                  15      


Val Tyr Ile Lys Leu Asp 
            20          


<210>  330

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  330

Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly 
1               5                   10                  15      


Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro 
            20                  25          


<210>  331

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  331

Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly Asp Glu 
1               5                   10                  15      


Val Tyr Ile Lys 
            20  


<210>  332

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  332

Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro 
            20                  25          


<210>  333

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  333

Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys 
            20                  25          


<210>  334

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  334

Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
1               5                   10                  15      


Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro 
            20                  25          


<210>  335

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  335

Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu 
            20                  25                  


<210>  336

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  336

Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro 
            20                  25          


<210>  337

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  337

Gln His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn 
1               5                   10                  15      


Leu Gly Asn His Tyr Asp Pro Thr Thr Gly Lys 
            20                  25          


<210>  338

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  338

Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly 
1               5                   10                  15      


Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn 
            20                  25          


<210>  339

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  339

Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly 
1               5                   10                  15      


Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln 
            20                  25          


<210>  340

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  340

Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu 
            20                  25                  


<210>  341

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  341

Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu 
            20                  25                  


<210>  342

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  342

Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro 
1               5                   10                  15      


Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro 
            20                  25                  30          


Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser 
        35                  40                  


<210>  343

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  343

Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro 
            20                  25          


<210>  344

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  344

Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly 
1               5                   10                  15      


Pro Pro Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile 
            20                  25                  


<210>  345

<211>  452

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (1)..(452)

<223>  n = A, T, G, or C



<400>  345
ttcccgagtc gcccacgcgt ccgggctcct tatgatgggc gctacctgat cacggccacc     60

ctcacccccg agagagacgc ctacgtggaa gcagtgctgt cggtctccaa cgccagcgtg    120

gcccagctgc ataccgctgg gtacaggaga gagttcctgg aataccaccg ccctccagga    180

gctttgcata cctgcggggg cccgggggca ttccacctca tcgtgcacct gaaggcggga    240

gatgcagtca acgtcgtggt gactgggggc aagctggctc acacagactt tgatgaaatg    300

tactccacat ttagtggggt tttcttatat cctttccttt cccacctcta aggtggctgg    360

ggagatgtca ggggaaagat agatagttgt aaaaactcta aagctttaat atattcggtt    420

tgtatgtaat ggaagcacgg ngctagagtt tc                                  452


<210>  346

<211>  3122

<212>  DNA

<213>  Homo sapiens



<400>  346
cgtccccggc gcataaggct tcgcgggcgc accaggatac ccgaagtcac ctcctgtagc     60

ttccccagga gctgcggtgc cttctctggt gtctttttct gcggggctca cccagaagcc    120

tttccccagt gatgggggcg ttgtcctctt taacaaagtg ctggtgaacg acggggatgt    180

ttacaacccc agcaccgggg tcttcacggc tccttatgat gggcgctacc tgatcacggc    240

caccctcacc cccgagagag acgcctacgt ggaagcagtg ctgtcggtct ccaacgccag    300

cgtggcccag ctgcataccg ctgggtacag gagagagttc ctggaatacc accgccctcc    360

aggagctttg catacctgcg ggggcccggg ggcattccac ctcatcgtgc acctgaaggc    420

gggagatgca gtcaacgtcg tggtgactgg gggcaagctg gctcacacag actttgatga    480

aatgtactcc acatttagtg gggttttctt atatcctttc ctttcccacc tctaaggtgg    540

ctggggagat gtcaggggaa agatagatag ttgtaaaaac tctaaagctt taatatattc    600

ggtttgtatg taatggaagc acggggctag agtttccaca taggccccaa cataaaggcc    660

ttccctcgct gttgaggcca ccatgcctta ctgcatccag ccaggctgca gggagtgagg    720

cacacggtga acatggccac tgacttttct gccactctaa ctggacaact ggaagacttg    780

gaaaggcctc cacctgtatc tacactctga gggccctgga ctgggcctga gcttgccaca    840

gaggctccgt ctgactgtgg gctgggagga gggaggcagg ggagagccgg tcacggtggc    900

tggtctttac tgcagggcag cactgtggcc agctgtctgt ctttacactg catgcagaag    960

tttaaacact gaagtgccga agtggcccgt gccgccgcac agagaccccg actttagttt   1020

gggctgttcc acgcttggct caccattgcc gcctgggact taacctgctc aggcgggcct   1080

tcgcccagct gcaaataggg atgcgttaga gactgttccc aaagcttgtt gggctcctta   1140

aatggcatgt acaatttaag tgcaaagaca gggagtgtca ataaagatgg aaagccattt   1200

ccagttaact tttgttaatt taagtgtggt cccttacaga tcgggagttg ttgctaaaaa   1260

gcaaactgaa gaaatgtttt gtttcaaaaa gggctacaga aagtaacctt gagtaaaatt   1320

aatctcagct acaaaactgt tacccctccg catccaagct atacacttgg gttttgtttc   1380

tggcttgtga agacggacca gatgtgcacg gaggtcacgg ccccatgtca tctgcagctg   1440

gagcggctcc tctggggatg ctgcactcag atcccacagc agctgcccag gctaacttga   1500

tccctgctgc ttcactgcac caatctccag cagacacagc tcgccgagct cttgggtttc   1560

taagcagcag gaagctcaac ctaacgctgg ccacacgctg acagctgagc ccatctgaga   1620

acacggcatc ttcacacagc gagacgcctc cactgagggg aggcccggga gtatcaatct   1680

gtcaccagtg gccacggaga cctctcagca cccttagttc aaggtagtct ctgtggatca   1740

ggttggtaac acctactggt taatcaagtc ccactgggga aaggtttgga cggtagaatc   1800

aagagctgca gtttccttgg cccacaagat gctcttatgc tgtaaaaaaa atgctttaag   1860

aattgtttgc aaatgaattt acagggtggc cactggacac ttcagagttc ctatttactc   1920

cccccgccac agctaggaag accagcaaga actaaaggtt tgccgtttta ctatttaaaa   1980

tgtggacctc tttgtccagg agcgggaggg agaatggcat ctcaccccat tacaacagct   2040

ggggaactgg ctaaagagag ctgtcagaga gtatccttgg ctgtcctagg aatgactcat   2100

ggaaagcgcc ccagtgcagc agtgttttca ggaaaaccca gtgggcacgc gccatcgccc   2160

tctcctctcc tctcacgctc cttttgaaaa gaccgcactc ggcgcccaag gggacgtgct   2220

caagagctgc aggggcaggg cccaggcaaa aggtgggtga tgactacctg ctgctttccc   2280

tactccgtag atgggtctgg aacatcgggt aaaacccagt cctcctctca gtgcatctct   2340

actcaccaac aatggtgaat ctcagctctg tgtattcaag acaggcaaaa cagaatatgc   2400

ctcattatgg ctggagcgtg cctctacttt gagataaagc tggatgacag gtggatcctg   2460

gcccacttag gagacatctt tagaaaggga aaggctgtct ttttgtacag gtagtagaac   2520

aacaaggtca gctgagctta aggctgtggg gttcgaagca gcccttcaag aagtcatcac   2580

ccctgaagta gtgcctgcga gtcagtcaga ggcataccaa accctgagac agaatcaggc   2640

acaagttcac aacttttttt ttttttgggg gggagacagt cctactctgt cgcccaggct   2700

ggagtgcagt agcgcgatct cagctcactg caacctccgc ctcccgggtt caagcaattc   2760

tcctacctca gcctcccgag tagcggggac tacaggtgca tgccgccacg cccggttaat   2820

tttttgtatt ttagtagaga tggggtttca ccgtgttgcc caggctggtc gcgaactcct   2880

gagctcagcc aatccgccca cctcggcctc ccaaagtgct gggattacag gtatgagcca   2940

ccatgcccag ccaagttcac aacttctgat atcaagttgt tgctgagaaa aggtcaggac   3000

acttcttaag tagagaagga ctgtgacatc ccctccaaac ctccatgtaa cactaacaaa   3060

tggcctcatt tacacgatta aaaacaaaat ggtatcgtca ataaatgcaa accttaaact   3120

gc                                                                  3122


<210>  347

<211>  2216

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1542)

<223>  



<400>  347
atg gag ggg gat gcc cag ctg gca gtg gag ggt gtg agc att ggg cct       48
Met Glu Gly Asp Ala Gln Leu Ala Val Glu Gly Val Ser Ile Gly Pro         
1               5                   10                  15              

ggg acc gca gtt cct cct gct cca cag gtt ctg agg acg tgg aga ttt       96
Gly Thr Ala Val Pro Pro Ala Pro Gln Val Leu Arg Thr Trp Arg Phe         
            20                  25                  30                  

ggc act gag cgg gga tct gtg tgc tcc tct gtt gag ggg gag acc aac      144
Gly Thr Glu Arg Gly Ser Val Cys Ser Ser Val Glu Gly Glu Thr Asn         
        35                  40                  45                      

tgt ttc ttc gaa aaa gcc cct tta tct aag ctc acc ccg ggc cca ttt      192
Cys Phe Phe Glu Lys Ala Pro Leu Ser Lys Leu Thr Pro Gly Pro Phe         
    50                  55                  60                          

agc acc aca agc gac agt ttc tct gaa ttt tct gat gag tcc agc att      240
Ser Thr Thr Ser Asp Ser Phe Ser Glu Phe Ser Asp Glu Ser Ser Ile         
65                  70                  75                  80          

tct cat gct tca gtc cgt gat ggg agt ttt aaa aca aaa cta gac ggc      288
Ser His Ala Ser Val Arg Asp Gly Ser Phe Lys Thr Lys Leu Asp Gly         
                85                  90                  95              

agg tcg gga ggc agc cgc cga ttt ttg tcg ggt cct aaa caa aaa tca      336
Arg Ser Gly Gly Ser Arg Arg Phe Leu Ser Gly Pro Lys Gln Lys Ser         
            100                 105                 110                 

aat gtg ttg cgc ttt gga act ctg ggc atc gtg ggc acc agg ctg acg      384
Asn Val Leu Arg Phe Gly Thr Leu Gly Ile Val Gly Thr Arg Leu Thr         
        115                 120                 125                     

ggg gcg gcg ggg atg gcg ttt ctt ggc gag cgg gtc cct cag cca ggc      432
Gly Ala Ala Gly Met Ala Phe Leu Gly Glu Arg Val Pro Gln Pro Gly         
    130                 135                 140                         

ccg ggt att gtc agg cgt ccc gtg gac ggt cgg gag ggg ctt cct gga      480
Pro Gly Ile Val Arg Arg Pro Val Asp Gly Arg Glu Gly Leu Pro Gly         
145                 150                 155                 160         

ggg ctc gtt ccg gga acg agt tca aag gag gaa agg gcg gca gct tcc      528
Gly Leu Val Pro Gly Thr Ser Ser Lys Glu Glu Arg Ala Ala Ala Ser         
                165                 170                 175             

ggc gcc ttc ccc aga ggg ccg gga gac gca cgc cag gag ctt cct ccg      576
Gly Ala Phe Pro Arg Gly Pro Gly Asp Ala Arg Gln Glu Leu Pro Pro         
            180                 185                 190                 

ttg gaa gtc cct tcc gct ggc gac gtg ggc gct gtg gcc gcg gcc ctc      624
Leu Glu Val Pro Ser Ala Gly Asp Val Gly Ala Val Ala Ala Ala Leu         
        195                 200                 205                     

gtg gag cct gag ccc tcc tca cgg cct ccg cgc agc cct ggg gcc ccc      672
Val Glu Pro Glu Pro Ser Ser Arg Pro Pro Arg Ser Pro Gly Ala Pro         
    210                 215                 220                         

cgg cag ggt ccc tcg gca gcc cgc ggg aga ggc cgt ggg gcc ccg gca      720
Arg Gln Gly Pro Ser Ala Ala Arg Gly Arg Gly Arg Gly Ala Pro Ala         
225                 230                 235                 240         

gga gtg tgg ttc aga gac gag gcg ccc tcg ccc ccg ccg ccc gca gag      768
Gly Val Trp Phe Arg Asp Glu Ala Pro Ser Pro Pro Pro Pro Ala Glu         
                245                 250                 255             

gcc ccg aag gag ccg ctg cag ccc gag ccc gcc ccg ccg agg ccc agc      816
Ala Pro Lys Glu Pro Leu Gln Pro Glu Pro Ala Pro Pro Arg Pro Ser         
            260                 265                 270                 

ggc ccc gca acc gca gag gac cct ggg cga cgg ccc gtc ctg ccc cag      864
Gly Pro Ala Thr Ala Glu Asp Pro Gly Arg Arg Pro Val Leu Pro Gln         
        275                 280                 285                     

cgg ccc ccc gag gag agg ccg ccc cag ccg cca ggc tcc acc ggg gtc      912
Arg Pro Pro Glu Glu Arg Pro Pro Gln Pro Pro Gly Ser Thr Gly Val         
    290                 295                 300                         

atc gcg gag acg ggc cag gcc ggg ccc ccc gca ggc gca ggc gtg tct      960
Ile Ala Glu Thr Gly Gln Ala Gly Pro Pro Ala Gly Ala Gly Val Ser         
305                 310                 315                 320         

ggg cgg ggt ctg ccg cgg ggc gtg gac ggc cag acc ggg agc ggc acc     1008
Gly Arg Gly Leu Pro Arg Gly Val Asp Gly Gln Thr Gly Ser Gly Thr         
                325                 330                 335             

gtc ccc ggc gca gaa ggc ttc gcg ggc gca cca gga tac ccg aag tca     1056
Val Pro Gly Ala Glu Gly Phe Ala Gly Ala Pro Gly Tyr Pro Lys Ser         
            340                 345                 350                 

cct cct gta gct tcc cca gga gct ccg gtg cct tct ctg gtg tct ttt     1104
Pro Pro Val Ala Ser Pro Gly Ala Pro Val Pro Ser Leu Val Ser Phe         
        355                 360                 365                     

tct gcg ggg ctc acc cag aag cct ttc ccc agt gat ggg ggc gtt gtc     1152
Ser Ala Gly Leu Thr Gln Lys Pro Phe Pro Ser Asp Gly Gly Val Val         
    370                 375                 380                         

ctc ttt aac aaa gtg ctg gtg aac gac ggg gat gtt tac aac ccc agc     1200
Leu Phe Asn Lys Val Leu Val Asn Asp Gly Asp Val Tyr Asn Pro Ser         
385                 390                 395                 400         

acc ggg gtc ttc acg gct cct tat gat ggg cgc tac ctg atc acg gcc     1248
Thr Gly Val Phe Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile Thr Ala         
                405                 410                 415             

acc ctc acc ccc gag aga gac gcc tac gtg gaa gca gtg ctg tcg gtc     1296
Thr Leu Thr Pro Glu Arg Asp Ala Tyr Val Glu Ala Val Leu Ser Val         
            420                 425                 430                 

tcc aac gcc agc gtg gcc cag ctg cat acc gct ggg tac agg aga gag     1344
Ser Asn Ala Ser Val Ala Gln Leu His Thr Ala Gly Tyr Arg Arg Glu         
        435                 440                 445                     

ttc ctg gaa tac cac cgc cct aca gga gct ttg cat acc tgc ggg ggc     1392
Phe Leu Glu Tyr His Arg Pro Thr Gly Ala Leu His Thr Cys Gly Gly         
    450                 455                 460                         

ccg ggg gca ttc cac ctc atc gtg cac ctg aag gcg gga gat gca gtc     1440
Pro Gly Ala Phe His Leu Ile Val His Leu Lys Ala Gly Asp Ala Val         
465                 470                 475                 480         

aac gtc gtg gtg act ggg ggc aag ctg gct cac aca gac ttt gat gaa     1488
Asn Val Val Val Thr Gly Gly Lys Leu Ala His Thr Asp Phe Asp Glu         
                485                 490                 495             

atg tac tcc aca ttt agt ggg gtt ttc tta tat cct ttc ctt tcc cac     1536
Met Tyr Ser Thr Phe Ser Gly Val Phe Leu Tyr Pro Phe Leu Ser His         
            500                 505                 510                 

ctc taa ggtggctggg gagatgtcag gggaaagata gatagttgta aaaactctaa      1592
Leu                                                                     
                                                                        

agctttaata tattcggttt gtatgtaatg gaagcacggg gctagagttt ccacataggc   1652

cccaacataa aggccttccc tcgctgttga ggccaccatg ccttactgca tccagccagg   1712

ctgcagggag tgaggcacac ggtgaacatg gccactgact tttctgccac tctaactgga   1772

caactggaag acttggaaag gcctccacct gtatctacac tctgagggcc ctggactggg   1832

cctgagcttg ccacagaggc tccgtctgac tgtgggctgg gaggagggag gcaggggaga   1892

gccggtcacg gtggctggtc tttactgcag ggcagcactg tggccagctg tctgtcttta   1952

cactgcatgc agaagtttaa acactgaagt gccgaagtgg cccgtgccgc cgcacagaga   2012

ccccgacttt agtttgggct gttgcacgct tggctcacca ttgccacctg ggacttaacc   2072

tgctcaggcg ggccttcgcc cagctgcaaa tagggatgcg ttagagactg ttcccaaagc   2132

ttgttgggct ccttaaatgg catgtacaat ttaagtgcaa agacagggag tgtcaataaa   2192

gatggaaagc caaaaaaaaa aaaa                                          2216


<210>  348

<211>  513

<212>  PRT

<213>  Homo sapiens



<400>  348

Met Glu Gly Asp Ala Gln Leu Ala Val Glu Gly Val Ser Ile Gly Pro 
1               5                   10                  15      


Gly Thr Ala Val Pro Pro Ala Pro Gln Val Leu Arg Thr Trp Arg Phe 
            20                  25                  30          


Gly Thr Glu Arg Gly Ser Val Cys Ser Ser Val Glu Gly Glu Thr Asn 
        35                  40                  45              


Cys Phe Phe Glu Lys Ala Pro Leu Ser Lys Leu Thr Pro Gly Pro Phe 
    50                  55                  60                  


Ser Thr Thr Ser Asp Ser Phe Ser Glu Phe Ser Asp Glu Ser Ser Ile 
65                  70                  75                  80  


Ser His Ala Ser Val Arg Asp Gly Ser Phe Lys Thr Lys Leu Asp Gly 
                85                  90                  95      


Arg Ser Gly Gly Ser Arg Arg Phe Leu Ser Gly Pro Lys Gln Lys Ser 
            100                 105                 110         


Asn Val Leu Arg Phe Gly Thr Leu Gly Ile Val Gly Thr Arg Leu Thr 
        115                 120                 125             


Gly Ala Ala Gly Met Ala Phe Leu Gly Glu Arg Val Pro Gln Pro Gly 
    130                 135                 140                 


Pro Gly Ile Val Arg Arg Pro Val Asp Gly Arg Glu Gly Leu Pro Gly 
145                 150                 155                 160 


Gly Leu Val Pro Gly Thr Ser Ser Lys Glu Glu Arg Ala Ala Ala Ser 
                165                 170                 175     


Gly Ala Phe Pro Arg Gly Pro Gly Asp Ala Arg Gln Glu Leu Pro Pro 
            180                 185                 190         


Leu Glu Val Pro Ser Ala Gly Asp Val Gly Ala Val Ala Ala Ala Leu 
        195                 200                 205             


Val Glu Pro Glu Pro Ser Ser Arg Pro Pro Arg Ser Pro Gly Ala Pro 
    210                 215                 220                 


Arg Gln Gly Pro Ser Ala Ala Arg Gly Arg Gly Arg Gly Ala Pro Ala 
225                 230                 235                 240 


Gly Val Trp Phe Arg Asp Glu Ala Pro Ser Pro Pro Pro Pro Ala Glu 
                245                 250                 255     


Ala Pro Lys Glu Pro Leu Gln Pro Glu Pro Ala Pro Pro Arg Pro Ser 
            260                 265                 270         


Gly Pro Ala Thr Ala Glu Asp Pro Gly Arg Arg Pro Val Leu Pro Gln 
        275                 280                 285             


Arg Pro Pro Glu Glu Arg Pro Pro Gln Pro Pro Gly Ser Thr Gly Val 
    290                 295                 300                 


Ile Ala Glu Thr Gly Gln Ala Gly Pro Pro Ala Gly Ala Gly Val Ser 
305                 310                 315                 320 


Gly Arg Gly Leu Pro Arg Gly Val Asp Gly Gln Thr Gly Ser Gly Thr 
                325                 330                 335     


Val Pro Gly Ala Glu Gly Phe Ala Gly Ala Pro Gly Tyr Pro Lys Ser 
            340                 345                 350         


Pro Pro Val Ala Ser Pro Gly Ala Pro Val Pro Ser Leu Val Ser Phe 
        355                 360                 365             


Ser Ala Gly Leu Thr Gln Lys Pro Phe Pro Ser Asp Gly Gly Val Val 
    370                 375                 380                 


Leu Phe Asn Lys Val Leu Val Asn Asp Gly Asp Val Tyr Asn Pro Ser 
385                 390                 395                 400 


Thr Gly Val Phe Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile Thr Ala 
                405                 410                 415     


Thr Leu Thr Pro Glu Arg Asp Ala Tyr Val Glu Ala Val Leu Ser Val 
            420                 425                 430         


Ser Asn Ala Ser Val Ala Gln Leu His Thr Ala Gly Tyr Arg Arg Glu 
        435                 440                 445             


Phe Leu Glu Tyr His Arg Pro Thr Gly Ala Leu His Thr Cys Gly Gly 
    450                 455                 460                 


Pro Gly Ala Phe His Leu Ile Val His Leu Lys Ala Gly Asp Ala Val 
465                 470                 475                 480 


Asn Val Val Val Thr Gly Gly Lys Leu Ala His Thr Asp Phe Asp Glu 
                485                 490                 495     


Met Tyr Ser Thr Phe Ser Gly Val Phe Leu Tyr Pro Phe Leu Ser His 
            500                 505                 510         


Leu 
    


<210>  349

<211>  1542

<212>  DNA

<213>  Homo sapiens



<400>  349
atggaggggg atgcccagct ggcagtggag ggtgtgagca ttgggcctgg gaccgcagtt     60

cctcctgctc cacaggttct gaggacgtgg agatttggca ctgagcgggg atctgtgtgc    120

tcctctgttg agggggagac caactgtttc ttcgaaaaag cccctttatc taagctcacc    180

ccgggcccat ttagcaccac aagcgacagt ttctctgaat tttctgatga gtccagcatt    240

tctcatgctt cagtccgtga tgggagtttt aaaacaaaac tagacggcag gtcgggaggc    300

agccgccgat ttttgtcggg tcctaaacaa aaatcaaatg tgttgcgctt tggaactctg    360

ggcatcgtgg gcaccaggct gacgggggcg gcggggatgg cgtttcttgg cgagcgggtc    420

cctcagccag gcccgggtat tgtcaggcgt cccgtggacg gtcgggaggg gcttcctgga    480

gggctcgttc cgggaacgag ttcaaaggag gaaagggcgg cagcttccgg cgccttcccc    540

agagggccgg gagacgcacg ccaggagctt cctccgttgg aagtcccttc cgctggcgac    600

gtgggcgctg tggccgcggc cctcgtggag cctgagccct cctcacggcc tccgcgcagc    660

cctggggccc cccggcaggg tccctcggca gcccgcggga gaggccgtgg ggccccggca    720

ggagtgtggt tcagagacga ggcgccctcg cccccgccgc ccgcagaggc cccgaaggag    780

ccgctgcagc ccgagcccgc cccgccgagg cccagcggcc ccgcaaccgc agaggaccct    840

gggcgacggc ccgtcctgcc ccagcggccc cccgaggaga ggccgcccca gccgccaggc    900

tccaccgggg tcatcgcgga gacgggccag gccgggcccc ccgcaggcgc aggcgtgtct    960

gggcggggtc tgccgcgggg cgtggacggc cagaccggga gcggcaccgt ccccggcgca   1020

gaaggcttcg cgggcgcacc aggatacccg aagtcacctc ctgtagcttc cccaggagct   1080

ccggtgcctt ctctggtgtc tttttctgcg gggctcaccc agaagccttt ccccagtgat   1140

gggggcgttg tcctctttaa caaagtgctg gtgaacgacg gggatgttta caaccccagc   1200

accggggtct tcacggctcc ttatgatggg cgctacctga tcacggccac cctcaccccc   1260

gagagagacg cctacgtgga agcagtgctg tcggtctcca acgccagcgt ggcccagctg   1320

cataccgctg ggtacaggag agagttcctg gaataccacc gccctacagg agctttgcat   1380

acctgcgggg gcccgggggc attccacctc atcgtgcacc tgaaggcggg agatgcagtc   1440

aacgtcgtgg tgactggggg caagctggct cacacagact ttgatgaaat gtactccaca   1500

tttagtgggg ttttcttata tcctttcctt tcccacctct aa                      1542


<210>  350

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  350

Val Val Leu Phe Asn Lys Val Leu Val Asn Asp Gly Asp Val Tyr Asn 
1               5                   10                  15      


Pro Ser Thr Gly Val Phe Thr Ala Pro Tyr Asp Gly Arg Tyr Leu Ile 
            20                  25                  30          


Thr Ala Thr Leu 
        35      


<210>  351

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  351

Phe Pro Ser Asp Gly Gly Val Val Leu Phe Asn Lys Val Leu Val Asn 
1               5                   10                  15      


Asp Gly Asp Val Tyr Asn Pro Ser Thr Gly Val 
            20                  25          


<210>  352

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  352

Glu Thr Ser Leu Glu Arg Glu Arg Leu Ser Phe Cys Thr Gly Ser Arg 
1               5                   10                  15      


Thr Thr Arg Ser Ala Glu Leu Lys Ala Val Gly Phe Glu Ala Ala Leu 
            20                  25                  30          


Gln Glu Val Ile Thr Pro Glu Val Val Pro Ala Ser Gln Ser Glu Ala 
        35                  40                  45              


Tyr Gln Thr Leu Arg Gln Asn Gln Ala Gln Val His Asn Phe Phe Phe 
    50                  55                  60                  


Phe Trp Gly Gly Asp Ser Pro Thr Leu Ser Pro Arg Leu Glu Cys Ser 
65                  70                  75                  80  


Ser Ala Ile Ser Ala His Cys Asn Leu Arg Leu Pro Gly Ser Ser Asn 
                85                  90                  95      


Ser Pro Thr Ser Ala Ser Arg Val Ala Gly Thr Thr Gly Ala Cys Arg 
            100                 105                 110         


His Ala Arg Leu Ile Phe Cys Ile Leu Val Glu Met Gly Phe His Arg 
        115                 120                 125             


Val Ala Gln Ala Gly Arg Glu Leu Leu Ser Ser Ala Asn Pro Pro Thr 
    130                 135                 140                 


Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Met Ser His His Ala Gln 
145                 150                 155                 160 


Pro Ser Ser Gln Leu Leu Ile Ser Ser Cys Cys 
                165                 170     


<210>  353

<211>  418

<212>  DNA

<213>  Homo sapiens



<400>  353
gaattcttcg tcgacgattc cgtgtccact gggaggaggg agcaggccgg acgtctgccc     60

cgtccccggt gggtgcgggg gcgtcaggtg ggcaaaaccc cagcgagggg aagctccagg    120

atcgttgcag tgccatttct aggtccctcc tcctctcccc acttcccttt tctctgcacc    180

catttgacag gagcctctgc aatcatctgc ttattgcgcg tcaccgtcat ccagtgggag    240

agccttgtgg taccaccttt ctccacctat ggctgcggcc cgcaggaaga tgacgggttg    300

ctcttctgct ctggagccat ccctgttgcc ggtaactgca acccgcaaga tgatgccaga    360

gctcagcttc cctcttttta tgttgcaaag tatatgctgc cctgcactga gcagaccc      418


<210>  354

<211>  1613

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (683)..(1564)

<223>  



<400>  354
aggaaggtta gggaggcgga gagggaccgc gcccgcagag agaggcgcgg gccagggcta     60

ctagcaggga ctggggccgc ggcaggggta gcaaggtgag tcggtgcttg ccaagaggca    120

gagcgcaaaa cctactagga gatcgcgccc ggtgagcagc acccgcagct cagagcccgg    180

gacgtccgga gcgcggggag cagtcccctc tccatcaggg agtggtctat ctgggcagtc    240

tgggacccag gcaccgcgcc atccctgaga gagcagcagt ctggagagca ggcatctcag    300

atccctaaga aaccagccgt ccgagaagcc gcggatctca ggtgcccagg atcgttagga    360

ctgaacggga gggtactaga ggaccactgg ctctggaccg tcgggagctg cccctgacgt    420

aacccacgag gggcctcccc ttgacggacg gcttggggag cggcaccgcc ggcctggagc    480

ccgcagaggc agggtaaggg gagcgggggg cagccgtcgg gggagtgcag acccaggccc    540

aaggcgggtc accgctcctg gcccgcggag agccccggcc ccggcagcca ttgcgcccaa    600

gagtgaggaa gatttgctgg ccctggcagc gtcgcggctg agccggcgca agagggtggc    660

gggcgcggcc gtcggagtgg cc atg gtg ctg ctg ctg ctg gtg gcc atc ccg     712
                         Met Val Leu Leu Leu Leu Val Ala Ile Pro        
                         1               5                   10         

ctg ctg gtg cac agc tcc cgc ggg cca gcg cac tac gag atg ctg ggt      760
Leu Leu Val His Ser Ser Arg Gly Pro Ala His Tyr Glu Met Leu Gly         
                15                  20                  25              

cgc tgc cgc atg gtg tgc gac ccg cat ggg ccc cgt ggc cct ggt ccc      808
Arg Cys Arg Met Val Cys Asp Pro His Gly Pro Arg Gly Pro Gly Pro         
            30                  35                  40                  

gac ggc gcg cct gct tcc gtg ccc ccc ttc ccg cca ggc gcc aag gga      856
Asp Gly Ala Pro Ala Ser Val Pro Pro Phe Pro Pro Gly Ala Lys Gly         
        45                  50                  55                      

gag gtg ggc cgg cgc ggg aaa gca ggc ctg cgg ggg ccc cct gga cca      904
Glu Val Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro         
    60                  65                  70                          

cca ggt cca aga ggg ccc cca gga gaa ccc ggc agg cca ggc ccc ccg      952
Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro         
75                  80                  85                  90          

ggc cct ccc ggt cca ggt ccg ggc ggg gtg gcg ccc gct gcc ggc tac     1000
Gly Pro Pro Gly Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr         
                95                  100                 105             

gtg cct cgc att gct ttc tac gcg ggc ctg cgg cgg ccc cac gag ggt     1048
Val Pro Arg Ile Ala Phe Tyr Ala Gly Leu Arg Arg Pro His Glu Gly         
            110                 115                 120                 

tac gag gtg ctg cgc ttc gac gac gtg gtg acc aac gtg ggc aac gcc     1096
Tyr Glu Val Leu Arg Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala         
        125                 130                 135                     

tac gag gca gcc agc ggc aag ttt act tgc ccc atg cca ggc gtc tac     1144
Tyr Glu Ala Ala Ser Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr         
    140                 145                 150                         

ttc ttc gct tac cac gtg ctc atg cgc ggc ggc gac ggc acc agc atg     1192
Phe Phe Ala Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met         
155                 160                 165                 170         

tgg gcc gac ctc atg aag aac gga cag ggc tgg ggg cct aga acg gcc     1240
Trp Ala Asp Leu Met Lys Asn Gly Gln Gly Trp Gly Pro Arg Thr Ala         
                175                 180                 185             

ttg ccc tca gca gag tct gtg gct tgg cag ctc aag ggc cag cca gga     1288
Leu Pro Ser Ala Glu Ser Val Ala Trp Gln Leu Lys Gly Gln Pro Gly         
            190                 195                 200                 

gcc tct gca atc atc tgc tta ttg cgc gtc acc gtc atc cag tgg gag     1336
Ala Ser Ala Ile Ile Cys Leu Leu Arg Val Thr Val Ile Gln Trp Glu         
        205                 210                 215                     

agc ctt gtg gta cca cct ttc tcc acc tat ggc tgc ggc ccg cag gaa     1384
Ser Leu Val Val Pro Pro Phe Ser Thr Tyr Gly Cys Gly Pro Gln Glu         
    220                 225                 230                         

gat gac ggg ttg cgc ttc tgc tct gga gcc agc cct gtt gcc ggg aac     1432
Asp Asp Gly Leu Arg Phe Cys Ser Gly Ala Ser Pro Val Ala Gly Asn         
235                 240                 245                 250         

tgc aac ccg caa gat gat gcc aga gct cag ctt ccc tct ttt tat gtt     1480
Cys Asn Pro Gln Asp Asp Ala Arg Ala Gln Leu Pro Ser Phe Tyr Val         
                255                 260                 265             

gca gag ttt atg ctg ccc tgc act gag cag acg ctt tcg ctt acg cag     1528
Ala Glu Phe Met Leu Pro Cys Thr Glu Gln Thr Leu Ser Leu Thr Gln         
            270                 275                 280                 

ccc tgc cct tca cct tgc cca gtg att ccg gaa taa ccttccggac          1574
Pro Cys Pro Ser Pro Cys Pro Val Ile Pro Glu                             
        285                 290                                         

cctcctactt gcagaggttc gttgcttcaa gcgtcataa                          1613


<210>  355

<211>  293

<212>  PRT

<213>  Homo sapiens



<400>  355

Met Val Leu Leu Leu Leu Val Ala Ile Pro Leu Leu Val His Ser Ser 
1               5                   10                  15      


Arg Gly Pro Ala His Tyr Glu Met Leu Gly Arg Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro His Gly Pro Arg Gly Pro Gly Pro Asp Gly Ala Pro Ala Ser 
        35                  40                  45              


Val Pro Pro Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg Gly 
    50                  55                  60                  


Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
65                  70                  75                  80  


Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
                85                  90                  95      


Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro Arg Ile Ala Phe 
            100                 105                 110         


Tyr Ala Gly Leu Arg Arg Pro His Glu Gly Tyr Glu Val Leu Arg Phe 
        115                 120                 125             


Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu Ala Ala Ser Gly 
    130                 135                 140                 


Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His Val 
145                 150                 155                 160 


Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Met Lys 
                165                 170                 175     


Asn Gly Gln Gly Trp Gly Pro Arg Thr Ala Leu Pro Ser Ala Glu Ser 
            180                 185                 190         


Val Ala Trp Gln Leu Lys Gly Gln Pro Gly Ala Ser Ala Ile Ile Cys 
        195                 200                 205             


Leu Leu Arg Val Thr Val Ile Gln Trp Glu Ser Leu Val Val Pro Pro 
    210                 215                 220                 


Phe Ser Thr Tyr Gly Cys Gly Pro Gln Glu Asp Asp Gly Leu Arg Phe 
225                 230                 235                 240 


Cys Ser Gly Ala Ser Pro Val Ala Gly Asn Cys Asn Pro Gln Asp Asp 
                245                 250                 255     


Ala Arg Ala Gln Leu Pro Ser Phe Tyr Val Ala Glu Phe Met Leu Pro 
            260                 265                 270         


Cys Thr Glu Gln Thr Leu Ser Leu Thr Gln Pro Cys Pro Ser Pro Cys 
        275                 280                 285             


Pro Val Ile Pro Glu 
    290             


<210>  356

<211>  882

<212>  DNA

<213>  Homo sapiens



<400>  356
atggtgctgc tgctgctggt ggccatcccg ctgctggtgc acagctcccg cgggccagcg     60

cactacgaga tgctgggtcg ctgccgcatg gtgtgcgacc cgcatgggcc ccgtggccct    120

ggtcccgacg gcgcgcctgc ttccgtgccc cccttcccgc caggcgccaa gggagaggtg    180

ggccggcgcg ggaaagcagg cctgcggggg ccccctggac caccaggtcc aagagggccc    240

ccaggagaac ccggcaggcc aggccccccg ggccctcccg gtccaggtcc gggcggggtg    300

gcgcccgctg ccggctacgt gcctcgcatt gctttctacg cgggcctgcg gcggccccac    360

gagggttacg aggtgctgcg cttcgacgac gtggtgacca acgtgggcaa cgcctacgag    420

gcagccagcg gcaagtttac ttgccccatg ccaggcgtct acttcttcgc ttaccacgtg    480

ctcatgcgcg gcggcgacgg caccagcatg tgggccgacc tcatgaagaa cggacagggc    540

tgggggccta gaacggcctt gccctcagca gagtctgtgg cttggcagct caagggccag    600

ccaggagcct ctgcaatcat ctgcttattg cgcgtcaccg tcatccagtg ggagagcctt    660

gtggtaccac ctttctccac ctatggctgc ggcccgcagg aagatgacgg gttgcgcttc    720

tgctctggag ccagccctgt tgccgggaac tgcaacccgc aagatgatgc cagagctcag    780

cttccctctt tttatgttgc agagtttatg ctgccctgca ctgagcagac gctttcgctt    840

acgcagccct gcccttcacc ttgcccagtg attccggaat aa                       882


<210>  357

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  357

Met Val Leu Leu Leu Leu Val Ala Ile Pro Leu Leu Val His Ser 
1               5                   10                  15  


<210>  358

<211>  278

<212>  PRT

<213>  Homo sapiens



<400>  358

Ser Arg Gly Pro Ala His Tyr Glu Met Leu Gly Arg Cys Arg Met Val 
1               5                   10                  15      


Cys Asp Pro His Gly Pro Arg Gly Pro Gly Pro Asp Gly Ala Pro Ala 
            20                  25                  30          


Ser Val Pro Pro Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg 
        35                  40                  45              


Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
    50                  55                  60                  


Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
65                  70                  75                  80  


Gly Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro Arg Ile Ala 
                85                  90                  95      


Phe Tyr Ala Gly Leu Arg Arg Pro His Glu Gly Tyr Glu Val Leu Arg 
            100                 105                 110         


Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu Ala Ala Ser 
        115                 120                 125             


Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His 
    130                 135                 140                 


Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Met 
145                 150                 155                 160 


Lys Asn Gly Gln Gly Trp Gly Pro Arg Thr Ala Leu Pro Ser Ala Glu 
                165                 170                 175     


Ser Val Ala Trp Gln Leu Lys Gly Gln Pro Gly Ala Ser Ala Ile Ile 
            180                 185                 190         


Cys Leu Leu Arg Val Thr Val Ile Gln Trp Glu Ser Leu Val Val Pro 
        195                 200                 205             


Pro Phe Ser Thr Tyr Gly Cys Gly Pro Gln Glu Asp Asp Gly Leu Arg 
    210                 215                 220                 


Phe Cys Ser Gly Ala Ser Pro Val Ala Gly Asn Cys Asn Pro Gln Asp 
225                 230                 235                 240 


Asp Ala Arg Ala Gln Leu Pro Ser Phe Tyr Val Ala Glu Phe Met Leu 
                245                 250                 255     


Pro Cys Thr Glu Gln Thr Leu Ser Leu Thr Gln Pro Cys Pro Ser Pro 
            260                 265                 270         


Cys Pro Val Ile Pro Glu 
        275             


<210>  359

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  359

Val Leu Arg Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu 
1               5                   10                  15      


Ala Ala Ser Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe 
            20                  25                  30          


Ala Tyr His Val 
        35      


<210>  360

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  360

Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His Val Leu 
1               5                   10                  15      


Met Arg Gly Gly 
            20  


<210>  361

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  361

Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly Gly 
            20                  25          


<210>  362

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  362

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
            20                  25          


<210>  363

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  363

Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro 
            20                  25          


<210>  364

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  364

Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly 
            20                  25          


<210>  365

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  365

Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly Gly Val Ala 
            20                  25                  


<210>  366

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  366

Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro 
            20                  25          


<210>  367

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  367

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly 
            20                  25                  


<210>  368

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  368

Gly Ala Lys Gly Glu Val Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu 
            20                  25                  


<210>  369

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  369

Pro His Glu Gly Tyr Glu Val Leu Arg Phe Asp Asp Val Val Thr Asn 
1               5                   10                  15      


Val Gly Asn Ala Tyr Glu Ala Ala Ser Gly Lys 
            20                  25          


<210>  370

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  370

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu 
1               5                   10                  


<210>  371

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  371

Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro 
            20                  25          


<210>  372

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  372

Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Gly Pro Gly Gly Val Ala Pro 
            20                  25          


<210>  373

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  373

Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gly Val Ala Pro Ala Ala Gly 
            20                  


<210>  374

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  374

Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro 
1               5                   10                  15      


Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro 
            20                  25                  30          


Gly Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly 
        35                  40                  


<210>  375

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  375

Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro 
            20                  25          


<210>  376

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  376

Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg Gly Lys Ala Gly 
1               5                   10                  15      


Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
            20                  25                  


<210>  377

<211>  2016

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (683)..(1399)

<223>  



<400>  377
aggaaggtta gggaggcgga gagggaccgc gcccgcagag agaggcgcgg gccagggcta     60

ctagcaggga ctggggccgc ggcaggggta gcaaggtgag tcggtgcttg ccaagaggca    120

gagcgcaaaa cctactagga gatcgcgccc ggtgagcagc acccgcagct cagagcccgg    180

gacgtccgga gcgcggggag cagtcccctc tccatcaggg agtggtctat ctgggcagtc    240

tgggacccag gcaccgcgcc atccctgaga gagcagcagt ctggagagca ggcatctcag    300

atccctaaga aaccagccgt ccgagaagcc gcggatctca ggtgcccagg atcgttagga    360

ctgaacggga gggtactaga ggaccactgg ctctggaccg tcgggagctg cccctgacgt    420

aacccacgag gggcctcccc ttgacggacg gcttggggag cggcaccgcc ggcctggagc    480

ccgcagaggc agggtaaggg gagcgggggg cagccgtcgg gggagtgcag acccaggccc    540

aaggcgggtc accgctcctg gcccgcggag agccccggcc ccggcagcca ttgcgcccaa    600

gagtgaggaa gatttgctgg ccctggcagc gtcgcggctg agccggcgca agagggtggc    660

gggcgcggcc gtcggagtgg cc atg gtg ctg ctg ctg ctg gtg gcc atc ccg     712
                         Met Val Leu Leu Leu Leu Val Ala Ile Pro        
                         1               5                   10         

ctg ctg gtg cac agc tcc cgc ggg cca gcg cac tac gag atg ctg ggt      760
Leu Leu Val His Ser Ser Arg Gly Pro Ala His Tyr Glu Met Leu Gly         
                15                  20                  25              

cgc tgc cgc atg gtg tgc gac ccg cat ggg ccc cgt ggc cct ggt ccc      808
Arg Cys Arg Met Val Cys Asp Pro His Gly Pro Arg Gly Pro Gly Pro         
            30                  35                  40                  

gac ggc gcg cct gct tcc gtg ccc ccc ttc ccg cca ggc gcc aag gga      856
Asp Gly Ala Pro Ala Ser Val Pro Pro Phe Pro Pro Gly Ala Lys Gly         
        45                  50                  55                      

gag gtg ggc cgg cgc ggg aaa gca ggc ctg cgg ggg ccc cct gga cca      904
Glu Val Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro         
    60                  65                  70                          

cca ggt cca aga ggg ccc cca gga gaa ccc ggc agg cca ggc ccc ccg      952
Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro         
75                  80                  85                  90          

ggc cct ccc ggt cca ggt ccg ggc ggg gtg gcg ccc gct gcc ggc tac     1000
Gly Pro Pro Gly Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr         
                95                  100                 105             

gtg cct cgc att gct ttc tac gcg ggc ctg cgg cgg ccc cac gag ggt     1048
Val Pro Arg Ile Ala Phe Tyr Ala Gly Leu Arg Arg Pro His Glu Gly         
            110                 115                 120                 

tac gag gtg ctg cgc ttc gac gac gtg gtg acc aac gtg ggc aac gcc     1096
Tyr Glu Val Leu Arg Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala         
        125                 130                 135                     

tac gag gca gcc agc ggc aag ttt act tgc ccc atg cca ggc gtc tac     1144
Tyr Glu Ala Ala Ser Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr         
    140                 145                 150                         

ttc ttc gct tac cac gtg ctc atg cgc ggc ggc gac ggc acc agc atg     1192
Phe Phe Ala Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met         
155                 160                 165                 170         

tgg gcc gac ctc atg aag aac gga cag gtc cgg gcc agc gcc att gct     1240
Trp Ala Asp Leu Met Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala         
                175                 180                 185             

cag gac gcg gac cag aac tac gac tac gcc agc aac agc gtc att ctg     1288
Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu         
            190                 195                 200                 

cac ctg gac gtg ggc gac gag gtc ttc atc aag ctg gac ggc ggg aaa     1336
His Leu Asp Val Gly Asp Glu Val Phe Ile Lys Leu Asp Gly Gly Lys         
        205                 210                 215                     

gtg cac ggc ggc aac acc aac aag tac agc acc ttc tcc ggc ttc atc     1384
Val His Gly Gly Asn Thr Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile         
    220                 225                 230                         

atc tac ccc gac tga gccggccccg ccccgtgccc ccgctcgccc cttctctccc     1439
Ile Tyr Pro Asp                                                         
235                                                                     

gtcctcaccc acctcctgcc cgccccaccc gaggcgccac cccacccttt gagagcctgg   1499

cggtggggtg gacccttccg ttcccggagg cggcctaaat gggcgaactc ttggtgctca   1559

agggtataag tggccgggaa gaggaggaga cccggccaga ggagcagagc gacttccgga   1619

gggatcaccc gcacccaagt gcgcgctgga ccccataggg gcagaggtcg tggctttctc   1679

ttttgtacag agatggggag cagttttaat agcgggactc agaggcccag aaagccggag   1739

ggaagccccc gcagcttgcg agggaaataa cagaaacagg aggagcccat ttaggcaaga   1799

gaagacatta aaacagggta gtgcaggttc tccgtcacaa ctttctctcg ccaccctctc   1859

gtcccctcgt ctccactttc aggctcaggc tccagccttg gcagccttcc tgtgaactgg   1919

aggaaccagt gaattctttc ctggcattta aaacgcattc tgtacagtcc ccattccccc   1979

ctatccggac taggccctgg ggctacagct gctgctg                            2016


<210>  378

<211>  238

<212>  PRT

<213>  Homo sapiens



<400>  378

Met Val Leu Leu Leu Leu Val Ala Ile Pro Leu Leu Val His Ser Ser 
1               5                   10                  15      


Arg Gly Pro Ala His Tyr Glu Met Leu Gly Arg Cys Arg Met Val Cys 
            20                  25                  30          


Asp Pro His Gly Pro Arg Gly Pro Gly Pro Asp Gly Ala Pro Ala Ser 
        35                  40                  45              


Val Pro Pro Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg Gly 
    50                  55                  60                  


Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
65                  70                  75                  80  


Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
                85                  90                  95      


Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro Arg Ile Ala Phe 
            100                 105                 110         


Tyr Ala Gly Leu Arg Arg Pro His Glu Gly Tyr Glu Val Leu Arg Phe 
        115                 120                 125             


Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu Ala Ala Ser Gly 
    130                 135                 140                 


Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His Val 
145                 150                 155                 160 


Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Met Lys 
                165                 170                 175     


Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln Asn 
            180                 185                 190         


Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu Asp Val Gly Asp 
        195                 200                 205             


Glu Val Phe Ile Lys Leu Asp Gly Gly Lys Val His Gly Gly Asn Thr 
    210                 215                 220                 


Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Pro Asp 
225                 230                 235             


<210>  379

<211>  717

<212>  DNA

<213>  Homo sapiens



<400>  379
atggtgctgc tgctgctggt ggccatcccg ctgctggtgc acagctcccg cgggccagcg     60

cactacgaga tgctgggtcg ctgccgcatg gtgtgcgacc cgcatgggcc ccgtggccct    120

ggtcccgacg gcgcgcctgc ttccgtgccc cccttcccgc caggcgccaa gggagaggtg    180

ggccggcgcg ggaaagcagg cctgcggggg ccccctggac caccaggtcc aagagggccc    240

ccaggagaac ccggcaggcc aggccccccg ggccctcccg gtccaggtcc gggcggggtg    300

gcgcccgctg ccggctacgt gcctcgcatt gctttctacg cgggcctgcg gcggccccac    360

gagggttacg aggtgctgcg cttcgacgac gtggtgacca acgtgggcaa cgcctacgag    420

gcagccagcg gcaagtttac ttgccccatg ccaggcgtct acttcttcgc ttaccacgtg    480

ctcatgcgcg gcggcgacgg caccagcatg tgggccgacc tcatgaagaa cggacaggtc    540

cgggccagcg ccattgctca ggacgcggac cagaactacg actacgccag caacagcgtc    600

attctgcacc tggacgtggg cgacgaggtc ttcatcaagc tggacggcgg gaaagtgcac    660

ggcggcaaca ccaacaagta cagcaccttc tccggcttca tcatctaccc cgactga       717


<210>  380

<211>  223

<212>  PRT

<213>  Homo sapiens



<400>  380

Ser Arg Gly Pro Ala His Tyr Glu Met Leu Gly Arg Cys Arg Met Val 
1               5                   10                  15      


Cys Asp Pro His Gly Pro Arg Gly Pro Gly Pro Asp Gly Ala Pro Ala 
            20                  25                  30          


Ser Val Pro Pro Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg 
        35                  40                  45              


Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
    50                  55                  60                  


Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro 
65                  70                  75                  80  


Gly Pro Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro Arg Ile Ala 
                85                  90                  95      


Phe Tyr Ala Gly Leu Arg Arg Pro His Glu Gly Tyr Glu Val Leu Arg 
            100                 105                 110         


Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu Ala Ala Ser 
        115                 120                 125             


Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His 
    130                 135                 140                 


Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Met 
145                 150                 155                 160 


Lys Asn Gly Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln 
                165                 170                 175     


Asn Tyr Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu Asp Val Gly 
            180                 185                 190         


Asp Glu Val Phe Ile Lys Leu Asp Gly Gly Lys Val His Gly Gly Asn 
        195                 200                 205             


Thr Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Pro Asp 
    210                 215                 220             


<210>  381

<211>  36

<212>  PRT

<213>  Homo sapiens



<400>  381

Val Leu Arg Phe Asp Asp Val Val Thr Asn Val Gly Asn Ala Tyr Glu 
1               5                   10                  15      


Ala Ala Ser Gly Lys Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe 
            20                  25                  30          


Ala Tyr His Val 
        35      


<210>  382

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  382

Phe Thr Cys Pro Met Pro Gly Val Tyr Phe Phe Ala Tyr His Val Leu 
1               5                   10                  15      


Met Arg Gly Gly 
            20  


<210>  383

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  383

Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly Gly 
            20                  25          


<210>  384

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  384

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
            20                  25          


<210>  385

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  385

Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu Asp Val Gly Asp Glu 
1               5                   10                  15      


Val Phe Ile Lys Leu Asp 
            20          


<210>  386

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  386

Asp Tyr Ala Ser Asn Ser Val Ile Leu His Leu Asp Val Gly Asp Glu 
1               5                   10                  15      


Val Phe Ile Lys 
            20  


<210>  387

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  387

Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly 
1               5                   10                  15      


Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro 
            20                  25          


<210>  388

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  388

Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly 
            20                  25          


<210>  389

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  389

Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly Gly Val Ala 
            20                  25                  


<210>  390

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  390

Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly 
1               5                   10                  15      


Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro 
            20                  25          


<210>  391

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  391

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
1               5                   10                  15      


Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro Gly 
            20                  25                  


<210>  392

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  392

Gly Ala Lys Gly Glu Val Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu 
            20                  25                  


<210>  393

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  393

Pro His Glu Gly Tyr Glu Val Leu Arg Phe Asp Asp Val Val Thr Asn 
1               5                   10                  15      


Val Gly Asn Ala Tyr Glu Ala Ala Ser Gly Lys 
            20                  25          


<210>  394

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  394

Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro Pro Gly Glu 
1               5                   10                  


<210>  395

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  395

Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gly Val Ala Pro Ala Ala Gly Tyr Val Pro 
            20                  25          


<210>  396

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  396

Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Pro Gly Pro Gly Pro Gly Gly Val Ala Pro 
            20                  25          


<210>  397

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  397

Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gly Val Ala Pro Ala Ala Gly 
            20                  


<210>  398

<211>  44

<212>  PRT

<213>  Homo sapiens



<400>  398

Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro 
1               5                   10                  15      


Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro Gly Pro Pro Gly Pro Pro 
            20                  25                  30          


Gly Pro Gly Pro Gly Gly Val Ala Pro Ala Ala Gly 
        35                  40                  


<210>  399

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  399

Gly Arg Arg Gly Lys Ala Gly Leu Arg Gly Pro Pro Gly Pro Pro Gly 
1               5                   10                  15      


Pro Arg Gly Pro Pro Gly Glu Pro Gly Arg Pro 
            20                  25          


<210>  400

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  400

Ser Thr Phe Ser Gly Phe Ile Ile Tyr Pro 
1               5                   10  


<210>  401

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  401

Phe Pro Pro Gly Ala Lys Gly Glu Val Gly Arg Arg Gly Lys Ala Gly 
1               5                   10                  15      


Leu Arg Gly Pro Pro Gly Pro Pro Gly Pro Arg Gly Pro 
            20                  25                  


<210>  402

<211>  243

<212>  PRT

<213>  Macaca mulatta



<400>  402

Met Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Ser His Gly 
1               5                   10                  15      


Gln Asp Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro Lys 
            20                  25                  30          


Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly His 
        35                  40                  45              


Asn Gly Val Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu Lys 
    50                  55                  60                  


Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Thr Gly 
65                  70                  75                  80  


Glu Thr Gly Val Thr Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly Ile 
                85                  90                  95      


Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg Ser 
            100                 105                 110         


Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Val Pro Asn Met Pro 
        115                 120                 125             


Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp Gly 
    130                 135                 140                 


Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe Ala 
145                 150                 155                 160 


Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe Lys 
                165                 170                 175     


Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn Asn 
            180                 185                 190         


Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly Asp 
        195                 200                 205             


Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu Tyr 
    210                 215                 220                 


Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr His 
225                 230                 235                 240 


Asp Thr Asn 
            


<210>  403

<211>  240

<212>  PRT

<213>  Bos taurus



<400>  403

Met Leu Leu Gln Gly Ala Leu Leu Leu Leu Leu Ala Leu Pro Ser His 
1               5                   10                  15      


Gly Glu Asp Asn Met Glu Asp Pro Pro Leu Pro Lys Gly Ala Cys Ala 
            20                  25                  30          


Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly His Asn Gly Thr Pro 
        35                  40                  45              


Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu Lys Gly Glu Lys Gly 
    50                  55                  60                  


Asp Ala Gly Leu Leu Gly Pro Lys Gly Glu Thr Gly Asp Val Gly Met 
65                  70                  75                  80  


Thr Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly Thr Pro Gly Arg Lys 
                85                  90                  95      


Gly Glu Pro Gly Glu Ala Ala Tyr Val Tyr Arg Ser Ala Phe Ser Val 
            100                 105                 110         


Gly Leu Glu Thr Arg Val Thr Val Pro Asn Val Pro Ile Arg Phe Thr 
        115                 120                 125             


Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp Gly Ser Thr Gly Lys 
    130                 135                 140                 


Phe Tyr Cys Asn Ile Pro Gly Leu Tyr Tyr Phe Ser Tyr His Ile Thr 
145                 150                 155                 160 


Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe Lys Lys Asp Lys Ala 
                165                 170                 175     


Val Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Lys Asn Val Asp Gln Ala 
            180                 185                 190         


Ser Gly Ser Val Leu Leu His Leu Glu Val Gly Asp Gln Val Trp Leu 
        195                 200                 205             


Gln Val Tyr Glu Gly Glu Asn His Asn Gly Val Tyr Ala Asp Asn Val 
    210                 215                 220                 


Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr His Asn Ile Val Glu 
225                 230                 235                 240 


<210>  404

<211>  244

<212>  PRT

<213>  Homo sapiens



<400>  404

Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 
1               5                   10                  15      


Asp Gln Glu Thr Thr Ile Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 
            20                  25                  30          


Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 
        35                  40                  45              


His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 
    50                  55                  60                  


Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 
65                  70                  75                  80  


Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 
                85                  90                  95      


Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 
            100                 105                 110         


Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Tyr Thr Ile Pro Asn Met 
        115                 120                 125             


Pro Glu Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 
    130                 135                 140                 


Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 
145                 150                 155                 160 


Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 
                165                 170                 175     


Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 
            180                 185                 190         


Asn Tyr Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 
        195                 200                 205             


Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 
    210                 215                 220                 


Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 
225                 230                 235                 240 


His Asp Thr Asn 
                


<210>  405

<211>  423

<212>  DNA

<213>  Homo sapiens



<400>  405
attttacaag acatgggcat tacggatatc tttgatgaaa cgagggctga tcttactgga     60

atctctccaa gtcccaattt gtacttgtca aaaattatcc acaaaacctt tgtggaggtg    120

gatgaaaacg gtacccaggc agctgcagcc actggggctg ttgtctcgga aaggtcacta    180

cgatcttggg tggagtttaa tgccaaccac ccttttctct ttttcattag acacaacaaa    240

acccaaacca ttctctttta tggcagggtc tgctctcctt aaaaggggag cagtgtctag    300

tactttggag ctggaggaaa atatcaatac aatcttcccc tggcataaga tgggcatttg    360

agtttttggt aatatctaaa gcatctcctt catcctccag ccatcggctt gtgcttatct    420

tgg                                                                  423


<210>  406

<211>  1854

<212>  DNA

<213>  Homo sapiens



<400>  406
atgagggcct ctcctttaga ggggaacagt gggaaaaaca cagattcatc aaacatcact     60

cagaagccag aattagtacc acctgatctg tggacacacc ctgagaggtt agcaacccct    120

cagcaaactc ctactgaact tcaagaatca tttgcatcta ccatagagac aacctcttta    180

atctcaaaca acctgctctt gaagatgagt cagagcaaag ccactgttga aggtcttaag    240

gaagctaaac tagggtggtc cctgtctccc ggccccacac acctggtgct cacagagcca    300

catcagatcg ttataagttt tacaatggac tctcttgtta cagcaaacac caaattttgc    360

tttgatcttt ttcaagagat aggcaaagat gatcgtcata aaaacatatt tttctctccc    420

ctgagcctct cagctgccct tggtatggta cgcttgggtg ctagaagtga cagtgcacat    480

cagattgatg aggtactaca cttcaacgaa ttttcccaga atgaaagcaa agaacctgac    540

ccttgtctga aaagcaacaa acaaaaagtg ctggctgaca gctctctgga ggggcagaaa    600

aaaacgacag agcctctgga tcagcaggct gggtccttaa acaatgagag cggactggtc    660

agctgctact ttgggcagct tctctccaaa ttagacagga tcaagactga ttacacactg    720

agtattgcca acaggcttta tggagagcag gaattcccaa tctgtcagga atacttagat    780

ggtgtgattc aattttacca cacgacgatt gaaagtgttg atttccaaaa aaaccctgaa    840

aaatccagac aagagattaa cttctgggtt gaatgtcaat cccaaggtaa aatcaaggaa    900

ctcttcagca aggacgctat taatgctgag actgtgctgg tactggtgaa tgctgtttac    960

ttcaaggcca aatgggaaac atactttgac catgaaaaca cggtggatgc acctttctgt   1020

ctaaatgcga atgaaaacaa gagtgtgaag atgatgacgc aaaaaggcct ctacagaatt   1080

ggcttcatag aggaggtgaa ggcacagatc ctggaaatga ggtacaccaa ggggaagctc   1140

agcatgttcg tgctgctgcc atctcactct aaagataacc tgaagggtct ggaagagctt   1200

gaaaggaaaa tcacctatga aaaaatggtg gcctggagca gctcagaaaa catgtcagaa   1260

gaatcggtgg tcctgtcctt cccccggttc accctggaag acagctatga tctcaattcc   1320

attttacaag acatgggcat tacggatatc tttgatgaaa cgagggctga tcttactgga   1380

atctctccaa gtcccaattt gtacttgtca aaaattatcc acaaaacctt tgtggaggtg   1440

gatgaaaacg gtacccaggc agctgcagcc actggggctg ttgtctcgga aagctccaag   1500

aattcccacc tgtggctagc tccttttatg cacccagcac aggcaggtgt caagagaagt   1560

gctgctggca ttgtggacgg ctggcctccg tatgcccctc tctctgcctt ctggccacct   1620

gaatgttctg ccatgaccac tgacacgtcc aactcacatc tctttggagt cagtctcttt   1680

cctatcgagc tgccaccagt cgttcagtgt ggccacgcag tttttttgca gaaggcaggc   1740

ctggaacaga caaaggaaat ggcattattc tccattagag atgagataga tacagacgtg   1800

tccctggaac ttctgaccgc atttgaggag tcttgccagt tgcacgtggc ctga         1854


<210>  407

<211>  1496

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (78)..(1355)

<223>  



<400>  407
gcttttgtga gcacaagtgt tatctgctcc agagggtggc ctggtatagg aggaaagaga     60

tcgttataag ttttaca atg gac tct ctt gtt aca gca aac acc aaa ttt       110
                   Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe          
                   1               5                   10               

tgc ttt gat ctt ttt caa gag ata ggc aaa gat gat cgt cat aaa aac      158
Cys Phe Asp Leu Phe Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn         
            15                  20                  25                  

ata ttt ttc tct ccc ctg agc ctc tca gct gcc ctt ggt atg gta cgc      206
Ile Phe Phe Ser Pro Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg         
        30                  35                  40                      

ctg ggt gct aga agt gac agt gca cat cag att gat gag gta cta cac      254
Leu Gly Ala Arg Ser Asp Ser Ala His Gln Ile Asp Glu Val Leu His         
    45                  50                  55                          

ttc aac gaa ttt tcc cag aat gaa agc aaa gaa cct gac cct tgt ctg      302
Phe Asn Glu Phe Ser Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu         
60                  65                  70                  75          

aaa agc aac aaa caa aaa gtg ctg gct gac agc tct ctg gag ggg cag      350
Lys Ser Asn Lys Gln Lys Val Leu Ala Asp Ser Ser Leu Glu Gly Gln         
                80                  85                  90              

aaa aaa acg aca gag cct ctg gat cag cag gct ggg tcc tta aac aat      398
Lys Lys Thr Thr Glu Pro Leu Asp Gln Gln Ala Gly Ser Leu Asn Asn         
            95                  100                 105                 

gag agc gga ctg gtc agc tgc tac ttt ggg cag ctt ctc tcc aaa tta      446
Glu Ser Gly Leu Val Ser Cys Tyr Phe Gly Gln Leu Leu Ser Lys Leu         
        110                 115                 120                     

gac agg atc aag act gat tac aca ctg agt att gcc aac agg ctt tat      494
Asp Arg Ile Lys Thr Asp Tyr Thr Leu Ser Ile Ala Asn Arg Leu Tyr         
    125                 130                 135                         

gga gag cag gaa ttc cca atc tgt cag gaa tac tta gat ggt gtg att      542
Gly Glu Gln Glu Phe Pro Ile Cys Gln Glu Tyr Leu Asp Gly Val Ile         
140                 145                 150                 155         

caa ttt tac cac acg acg att gaa agt gtt gat ttc caa aaa aac cct      590
Gln Phe Tyr His Thr Thr Ile Glu Ser Val Asp Phe Gln Lys Asn Pro         
                160                 165                 170             

gaa aaa tcc aga caa gag att aac ttc tgg gtt gaa tgt caa tcc caa      638
Glu Lys Ser Arg Gln Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln         
            175                 180                 185                 

ggt aaa atc aag gaa ctc ttc agc aag gac gct att aat gct gag act      686
Gly Lys Ile Lys Glu Leu Phe Ser Lys Asp Ala Ile Asn Ala Glu Thr         
        190                 195                 200                     

gtg ctg gta ctg gtg aat gct gtt tac ttc aag gcc aaa tgg gaa aca      734
Val Leu Val Leu Val Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu Thr         
    205                 210                 215                         

tac ttt gac cat gaa aac acg gtg gat gca cct ttc tgt cta aat gcg      782
Tyr Phe Asp His Glu Asn Thr Val Asp Ala Pro Phe Cys Leu Asn Ala         
220                 225                 230                 235         

aat gaa aac aag agt gtg aag atg atg acg caa aaa ggc ctc tac aga      830
Asn Glu Asn Lys Ser Val Lys Met Met Thr Gln Lys Gly Leu Tyr Arg         
                240                 245                 250             

att ggc ttc ata gag gag gtg aag gca cag atc ctg gaa atg agg tac      878
Ile Gly Phe Ile Glu Glu Val Lys Ala Gln Ile Leu Glu Met Arg Tyr         
            255                 260                 265                 

acc aag ggg aag ctc agc atg ttc gtg ctg ctg cca tct cac tct aaa      926
Thr Lys Gly Lys Leu Ser Met Phe Val Leu Leu Pro Ser His Ser Lys         
        270                 275                 280                     

gat aac ctg aag ggt ctg gaa gag ctt gaa agg aaa atc acc tat gaa      974
Asp Asn Leu Lys Gly Leu Glu Glu Leu Glu Arg Lys Ile Thr Tyr Glu         
    285                 290                 295                         

aaa atg gtg gcc tgg agc agc tca gaa aac atg tca gaa gaa tcg gtg     1022
Lys Met Val Ala Trp Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val         
300                 305                 310                 315         

gtc ctg tcc ttc ccc cgg ttc acc ctg gaa ggc agc tat gat ctc aat     1070
Val Leu Ser Phe Pro Arg Phe Thr Leu Glu Gly Ser Tyr Asp Leu Asn         
                320                 325                 330             

tcc att tta caa gac atg ggc att acg gat atc ttt gat gaa acg agg     1118
Ser Ile Leu Gln Asp Met Gly Ile Thr Asp Ile Phe Asp Glu Thr Arg         
            335                 340                 345                 

gct gat ctt act gga atc tct cca agt ccc aat ttg tac ttg tca aaa     1166
Ala Asp Leu Thr Gly Ile Ser Pro Ser Pro Asn Leu Tyr Leu Ser Lys         
        350                 355                 360                     

att atc cac aaa acc ttt gtg gag gtg gat gaa aac ggt acc cag gca     1214
Ile Ile His Lys Thr Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala         
    365                 370                 375                         

gct gca gcc act ggg gct gtt gtc tcg gaa agg tca cta cga tct tgg     1262
Ala Ala Ala Thr Gly Ala Val Val Ser Glu Arg Ser Leu Arg Ser Trp         
380                 385                 390                 395         

gtg gag ttt aat gcc aac cac cct ttt ctc ttt ttc att aga cac aac     1310
Val Glu Phe Asn Ala Asn His Pro Phe Leu Phe Phe Ile Arg His Asn         
                400                 405                 410             

aaa acc caa acc att ctc ttt tat ggc agg gtc tgc tct cct taa         1355
Lys Thr Gln Thr Ile Leu Phe Tyr Gly Arg Val Cys Ser Pro                 
            415                 420                 425                 

aaggggagca gtgtctagta ctttggagct ggaggaaaat atcaatacaa tcttcccctg   1415

gcataagatg ggcatttgag tttttggtaa tatctaaagc atctccttca tcctccagcc   1475

atcggcttgt gcttatcttg g                                             1496


<210>  408

<211>  425

<212>  PRT

<213>  Homo sapiens



<400>  408

Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe 
1               5                   10                  15      


Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro 
            20                  25                  30          


Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser 
        35                  40                  45              


Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser 
    50                  55                  60                  


Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln 
65                  70                  75                  80  


Lys Val Leu Ala Asp Ser Ser Leu Glu Gly Gln Lys Lys Thr Thr Glu 
                85                  90                  95      


Pro Leu Asp Gln Gln Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val 
            100                 105                 110         


Ser Cys Tyr Phe Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr 
        115                 120                 125             


Asp Tyr Thr Leu Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe 
    130                 135                 140                 


Pro Ile Cys Gln Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr 
145                 150                 155                 160 


Thr Ile Glu Ser Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln 
                165                 170                 175     


Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu 
            180                 185                 190         


Leu Phe Ser Lys Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val 
        195                 200                 205             


Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu 
    210                 215                 220                 


Asn Thr Val Asp Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser 
225                 230                 235                 240 


Val Lys Met Met Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu 
                245                 250                 255     


Glu Val Lys Ala Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu 
            260                 265                 270         


Ser Met Phe Val Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly 
        275                 280                 285             


Leu Glu Glu Leu Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp 
    290                 295                 300                 


Ser Ser Ser Glu Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro 
305                 310                 315                 320 


Arg Phe Thr Leu Glu Gly Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp 
                325                 330                 335     


Met Gly Ile Thr Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly 
            340                 345                 350         


Ile Ser Pro Ser Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr 
        355                 360                 365             


Phe Val Glu Val Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly 
    370                 375                 380                 


Ala Val Val Ser Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala 
385                 390                 395                 400 


Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile 
                405                 410                 415     


Leu Phe Tyr Gly Arg Val Cys Ser Pro 
            420                 425 


<210>  409

<211>  1278

<212>  DNA

<213>  Homo sapiens



<400>  409
atggactctc ttgttacagc aaacaccaaa ttttgctttg atctttttca agagataggc     60

aaagatgatc gtcataaaaa catatttttc tctcccctga gcctctcagc tgcccttggt    120

atggtacgcc tgggtgctag aagtgacagt gcacatcaga ttgatgaggt actacacttc    180

aacgaatttt cccagaatga aagcaaagaa cctgaccctt gtctgaaaag caacaaacaa    240

aaagtgctgg ctgacagctc tctggagggg cagaaaaaaa cgacagagcc tctggatcag    300

caggctgggt ccttaaacaa tgagagcgga ctggtcagct gctactttgg gcagcttctc    360

tccaaattag acaggatcaa gactgattac acactgagta ttgccaacag gctttatgga    420

gagcaggaat tcccaatctg tcaggaatac ttagatggtg tgattcaatt ttaccacacg    480

acgattgaaa gtgttgattt ccaaaaaaac cctgaaaaat ccagacaaga gattaacttc    540

tgggttgaat gtcaatccca aggtaaaatc aaggaactct tcagcaagga cgctattaat    600

gctgagactg tgctggtact ggtgaatgct gtttacttca aggccaaatg ggaaacatac    660

tttgaccatg aaaacacggt ggatgcacct ttctgtctaa atgcgaatga aaacaagagt    720

gtgaagatga tgacgcaaaa aggcctctac agaattggct tcatagagga ggtgaaggca    780

cagatcctgg aaatgaggta caccaagggg aagctcagca tgttcgtgct gctgccatct    840

cactctaaag ataacctgaa gggtctggaa gagcttgaaa ggaaaatcac ctatgaaaaa    900

atggtggcct ggagcagctc agaaaacatg tcagaagaat cggtggtcct gtccttcccc    960

cggttcaccc tggaaggcag ctatgatctc aattccattt tacaagacat gggcattacg   1020

gatatctttg atgaaacgag ggctgatctt actggaatct ctccaagtcc caatttgtac   1080

ttgtcaaaaa ttatccacaa aacctttgtg gaggtggatg aaaacggtac ccaggcagct   1140

gcagccactg gggctgttgt ctcggaaagg tcactacgat cttgggtgga gtttaatgcc   1200

aaccaccctt ttctcttttt cattagacac aacaaaaccc aaaccattct cttttatggc   1260

agggtctgct ctccttaa                                                 1278


<210>  410

<211>  42

<212>  PRT

<213>  Homo sapiens



<400>  410

Thr Val Leu Val Leu Val Asn Ala Val Tyr Phe Lys Ala Lys Trp Glu 
1               5                   10                  15      


Thr Tyr Phe Asp His Glu Asn Thr Val Asp Ala Pro Phe Cys Leu Asn 
            20                  25                  30          


Ala Asn Glu Asn Lys Ser Val Lys Met Met 
        35                  40          


<210>  411

<211>  25

<212>  PRT

<213>  Homo sapiens



<400>  411

Asn His Pro Phe Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile 
1               5                   10                  15      


Leu Phe Tyr Gly Arg Val Cys Ser Pro 
            20                  25  


<210>  412

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  412

Leu Ser Phe Pro Arg Phe Thr Leu Glu Gly Ser Tyr Asp Leu Asn Ser 
1               5                   10                  15      


Ile Leu Gln Asp Met Gly Ile Thr Asp Ile Phe 
            20                  25          


<210>  413

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  413

Asn Ile Phe Phe Ser Pro Leu Ser Leu Ser Ala Ala Leu Gly Met Val 
1               5                   10                  15      


Arg Leu Gly Ala Arg Ser Asp Ser 
            20                  


<210>  414

<211>  21

<212>  PRT

<213>  Homo sapiens



<400>  414

Ser Arg Gln Glu Ile Asn Phe Trp Val Glu Cys Gln Ser Gln Gly Lys 
1               5                   10                  15      


Ile Lys Glu Leu Phe 
            20      


<210>  415

<211>  617

<212>  PRT

<213>  Homo sapiens



<400>  415

Met Arg Ala Ser Pro Leu Glu Gly Asn Ser Gly Lys Asn Thr Asp Ser 
1               5                   10                  15      


Ser Asn Ile Thr Gln Lys Pro Glu Leu Val Pro Pro Asp Leu Trp Thr 
            20                  25                  30          


His Pro Glu Arg Leu Ala Thr Pro Gln Gln Thr Pro Thr Glu Leu Gln 
        35                  40                  45              


Glu Ser Phe Ala Ser Thr Ile Glu Thr Thr Ser Leu Ile Ser Asn Asn 
    50                  55                  60                  


Leu Leu Leu Lys Met Ser Gln Ser Lys Ala Thr Val Glu Gly Leu Lys 
65                  70                  75                  80  


Glu Ala Lys Leu Gly Trp Ser Leu Ser Pro Gly Pro Thr His Leu Val 
                85                  90                  95      


Leu Thr Glu Pro His Gln Ile Val Ile Ser Phe Thr Met Asp Ser Leu 
            100                 105                 110         


Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe Gln Glu Ile Gly 
        115                 120                 125             


Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro Leu Ser Leu Ser 
    130                 135                 140                 


Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser Asp Ser Ala His 
145                 150                 155                 160 


Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser Gln Asn Glu Ser 
                165                 170                 175     


Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln Lys Val Leu Ala 
            180                 185                 190         


Asp Ser Ser Leu Glu Gly Gln Lys Lys Thr Thr Glu Pro Leu Asp Gln 
        195                 200                 205             


Gln Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val Ser Cys Tyr Phe 
    210                 215                 220                 


Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr Asp Tyr Thr Leu 
225                 230                 235                 240 


Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe Pro Ile Cys Gln 
                245                 250                 255     


Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr Thr Ile Glu Ser 
            260                 265                 270         


Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln Glu Ile Asn Phe 
        275                 280                 285             


Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu Leu Phe Ser Lys 
    290                 295                 300                 


Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val Asn Ala Val Tyr 
305                 310                 315                 320 


Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu Asn Thr Val Asp 
                325                 330                 335     


Ala Pro Phe Trp Leu Asn Ala Asn Glu Asn Lys Ser Val Lys Met Met 
            340                 345                 350         


Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu Glu Val Lys Ala 
        355                 360                 365             


Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu Ser Met Phe Val 
    370                 375                 380                 


Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly Leu Glu Glu Leu 
385                 390                 395                 400 


Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp Ser Ser Ser Glu 
                405                 410                 415     


Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro Arg Phe Thr Leu 
            420                 425                 430         


Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp Met Gly Ile Thr 
        435                 440                 445             


Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly Ile Ser Pro Ser 
    450                 455                 460                 


Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr Phe Val Glu Val 
465                 470                 475                 480 


Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly Ala Val Val Ser 
                485                 490                 495     


Glu Ser Ser Lys Asn Ser His Leu Trp Leu Ala Pro Phe Met His Pro 
            500                 505                 510         


Ala Gln Ala Gly Val Lys Arg Ser Ala Ala Gly Ile Val Asp Gly Trp 
        515                 520                 525             


Pro Pro Tyr Ala Pro Leu Ser Ala Phe Trp Pro Pro Glu Cys Ser Ala 
    530                 535                 540                 


Met Thr Thr Asp Thr Ser Asn Ser His Leu Phe Gly Val Ser Leu Phe 
545                 550                 555                 560 


Pro Ile Glu Leu Pro Pro Val Val Gln Cys Gly His Ala Val Phe Leu 
                565                 570                 575     


Gln Lys Ala Gly Leu Glu Gln Thr Lys Glu Met Ala Leu Phe Ser Ile 
            580                 585                 590         


Arg Asp Glu Ile Asp Thr Asp Val Ser Leu Glu Leu Leu Thr Ala Phe 
        595                 600                 605             


Glu Glu Ser Cys Gln Leu His Val Ala 
    610                 615         


<210>  416

<211>  405

<212>  PRT

<213>  Homo sapiens



<400>  416

Met Asp Ser Leu Val Thr Ala Asn Thr Lys Phe Cys Phe Asp Leu Phe 
1               5                   10                  15      


Gln Glu Ile Gly Lys Asp Asp Arg His Lys Asn Ile Phe Phe Ser Pro 
            20                  25                  30          


Leu Ser Leu Ser Ala Ala Leu Gly Met Val Arg Leu Gly Ala Arg Ser 
        35                  40                  45              


Asp Ser Ala His Gln Ile Asp Glu Val Leu His Phe Asn Glu Phe Ser 
    50                  55                  60                  


Gln Asn Glu Ser Lys Glu Pro Asp Pro Cys Leu Lys Ser Asn Lys Gln 
65                  70                  75                  80  


Lys Ala Gly Ser Leu Asn Asn Glu Ser Gly Leu Val Ser Cys Tyr Phe 
                85                  90                  95      


Gly Gln Leu Leu Ser Lys Leu Asp Arg Ile Lys Thr Asp Tyr Thr Leu 
            100                 105                 110         


Ser Ile Ala Asn Arg Leu Tyr Gly Glu Gln Glu Phe Pro Ile Cys Gln 
        115                 120                 125             


Glu Tyr Leu Asp Gly Val Ile Gln Phe Tyr His Thr Thr Ile Glu Ser 
    130                 135                 140                 


Val Asp Phe Gln Lys Asn Pro Glu Lys Ser Arg Gln Glu Ile Asn Phe 
145                 150                 155                 160 


Trp Val Glu Cys Gln Ser Gln Gly Lys Ile Lys Glu Leu Phe Ser Lys 
                165                 170                 175     


Asp Ala Ile Asn Ala Glu Thr Val Leu Val Leu Val Asn Ala Val Tyr 
            180                 185                 190         


Phe Lys Ala Lys Trp Glu Thr Tyr Phe Asp His Glu Asn Thr Val Asp 
        195                 200                 205             


Ala Pro Phe Cys Leu Asn Ala Asn Glu Asn Lys Ser Val Lys Met Met 
    210                 215                 220                 


Thr Gln Lys Gly Leu Tyr Arg Ile Gly Phe Ile Glu Glu Val Lys Ala 
225                 230                 235                 240 


Gln Ile Leu Glu Met Arg Tyr Thr Lys Gly Lys Leu Ser Met Phe Val 
                245                 250                 255     


Leu Leu Pro Ser His Ser Lys Asp Asn Leu Lys Gly Leu Glu Glu Leu 
            260                 265                 270         


Glu Arg Lys Ile Thr Tyr Glu Lys Met Val Ala Trp Ser Ser Ser Glu 
        275                 280                 285             


Asn Met Ser Glu Glu Ser Val Val Leu Ser Phe Pro Arg Phe Thr Leu 
    290                 295                 300                 


Glu Asp Ser Tyr Asp Leu Asn Ser Ile Leu Gln Asp Met Gly Ile Thr 
305                 310                 315                 320 


Asp Ile Phe Asp Glu Thr Arg Ala Asp Leu Thr Gly Ile Ser Pro Ser 
                325                 330                 335     


Pro Asn Leu Tyr Leu Ser Lys Ile Ile His Lys Thr Phe Val Glu Val 
            340                 345                 350         


Asp Glu Asn Gly Thr Gln Ala Ala Ala Ala Thr Gly Ala Val Val Ser 
        355                 360                 365             


Glu Arg Ser Leu Arg Ser Trp Val Glu Phe Asn Ala Asn His Pro Phe 
    370                 375                 380                 


Leu Phe Phe Ile Arg His Asn Lys Thr Gln Thr Ile Leu Phe Tyr Gly 
385                 390                 395                 400 


Arg Val Cys Ser Pro 
                405 


<210>  417

<211>  390

<212>  PRT

<213>  Homo sapiens



<400>  417

Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe 
1               5                   10                  15      


Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile 
            20                  25                  30          


Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn 
        35                  40                  45              


Thr Ala Gln Gln Ile Ser Lys Val Leu His Phe Asp Gln Val Thr Glu 
    50                  55                  60                  


Asn Thr Thr Glu Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn 
65                  70                  75                  80  


Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr 
                85                  90                  95      


Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr 
            100                 105                 110         


Tyr Gln Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln 
        115                 120                 125             


Thr Ser Val Glu Ser Thr Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg 
    130                 135                 140                 


Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys 
145                 150                 155                 160 


Asn Leu Phe Pro Asp Gly Thr Ile Gly Asn Asp Thr Thr Leu Val Leu 
                165                 170                 175     


Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Asn Lys Phe Lys Lys 
            180                 185                 190         


Glu Asn Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Asn Thr Tyr Lys 
        195                 200                 205             


Ser Val Gln Met Met Arg Gln Tyr Asn Ser Phe Asn Phe Ala Leu Leu 
    210                 215                 220                 


Glu Asp Val Gln Ala Lys Val Leu Glu Ile Pro Tyr Lys Gly Lys Asp 
225                 230                 235                 240 


Leu Ser Met Ile Val Leu Leu Pro Asn Glu Ile Asp Gly Leu Gln Lys 
                245                 250                 255     


Leu Glu Glu Lys Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu 
            260                 265                 270         


Gln Asn Met Arg Glu Thr Cys Val Asp Leu His Leu Pro Arg Phe Lys 
        275                 280                 285             


Met Glu Glu Ser Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met 
    290                 295                 300                 


Val Asn Ile Phe Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Trp Ser 
305                 310                 315                 320 


His Gly Leu Ser Val Ser Lys Val Leu His Lys Ala Phe Val Glu Val 
                325                 330                 335     


Thr Glu Glu Gly Val Glu Ala Ala Ala Ala Thr Ala Val Val Val Val 
            340                 345                 350         


Glu Leu Ser Ser Pro Ser Thr Asn Glu Glu Phe Cys Cys Asn His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210>  418

<211>  2499

<212>  DNA

<213>  Homo sapiens



<400>  418
atgaatggga agaataagac caacatttat caagagccga ctgtatgcca ggcactgcat     60

tggaccctgg cacggatagg aaaggaggag ccgcggcgcg ggcagcgggg cgaggggctt    120

ctgtgctcgc gggagcggca gcccaggggg ctcagcagcc ccggcaccgc cgcacctgcg    180

gctccagcag ccccaacccc gccagcgctg cctggccacc gtacccgaag cggctccccc    240

cgagggcccc gagcctatcc tacgccgggg cggctccgcg gacgcgccgg gccgagtcaa    300

gacctgggtc aaccgccctg cagcctttgt agggaagtgc ctaggtgatg ggtctgctga    360

taccgcctgt gaccaggcca tgaagggcca gaggggctcc aatcgcaagc gcaaaacctc    420

gcacagcctc acgtttccca ccagctcaga catgcacgct ggcggacttt cagcggctca    480

cccgtgtgca cactcacgtg cccccccccc cgcttcccca agcccgtaca aaggcagcct    540

gggcacacgg acagacggac tgacggactc tcgagcggac agcgcagcta gcggggcgcg    600

ggcgctgggc gtcgacggcc agccccagcc ttccccgccc cgtcgcgccc cgccccgtcc    660

cgtcggggcc gatggctcct cccgaggccc gcagcccggg cggcgcaggg tagagcgccg    720

cggcccggcc acgcagcccg gggactcccg ggccctcccg gagccccgcg gggtccccgc    780

cgtgcatccg gcgggctcag ggagcgagtg ggagcgccct ccccccgctg ccccctcccc    840

cgagcatcga gacaagatgc tgcccgggct caggcgcctg ctgcaagcat ctgcccgcag    900

gccccagccc ttccctgaag cagcccgttg ggtgtggagc ccttgcttct cgtctgggac    960

cctgtgcccc tccttccaga gcgagaggcc tctgctgcct ttccagggag catcctttcc   1020

tgggaccact ctgcaccagc gactctgccc tgtggctgct ttgcacggca gtggcaaggg   1080

ccagaaatgg caacagagtc actgttatgc agcagctgtt atggaggagc ccccagcacc   1140

gggtcgctct tcagagagcc tgcagggacc actatcatgg gctgggggag ctcccgcctc   1200

ggcctgcctc ctgctgatgc tcctggccct gcccctggcg gcccccagct gccccatgct   1260

ctgcacctgc tactcatccc cgcccaccgt gagctgccag gccaacaact tcttcttctg   1320

ggccgctggc cctggcaccc aacacttaac gactctttct ggaaaacaac cttattcgca   1380

cgctgggggc caggcacctt tgggtccaac ctgctcaccc tgtggctctt ctccaacaac   1440

ctctccacca tctacccggg cactttccgc cacttgcaag ccctggagga gctggacctc   1500

ggtgacaacc ggcacctgcg ctcgctggag cccgacacct tccagggcct ggagcggctg   1560

cagtcgctgc atttgtaccg ctgccagctc agcagcctgc ccggcaacat cttccgaggc   1620

ctggtcagcc tgcagtacct ctacctccag gagaacagcc tgctccacct acaggatgac   1680

ttgttcgcgg acctggccaa cctgagccac ctcttcctcc acgggaaccg cctgcggctg   1740

ctcacagagc acgtgtttcg cggcctgggc agcctggacc ggctgctgct gcacgggaac   1800

cggctgcagg gcgtgcaccg cgcggccttc cgcggcctca gccgcctcac catcctctac   1860

ctgttcaaca acagcctggc ctcgctgccc ggcgaggcgc tcgccgacct gccctcgctc   1920

gagttcctgc ggctcaacgc taacccctgg gcgtgcgact gccgcgcgcg gccgctctgg   1980

gcctggttcc agcgcgcgcg cgtgtccagc tccgacgtga cctgcgccac ccccccggag   2040

cgccagggcc gagacctgcg cgcgctccgc gagggccgac ttccaggcgt gtccgcccgc   2100

ggcacccacg cggccggggc agccgcgccc gcggcaacag ctcctccaac cacctgtacg   2160

gggtggccga ggccggggcg cccccagccg atccctccac cctctaccga gatctgcctg   2220

ccgaagactc gcgggggcgc cagggcgggg acgcgcctac tgaggacgac tactgggggg   2280

gctacggggg tgaggaccag cgaggggagc agatgtgccc cggcgctgcc tgccaggcgc   2340

ccccggactc ccgaggccct gcgctctcgg ccgggctccc cagccctctg ctttgcctcc   2400

tgctcctggt gccccaccac ctctgactgc ggtgctgaga tcgaataagc cagtgtccta   2460

taccgccttc ccgtccaccc ggggcttcgg ctacggccg                          2499


<210>  419

<211>  2182

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (366)..(1628)

<223>  



<400>  419
aaggatctta attaaattaa tccccccccc cccgctcggc tagcagcctg ggcacacgga     60

cagacggact gacggactct cgagcggaca gcgcagctag cggggcgcgg gcgctgggcg    120

tcgacggcca gccccagcct tccccgcccc gtcgcgcccc gccccgtccc gtcggggccg    180

atggctcctc ccgaggcccg cagcccgggc ggcgcagggt agagcgccgc ggcccggcca    240

cgcagcccgg ggactcccgg gccctcccgg agccccgcgg ggtccccgcc gtgcatccgg    300

cgggctcagg gagcgagtgg gagcgccctc cccccgctgc cccctccccc gagcatcgag    360

acaag atg ctg ccc ggg ctc agg cgc ctg ctg caa gct ccc gcc tcg gcc    410
      Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala       
      1               5                   10                  15        

tgc ctc ctg ctg atg ctc ctg gcc ctg ccc ctg gcg gcc ccc agc tgc      458
Cys Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys         
                20                  25                  30              

ccc atg ctc tgc acc tgc tac tca tcc ccg ccc acc gtg agc tgc cag      506
Pro Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln         
            35                  40                  45                  

gcc aac aac ttc tcc tct gtg ccg ctg tcc ctg cca ccc agc act cag      554
Ala Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln         
        50                  55                  60                      

cga ctc ttc ctg cag aac aac ctc atc cgc acg ctg cgg cca ggc acc      602
Arg Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr         
    65                  70                  75                          

ttt ggg tcc aac ctg ctc acc ctg tgg ctc ttc tcc aac aac ctc tcc      650
Phe Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser         
80                  85                  90                  95          

acc atc tac ccg ggc act ttc cgc cac ttg caa gcc ctg gag gag ctg      698
Thr Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu         
                100                 105                 110             

gac ctc ggt gac aac cgg cac ctg cgc tcg ctg gag ccc gac acc ttc      746
Asp Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe         
            115                 120                 125                 

cag ggc ctg gag cgg ctg cag tcg ctg cat ttg tac cgc tgc cag ctc      794
Gln Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu         
        130                 135                 140                     

agc agc ctg ccc ggc aac atc ttc cga ggc ctg gtc agc ctg cag tac      842
Ser Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr         
    145                 150                 155                         

ctc tac ctc cag gag aac agc ctg ctc cac cta cag gat gac ttg ttc      890
Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe         
160                 165                 170                 175         

gcg gac ctg gcc aac ctg agc cac ctc ttc ctc cac ggg aac cgc ctg      938
Ala Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu         
                180                 185                 190             

cgg ctg ctc aca gag cac gtg ttt cgc ggc ctg ggc agc ctg gac cgg      986
Arg Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg         
            195                 200                 205                 

ctg ctg ctg cac ggg aac cgg ctg cag ggc gtg cac cgc gcg gcc ttc     1034
Leu Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe         
        210                 215                 220                     

cgc ggc ctc agc cgc ctc acc atc ctc tac ctg ttc aac aac agc ctg     1082
Arg Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu         
    225                 230                 235                         

gcc tcg ctg ccc ggc gag gcg ctc gcc gac ctg ccc tcg ctc gag ttc     1130
Ala Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe         
240                 245                 250                 255         

ctg cgg ctc aac gct aac ccc tgg gcg tgc gac tgc cgc gcg cgg ccg     1178
Leu Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro         
                260                 265                 270             

ctc tgg gcc tgg ttc cag cgc gcg cgc gtg tcc agc tcc gac gtg acc     1226
Leu Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr         
            275                 280                 285                 

tgc gcc acc ccc ccg gag cgc cag ggc cga gac ctg cgc gcg ctc cgc     1274
Cys Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg         
        290                 295                 300                     

gag gcc gac ttc cag gcg tgt ccg ccc gcg gca ccc acg cgg ccg ggc     1322
Glu Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly         
    305                 310                 315                         

agc cgc gcc cgc ggc aac agc tcc tcc aac cac ctg tac ggg gtg gcc     1370
Ser Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala         
320                 325                 330                 335         

gag gcc ggg gcg ccc cca gcc gat ccc tcc acc ctc tac cga gat ctg     1418
Glu Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu         
                340                 345                 350             

cct gcc gaa gac tcg cgg ggg cgc cag ggc ggg gac gcg cct act gag     1466
Pro Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu         
            355                 360                 365                 

gac gac tac tgg ggg ggc tac ggg ggt gag gac cag cga ggg gag cag     1514
Asp Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln         
        370                 375                 380                     

atg tgc ccc ggc gct gcc tgc cag gcg ccc ccg gac tcc cga ggc cct     1562
Met Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro         
    385                 390                 395                         

gcg ctc tcg gcc ggg ctc ccc agc cct ctg ctt tgc ctc ctg ctc ctg     1610
Ala Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu         
400                 405                 410                 415         

gtg ccc cac cac ctc tga ctgcggtgct gagatcgaag aggccagtgt            1658
Val Pro His His Leu                                                     
                420                                                     

ccgatccccg cttcccgtcc acccggggct gcggctccgg ccccagtcgc cccaccttcc   1718

ctggccttgc tgcctccctt tcccctccca gctcctctcc tccccgggga gcaggccgct   1778

ctccttgcct gccccctggg ctgtcctgac ttgtggcagc cccaagaggg cgtgtgtggt   1838

ggctcagccc tgccctcccc agttctggcc attaactctt ccccatccca aggctggggt   1898

ggggcccccc aggcagccgc tgacccgcac tcctaagggc ccacagcgga caccagaggg   1958

gcttttgtct gcagagcgtc ttccaccagc agagcctttg gaagctcccc cagggagccc   2018

acccaggacc ctttggggga tgcctcagtc agggccaggc tgaccctgac cctgcttacc   2078

ctagtcccct caactcctga cactggagga atacttttct cctaagtcta ccctggaaca   2138

cttttagggg cactggagag aactttcctc tccactgtgg acct                    2182


<210>  420

<211>  420

<212>  PRT

<213>  Homo sapiens



<400>  420

Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys 
1               5                   10                  15      


Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro 
            20                  25                  30          


Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala 
        35                  40                  45              


Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg 
    50                  55                  60                  


Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe 
65                  70                  75                  80  


Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr 
                85                  90                  95      


Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp 
            100                 105                 110         


Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln 
        115                 120                 125             


Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser 
    130                 135                 140                 


Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu 
145                 150                 155                 160 


Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala 
                165                 170                 175     


Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg 
            180                 185                 190         


Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu 
        195                 200                 205             


Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg 
    210                 215                 220                 


Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala 
225                 230                 235                 240 


Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu 
                245                 250                 255     


Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu 
            260                 265                 270         


Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys 
        275                 280                 285             


Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu 
    290                 295                 300                 


Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser 
305                 310                 315                 320 


Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu 
                325                 330                 335     


Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro 
            340                 345                 350         


Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp 
        355                 360                 365             


Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met 
    370                 375                 380                 


Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala 
385                 390                 395                 400 


Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val 
                405                 410                 415     


Pro His His Leu 
            420 


<210>  421

<211>  1263

<212>  DNA

<213>  Homo sapiens



<400>  421
atgctgcccg ggctcaggcg cctgctgcaa gctcccgcct cggcctgcct cctgctgatg     60

ctcctggccc tgcccctggc ggcccccagc tgccccatgc tctgcacctg ctactcatcc    120

ccgcccaccg tgagctgcca ggccaacaac ttctcctctg tgccgctgtc cctgccaccc    180

agcactcagc gactcttcct gcagaacaac ctcatccgca cgctgcggcc aggcaccttt    240

gggtccaacc tgctcaccct gtggctcttc tccaacaacc tctccaccat ctacccgggc    300

actttccgcc acttgcaagc cctggaggag ctggacctcg gtgacaaccg gcacctgcgc    360

tcgctggagc ccgacacctt ccagggcctg gagcggctgc agtcgctgca tttgtaccgc    420

tgccagctca gcagcctgcc cggcaacatc ttccgaggcc tggtcagcct gcagtacctc    480

tacctccagg agaacagcct gctccaccta caggatgact tgttcgcgga cctggccaac    540

ctgagccacc tcttcctcca cgggaaccgc ctgcggctgc tcacagagca cgtgtttcgc    600

ggcctgggca gcctggaccg gctgctgctg cacgggaacc ggctgcaggg cgtgcaccgc    660

gcggccttcc gcggcctcag ccgcctcacc atcctctacc tgttcaacaa cagcctggcc    720

tcgctgcccg gcgaggcgct cgccgacctg ccctcgctcg agttcctgcg gctcaacgct    780

aacccctggg cgtgcgactg ccgcgcgcgg ccgctctggg cctggttcca gcgcgcgcgc    840

gtgtccagct ccgacgtgac ctgcgccacc cccccggagc gccagggccg agacctgcgc    900

gcgctccgcg aggccgactt ccaggcgtgt ccgcccgcgg cacccacgcg gccgggcagc    960

cgcgcccgcg gcaacagctc ctccaaccac ctgtacgggg tggccgaggc cggggcgccc   1020

ccagccgatc cctccaccct ctaccgagat ctgcctgccg aagactcgcg ggggcgccag   1080

ggcggggacg cgcctactga ggacgactac tgggggggct acgggggtga ggaccagcga   1140

ggggagcaga tgtgccccgg cgctgcctgc caggcgcccc cggactcccg aggccctgcg   1200

ctctcggccg ggctccccag ccctctgctt tgcctcctgc tcctggtgcc ccaccacctc   1260

tga                                                                 1263


<210>  422

<211>  30

<212>  PRT

<213>  Homo sapiens



<400>  422

Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys 
1               5                   10                  15      


Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser 
            20                  25                  30  


<210>  423

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  423

Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser 
1               5                   10                  15  


<210>  424

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  424

Leu Val Ser Leu Gln Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu 
1               5                   10                  15  


<210>  425

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  425

Leu Gln Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln 
1               5                   10                  15  


<210>  426

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  426

Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg 
1               5                   10                  15  


<210>  427

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  427

Leu Pro Ser Leu Glu Phe Leu Arg Leu Asn Ala Asn Pro Trp Ala 
1               5                   10                  15  


<210>  428

<211>  22

<212>  PRT

<213>  Homo sapiens



<400>  428

Ser Thr Gln Arg Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg 
1               5                   10                  15      


Pro Gly Thr Phe Gly Ser 
            20          


<210>  429

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  429

Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr Ile Tyr 
1               5                   10                  15      


Pro Gly Thr Phe Arg His Leu Gln 
            20                  


<210>  430

<211>  25

<212>  PRT

<213>  Homo sapiens



<400>  430

Ala Leu Glu Glu Leu Asp Leu Gly Asp Asn Arg His Leu Arg Ser Leu 
1               5                   10                  15      


Glu Pro Asp Thr Phe Gln Gly Leu Glu 
            20                  25  


<210>  431

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  431

Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser Ser Leu Pro 
1               5                   10                  15      


Gly Asn Ile Phe Arg Gly Leu Val 
            20                  


<210>  432

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  432

Ser Leu Gln Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln 
1               5                   10                  15      


Asp Asp Leu Phe Ala Asp Leu Ala 
            20                  


<210>  433

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  433

Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg Leu Leu Thr 
1               5                   10                  15      


Glu His Val Phe Arg Gly Leu Gly 
            20                  


<210>  434

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  434

Ser Leu Asp Arg Leu Leu Leu His Gly Asn Arg Leu Gln Gly Val His 
1               5                   10                  15      


Arg Ala Ala Phe Arg Gly Leu Ser 
            20                  


<210>  435

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  435

Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala Ser Leu Pro 
1               5                   10                  15      


Gly Glu Ala Leu Ala Asp Leu Pro 
            20                  


<210>  436

<211>  51

<212>  PRT

<213>  Homo sapiens



<400>  436

Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu Trp Ala Trp Phe 
1               5                   10                  15      


Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys Ala Thr Pro Pro 
            20                  25                  30          


Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu Ala Asp Phe Gln 
        35                  40                  45              


Ala Cys Pro 
    50      


<210>  437

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  437

Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu 
1               5                   10                  


<210>  438

<211>  401

<212>  PRT

<213>  Homo sapiens



<400>  438

Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys 
1               5                   10                  15      


Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro 
            20                  25                  30          


Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala 
        35                  40                  45              


Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg 
    50                  55                  60                  


Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe 
65                  70                  75                  80  


Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr 
                85                  90                  95      


Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp 
            100                 105                 110         


Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln 
        115                 120                 125             


Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser 
    130                 135                 140                 


Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu 
145                 150                 155                 160 


Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala 
                165                 170                 175     


Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg 
            180                 185                 190         


Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu 
        195                 200                 205             


Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg 
    210                 215                 220                 


Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala 
225                 230                 235                 240 


Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu 
                245                 250                 255     


Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu 
            260                 265                 270         


Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys 
        275                 280                 285             


Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu 
    290                 295                 300                 


Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser 
305                 310                 315                 320 


Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu 
                325                 330                 335     


Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro 
            340                 345                 350         


Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp 
        355                 360                 365             


Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met 
    370                 375                 380                 


Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala 
385                 390                 395                 400 


Leu 
    


<210>  439

<211>  390

<212>  PRT

<213>  Homo sapiens



<400>  439

Cys Pro Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys 
1               5                   10                  15      


Gln Ala Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr 
            20                  25                  30          


Gln Arg Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly 
        35                  40                  45              


Thr Phe Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu 
    50                  55                  60                  


Ser Thr Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Asp Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr 
                85                  90                  95      


Phe Gln Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln 
            100                 105                 110         


Leu Ser Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln 
        115                 120                 125             


Tyr Leu Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu 
    130                 135                 140                 


Phe Ala Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg 
145                 150                 155                 160 


Leu Arg Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp 
                165                 170                 175     


Arg Leu Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala 
            180                 185                 190         


Phe Arg Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser 
        195                 200                 205             


Leu Ala Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu 
    210                 215                 220                 


Phe Leu Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg 
225                 230                 235                 240 


Pro Leu Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val 
                245                 250                 255     


Thr Cys Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu 
            260                 265                 270         


Arg Glu Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro 
        275                 280                 285             


Gly Ser Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val 
    290                 295                 300                 


Ala Glu Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp 
305                 310                 315                 320 


Leu Pro Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr 
                325                 330                 335     


Glu Asp Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu 
            340                 345                 350         


Gln Met Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly 
        355                 360                 365             


Pro Ala Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu 
    370                 375                 380                 


Leu Val Pro His His Leu 
385                 390 


<210>  440

<211>  473

<212>  PRT

<213>  Homo sapiens



<400>  440

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp 
305                 310                 315                 320 


Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro 
            340                 345                 350         


Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Ser 
        355                 360                 365             


Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe 
    370                 375                 380                 


Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Val Arg Pro 
385                 390                 395                 400 


Glu Gly Ser Glu Pro Pro Gly Phe Pro Thr Ser Gly Pro Arg Arg Arg 
                405                 410                 415     


Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly 
            420                 425                 430         


Gln Ala Gly Ser Gly Gly Gly Gly Thr Gly Asp Ser Glu Gly Ser Gly 
        435                 440                 445             


Ala Leu Pro Ser Leu Thr Cys Ser Leu Thr Pro Leu Gly Leu Ala Leu 
    450                 455                 460                 


Val Leu Trp Thr Val Leu Gly Pro Cys 
465                 470             


<210>  441

<211>  378

<212>  DNA

<213>  Homo sapiens



<400>  441
ctgggaccca aaggtgatca gggggatgaa ggaaaggaag gcaggcctgg catccctgga     60

ttgcctggac ttcgaggtct gcccggggag agaggtaccc caggattgcc cgggcccaag    120

ggcaatgatg ggaagctggg ggccacagga ccaatgggca tgcgtgggtt caaaggtgac    180

cgaggcccac aaggagagaa aggagagaaa ggagacagag ctggggatgc cagtggcgtg    240

gaggccccga tgatgatccg cctggtgaat ggctcaggtc cgcacgaggg ccgcgtggaa    300

gtgtaccacg accggcgctg gggcaccgtg tgtgacgacg gctgggacaa gaaggacgga    360

gacgtggtgt gccgcatg                                                  378


<210>  442

<211>  383

<212>  DNA

<213>  Homo sapiens



<400>  442
ggccaccggg acccaaaggt gatcaggggg atgaaggaaa ggaaggcagg cctggcatcc     60

ctggattgcc tggacttcga ggtctgcccg gggagagagg taccccagga ttgcccgggc    120

ccaagggcaa tgatgggaag ctgggggcca caggaccaat gggcatgcgt gggttcaaag    180

gtgaccgagg cccaaaagga gagaaaggag agaaaggaga cagagctggg gatgccagtg    240

gcgtggaggc cccgatgatg atccgcctgg tgaatggctc aggtccgcac gagggccgcg    300

tggaagtgta ccacgaccgg cgctggggca ccgtgtgtga cgacggctgg gacaagaagg    360

acggagacgt ggtgtgccgc atg                                            383


<210>  443

<211>  2885

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (417)..(1904)

<223>  



<220>

<221>  misc_feature

<222>  (2851)..(2851)

<223>  n = g, a, t, or c



<220>

<221>  misc_feature

<222>  (2866)..(2866)

<223>  n = g, a, t, or c



<400>  443
agagcagctg cagttcgcat ctcaggcagt acctagagga gctgccggtg cctcctcaga     60

acatctcctg atcgctaccc aggaccaggc accaaggaca gggagtccca ggcgcacacc    120

ccccattctg ggtcccccag gcccagaccc ccactctgcc acaggttgca tcttgacctg    180

gtcctcctgc agaagtggcc cctgtggtcc tgctctgaga ctcgtccctg ggcgcccctg    240

cagccccttt ctatgactcc atctggattt ggctggctgt ggggacgcgg tccgaggggc    300

ggcctggctc tcagcgtggt ggcagccagc tctctggcca ccatggcaaa tgctgagatc    360

tgaggggaca aggctctaca gcctcagcca ggggcactca gctgttgcag ggtgtg atg    419
                                                              Met       
                                                              1         

gag aac aaa gct atg tac cta cac acc gtc agc gac tgt gac acc agc      467
Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr Ser         
            5                   10                  15                  

tcc atc tgt gag gat tcc ttt gat ggc agg agc ctg tcc aag ctg aac      515
Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu Asn         
        20                  25                  30                      

ctg tgt gag gat ggt cca tgt cac aaa cgg cgg gca agc atc tgc tgt      563
Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys Cys         
    35                  40                  45                          

acc cag ctg ggg tcc ctg tcg gcc ctg aag cat gct gtc ctg ggg ctc      611
Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly Leu         
50                  55                  60                  65          

tac ctg ctg gtc ttc ctg att ctt gtg ggc atc ttc atc tta gca gtg      659
Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala Val         
                70                  75                  80              

tcc agg ccg cgc agc tcc cct gac gac ctg aag gcc ctg act cgc aat      707
Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg Asn         
            85                  90                  95                  

gtg aac cgg ctg aat gag agc ttc cgg gac ttg cag ctg cgg ctg ctg      755
Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu Leu         
        100                 105                 110                     

cag gct ccg ctg caa gcg gac ctg acg gag cag gtg tgg aag gtg cag      803
Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val Gln         
    115                 120                 125                         

gac gcg ctg cag aac cag tca gac tcg ttg ctg gcg ctg gcg ggc gca      851
Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly Ala         
130                 135                 140                 145         

gtg cag cgg ctg gag ggc gcg cta tgg ggg ctg cag gcg cag gcg gtg      899
Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala Val         
                150                 155                 160             

cag acc gag cag gcg gtg gcc ctg ctg cgg gac cgc acg ggc cag cag      947
Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln Gln         
            165                 170                 175                 

agc gac acg gcg cag ctg gag ctc tac cag ctg cag gtg gag agc aac      995
Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser Asn         
        180                 185                 190                     

agt agc cag ctg ctg ctg agg cgc cac gcg ggc ctg ctg gac ggg ctg     1043
Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly Leu         
    195                 200                 205                         

gcg cgc agg gtg ggc atc ctg ggc gag gag ctg gcc gac gtg ggc ggc     1091
Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly Gly         
210                 215                 220                 225         

gtg ctg cgc ggc ctc aac cac agc ctg tcc tac gac gtg gcc ctc cac     1139
Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu His         
                230                 235                 240             

tgc acg cgg ctg cag gac ctg cgg gtg ctg gtg agc aac gcc agc gag     1187
Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser Glu         
            245                 250                 255                 

gac acg cgc cgc ctg cgc ctg gcg cac gta ggc atg gag ctg cag ctg     1235
Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln Leu         
        260                 265                 270                     

aag cag gag ctg gcc atg ctc aac gcg gtc acc gag gac ctg cgc ctc     1283
Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg Leu         
    275                 280                 285                         

aag gac tgg gag cac tcc atc gca ctg cgg aac atc tcc ctc gcg aaa     1331
Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala Lys         
290                 295                 300                 305         

ggg cca ccg gga ccc aaa ggt gat cag ggg gat gaa gga aag gaa ggc     1379
Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly         
                310                 315                 320             

agg cct ggc atc cct gga ttg cct gga ctt cga ggt ctg ccc ggg gag     1427
Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu         
            325                 330                 335                 

aga ggt acc cca gga ttg ccc ggg ccc aag ggc gat gat ggg aag ctg     1475
Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu         
        340                 345                 350                     

ggg gcc aca gga cca atg ggc atg cgt ggg ttc aaa ggt gac cga ggc     1523
Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly         
    355                 360                 365                         

cca aaa gga gag aaa gga gag aaa gga gac aga gct ggg gat gcc agt     1571
Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser         
370                 375                 380                 385         

ggc gtg gag gcc ccg atg atg atc cgc ctg gtg aat ggc tca ggt ccg     1619
Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro         
                390                 395                 400             

cac gag ggc cgc gtg gaa gtg tac cac gac cgg cgt tgg ggc acc gtg     1667
His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val         
            405                 410                 415                 

tgt gac gac ggc tgg gac aag aag gac gga gac gtg gtg tgc cgc atg     1715
Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met         
        420                 425                 430                     

ctc ggc ttc cgc ggt gtg gag gag gtg tac cgc aca gct cga ttc ggg     1763
Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly         
    435                 440                 445                         

caa ggc act ggg agg atc tgg atg gat gac gtt gcc tgc aag ggc aca     1811
Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly Thr         
450                 455                 460                 465         

gag gaa acc att ttc cgc tgc agc ttc tcc aaa tgg ggg gtg aca aac     1859
Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr Asn         
                470                 475                 480             

tgt gga cat gcc gaa gat gcc agc gtg aca tgc aac aga cac tga         1904
Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His                 
            485                 490                 495                 

aagtgggcag agcccaagtt cggggtcctg cacagagcac ccttcctgca tccctggggt   1964

ggggcacagc tcggggccat cctgaccatg cctcgaccac accccgtcca gcattctcag   2024

tcctcacacc tgcatcccag gaccgtgggg gccggtcgtc atttccctct tgaacatgtg   2084

ctccgaagta taactctggg acctactgcc cgtctctctc ttccaccagg ttcctgcatg   2144

aggagccctg atcaactgga tcaccacttt gcccagcctc tgaacaccat gcaccaggcc   2204

tcaatatccc agttcccttt ggccttttag ttacaggtga atgctgagaa tgtgtcagag   2264

acaagtgcag cagcagcgat ggttggtagt atagatcatt tactcttcag acaattccca   2324

aacctccatt agtccaagag tttctacatc ttcctcccca gcaagaggca acgtcaagtg   2384

atgaatttcc cccctttact ctgcctctgc tccccatttg ctagtttgag gaagtgacat   2444

agaggagaag ccagctgtag gggcaagagg gaaatgcaag tcacctgcag gaatccagct   2504

agatttggag aagggaatga aactaacatt gaatgactac catggcacgc taaatagtat   2564

cttgggtgcc aaattcatgt atccacttag ctgcattggt ccagggcatg tcagtctgga   2624

tacagcctta cctccaggta gcacttaact ggtccattca cctagactgc aagtaagaag   2684

acaaaatgac tgagaccgtg tgcccacctg aacttattgt ctttacttgg cctgagctaa   2744

aagcttgggt gcaggacctg tgtaactaga aagttgccta cttcagaacc tccagggcgt   2804

gagtgcaagg tcaaacatga ctggcttcag gccgaccatc aatgtangaa gagagctgat   2864

gntgaggctg acatgacggc t                                             2885


<210>  444

<211>  495

<212>  PRT

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (2851)..(2851)

<223>  n = g, a, t, or c

<220>

<221>  misc_feature

<222>  (2866)..(2866)

<223>  n = g, a, t, or c

<400>  444

Met Glu Asn Lys Ala Met Tyr Leu His Thr Val Ser Asp Cys Asp Thr 
1               5                   10                  15      


Ser Ser Ile Cys Glu Asp Ser Phe Asp Gly Arg Ser Leu Ser Lys Leu 
            20                  25                  30          


Asn Leu Cys Glu Asp Gly Pro Cys His Lys Arg Arg Ala Ser Ile Cys 
        35                  40                  45              


Cys Thr Gln Leu Gly Ser Leu Ser Ala Leu Lys His Ala Val Leu Gly 
    50                  55                  60                  


Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile Phe Ile Leu Ala 
65                  70                  75                  80  


Val Ser Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg 
                85                  90                  95      


Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu 
            100                 105                 110         


Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val 
        115                 120                 125             


Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly 
    130                 135                 140                 


Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala 
145                 150                 155                 160 


Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln 
                165                 170                 175     


Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser 
            180                 185                 190         


Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly 
        195                 200                 205             


Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly 
    210                 215                 220                 


Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu 
225                 230                 235                 240 


His Cys Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser 
                245                 250                 255     


Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln 
            260                 265                 270         


Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg 
        275                 280                 285             


Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala 
    290                 295                 300                 


Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu 
305                 310                 315                 320 


Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
                325                 330                 335     


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            340                 345                 350         


Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
        355                 360                 365             


Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala 
    370                 375                 380                 


Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly 
385                 390                 395                 400 


Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr 
                405                 410                 415     


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
            420                 425                 430         


Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
        435                 440                 445             


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly 
    450                 455                 460                 


Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr 
465                 470                 475                 480 


Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                485                 490                 495 


<210>  445

<211>  55

<212>  PRT

<213>  Homo sapiens



<400>  445

Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg 
1               5                   10                  15      


Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp 
            20                  25                  30          


Val Val Cys Arg Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg 
        35                  40                  45              


Thr Ala Arg Phe Gly Gln Gly 
    50                  55  


<210>  446

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  446

Ile Arg Leu Val Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val 
1               5                   10                  15      


Tyr 
    


<210>  447

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  447

Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly 
1               5                   10                  15      


Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp 
            20                  25          


<210>  448

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  448

Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys 
1               5                   10      


<210>  449

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  449

Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp 
1               5                   10          


<210>  450

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  450

Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly 
1               5                   10                  15      


Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu 
            20                  25                  


<210>  451

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  451

Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly 
1               5                   10                  15      


Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg 
            20                  25          


<210>  452

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  452

Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly 
1               5                   10                  15      


Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys 
            20                  25                  


<210>  453

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  453

Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly 
1               5                   10                  15      


Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met 
            20                  25          


<210>  454

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  454

Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn 
1               5                   10              


<210>  455

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  455

Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly 
1               5                   10                  15      


Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu 
            20                  25                  


<210>  456

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  456

Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly 
1               5                   10                  15      


Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro 
            20                  25          


<210>  457

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  457

Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
1               5                   10                  15      


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys 
            20                  25          


<210>  458

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  458

Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu 
            20                  25          


<210>  459

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  459

Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly 
1               5                   10                  15      


Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu 
            20                  25                  


<210>  460

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  460

Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly 
1               5                   10                  15      


Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg 
            20                  25          


<210>  461

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  461

Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly 
1               5                   10                  15      


Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp 
            20                  25                  


<210>  462

<211>  11

<212>  PRT

<213>  Homo sapiens



<400>  462

Gly Asp Val Val Cys Arg Met Leu Gly Phe Arg 
1               5                   10      


<210>  463

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  463

Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly 
1               5                   10                  15      


Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg 
            20                  25          


<210>  464

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  464

Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly 
1               5                   10                  15      


Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro 
            20                  25          


<210>  465

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  465

Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly 
1               5                   10                  15      


Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe 
            20                  25                  


<210>  466

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  466

Asp Asp Val Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe Arg Cys 
1               5                   10                  15  


<210>  467

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  467

Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly 
1               5                   10                  15      


Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr 
            20                  25                  


<210>  468

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  468

Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
1               5                   10                  15      


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp 
            20                  25                  


<210>  469

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  469

Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly 
1               5                   10                  15      


Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala 
            20                  25                  


<210>  470

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  470

Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly 
1               5                   10                  15      


Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr 
            20                  25          


<210>  471

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  471

Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly 
1               5                   10                  15      


Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro 
            20                  25          


<210>  472

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  472

Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly 
1               5                   10                  15      


Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg 
            20                  25          


<210>  473

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  473

Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly 
1               5                   10                  15      


Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu 
            20                  25                  


<210>  474

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  474

Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
1               5                   10                  15      


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys 
            20                  25          


<210>  475

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  475

Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly 
1               5                   10                  15      


Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp 
            20                  25                  


<210>  476

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  476

Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly 
1               5                   10                  15      


Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met 
            20                  25                  


<210>  477

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  477

Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly 
1               5                   10                  15      


Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
            20                  25                  


<210>  478

<211>  29

<212>  PRT

<213>  Homo sapiens



<400>  478

Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly 
1               5                   10                  15      


Met Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu 
            20                  25                  


<210>  479

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  479

Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly 
1               5                   10                  15      


Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro 
            20                  25          


<210>  480

<211>  127

<212>  PRT

<213>  Homo sapiens



<400>  480

Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg 
1               5                   10                  15      


Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg 
            20                  25                  30          


Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asn Asp Gly Lys Leu Gly 
        35                  40                  45              


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
    50                  55                  60                  


Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly 
65                  70                  75                  80  


Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His 
                85                  90                  95      


Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys 
            100                 105                 110         


Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met 
        115                 120                 125         


<210>  481

<211>  454

<212>  PRT

<213>  Mus musculus



<400>  481

Met Thr Glu Asn Gln Arg Leu Cys Pro His Glu Arg Glu Asp Ala Asp 
1               5                   10                  15      


Cys Ser Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Ser 
            20                  25                  30          


Leu Pro His Ser Thr Lys Asn Gly Pro Ser Val Gln Glu Lys Leu Lys 
        35                  40                  45              


Ser Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val 
    50                  55                  60                  


Leu Ile Pro Val Val Gly Ile Val Thr Ala Gln Leu Leu Asn Trp Glu 
65                  70                  75                  80  


Met Lys Asn Cys Leu Val Cys Ser Arg Asn Thr Ser Asp Thr Ser Gln 
                85                  90                  95      


Gly Pro Met Glu Lys Glu Asn Thr Ser Asn Val Glu Met Arg Phe Thr 
            100                 105                 110         


Ile Ile Met Ala His Met Lys Asp Met Glu Glu Arg Ile Gln Ser Ile 
        115                 120                 125             


Ser Asn Ser Lys Ala Asp Leu Ile Asp Thr Gly Arg Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Ala Thr Asp Gln Arg Leu Asn Asp Ile Leu Leu Gln Leu Asn 
145                 150                 155                 160 


Ser Leu Ile Leu Ser Val Gln Glu His Gly Asn Ser Leu Asp Ala Ile 
                165                 170                 175     


Ser Lys Ser Leu Gln Ser Leu Asn Met Thr Leu Leu Asp Val Gln Leu 
            180                 185                 190         


His Thr Glu Thr Leu His Val Arg Val Arg Glu Ser Thr Ala Lys Gln 
        195                 200                 205             


Gln Glu Asp Ile Ser Lys Leu Glu Glu Arg Val Tyr Lys Val Ser Ala 
    210                 215                 220                 


Glu Val Gln Ser Val Lys Glu Glu Gln Ala His Val Glu Gln Glu Val 
225                 230                 235                 240 


Lys Gln Glu Val Arg Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Lys Asn Ile Thr Phe Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Gln Gly Glu Lys Gly Asp Arg Gly Leu Thr Gly 
        275                 280                 285             


Gln Thr Gly Pro Pro Gly Ala Pro Gly Ile Arg Gly Ile Pro Gly Val 
    290                 295                 300                 


Lys Gly Asp Arg Gly Gln Ile Gly Phe Pro Gly Gly Arg Gly Asn Pro 
305                 310                 315                 320 


Gly Ala Pro Gly Lys Pro Gly Arg Ser Gly Ser Pro Gly Pro Lys Gly 
                325                 330                 335     


Gln Lys Gly Glu Lys Gly Ser Val Gly Gly Ser Thr Pro Leu Lys Thr 
            340                 345                 350         


Val Arg Leu Val Gly Gly Ser Gly Ala His Glu Gly Arg Val Glu Ile 
        355                 360                 365             


Phe His Gln Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Asp Ile 
    370                 375                 380                 


Arg Ala Gly Gln Val Val Cys Arg Ser Leu Gly Tyr Gln Glu Val Leu 
385                 390                 395                 400 


Ala Val His Lys Arg Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp 
                405                 410                 415     


Leu Asn Glu Val Met Cys Phe Gly Arg Glu Ser Ser Ile Glu Asn Cys 
            420                 425                 430         


Lys Ile Asn Gln Trp Gly Val Leu Ser Cys Ser His Ser Glu Asp Ala 
        435                 440                 445             


Gly Val Thr Cys Thr Ser 
    450                 


<210>  482

<211>  98

<212>  PRT

<213>  Homo sapiens



<400>  482

Val Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp 
1               5                   10                  15      


Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly 
            20                  25                  30          


Asp Val Val Cys Arg Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr 
        35                  40                  45              


Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp 
    50                  55                  60                  


Val Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser 
65                  70                  75                  80  


Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr 
                85                  90                  95      


Cys Asn 
        


<210>  483

<211>  60

<212>  PRT

<213>  Homo sapiens



<400>  483

Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly 
1               5                   10                  15      


Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro 
            20                  25                  30          


Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg 
        35                  40                  45              


Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys 
    50                  55                  60  


<210>  484

<211>  21

<212>  PRT

<213>  Homo sapiens



<400>  484

Ala Val Leu Gly Leu Tyr Leu Leu Val Phe Leu Ile Leu Val Gly Ile 
1               5                   10                  15      


Phe Ile Leu Ala Val 
            20      


<210>  485

<211>  390

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (390)..(390)

<223>  n = g, a, t, or c



<400>  485
atcaggaatg acctgaatct caacccaaat attaaacaaa atccacataa tccctcattt     60

caatttccaa ttccattaag ggaccctctc tttttggatg gcagagatgg ttttttaatg    120

aaatcccacc atctatctga gtgagtctgg caggcttttt agttcctgag ttaaatttgt    180

aatagaacca aggcaatgct gctgactttg atatgtatga ctcagtcttt caatatgtgg    240

ttttcaaaaa attgttgaag acgtgacttc atagcaatat atagagaata aattaaaatc    300

agcagattga gttttcaaca ttgcaaaatc agttttttac ctctttccta ccaatttcac    360

attttgcaga aacttgttca tatttccaan                                     390


<210>  486

<211>  5357

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (178)..(3264)

<223>  



<400>  486
tttcgtggaa gcagggactt gctgagagct gaacatctct gtttgatttg ctgtaacatg     60

taaagcgaaa ctgggacatt ttactttaca gtctattaaa ggttatacaa aacttaaaag    120

aagcagcaat tctattcgct tgttattgga cttgaaactc cctttgacct cggaaag       177

atg agg ttg cca tgg gaa ctg ctg gta ctg caa tca ttc att ttg tgc      225
Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys         
1               5                   10                  15              

ctt gca gat gat tcc aca ctg cat ggc ccg att ttt att caa gaa cca      273
Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro         
            20                  25                  30                  

agt cct gta atg ttc cct ttg gat tct gag gag aaa aaa gtg aag ctc      321
Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu         
        35                  40                  45                      

aat tgt gaa gtt aaa gga aat cca aaa cct cat tat agg tgg aag tta      369
Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu         
    50                  55                  60                          

aat gga aca gat gtt gac act ggt atg gat ttc cgc tac agt gtt gtt      417
Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val         
65                  70                  75                  80          

gaa ggg agc ttg ttg atc aat aac ccc aat aaa acc caa gat gct gga      465
Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly         
                85                  90                  95              

acg tac cag tgc aca gcg aca aac tcg ttt gga aca att gtt agc aga      513
Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg         
            100                 105                 110                 

gaa gca aag ctt cag ttt gct tat ctt gaa aat ttt aaa acc aaa atg      561
Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met         
        115                 120                 125                     

agg agt aca gtg tct gtg cgt gaa ggc cag gga gtt gtg ctg ctc tgc      609
Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys         
    130                 135                 140                         

ggc ccc cca cca cac tct gga gaa ctg tca tat gct tgg atc ttc aat      657
Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn         
145                 150                 155                 160         

gaa tac cca tcg ttt gtt gaa gaa gat agt cgg aga ttt gtc tcc cag      705
Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln         
                165                 170                 175             

gag aca ggg cac ctc tac ata tct aag gtg gag ccg tct gat gtg gga      753
Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly         
            180                 185                 190                 

aat tac aca tgt gtg gtg aca agt atg gtg aca aat gcc cga gtg ctg      801
Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu         
        195                 200                 205                     

ggc tct cca act cct ttg gtg cta cgt tct gat ggt gtg atg ggt gaa      849
Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu         
    210                 215                 220                         

tat gaa cct aaa ata gaa gtt cag ttt cca gaa act ctt cca gca gct      897
Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala         
225                 230                 235                 240         

aaa ggt tcg act gtg aaa ttg gaa tgt ttt gcc ctt gga aat ccc ata      945
Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile         
                245                 250                 255             

cct cag att aat tgg aga aga agt gat ggg ctg cca ttt tcc agc aaa      993
Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys         
            260                 265                 270                 

att aaa tta agg aag ttc agt ggt gtg ctt gaa atc ccc aac ttc caa     1041
Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln         
        275                 280                 285                     

cag gaa gat gca ggt tcc tat gaa tgc att gct gag aat tca cga gga     1089
Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly         
    290                 295                 300                         

aaa aat gtt gcc aga ggg cgt ctc act tac tat gca aag ccc cat tgg     1137
Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp         
305                 310                 315                 320         

gtt caa ctc ata aag gat gtg gaa ata gcc gtg gag gac agt ctt tat     1185
Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr         
                325                 330                 335             

tgg gaa tgc agg gca agc ggc aag ccc aag cct tcc tac cga tgg ctg     1233
Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu         
            340                 345                 350                 

aaa aat gga gca gcc ctg gtg cta gag gag aga aca cag ata gaa aat     1281
Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn         
        355                 360                 365                     

ggt gcc ctt aca ata tca aac cta agt gtg act gat tct ggc atg ttc     1329
Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe         
    370                 375                 380                         

cag tgc ata gca gaa aac aaa cat ggc ctt gtt tat tcc agt gct gag     1377
Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu         
385                 390                 395                 400         

ctc aaa gtt gtt gct tct gct cca gat ttt tca aag aat cca atg aag     1425
Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys         
                405                 410                 415             

aag ttg gtt cag gtg cag gtg ggc agc ctg gtc agc ttg gat tgt aaa     1473
Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys         
            420                 425                 430                 

ccc aga gcc tcc cca agg gca ctc tct tcc tgg aag aag ggg gat gtg     1521
Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val         
        435                 440                 445                     

agc gtg cag gag cat gaa aga att tct ttg tta aac gat gga gga ctc     1569
Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu         
    450                 455                 460                         

aaa ata gcc aat gtg act aaa gct gat gct gga act tac acc tgc atg     1617
Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met         
465                 470                 475                 480         

gca gaa aac cag ttt ggg aaa gca aat ggc aca aca cat ttg gtt gtt     1665
Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val         
                485                 490                 495             

acg gaa cca aca aga ata act ttg gca cca tct aac atg gat gtt tct     1713
Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser         
            500                 505                 510                 

gtt ggt gaa agc gtc ata ttg ccc tgc cag gta caa cat gac ccg ctg     1761
Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu         
        515                 520                 525                     

tta gac atc atc ttt acc tgg tat ttc aat ggg gcc ctt gca gat ttt     1809
Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe         
    530                 535                 540                         

aag aaa gat gga tct cac ttt gag aaa gtt ggt ggg agt tca tct ggt     1857
Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly         
545                 550                 555                 560         

gat tta atg atc aga aac att cag ctg aaa cac agt ggg aaa tat gtt     1905
Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val         
                565                 570                 575             

tgt atg gtg caa acg ggg gtg gac agt gtt tca tct gct gct gac ctc     1953
Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu         
            580                 585                 590                 

ata gta aga ggt tca cct gga cca cca gaa aat gtg aag gta gat gaa     2001
Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu         
        595                 600                 605                     

att aca gac aca aca gcc caa ctc tct tgg aaa gaa ggt aaa gac aac     2049
Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn         
    610                 615                 620                         

cat agc cca gtt ata tcc tat tct atc cag gct cgg aca cct ttc tcc     2097
His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser         
625                 630                 635                 640         

gtg ggt tgg caa acc gtc aca aca gtg cct gag gtc atc gat ggg aag     2145
Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys         
                645                 650                 655             

acg cac aca gcc act gta gtt gag tta aac cca tgg gtg gaa tat gaa     2193
Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu         
            660                 665                 670                 

ttt cgg gtt gta gcc agt aac aaa att gga ggt gga gaa cca agt tta     2241
Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu         
        675                 680                 685                     

ccc tca gaa aaa gta aga act gaa gag gca gtt cca gaa gtg cct cct     2289
Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro         
    690                 695                 700                         

tct gaa gtc aat gga gga ggc gga agc cgg tct gaa ctt gtg ata acc     2337
Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr         
705                 710                 715                 720         

tgg gat cca gtc cct gaa gaa cta cag aat ggt gaa ggt ttt ggg tat     2385
Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr         
                725                 730                 735             

gtt gtt gct ttc cgc cct ctt ggg gtt acc acc tgg atc cag aca gtg     2433
Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val         
            740                 745                 750                 

gtg aca tcc cct gac acc cca aga tat gtc ttt agg aat gaa agc atc     2481
Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile         
        755                 760                 765                     

gtg cca tat tca cca tat gaa gtt aaa gtg ggt gtt tat aat aac aaa     2529
Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys         
    770                 775                 780                         

ggt gaa gga cca ttt agc cca gtg aca aca gtg ttc tct gca gaa gaa     2577
Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu         
785                 790                 795                 800         

gag cct aca gtg gcc cca tct caa gtc tct gca aat agc cta tct tcc     2625
Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser         
                805                 810                 815             

tca gaa att gag gtt tca tgg aac acc att cct tgg aag ttg agc aat     2673
Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn         
            820                 825                 830                 

gga cat tta ctg ggc tat gag gtg cgg tac tgg aat ggg ggt gga aag     2721
Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys         
        835                 840                 845                     

gag gaa tca tcc agt aag atg aaa gtg gca gga aat gag aca tca gcc     2769
Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala         
    850                 855                 860                         

aga cta cgg ggc ctg aag agc aac ctg gcc tat tac acg gct gtc cgg     2817
Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg         
865                 870                 875                 880         

gct tac aac agt gcc ggc gct ggg cct ttt agc gcc aca gtt aat gta     2865
Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val         
                885                 890                 895             

acc acc aag aaa acg cct ccc agt cag cca cca gga aat gtt gtt tgg     2913
Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp         
            900                 905                 910                 

aat gcc aca gac act aaa gtg tta ctt aat tgg gag caa gtt aaa gcc     2961
Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala         
        915                 920                 925                     

atg gag aat gag tca gaa gta aca gga tat aaa gtt ttc tat agg act     3009
Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr         
    930                 935                 940                         

agc agt caa aat aac gta caa gta ctg aac aca aat aaa act tca gct     3057
Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala         
945                 950                 955                 960         

gaa ctt gtg ctg ccc att aaa gag gac tac att att gaa gtc aag gcc     3105
Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala         
                965                 970                 975             

aca aca gat gga ggg gat ggg acc agt agt gaa cag atc agg att cca     3153
Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro         
            980                 985                 990                 

cga ata acc agt atg gat gca aga  gga tcc act tca gcc  atc tcg aat   3201
Arg Ile Thr Ser Met Asp Ala Arg  Gly Ser Thr Ser Ala  Ile Ser Asn       
        995                 1000                 1005                   

gtc cac  cct atg tca agt tat  atg cct ata gta ctg  ttc tta att      3246
Val His  Pro Met Ser Ser Tyr  Met Pro Ile Val Leu  Phe Leu Ile          
    1010                 1015                 1020                      

gta tat  gtc ctg tgg tga tattaactcc tttttattat ttattggaaa           3294
Val Tyr  Val Leu Trp                                                    
    1025                                                                

gttatttggt taccaaaaaa agtgctttca tgaaatgcag ggattatgca tgtttttttc   3354

aactcttatt tttaactttc tacttcatta taggtaaata tgaatataat taaaaaaaca   3414

gtaaatcctt ttaggggaat ctgaaatgcc ttaatattaa cttgataaac caaaggaatt   3474

tacatattac atacttcaga cttttgatat aaatgttctt aaactatgag tttaagcact   3534

gcctatggat aaagactcac acactctcac atgtacacac acacgcatga gaatttcttt   3594

ttacattgaa aaactctttc atttaattca aatgctattt tcccattata atagcattat   3654

ttggaagact taaccagtat caatttgaaa tgctgattta agtccccaag gatgaaaaat   3714

acattttaaa aattattttg ttggagagga gtggcatgtg attcaaaaga gcattgttgg   3774

aaaatgctac tgtggggctt agaagaatga tgtttggttt ggtatgctgc taactagttg   3834

taagacttta caaatcactt tgccatctgt acctctcaat tattcctcta taaaatatgg   3894

agataataat acctatctga tcagactttg ccccatgaat tagtttttaa aagataaaga   3954

ctgaagtatg aaagtgcttt tgtcacccca aatgcaattg acccatgcaa aatattagca   4014

tgaatttatt taatcacata aaagtcatga agaccagcca gattttcaag cttcattctg   4074

tttcattcag ttatattcca aaattcaaat gatcacattt tattctttct caaaaaaaaa   4134

aagttttttt aaattaaaaa aggaattgtt tccttcacag ctatgaataa gctttcaggt   4194

tttattaaaa cctagaggaa aaaatcagga atgacctgaa tctcaaccca aatattaaac   4254

aaaatccaca taatccctca tttcaatttc caattccatt aagggaccct ctctttttgg   4314

atggcagaga tggtttttta atgaaatccc accatctatc tgagtgagtc tggcaggctt   4374

tttagttcct gagttaaatt tgtaatagaa ccaaggcaat gctgctgact ttgatatgta   4434

tgactcagtc tttcaatatg tggttttcaa aaaattgttg aagacgtgac ttcatagcaa   4494

tatatagaga ataaattaaa atcagcagat tgagttttca acattgcaaa atcagttttt   4554

tacctctttc ctaccaattt cacattttgc agaaacttgt tcatatttcc aacaatatca   4614

gaattagaaa acagttcaga taacaagaaa gattaaaaat tagggaaatt ctgatatcac   4674

cataaagcac tattttacat ttagagatta catttaagat aaagtcatca tacacaaaaa   4734

caataaatat ttataacttt ctctataagg tccgcatata ctgtatatat tgaaacaatc   4794

tgaatgacta gtagatttca tatgaccatt gttatttcca ctttctccaa tacttgtatt   4854

ttatgctaca tgtaatgaag ttggaccttt ttattattta gtaattccta tatgttccta   4914

tacttttcat tttcaagatg attgctctat tgtttcatgt tgtttctagc aatatatctc   4974

catgagatat gcactttgtt tcatattgaa aagtataaaa tttatctttc aattcctgtg   5034

tgtgtatcct atggttatct gtatgtatta ttttctattc taataaaatt tataacaagc   5094

aaaaaaaaaa aaaaacacac acaaagtaga acacaagaaa agagggggcg ccgcaaaaag   5154

gatccgccag gggagccaac aataacaata cccccaatgt cgtgcgtaac aacaggccac   5214

aaaagggggt gcgtacaaag agaagcacac gcgcgcagtt atacagacgc gatgaagagc   5274

gaaacactga cgaggagaat aggagagaca ccaacacggg cggaagacat gcggcagcgc   5334

gacgaaatta acacacgaga aat                                           5357


<210>  487

<211>  1028

<212>  PRT

<213>  Homo sapiens



<400>  487

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln 
                165                 170                 175     


Glu Thr Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu 
        195                 200                 205             


Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala 
225                 230                 235                 240 


Lys Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile 
                245                 250                 255     


Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys 
            260                 265                 270         


Ile Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly 
    290                 295                 300                 


Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp 
305                 310                 315                 320 


Val Gln Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr 
                325                 330                 335     


Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu 
            340                 345                 350         


Lys Asn Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn 
        355                 360                 365             


Gly Ala Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe 
    370                 375                 380                 


Gln Cys Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu 
385                 390                 395                 400 


Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys 
                405                 410                 415     


Lys Leu Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys 
            420                 425                 430         


Pro Arg Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val 
        435                 440                 445             


Ser Val Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu 
    450                 455                 460                 


Lys Ile Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met 
465                 470                 475                 480 


Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val 
                485                 490                 495     


Thr Glu Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser 
            500                 505                 510         


Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu 
        515                 520                 525             


Leu Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe 
    530                 535                 540                 


Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val 
                565                 570                 575     


Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu 
            580                 585                 590         


Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu 
        595                 600                 605             


Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn 
    610                 615                 620                 


His Ser Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys 
                645                 650                 655     


Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu 
        675                 680                 685             


Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro 
    690                 695                 700                 


Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr 
705                 710                 715                 720 


Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr 
                725                 730                 735     


Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val 
            740                 745                 750         


Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile 
        755                 760                 765             


Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys 
    770                 775                 780                 


Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu 
785                 790                 795                 800 


Glu Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser 
                805                 810                 815     


Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn 
            820                 825                 830         


Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys 
        835                 840                 845             


Glu Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala 
    850                 855                 860                 


Arg Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val 
                885                 890                 895     


Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp 
            900                 905                 910         


Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr 
    930                 935                 940                 


Ser Ser Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala 
945                 950                 955                 960 


Glu Leu Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala 
                965                 970                 975     


Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro 
            980                 985                 990         


Arg Ile Thr Ser Met Asp Ala Arg  Gly Ser Thr Ser Ala  Ile Ser Asn 
        995                 1000                 1005             


Val His  Pro Met Ser Ser Tyr  Met Pro Ile Val Leu  Phe Leu Ile 
    1010                 1015                 1020             


Val Tyr  Val Leu Trp 
    1025             


<210>  488

<211>  3087

<212>  DNA

<213>  Homo sapiens



<400>  488
atgaggttgc catgggaact gctggtactg caatcattca ttttgtgcct tgcagatgat     60

tccacactgc atggcccgat ttttattcaa gaaccaagtc ctgtaatgtt ccctttggat    120

tctgaggaga aaaaagtgaa gctcaattgt gaagttaaag gaaatccaaa acctcattat    180

aggtggaagt taaatggaac agatgttgac actggtatgg atttccgcta cagtgttgtt    240

gaagggagct tgttgatcaa taaccccaat aaaacccaag atgctggaac gtaccagtgc    300

acagcgacaa actcgtttgg aacaattgtt agcagagaag caaagcttca gtttgcttat    360

cttgaaaatt ttaaaaccaa aatgaggagt acagtgtctg tgcgtgaagg ccagggagtt    420

gtgctgctct gcggcccccc accacactct ggagaactgt catatgcttg gatcttcaat    480

gaatacccat cgtttgttga agaagatagt cggagatttg tctcccagga gacagggcac    540

ctctacatat ctaaggtgga gccgtctgat gtgggaaatt acacatgtgt ggtgacaagt    600

atggtgacaa atgcccgagt gctgggctct ccaactcctt tggtgctacg ttctgatggt    660

gtgatgggtg aatatgaacc taaaatagaa gttcagtttc cagaaactct tccagcagct    720

aaaggttcga ctgtgaaatt ggaatgtttt gcccttggaa atcccatacc tcagattaat    780

tggagaagaa gtgatgggct gccattttcc agcaaaatta aattaaggaa gttcagtggt    840

gtgcttgaaa tccccaactt ccaacaggaa gatgcaggtt cctatgaatg cattgctgag    900

aattcacgag gaaaaaatgt tgccagaggg cgtctcactt actatgcaaa gccccattgg    960

gttcaactca taaaggatgt ggaaatagcc gtggaggaca gtctttattg ggaatgcagg   1020

gcaagcggca agcccaagcc ttcctaccga tggctgaaaa atggagcagc cctggtgcta   1080

gaggagagaa cacagataga aaatggtgcc cttacaatat caaacctaag tgtgactgat   1140

tctggcatgt tccagtgcat agcagaaaac aaacatggcc ttgtttattc cagtgctgag   1200

ctcaaagttg ttgcttctgc tccagatttt tcaaagaatc caatgaagaa gttggttcag   1260

gtgcaggtgg gcagcctggt cagcttggat tgtaaaccca gagcctcccc aagggcactc   1320

tcttcctgga agaaggggga tgtgagcgtg caggagcatg aaagaatttc tttgttaaac   1380

gatggaggac tcaaaatagc caatgtgact aaagctgatg ctggaactta cacctgcatg   1440

gcagaaaacc agtttgggaa agcaaatggc acaacacatt tggttgttac ggaaccaaca   1500

agaataactt tggcaccatc taacatggat gtttctgttg gtgaaagcgt catattgccc   1560

tgccaggtac aacatgaccc gctgttagac atcatcttta cctggtattt caatggggcc   1620

cttgcagatt ttaagaaaga tggatctcac tttgagaaag ttggtgggag ttcatctggt   1680

gatttaatga tcagaaacat tcagctgaaa cacagtggga aatatgtttg tatggtgcaa   1740

acgggggtgg acagtgtttc atctgctgct gacctcatag taagaggttc acctggacca   1800

ccagaaaatg tgaaggtaga tgaaattaca gacacaacag cccaactctc ttggaaagaa   1860

ggtaaagaca accatagccc agttatatcc tattctatcc aggctcggac acctttctcc   1920

gtgggttggc aaaccgtcac aacagtgcct gaggtcatcg atgggaagac gcacacagcc   1980

actgtagttg agttaaaccc atgggtggaa tatgaatttc gggttgtagc cagtaacaaa   2040

attggaggtg gagaaccaag tttaccctca gaaaaagtaa gaactgaaga ggcagttcca   2100

gaagtgcctc cttctgaagt caatggagga ggcggaagcc ggtctgaact tgtgataacc   2160

tgggatccag tccctgaaga actacagaat ggtgaaggtt ttgggtatgt tgttgctttc   2220

cgccctcttg gggttaccac ctggatccag acagtggtga catcccctga caccccaaga   2280

tatgtcttta ggaatgaaag catcgtgcca tattcaccat atgaagttaa agtgggtgtt   2340

tataataaca aaggtgaagg accatttagc ccagtgacaa cagtgttctc tgcagaagaa   2400

gagcctacag tggccccatc tcaagtctct gcaaatagcc tatcttcctc agaaattgag   2460

gtttcatgga acaccattcc ttggaagttg agcaatggac atttactggg ctatgaggtg   2520

cggtactgga atgggggtgg aaaggaggaa tcatccagta agatgaaagt ggcaggaaat   2580

gagacatcag ccagactacg gggcctgaag agcaacctgg cctattacac ggctgtccgg   2640

gcttacaaca gtgccggcgc tgggcctttt agcgccacag ttaatgtaac caccaagaaa   2700

acgcctccca gtcagccacc aggaaatgtt gtttggaatg ccacagacac taaagtgtta   2760

cttaattggg agcaagttaa agccatggag aatgagtcag aagtaacagg atataaagtt   2820

ttctatagga ctagcagtca aaataacgta caagtactga acacaaataa aacttcagct   2880

gaacttgtgc tgcccattaa agaggactac attattgaag tcaaggccac aacagatgga   2940

ggggatggga ccagtagtga acagatcagg attccacgaa taaccagtat ggatgcaaga   3000

ggatccactt cagccatctc gaatgtccac cctatgtcaa gttatatgcc tatagtactg   3060

ttcttaattg tatatgtcct gtggtga                                       3087


<210>  489

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  489

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala 
        


<210>  490

<211>  1010

<212>  PRT

<213>  Homo sapiens



<400>  490

Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro Ser Pro 
1               5                   10                  15      


Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu Asn Cys 
            20                  25                  30          


Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu Asn Gly 
        35                  40                  45              


Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val Glu Gly 
    50                  55                  60                  


Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly Thr Tyr 
65                  70                  75                  80  


Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg Glu Ala 
                85                  90                  95      


Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met Arg Ser 
            100                 105                 110         


Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys Gly Pro 
        115                 120                 125             


Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn Glu Tyr 
    130                 135                 140                 


Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln Glu Thr 
145                 150                 155                 160 


Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly Asn Tyr 
                165                 170                 175     


Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu Gly Ser 
            180                 185                 190         


Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu Tyr Glu 
        195                 200                 205             


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala Lys Gly 
    210                 215                 220                 


Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile Pro Gln 
225                 230                 235                 240 


Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys Ile Lys 
                245                 250                 255     


Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln Gln Glu 
            260                 265                 270         


Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly Lys Asn 
        275                 280                 285             


Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp Val Gln 
    290                 295                 300                 


Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr Trp Glu 
305                 310                 315                 320 


Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu Lys Asn 
                325                 330                 335     


Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn Gly Ala 
            340                 345                 350         


Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe Gln Cys 
        355                 360                 365             


Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu Leu Lys 
    370                 375                 380                 


Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys Lys Leu 
385                 390                 395                 400 


Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys Pro Arg 
                405                 410                 415     


Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val Ser Val 
            420                 425                 430         


Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu Lys Ile 
        435                 440                 445             


Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met Ala Glu 
    450                 455                 460                 


Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val Thr Glu 
465                 470                 475                 480 


Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser Val Gly 
                485                 490                 495     


Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu Leu Asp 
            500                 505                 510         


Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe Lys Lys 
        515                 520                 525             


Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly Asp Leu 
    530                 535                 540                 


Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val Cys Met 
545                 550                 555                 560 


Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu Ile Val 
                565                 570                 575     


Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu Ile Thr 
            580                 585                 590         


Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn His Ser 
        595                 600                 605             


Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser Val Gly 
    610                 615                 620                 


Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys Thr His 
625                 630                 635                 640 


Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg 
                645                 650                 655     


Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu Pro Ser 
            660                 665                 670         


Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro Ser Glu 
        675                 680                 685             


Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr Trp Asp 
    690                 695                 700                 


Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr Val Val 
705                 710                 715                 720 


Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val Val Thr 
                725                 730                 735     


Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile Val Pro 
            740                 745                 750         


Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly Glu 
        755                 760                 765             


Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu Glu Pro 
    770                 775                 780                 


Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser Ser Glu 
785                 790                 795                 800 


Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn Gly His 
                805                 810                 815     


Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys Glu Glu 
            820                 825                 830         


Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala Arg Leu 
        835                 840                 845             


Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg Ala Tyr 
    850                 855                 860                 


Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val Thr Thr 
865                 870                 875                 880 


Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp Asn Ala 
                885                 890                 895     


Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala Met Glu 
            900                 905                 910         


Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr Ser Ser 
        915                 920                 925             


Gln Asn Asn Val Gln Val Leu Asn Thr Asn Lys Thr Ser Ala Glu Leu 
    930                 935                 940                 


Val Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala Thr Thr 
945                 950                 955                 960 


Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro Arg Ile 
                965                 970                 975     


Thr Ser Met Asp Ala Arg Gly Ser Thr Ser Ala Ile Ser Asn Val His 
            980                 985                 990         


Pro Met Ser Ser Tyr Met Pro Ile  Val Leu Phe Leu Ile  Val Tyr Val 
        995                 1000                 1005             


Leu Trp  
    1010 


<210>  491

<211>  60

<212>  PRT

<213>  Homo sapiens



<400>  491

Glu Lys Lys Val Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro 
1               5                   10                  15      


His Tyr Arg Trp Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp 
            20                  25                  30          


Phe Arg Tyr Ser Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn 
        35                  40                  45              


Lys Thr Gln Asp Ala Gly Thr Tyr Gln Cys Thr Ala 
    50                  55                  60  


<210>  492

<211>  62

<212>  PRT

<213>  Homo sapiens



<400>  492

Gly Gln Gly Val Val Leu Leu Cys Gly Pro Pro Pro His Ser Gly Glu 
1               5                   10                  15      


Leu Ser Tyr Ala Trp Ile Phe Asn Glu Tyr Pro Ser Phe Val Glu Glu 
            20                  25                  30          


Asp Ser Arg Arg Phe Val Ser Gln Glu Thr Gly His Leu Tyr Ile Ser 
        35                  40                  45              


Lys Val Glu Pro Ser Asp Val Gly Asn Tyr Thr Cys Val Val 
    50                  55                  60          


<210>  493

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  493

Gly Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile Pro 
1               5                   10                  15      


Gln Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys Ile 
            20                  25                  30          


Lys Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln Gln 
        35                  40                  45              


Glu Asp Ala Gly Ser Tyr Glu Cys Ile Ala 
    50                  55              


<210>  494

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  494

Gly Ser Leu Val Ser Leu Asp Cys Lys Pro Arg Ala Ser Pro Arg Ala 
1               5                   10                  15      


Leu Ser Ser Trp Lys Lys Gly Asp Val Ser Val Gln Glu His Glu Arg 
            20                  25                  30          


Ile Ser Leu Leu Asn Asp Gly Gly Leu Lys Ile Ala Asn Val Thr Lys 
        35                  40                  45              


Ala Asp Ala Gly Thr Tyr Thr Cys Met Ala 
    50                  55              


<210>  495

<211>  66

<212>  PRT

<213>  Homo sapiens



<400>  495

Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu Leu 
1               5                   10                  15      


Asp Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe Lys 
            20                  25                  30          


Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly Asp 
        35                  40                  45              


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val Cys 
    50                  55                  60                  


Met Val 
65      


<210>  496

<211>  90

<212>  PRT

<213>  Homo sapiens



<400>  496

Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu Ile Thr Asp Thr Thr 
1               5                   10                  15      


Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn His Ser Pro Val Ile 
            20                  25                  30          


Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser Val Gly Trp Gln Thr 
        35                  40                  45              


Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys Thr His Thr Ala Thr 
    50                  55                  60                  


Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Val Val Ala 
65                  70                  75                  80  


Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser 
                85                  90  


<210>  497

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  497

Pro Glu Val Pro Pro Ser Glu Val Asn Gly Gly Gly Gly Ser Arg Ser 
1               5                   10                  15      


Glu Leu Val Ile Thr Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly 
            20                  25                  30          


Glu Gly Phe Gly Tyr Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr 
        35                  40                  45              


Trp Ile Gln Thr Val Val Thr Ser Pro Asp Thr Pro Arg Tyr Val Phe 
    50                  55                  60                  


Arg Asn Glu Ser Ile Val Pro Tyr Ser Pro Tyr Glu Val Lys Val Gly 
65                  70                  75                  80  


Val Tyr Asn Asn Lys Gly Glu Gly Pro Phe Ser 
                85                  90      


<210>  498

<211>  90

<212>  PRT

<213>  Homo sapiens



<400>  498

Pro Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser Ser 
1               5                   10                  15      


Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn Gly 
            20                  25                  30          


His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys Glu 
        35                  40                  45              


Glu Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala Arg 
    50                  55                  60                  


Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg Ala 
65                  70                  75                  80  


Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser 
                85                  90  


<210>  499

<211>  84

<212>  PRT

<213>  Homo sapiens



<400>  499

Pro Ser Gln Pro Pro Gly Asn Val Val Trp Asn Ala Thr Asp Thr Lys 
1               5                   10                  15      


Val Leu Leu Asn Trp Glu Gln Val Lys Ala Met Glu Asn Glu Ser Glu 
            20                  25                  30          


Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr Ser Ser Gln Asn Asn Val 
        35                  40                  45              


Gln Val Leu Asn Thr Asn Lys Thr Ser Ala Glu Leu Val Leu Pro Ile 
    50                  55                  60                  


Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala Thr Thr Asp Gly Gly Asp 
65                  70                  75                  80  


Gly Thr Ser Ser 
                


<210>  500

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  500

Ser Gln Pro Pro Gly Asn Val Val Trp Asn Ala Thr Asp Thr Lys Val 
1               5                   10                  15      


Leu 
    


<210>  501

<211>  885

<212>  PRT

<213>  Homo sapiens



<400>  501

Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro Ser Pro 
1               5                   10                  15      


Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu Asn Cys 
            20                  25                  30          


Glu Val Lys Gly Asn Pro Lys Pro His Tyr Arg Trp Lys Leu Asn Gly 
        35                  40                  45              


Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val Glu Gly 
    50                  55                  60                  


Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly Thr Tyr 
65                  70                  75                  80  


Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg Glu Ala 
                85                  90                  95      


Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Lys Met Arg Ser 
            100                 105                 110         


Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys Gly Pro 
        115                 120                 125             


Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn Glu Tyr 
    130                 135                 140                 


Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Phe Val Ser Gln Glu Thr 
145                 150                 155                 160 


Gly His Leu Tyr Ile Ser Lys Val Glu Pro Ser Asp Val Gly Asn Tyr 
                165                 170                 175     


Thr Cys Val Val Thr Ser Met Val Thr Asn Ala Arg Val Leu Gly Ser 
            180                 185                 190         


Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu Tyr Glu 
        195                 200                 205             


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala Lys Gly 
    210                 215                 220                 


Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Ile Pro Gln 
225                 230                 235                 240 


Ile Asn Trp Arg Arg Ser Asp Gly Leu Pro Phe Ser Ser Lys Ile Lys 
                245                 250                 255     


Leu Arg Lys Phe Ser Gly Val Leu Glu Ile Pro Asn Phe Gln Gln Glu 
            260                 265                 270         


Asp Ala Gly Ser Tyr Glu Cys Ile Ala Glu Asn Ser Arg Gly Lys Asn 
        275                 280                 285             


Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro His Trp Val Gln 
    290                 295                 300                 


Leu Ile Lys Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr Trp Glu 
305                 310                 315                 320 


Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu Lys Asn 
                325                 330                 335     


Gly Ala Ala Leu Val Leu Glu Glu Arg Thr Gln Ile Glu Asn Gly Ala 
            340                 345                 350         


Leu Thr Ile Ser Asn Leu Ser Val Thr Asp Ser Gly Met Phe Gln Cys 
        355                 360                 365             


Ile Ala Glu Asn Lys His Gly Leu Val Tyr Ser Ser Ala Glu Leu Lys 
    370                 375                 380                 


Val Val Ala Ser Ala Pro Asp Phe Ser Lys Asn Pro Met Lys Lys Leu 
385                 390                 395                 400 


Val Gln Val Gln Val Gly Ser Leu Val Ser Leu Asp Cys Lys Pro Arg 
                405                 410                 415     


Ala Ser Pro Arg Ala Leu Ser Ser Trp Lys Lys Gly Asp Val Ser Val 
            420                 425                 430         


Gln Glu His Glu Arg Ile Ser Leu Leu Asn Asp Gly Gly Leu Lys Ile 
        435                 440                 445             


Ala Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Met Ala Glu 
    450                 455                 460                 


Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val Thr Glu 
465                 470                 475                 480 


Pro Thr Arg Ile Thr Leu Ala Pro Ser Asn Met Asp Val Ser Val Gly 
                485                 490                 495     


Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu Leu Asp 
            500                 505                 510         


Ile Ile Phe Thr Trp Tyr Phe Asn Gly Ala Leu Ala Asp Phe Lys Lys 
        515                 520                 525             


Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly Asp Leu 
    530                 535                 540                 


Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val Cys Met 
545                 550                 555                 560 


Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Asp Leu Ile Val 
                565                 570                 575     


Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu Ile Thr 
            580                 585                 590         


Asp Thr Thr Ala Gln Leu Ser Trp Lys Glu Gly Lys Asp Asn His Ser 
        595                 600                 605             


Pro Val Ile Ser Tyr Ser Ile Gln Ala Arg Thr Pro Phe Ser Val Gly 
    610                 615                 620                 


Trp Gln Thr Val Thr Thr Val Pro Glu Val Ile Asp Gly Lys Thr His 
625                 630                 635                 640 


Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg 
                645                 650                 655     


Val Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu Pro Ser 
            660                 665                 670         


Glu Lys Val Arg Thr Glu Glu Ala Val Pro Glu Val Pro Pro Ser Glu 
        675                 680                 685             


Val Asn Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr Trp Asp 
    690                 695                 700                 


Pro Val Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr Val Val 
705                 710                 715                 720 


Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val Val Thr 
                725                 730                 735     


Ser Pro Asp Thr Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile Val Pro 
            740                 745                 750         


Tyr Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys Gly Glu 
        755                 760                 765             


Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu Glu Pro 
    770                 775                 780                 


Thr Val Ala Pro Ser Gln Val Ser Ala Asn Ser Leu Ser Ser Ser Glu 
785                 790                 795                 800 


Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn Gly His 
                805                 810                 815     


Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Gly Gly Gly Lys Glu Glu 
            820                 825                 830         


Ser Ser Ser Lys Met Lys Val Ala Gly Asn Glu Thr Ser Ala Arg Leu 
        835                 840                 845             


Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg Ala Tyr 
    850                 855                 860                 


Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Val Thr Thr 
865                 870                 875                 880 


Lys Lys Thr Pro Pro 
                885 


<210>  502

<211>  1028

<212>  PRT

<213>  Mus musculus



<400>  502

Met Met Leu Ser Trp Lys Gln Leu Ile Leu Leu Ser Phe Ile Gly Cys 
1               5                   10                  15      


Leu Ala Gly Glu Leu Leu Leu Gln Gly Pro Val Phe Ile Lys Glu Pro 
            20                  25                  30          


Ser Asn Ser Ile Phe Pro Val Asp Ser Glu Asp Lys Lys Ile Thr Leu 
        35                  40                  45              


Asn Cys Glu Ala Arg Gly Asn Pro Ser Pro His Tyr Arg Trp Gln Leu 
    50                  55                  60                  


Asn Gly Ser Asp Ile Asp Thr Ser Leu Asp His Arg Tyr Lys Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Leu Ile Val Ile Asn Pro Asn Arg Asn Trp Asp Thr Gly 
                85                  90                  95      


Ser Tyr Gln Cys Phe Ala Thr Asn Ser Leu Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Arg Met 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Val Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Phe Val Glu Glu Asp Ser Arg Arg Leu Val Ser Gln 
                165                 170                 175     


Glu Thr Gly His Leu Tyr Ile Ala Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Thr Cys Val Val Thr Ser Thr Val Thr Asn Thr Arg Val Leu 
        195                 200                 205             


Gly Ser Pro Thr Pro Leu Val Leu Arg Ser Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Leu Pro Ala Ala 
225                 230                 235                 240 


Lys Gly Ser Thr Val Arg Leu Glu Cys Phe Ala Leu Gly Asn Pro Val 
                245                 250                 255     


Pro Gln Ile Asn Trp Arg Arg Ser Asp Gly Met Pro Phe Pro Asn Lys 
            260                 265                 270         


Ile Lys Leu Arg Lys Phe Asn Gly Met Leu Glu Ile Gln Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Thr Gly Ser Tyr Glu Gly Ile Ala Glu Asn Ser Arg Gly 
    290                 295                 300                 


Lys Asn Val Ala Arg Gly Arg Leu Thr Tyr Tyr Ala Lys Pro Tyr Trp 
305                 310                 315                 320 


Leu Gln Leu Leu Arg Asp Val Glu Ile Ala Val Glu Asp Ser Leu Tyr 
                325                 330                 335     


Trp Glu Cys Arg Ala Ser Gly Lys Pro Lys Pro Ser Tyr Arg Trp Leu 
            340                 345                 350         


Lys Asn Gly Asp Ala Leu Val Leu Glu Glu Arg Ile Gln Ile Glu Asn 
        355                 360                 365             


Gly Ala Leu Thr Ile Thr Asn Leu Asn Val Thr Asp Ser Gly Met Phe 
    370                 375                 380                 


Gln Cys Ile Ala Glu Asn Lys His Gly Leu Ile Tyr Ser Ser Ala Glu 
385                 390                 395                 400 


Leu Lys Val Val Ala Ser Ala Pro Asp Phe Ser Arg Asn Pro Met Lys 
                405                 410                 415     


Lys Met Val Gln Val Gln Val Gly Ser Leu Val Ile Leu Asp Cys Lys 
            420                 425                 430         


Pro Arg Ala Ser Pro Arg Ala Leu Ser Phe Trp Lys Lys Gly Asp Met 
        435                 440                 445             


Met Val Arg Glu Gln Ala Arg Val Ser Phe Leu Asn Asp Gly Gly Leu 
    450                 455                 460                 


Lys Ile Met Asn Val Thr Lys Ala Asp Ala Gly Thr Tyr Thr Cys Thr 
465                 470                 475                 480 


Ala Glu Asn Gln Phe Gly Lys Ala Asn Gly Thr Thr His Leu Val Val 
                485                 490                 495     


Thr Glu Pro Thr Arg Ile Ile Leu Ala Pro Ser Asn Met Asp Val Ala 
            500                 505                 510         


Val Gly Glu Ser Val Ile Leu Pro Cys Gln Val Gln His Asp Pro Leu 
        515                 520                 525             


Leu Asp Ile Met Phe Ala Trp Tyr Phe Asn Gly Ala Leu Thr Asp Phe 
    530                 535                 540                 


Lys Lys Asp Gly Ser His Phe Glu Lys Val Gly Gly Ser Ser Ser Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ser Gly Lys Tyr Val 
                565                 570                 575     


Cys Met Val Gln Thr Gly Val Asp Ser Val Ser Ser Ala Ala Glu Leu 
            580                 585                 590         


Ile Val Arg Gly Ser Pro Gly Pro Pro Glu Asn Val Lys Val Asp Glu 
        595                 600                 605             


Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Thr Glu Gly Thr Asp Ser 
    610                 615                 620                 


His Ser Pro Val Ile Ser Tyr Ala Val Gln Ala Arg Thr Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Ser Val Arg Thr Val Pro Glu Val Ile Asp Gly Lys 
                645                 650                 655     


Thr His Thr Ala Thr Val Val Glu Leu Asn Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Ile Val Ala Ser Asn Lys Ile Gly Gly Gly Glu Pro Ser Leu 
        675                 680                 685             


Pro Ser Glu Lys Val Arg Thr Glu Glu Ala Ala Pro Glu Ile Ala Pro 
    690                 695                 700                 


Ser Glu Val Ser Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr 
705                 710                 715                 720 


Trp Asp Pro Val Pro Glu Glu Leu Gln Asn Gly Gly Gly Phe Gly Tyr 
                725                 730                 735     


Val Val Ala Phe Arg Pro Leu Gly Val Thr Thr Trp Ile Gln Thr Val 
            740                 745                 750         


Val Thr Ser Pro Asp Asn Pro Arg Tyr Val Phe Arg Asn Glu Ser Ile 
        755                 760                 765             


Val Pro Phe Ser Pro Tyr Glu Val Lys Val Gly Val Tyr Asn Asn Lys 
    770                 775                 780                 


Gly Glu Gly Pro Phe Ser Pro Val Thr Thr Val Phe Ser Ala Glu Glu 
785                 790                 795                 800 


Glu Pro Thr Val Ala Pro Ser His Ile Ser Ala His Ser Leu Ser Ser 
                805                 810                 815     


Ser Glu Ile Glu Val Ser Trp Asn Thr Ile Pro Trp Lys Leu Ser Asn 
            820                 825                 830         


Gly His Leu Leu Gly Tyr Glu Val Arg Tyr Trp Asn Asn Gly Gly Glu 
        835                 840                 845             


Glu Glu Ser Ser Arg Lys Val Lys Val Ala Gly Asn Gln Thr Ser Ala 
    850                 855                 860                 


Val Leu Arg Gly Leu Lys Ser Asn Leu Ala Tyr Tyr Thr Ala Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Ser Ala Gly Ala Gly Pro Phe Ser Ala Thr Val Asn Ala 
                885                 890                 895     


Thr Thr Lys Lys Thr Pro Pro Ser Gln Pro Pro Gly Asn Val Val Trp 
            900                 905                 910         


Asn Ala Thr Asp Thr Lys Val Leu Leu Asn Trp Glu Gln Val Lys Ala 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Thr Gly Tyr Lys Val Phe Tyr Arg Thr 
    930                 935                 940                 


Ser Ser Gln Asn Asn Val His Val Leu Asn Thr Asn Lys Thr Ser Ala 
945                 950                 955                 960 


Glu Leu Leu Leu Pro Ile Lys Glu Asp Tyr Ile Ile Glu Val Lys Ala 
                965                 970                 975     


Thr Thr Asp Gly Gly Asp Gly Thr Ser Ser Glu Gln Ile Arg Ile Pro 
            980                 985                 990         


Arg Ile Thr Ser Met Asp Ala Arg  Gly Ser Thr Ser Ala  Ile Ser Asn 
        995                 1000                 1005             


Ile His  Pro Leu Ser Gly Tyr  Met Ser Val Leu Leu  Phe Phe Ile 
    1010                 1015                 1020             


Val Asn  Ala Leu Trp 
    1025             


<210>  503

<211>  435

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (219)..(219)

<223>  n = g, a, t, or c



<220>

<221>  misc_feature

<222>  (381)..(381)

<223>  n = g, a, t, or c



<400>  503
tgaatggtaa aactgagaac tacatcctgg atactacacc tggctcccaa gcatctctga     60

tatgtgctgt tcaaaaccac accagagagg aagaactgct ctggtaccga gaggagggga    120

gagtggattt gaaatctgga aacaaaatca attccagctc tgtctgtgtc tcttccatca    180

gtgaaaatga caacggaatc agctttacct gcaggctgng gaggggatca gtccgtgtcc    240

gtttcggtgg tgctgaatgt tacttgtgag tgaggggaaa agaaacagct agtgggtctg    300

taatgtctgt aacacatgaa gtggtagttg aaatctaagt cttggtattg ccaaattgcc    360

caatttatgc tcctaccaca nagtatgaga gtacctattt cccctcaccc tcatgagcac    420

tgagtatcgc caaac                                                     435


<210>  504

<211>  830

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (17)..(709)

<223>  



<400>  504
gaagagcagt gtcata atg caa atg gga aga ttt ctt ctc tta gta att tta     52
                  Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu       
                  1               5                   10                

ttt ctg cca cgt gag atg aca agt tct gtt tta act gtg aat ggt aaa      100
Phe Leu Pro Arg Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys         
        15                  20                  25                      

act gag aac tac atc ctg gat act aca cct ggc tcc caa gca tct ctg      148
Thr Glu Asn Tyr Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu         
    30                  35                  40                          

ata tgt gct gtt caa aac cac acc aga gag gaa gaa ctg ctc tgg tac      196
Ile Cys Ala Val Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr         
45                  50                  55                  60          

cga gag gag ggg aga gtg gat ttg aaa tct gga aac aaa atc aat tcc      244
Arg Glu Glu Gly Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser         
                65                  70                  75              

agc tct gtc tgt gtc tct tcc atc agt gaa aat gac aac gga atc agc      292
Ser Ser Val Cys Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser         
            80                  85                  90                  

ttt acc tgc agg ctg ggg agg gat cag tcc gtg tcc gtt tcg gtg gtg      340
Phe Thr Cys Arg Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val Val         
        95                  100                 105                     

ctg aat gtt act ttt cct cct ctc cta agt gga aac gac ttc caa aca      388
Leu Asn Val Thr Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln Thr         
    110                 115                 120                         

gtt gag gaa ggc agt aat ctg aag ttg gtt tgc aat gtg aaa gcc aac      436
Val Glu Glu Gly Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn         
125                 130                 135                 140         

ccc cag gct caa atg atg tgg tac aaa aac agt agt ctc ctc gat tta      484
Pro Gln Ala Gln Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu         
                145                 150                 155             

gag aaa agc cgt cac caa atc caa cag aca agt gag tct ttt cag ctg      532
Glu Lys Ser Arg His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu         
            160                 165                 170                 

tca atc acc aaa gtc gag aag cct gac aac gga acc tac agt tgt atg      580
Ser Ile Thr Lys Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met         
        175                 180                 185                     

gca aag tca tct ctg aaa acg gag agc ttg gac ttt cac ctg att gtt      628
Ala Lys Ser Ser Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val         
    190                 195                 200                         

aaa gat aaa act gtg ggt gta cca ata gag ccc att att gct gca tgt      676
Lys Asp Lys Thr Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys         
205                 210                 215                 220         

gtt gtg atc ttt ctg aca ttg tgc ttg gac tga ttgctagaag aaagaacata    729
Val Val Ile Phe Leu Thr Leu Cys Leu Asp                                 
                225                 230                                 

atgaagctct gcttgaagga taaagaccct cacagtgaaa cagctctatg agaaagctga    789

gatgccatcg aataacgaga gagtttgcat caggacctcc a                        830


<210>  505

<211>  230

<212>  PRT

<213>  Homo sapiens



<400>  505

Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu Phe Leu Pro Arg 
1               5                   10                  15      


Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr 
            20                  25                  30          


Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val 
        35                  40                  45              


Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly 
    50                  55                  60                  


Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys 
65                  70                  75                  80  


Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg 
                85                  90                  95      


Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr 
            100                 105                 110         


Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly 
        115                 120                 125             


Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln 
    130                 135                 140                 


Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg 
145                 150                 155                 160 


His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys 
                165                 170                 175     


Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser 
            180                 185                 190         


Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr 
        195                 200                 205             


Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe 
    210                 215                 220                 


Leu Thr Leu Cys Leu Asp 
225                 230 


<210>  506

<211>  693

<212>  DNA

<213>  Homo sapiens



<400>  506
atgcaaatgg gaagatttct tctcttagta attttatttc tgccacgtga gatgacaagt     60

tctgttttaa ctgtgaatgg taaaactgag aactacatcc tggatactac acctggctcc    120

caagcatctc tgatatgtgc tgttcaaaac cacaccagag aggaagaact gctctggtac    180

cgagaggagg ggagagtgga tttgaaatct ggaaacaaaa tcaattccag ctctgtctgt    240

gtctcttcca tcagtgaaaa tgacaacgga atcagcttta cctgcaggct ggggagggat    300

cagtccgtgt ccgtttcggt ggtgctgaat gttacttttc ctcctctcct aagtggaaac    360

gacttccaaa cagttgagga aggcagtaat ctgaagttgg tttgcaatgt gaaagccaac    420

ccccaggctc aaatgatgtg gtacaaaaac agtagtctcc tcgatttaga gaaaagccgt    480

caccaaatcc aacagacaag tgagtctttt cagctgtcaa tcaccaaagt cgagaagcct    540

gacaacggaa cctacagttg tatggcaaag tcatctctga aaacggagag cttggacttt    600

cacctgattg ttaaagataa aactgtgggt gtaccaatag agcccattat tgctgcatgt    660

gttgtgatct ttctgacatt gtgcttggac tga                                 693


<210>  507

<211>  20

<212>  PRT

<213>  Homo sapiens



<400>  507

Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu Phe Leu Pro Arg 
1               5                   10                  15      


Glu Met Thr Ser 
            20  


<210>  508

<211>  210

<212>  PRT

<213>  Homo sapiens



<400>  508

Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr Ile Leu Asp Thr 
1               5                   10                  15      


Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln Asn His Thr 
            20                  25                  30          


Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg Val Asp Leu 
        35                  40                  45              


Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile 
    50                  55                  60                  


Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu Gly Arg Asp 
65                  70                  75                  80  


Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr Phe Pro Pro Leu 
                85                  90                  95      


Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly Ser Asn Leu Lys 
            100                 105                 110         


Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln Met Met Trp Tyr 
        115                 120                 125             


Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg His Gln Ile Gln 
    130                 135                 140                 


Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys Val Glu Lys Pro 
145                 150                 155                 160 


Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser Leu Lys Thr Glu 
                165                 170                 175     


Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr Val Gly Val Pro 
            180                 185                 190         


Ile Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe Leu Thr Leu Cys 
        195                 200                 205             


Leu Asp 
    210 


<210>  509

<211>  59

<212>  PRT

<213>  Homo sapiens



<400>  509

Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln Asn His Thr Arg Glu 
1               5                   10                  15      


Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg Val Asp Leu Lys Ser 
            20                  25                  30          


Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile Ser Glu 
        35                  40                  45              


Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu 
    50                  55                  


<210>  510

<211>  62

<212>  PRT

<213>  Homo sapiens



<400>  510

Gly Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala 
1               5                   10                  15      


Gln Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser 
            20                  25                  30          


Arg His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr 
        35                  40                  45              


Lys Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met Ala 
    50                  55                  60          


<210>  511

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  511

Ile Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe Leu Thr Leu Cys 
1               5                   10                  15      


Leu Asp 
        


<210>  512

<211>  192

<212>  PRT

<213>  Homo sapiens



<400>  512

Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr Ile Leu Asp Thr 
1               5                   10                  15      


Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln Asn His Thr 
            20                  25                  30          


Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg Val Asp Leu 
        35                  40                  45              


Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile 
    50                  55                  60                  


Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu Gly Arg Asp 
65                  70                  75                  80  


Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr Phe Pro Pro Leu 
                85                  90                  95      


Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly Ser Asn Leu Lys 
            100                 105                 110         


Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln Met Met Trp Tyr 
        115                 120                 125             


Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg His Gln Ile Gln 
    130                 135                 140                 


Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys Val Glu Lys Pro 
145                 150                 155                 160 


Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser Leu Lys Thr Glu 
                165                 170                 175     


Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr Val Gly Val Pro 
            180                 185                 190         


<210>  513

<211>  853

<212>  PRT

<213>  Bos taurus



<400>  513

Met Leu Gln Thr Lys Asn Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Ala Glu Asp Gly Thr Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Thr Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Val Gln Ala Arg Gln Ser Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asn Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Val Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Asn 
                245                 250                 255     


Glu Glu Asp Glu Lys Tyr Leu Phe Ser Asp Asp Ser Ser Glu Leu Thr 
            260                 265                 270         


Ile Arg Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Val Cys Ile Ala 
        275                 280                 285             


Glu Asn Lys Ala Gly Glu Gln Asp Ala Ser Ile His Leu Lys Val Phe 
    290                 295                 300                 


Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu Leu 
305                 310                 315                 320 


Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile Pro 
                325                 330                 335     


Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu Lys 
            340                 345                 350         


Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His Met 
        355                 360                 365             


Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile 
    370                 375                 380                 


Gln Tyr Thr Asp Ala Gly Glu Tyr Val Cys Thr Ala Ser Asn Thr Ile 
385                 390                 395                 400 


Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys 
                405                 410                 415     


Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn 
            420                 425                 430         


Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe 
        435                 440                 445             


Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile 
    450                 455                 460                 


Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu 
465                 470                 475                 480 


Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln 
                485                 490                 495     


Glu Ser Leu Glu Phe Val Leu Val Gln Ala Asp Thr Pro Ser Ser Pro 
            500                 505                 510         


Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe 
        515                 520                 525             


Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala 
    530                 535                 540                 


Glu Trp Arg Ala Met Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp 
545                 550                 555                 560 


Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys 
                565                 570                 575     


Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly 
            580                 585                 590         


Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Arg 
        595                 600                 605             


Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn 
    610                 615                 620                 


Ser Ile Lys Val Lys Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile 
625                 630                 635                 640 


Arg His Tyr Leu Val Lys Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro 
                645                 650                 655     


Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu 
            660                 665                 670         


Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln 
        675                 680                 685             


Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro 
    690                 695                 700                 


Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly 
705                 710                 715                 720 


Ala Ile Val Gly Ile Leu Val Val Thr Phe Val Leu Leu Leu Val Ala 
                725                 730                 735     


Val Asp Val Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Leu Met Cys 
            740                 745                 750         


Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys 
        755                 760                 765             


Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu 
    770                 775                 780                 


Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp 
785                 790                 795                 800 


Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro 
                805                 810                 815     


Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Thr Glu Thr Lys Pro Ala 
            820                 825                 830         


Pro Ala Glu Val Gln Thr Val Pro Asn Asp Ala Thr Gln Ile Lys Val 
        835                 840                 845             


Asn Glu Ser Lys Ala 
    850             


<210>  514

<211>  486

<212>  DNA

<213>  Homo sapiens



<400>  514
cccgaattcc cgggggccca ttctcctgct gcccttcttc cttgtagtac agcttgtagc     60

cctgaatagc agctgtgtcc tctacatctt gctgccacct cacagaaatg gtggtacagt    120

tcagaggctc caaatgcaac tctggagact taggggcttt cacgcttgta gctttgggcg    180

tcctatgtga agtccatact gatgactctc ccagccccac tctggtggca gcagtaatcc    240

gaaccaggta gacactgtca ggtttcaggc cttccaaaag gtactcatgc gtggtccccg    300

ggagctccag aacttggatt gaattctcag tacttaagcg gaaagacaag cgatacagca    360

ccacttggcc ccgccgatat ttggctggga ttggcagcca ggagatgaga atatcagtgg    420

gacttcgact tgtcaaacta atttcaggag gtctcacggg aacattctct aaagtattct    480

gtgtca                                                               486


<210>  515

<211>  2022

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(2022)

<223>  



<400>  515
atg tgg ttt gtt gag ttc att caa gta aac ctt tat cga gtg cct gtt       48
Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val         
1               5                   10                  15              

gta tgc agg gca ctg ttc tgg ctg tta gca aca cag aca agt aag aca       96
Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr         
            20                  25                  30                  

tgt tct ctg aac tca agg aat tta caa tct ctg gta aaa gtg att ggg      144
Cys Ser Leu Asn Ser Arg Asn Leu Gln Ser Leu Val Lys Val Ile Gly         
        35                  40                  45                      

gac ctg aat aat tgt agg gaa tgg tta aaa cca gtt act aat gag att      192
Asp Leu Asn Asn Cys Arg Glu Trp Leu Lys Pro Val Thr Asn Glu Ile         
    50                  55                  60                          

aat aag aga gtt cct gaa aag cag ttt agg gca ctg gtt agc aag aaa      240
Asn Lys Arg Val Pro Glu Lys Gln Phe Arg Ala Leu Val Ser Lys Lys         
65                  70                  75                  80          

atc aag cat cca ttg atc ata agt gat gtt tac cca aag agt gag aag      288
Ile Lys His Pro Leu Ile Ile Ser Asp Val Tyr Pro Lys Ser Glu Lys         
                85                  90                  95              

tta aaa gaa cta aaa agg cag ata aaa att aaa act att tct gca ttt      336
Leu Lys Glu Leu Lys Arg Gln Ile Lys Ile Lys Thr Ile Ser Ala Phe         
            100                 105                 110                 

gaa gtc cag cca att tcc act gag gtc cac gaa ggt gga gtt gct cga      384
Glu Val Gln Pro Ile Ser Thr Glu Val His Glu Gly Gly Val Ala Arg         
        115                 120                 125                     

ttt gca tgc aag att tca tcc cac cct cct gca gtc ata aca tgg gag      432
Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu         
    130                 135                 140                         

ttc aat cgg aca act cta cct atg act atg gac agg ata act gcc cta      480
Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu         
145                 150                 155                 160         

cca aca gga gta ttg cag atc tat gat gtc agc caa agg gat tct gga      528
Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly         
                165                 170                 175             

aat tat cgt tgt att gct gcc act gta gcc cac cga cgt aaa agt atg      576
Asn Tyr Arg Cys Ile Ala Ala Thr Val Ala His Arg Arg Lys Ser Met         
            180                 185                 190                 

gag gcc tcg cta act gtg att cca gct aag gag tca aaa tcc ttc cac      624
Glu Ala Ser Leu Thr Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His         
        195                 200                 205                     

aca cca aca att ata gca ggt cca cag aac ata aca aca tct ctt cat      672
Thr Pro Thr Ile Ile Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His         
    210                 215                 220                         

cag act gta gtt ttg gaa tgc atg gcc aca gga aat ccc aaa cca atc      720
Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile         
225                 230                 235                 240         

att tct tgg agc cgc ctt gat cac aaa tcc att gat gtc ttt aat act      768
Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr         
                245                 250                 255             

cgg gta ctt gga aat ggt aat ctc atg ata tct gat gtc agg cta caa      816
Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln         
            260                 265                 270                 

cat gct gga gta tat gtt tgt cgg gcc act acc cct ggc aca cgc aac      864
His Ala Gly Val Tyr Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn         
        275                 280                 285                     

ttt aca gtt gct atg gca act tta act gta tta gct cct cct tca ttt      912
Phe Thr Val Ala Met Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe         
    290                 295                 300                         

gtt gaa tgg cca gaa agt tta aca agg cct cga gct ggc act gct cga      960
Val Glu Trp Pro Glu Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg         
305                 310                 315                 320         

ttt gtg tgt cag gca gaa gga atc ccc tct ccc aag atg tca tgg ttg     1008
Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu         
                325                 330                 335             

aaa aat gga agg aag ata cat tcg aat ggt aga att aaa atg tac aac     1056
Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn         
            340                 345                 350                 

agt aaa ttg gta att aac cag att att cct gaa gat gat gct att tat     1104
Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr         
        355                 360                 365                     

cag tgc atg gct gag aat agc caa gga tct att tta tct aga gcc aga     1152
Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg         
    370                 375                 380                         

ctg act gta gtg atg tca gaa gac aga ccc agt gct ccc tat aat gta     1200
Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val         
385                 390                 395                 400         

cat gct gaa acc atg tca agc tca gcc att ctt tta gcc tgg gag agg     1248
His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg         
                405                 410                 415             

cca ctt tat aat tca gac aaa gtc att gcc tat tct gta cac tac atg     1296
Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met         
            420                 425                 430                 

aaa gca gaa ggt tta aat aat gaa gag tat caa gta gtc atc gga aat     1344
Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn         
        435                 440                 445                     

gac aca act cat tat att att gat gac tta gag cct gcc agc aat tat     1392
Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr         
    450                 455                 460                         

act ttc tac att gta gca tat atg cca atg gga gcc agc cag atg tct     1440
Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser         
465                 470                 475                 480         

gac cat gtg aca cag aat act cta gag gat gtt ccc ctg aga cct cct     1488
Asp His Val Thr Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro         
                485                 490                 495             

gaa att agt ttg aca agt cga agt ccc act gat att ctc atc tcc tgg     1536
Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser Trp         
            500                 505                 510                 

ctg cca atc cca gcc aaa tat cgg cgg ggc caa gtg gtg ctg tat cgc     1584
Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val Val Leu Tyr Arg         
        515                 520                 525                     

ttg tct ttc cgc cta agt act gag aat tca atc caa gtt ctg gag ctc     1632
Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu         
    530                 535                 540                         

ccg ggg acc acg cat gag tac ctt ttg gaa ggc ctg aaa cct gac agt     1680
Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser         
545                 550                 555                 560         

gtc tac ctg gtt cgg att act gct gcc acc aga gtg ggg ctg gga gag     1728
Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu         
                565                 570                 575             

tca tca gta tgg act tca cat agg acg ccc aaa gct aca agc gtg aaa     1776
Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys         
            580                 585                 590                 

gcc aag tct cca gag ttg cat ttg gag cct ctg aac tgt acc acc att     1824
Ala Lys Ser Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile         
        595                 600                 605                     

tct gtg agg tgg cag caa gat gta gag gac aca gct gct att cag ggc     1872
Ser Val Arg Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly         
    610                 615                 620                         

tac aag ctg tac tac aag gaa gaa ggg cag cag gag aat ggg ccc att     1920
Tyr Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile         
625                 630                 635                 640         

ttc ttg gat acc aag gac cta ctc tat act ctc agt ggc tta gac tgc     1968
Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Cys         
                645                 650                 655             

cct gtg aag gaa cta gag cag ctg cct cag ctg agt gtt aca gtg aca     2016
Pro Val Lys Glu Leu Glu Gln Leu Pro Gln Leu Ser Val Thr Val Thr         
            660                 665                 670                 

tct tag                                                             2022
Ser                                                                     
                                                                        


<210>  516

<211>  673

<212>  PRT

<213>  Homo sapiens



<400>  516

Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val 
1               5                   10                  15      


Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr 
            20                  25                  30          


Cys Ser Leu Asn Ser Arg Asn Leu Gln Ser Leu Val Lys Val Ile Gly 
        35                  40                  45              


Asp Leu Asn Asn Cys Arg Glu Trp Leu Lys Pro Val Thr Asn Glu Ile 
    50                  55                  60                  


Asn Lys Arg Val Pro Glu Lys Gln Phe Arg Ala Leu Val Ser Lys Lys 
65                  70                  75                  80  


Ile Lys His Pro Leu Ile Ile Ser Asp Val Tyr Pro Lys Ser Glu Lys 
                85                  90                  95      


Leu Lys Glu Leu Lys Arg Gln Ile Lys Ile Lys Thr Ile Ser Ala Phe 
            100                 105                 110         


Glu Val Gln Pro Ile Ser Thr Glu Val His Glu Gly Gly Val Ala Arg 
        115                 120                 125             


Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu 
    130                 135                 140                 


Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu 
145                 150                 155                 160 


Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly 
                165                 170                 175     


Asn Tyr Arg Cys Ile Ala Ala Thr Val Ala His Arg Arg Lys Ser Met 
            180                 185                 190         


Glu Ala Ser Leu Thr Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His 
        195                 200                 205             


Thr Pro Thr Ile Ile Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His 
    210                 215                 220                 


Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile 
225                 230                 235                 240 


Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr 
                245                 250                 255     


Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln 
            260                 265                 270         


His Ala Gly Val Tyr Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn 
        275                 280                 285             


Phe Thr Val Ala Met Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe 
    290                 295                 300                 


Val Glu Trp Pro Glu Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg 
305                 310                 315                 320 


Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu 
                325                 330                 335     


Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn 
            340                 345                 350         


Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr 
        355                 360                 365             


Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg 
    370                 375                 380                 


Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val 
385                 390                 395                 400 


His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg 
                405                 410                 415     


Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met 
            420                 425                 430         


Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn 
        435                 440                 445             


Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr 
    450                 455                 460                 


Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser 
465                 470                 475                 480 


Asp His Val Thr Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro 
                485                 490                 495     


Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser Trp 
            500                 505                 510         


Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val Val Leu Tyr Arg 
        515                 520                 525             


Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu 
    530                 535                 540                 


Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser 
545                 550                 555                 560 


Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu 
                565                 570                 575     


Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys 
            580                 585                 590         


Ala Lys Ser Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile 
        595                 600                 605             


Ser Val Arg Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly 
    610                 615                 620                 


Tyr Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile 
625                 630                 635                 640 


Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Cys 
                645                 650                 655     


Pro Val Lys Glu Leu Glu Gln Leu Pro Gln Leu Ser Val Thr Val Thr 
            660                 665                 670         


Ser 
    


<210>  517

<211>  2022

<212>  DNA

<213>  Homo sapiens



<400>  517
atgtggtttg ttgagttcat tcaagtaaac ctttatcgag tgcctgttgt atgcagggca     60

ctgttctggc tgttagcaac acagacaagt aagacatgtt ctctgaactc aaggaattta    120

caatctctgg taaaagtgat tggggacctg aataattgta gggaatggtt aaaaccagtt    180

actaatgaga ttaataagag agttcctgaa aagcagttta gggcactggt tagcaagaaa    240

atcaagcatc cattgatcat aagtgatgtt tacccaaaga gtgagaagtt aaaagaacta    300

aaaaggcaga taaaaattaa aactatttct gcatttgaag tccagccaat ttccactgag    360

gtccacgaag gtggagttgc tcgatttgca tgcaagattt catcccaccc tcctgcagtc    420

ataacatggg agttcaatcg gacaactcta cctatgacta tggacaggat aactgcccta    480

ccaacaggag tattgcagat ctatgatgtc agccaaaggg attctggaaa ttatcgttgt    540

attgctgcca ctgtagccca ccgacgtaaa agtatggagg cctcgctaac tgtgattcca    600

gctaaggagt caaaatcctt ccacacacca acaattatag caggtccaca gaacataaca    660

acatctcttc atcagactgt agttttggaa tgcatggcca caggaaatcc caaaccaatc    720

atttcttgga gccgccttga tcacaaatcc attgatgtct ttaatactcg ggtacttgga    780

aatggtaatc tcatgatatc tgatgtcagg ctacaacatg ctggagtata tgtttgtcgg    840

gccactaccc ctggcacacg caactttaca gttgctatgg caactttaac tgtattagct    900

cctccttcat ttgttgaatg gccagaaagt ttaacaaggc ctcgagctgg cactgctcga    960

tttgtgtgtc aggcagaagg aatcccctct cccaagatgt catggttgaa aaatggaagg   1020

aagatacatt cgaatggtag aattaaaatg tacaacagta aattggtaat taaccagatt   1080

attcctgaag atgatgctat ttatcagtgc atggctgaga atagccaagg atctatttta   1140

tctagagcca gactgactgt agtgatgtca gaagacagac ccagtgctcc ctataatgta   1200

catgctgaaa ccatgtcaag ctcagccatt cttttagcct gggagaggcc actttataat   1260

tcagacaaag tcattgccta ttctgtacac tacatgaaag cagaaggttt aaataatgaa   1320

gagtatcaag tagtcatcgg aaatgacaca actcattata ttattgatga cttagagcct   1380

gccagcaatt atactttcta cattgtagca tatatgccaa tgggagccag ccagatgtct   1440

gaccatgtga cacagaatac tctagaggat gttcccctga gacctcctga aattagtttg   1500

acaagtcgaa gtcccactga tattctcatc tcctggctgc caatcccagc caaatatcgg   1560

cggggccaag tggtgctgta tcgcttgtct ttccgcctaa gtactgagaa ttcaatccaa   1620

gttctggagc tcccggggac cacgcatgag taccttttgg aaggcctgaa acctgacagt   1680

gtctacctgg ttcggattac tgctgccacc agagtggggc tgggagagtc atcagtatgg   1740

acttcacata ggacgcccaa agctacaagc gtgaaagcca agtctccaga gttgcatttg   1800

gagcctctga actgtaccac catttctgtg aggtggcagc aagatgtaga ggacacagct   1860

gctattcagg gctacaagct gtactacaag gaagaagggc agcaggagaa tgggcccatt   1920

ttcttggata ccaaggacct actctatact ctcagtggct tagactgccc tgtgaaggaa   1980

ctagagcagc tgcctcagct gagtgttaca gtgacatctt ag                      2022


<210>  518

<211>  32

<212>  PRT

<213>  Homo sapiens



<400>  518

Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val 
1               5                   10                  15      


Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr 
            20                  25                  30          


<210>  519

<211>  673

<212>  PRT

<213>  Homo sapiens



<400>  519

Met Trp Phe Val Glu Phe Ile Gln Val Asn Leu Tyr Arg Val Pro Val 
1               5                   10                  15      


Val Cys Arg Ala Leu Phe Trp Leu Leu Ala Thr Gln Thr Ser Lys Thr 
            20                  25                  30          


Cys Ser Leu Asn Ser Arg Asn Leu Gln Ser Leu Val Lys Val Ile Gly 
        35                  40                  45              


Asp Leu Asn Asn Cys Arg Glu Trp Leu Lys Pro Val Thr Asn Glu Ile 
    50                  55                  60                  


Asn Lys Arg Val Pro Glu Lys Gln Phe Arg Ala Leu Val Ser Lys Lys 
65                  70                  75                  80  


Ile Lys His Pro Leu Ile Ile Ser Asp Val Tyr Pro Lys Ser Glu Lys 
                85                  90                  95      


Leu Lys Glu Leu Lys Arg Gln Ile Lys Ile Lys Thr Ile Ser Ala Phe 
            100                 105                 110         


Glu Val Gln Pro Ile Ser Thr Glu Val His Glu Gly Gly Val Ala Arg 
        115                 120                 125             


Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala Val Ile Thr Trp Glu 
    130                 135                 140                 


Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp Arg Ile Thr Ala Leu 
145                 150                 155                 160 


Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser Gln Arg Asp Ser Gly 
                165                 170                 175     


Asn Tyr Arg Cys Ile Ala Ala Thr Val Ala His Arg Arg Lys Ser Met 
            180                 185                 190         


Glu Ala Ser Leu Thr Val Ile Pro Ala Lys Glu Ser Lys Ser Phe His 
        195                 200                 205             


Thr Pro Thr Ile Ile Ala Gly Pro Gln Asn Ile Thr Thr Ser Leu His 
    210                 215                 220                 


Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro Ile 
225                 230                 235                 240 


Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn Thr 
                245                 250                 255     


Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu Gln 
            260                 265                 270         


His Ala Gly Val Tyr Val Cys Arg Ala Thr Thr Pro Gly Thr Arg Asn 
        275                 280                 285             


Phe Thr Val Ala Met Ala Thr Leu Thr Val Leu Ala Pro Pro Ser Phe 
    290                 295                 300                 


Val Glu Trp Pro Glu Ser Leu Thr Arg Pro Arg Ala Gly Thr Ala Arg 
305                 310                 315                 320 


Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro Lys Met Ser Trp Leu 
                325                 330                 335     


Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg Ile Lys Met Tyr Asn 
            340                 345                 350         


Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu Asp Asp Ala Ile Tyr 
        355                 360                 365             


Gln Cys Met Ala Glu Asn Ser Gln Gly Ser Ile Leu Ser Arg Ala Arg 
    370                 375                 380                 


Leu Thr Val Val Met Ser Glu Asp Arg Pro Ser Ala Pro Tyr Asn Val 
385                 390                 395                 400 


His Ala Glu Thr Met Ser Ser Ser Ala Ile Leu Leu Ala Trp Glu Arg 
                405                 410                 415     


Pro Leu Tyr Asn Ser Asp Lys Val Ile Ala Tyr Ser Val His Tyr Met 
            420                 425                 430         


Lys Ala Glu Gly Leu Asn Asn Glu Glu Tyr Gln Val Val Ile Gly Asn 
        435                 440                 445             


Asp Thr Thr His Tyr Ile Ile Asp Asp Leu Glu Pro Ala Ser Asn Tyr 
    450                 455                 460                 


Thr Phe Tyr Ile Val Ala Tyr Met Pro Met Gly Ala Ser Gln Met Ser 
465                 470                 475                 480 


Asp His Val Thr Gln Asn Thr Leu Glu Asp Val Pro Leu Arg Pro Pro 
                485                 490                 495     


Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp Ile Leu Ile Ser Trp 
            500                 505                 510         


Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln Val Val Leu Tyr Arg 
        515                 520                 525             


Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile Gln Val Leu Glu Leu 
    530                 535                 540                 


Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly Leu Lys Pro Asp Ser 
545                 550                 555                 560 


Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg Val Gly Leu Gly Glu 
                565                 570                 575     


Ser Ser Val Trp Thr Ser His Arg Thr Pro Lys Ala Thr Ser Val Lys 
            580                 585                 590         


Ala Lys Ser Pro Glu Leu His Leu Glu Pro Leu Asn Cys Thr Thr Ile 
        595                 600                 605             


Ser Val Arg Trp Gln Gln Asp Val Glu Asp Thr Ala Ala Ile Gln Gly 
    610                 615                 620                 


Tyr Lys Leu Tyr Tyr Lys Glu Glu Gly Gln Gln Glu Asn Gly Pro Ile 
625                 630                 635                 640 


Phe Leu Asp Thr Lys Asp Leu Leu Tyr Thr Leu Ser Gly Leu Asp Cys 
                645                 650                 655     


Pro Val Lys Glu Leu Glu Gln Leu Pro Gln Leu Ser Val Thr Val Thr 
            660                 665                 670         


Ser 
    


<210>  520

<211>  59

<212>  PRT

<213>  Homo sapiens



<400>  520

Gly Gly Val Ala Arg Phe Ala Cys Lys Ile Ser Ser His Pro Pro Ala 
1               5                   10                  15      


Val Ile Thr Trp Glu Phe Asn Arg Thr Thr Leu Pro Met Thr Met Asp 
            20                  25                  30          


Arg Ile Thr Ala Leu Pro Thr Gly Val Leu Gln Ile Tyr Asp Val Ser 
        35                  40                  45              


Gln Arg Asp Ser Gly Asn Tyr Arg Cys Ile Ala 
    50                  55                  


<210>  521

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  521

His Gln Thr Val Val Leu Glu Cys Met Ala Thr Gly Asn Pro Lys Pro 
1               5                   10                  15      


Ile Ile Ser Trp Ser Arg Leu Asp His Lys Ser Ile Asp Val Phe Asn 
            20                  25                  30          


Thr Arg Val Leu Gly Asn Gly Asn Leu Met Ile Ser Asp Val Arg Leu 
        35                  40                  45              


Gln His Ala Gly Val Tyr Val Cys Arg Ala 
    50                  55              


<210>  522

<211>  57

<212>  PRT

<213>  Homo sapiens



<400>  522

Ala Gly Thr Ala Arg Phe Val Cys Gln Ala Glu Gly Ile Pro Ser Pro 
1               5                   10                  15      


Lys Met Ser Trp Leu Lys Asn Gly Arg Lys Ile His Ser Asn Gly Arg 
            20                  25                  30          


Ile Lys Met Tyr Asn Ser Lys Leu Val Ile Asn Gln Ile Ile Pro Glu 
        35                  40                  45              


Asp Asp Ala Ile Tyr Gln Cys Met Ala 
    50                  55          


<210>  523

<211>  87

<212>  PRT

<213>  Homo sapiens



<400>  523

Pro Ser Ala Pro Tyr Asn Val His Ala Glu Thr Met Ser Ser Ser Ala 
1               5                   10                  15      


Ile Leu Leu Ala Trp Glu Arg Pro Leu Tyr Asn Ser Asp Lys Val Ile 
            20                  25                  30          


Ala Tyr Ser Val His Tyr Met Lys Ala Glu Gly Leu Asn Asn Glu Glu 
        35                  40                  45              


Tyr Gln Val Val Ile Gly Asn Asp Thr Thr His Tyr Ile Ile Asp Asp 
    50                  55                  60                  


Leu Glu Pro Ala Ser Asn Tyr Thr Phe Tyr Ile Val Ala Tyr Met Pro 
65                  70                  75                  80  


Met Gly Ala Ser Gln Met Ser 
                85          


<210>  524

<211>  87

<212>  PRT

<213>  Homo sapiens



<400>  524

Pro Leu Arg Pro Pro Glu Ile Ser Leu Thr Ser Arg Ser Pro Thr Asp 
1               5                   10                  15      


Ile Leu Ile Ser Trp Leu Pro Ile Pro Ala Lys Tyr Arg Arg Gly Gln 
            20                  25                  30          


Val Val Leu Tyr Arg Leu Ser Phe Arg Leu Ser Thr Glu Asn Ser Ile 
        35                  40                  45              


Gln Val Leu Glu Leu Pro Gly Thr Thr His Glu Tyr Leu Leu Glu Gly 
    50                  55                  60                  


Leu Lys Pro Asp Ser Val Tyr Leu Val Arg Ile Thr Ala Ala Thr Arg 
65                  70                  75                  80  


Val Gly Leu Gly Glu Ser Ser 
                85          


<210>  525

<211>  1252

<212>  PRT

<213>  Mus musculus



<400>  525

Met Ala Arg Ala Asp Thr Gly Arg Gly Leu Leu Val Leu Thr Phe Cys 
1               5                   10                  15      


Leu Leu Ser Ala Arg Gly Glu Leu Pro Leu Pro Gln Glu Thr Thr Val 
            20                  25                  30          


Lys Leu Ser Cys Asp Glu Gly Pro Leu Gln Val Ile Leu Gly Pro Glu 
        35                  40                  45              


Gln Ala Val Val Leu Asp Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro 
    50                  55                  60                  


Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Val Leu Glu His 
65                  70                  75                  80  


Glu Asn Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro 
                85                  90                  95      


Leu Glu Gln Glu Asp Ser Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys 
            100                 105                 110         


Val Thr Glu Gly Ser Tyr Ser Cys Leu Ala His Ser Pro Leu Gly Val 
        115                 120                 125             


Val Ala Ser Gln Val Ala Val Val Lys Leu Ala Thr Leu Glu Asp Phe 
    130                 135                 140                 


Ser Leu His Pro Glu Ser Gln Ile Val Glu Glu Asn Gly Thr Ala Arg 
145                 150                 155                 160 


Phe Glu Cys His Thr Lys Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu 
                165                 170                 175     


Lys Asp Gln Val Thr Val Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro 
            180                 185                 190         


Asn Gly Val Leu Gln Ile Leu Asp Val Gln Asp Ser Asp Ala Gly Ser 
        195                 200                 205             


Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu 
    210                 215                 220                 


Ala Ser Leu Thr Val Ala Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly 
225                 230                 235                 240 


Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val Ser 
                245                 250                 255     


Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr Pro 
            260                 265                 270         


Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp Val 
        275                 280                 285             


Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg 
    290                 295                 300                 


His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp 
305                 310                 315                 320 


Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala Ile 
                325                 330                 335     


Ser Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg 
            340                 345                 350         


Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu His Trp Leu 
        355                 360                 365             


His Asp Gly Ile Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln Gly 
    370                 375                 380                 


Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly 
385                 390                 395                 400 


Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala 
                405                 410                 415     


Ala Pro Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro Thr 
            420                 425                 430         


Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ser Val Leu Val Ala Trp 
        435                 440                 445             


Glu Arg Pro Glu Leu His Ser Glu Gln Ile Ile Gly Phe Ser Leu His 
    450                 455                 460                 


Tyr Gln Lys Ala Arg Gly Val Asp Asn Val Glu Tyr Gln Phe Ala Val 
465                 470                 475                 480 


Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn Thr 
                485                 490                 495     


Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg 
            500                 505                 510         


Thr Ser Ser Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser Ala 
        515                 520                 525             


Ala Pro Gln Leu Thr Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg Val 
    530                 535                 540                 


Ala Trp Leu Pro Leu Pro Ser Ser Leu Ser Asn Gly Gln Val Leu Lys 
545                 550                 555                 560 


Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Val Phe Ser Thr 
                565                 570                 575     


Glu Val Pro Gly Asn Glu Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro 
            580                 585                 590         


Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr 
        595                 600                 605             


Gly Val Pro Ser Gln Trp Met Gln His Arg Thr Pro Gly Val His Asn 
    610                 615                 620                 


Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Arg Ala Lys 
625                 630                 635                 640 


Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr Gln 
                645                 650                 655     


Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Thr Glu Glu Glu 
            660                 665                 670         


Ala Asp Gly Asp Arg Pro Pro Gly Gly Arg Gly Asp Gln Ala Trp Asp 
        675                 680                 685             


Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu Thr 
    690                 695                 700                 


Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe Asn 
705                 710                 715                 720 


Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu Lys 
                725                 730                 735     


Ala Pro Thr Pro Asp Leu Pro Ile Gln Arg Gly Pro Pro Leu Pro Pro 
            740                 745                 750         


Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu Arg 
        755                 760                 765             


Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr Val 
    770                 775                 780                 


Arg Phe Gly Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr Tyr 
785                 790                 795                 800 


Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe Thr 
                805                 810                 815     


Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly Pro 
            820                 825                 830         


Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser Thr 
        835                 840                 845             


Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val Arg 
    850                 855                 860                 


Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu Tyr 
865                 870                 875                 880 


Leu Ile Leu Tyr Ser Asn Asn His Thr Gln Pro Glu His Gln Trp Thr 
                885                 890                 895     


Leu Leu Thr Thr Glu Gly Asn Ile Phe Ser Ala Glu Val His Gly Leu 
            900                 905                 910         


Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu Val 
        915                 920                 925             


Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln Lys 
    930                 935                 940                 


Thr Phe Ser Asp Ser Leu Asp Val His Ala Val Thr Gly Ile Ile Val 
945                 950                 955                 960 


Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala Gly 
                965                 970                 975     


Leu Arg Arg Ser Ser His Arg Glu Ala Leu Pro Gly Leu Ser Ser Ser 
            980                 985                 990         


Gly Thr Pro Gly Asn Pro Ala Leu  Tyr Thr Arg Ala Arg  Leu Gly Pro 
        995                 1000                 1005             


Pro Ser  Val Pro Ala Ala His  Glu Leu Glu Ser Leu  Val His Pro 
    1010                 1015                 1020             


Arg Pro  Gln Asp Trp Ser Pro  Pro Pro Ser Asp Val  Glu Asp Lys 
    1025                 1030                 1035             


Ala Glu  Val His Ser Leu Met  Gly Gly Ser Val Ser  Asp Cys Arg 
    1040                 1045                 1050             


Gly His  Ser Lys Arg Lys Ile  Ser Trp Ala Gln Ala  Gly Gly Pro 
    1055                 1060                 1065             


Asn Trp  Ala Gly Ser Trp Ala  Gly Cys Glu Leu Pro  Gln Gly Ser 
    1070                 1075                 1080             


Gly Pro  Arg Pro Ala Leu Thr  Arg Ala Leu Leu Pro  Pro Ala Gly 
    1085                 1090                 1095             


Thr Gly  Gln Thr Leu Leu Leu  Gln Ala Leu Val Tyr  Asp Ala Ile 
    1100                 1105                 1110             


Lys Ser  Asn Gly Arg Lys Lys  Pro Ser Pro Ala Cys  Arg Asn Gln 
    1115                 1120                 1125             


Val Glu  Ala Glu Val Ile Val  His Ser Asp Phe Gly  Ala Ser Lys 
    1130                 1135                 1140             


Gly Cys  Pro Asp Leu His Leu  Gln Asp Leu Glu Pro  Glu Glu Pro 
    1145                 1150                 1155             


Leu Thr  Ala Glu Thr Leu Pro  Ser Thr Ser Gly Ala  Val Asp Leu 
    1160                 1165                 1170             


Ser Gln  Gly Ala Asp Trp Leu  Gly Arg Glu Leu Gly  Gly Cys Gln 
    1175                 1180                 1185             


Pro Thr  Thr Ser Gly Pro Glu  Arg Leu Thr Cys Leu  Pro Glu Ala 
    1190                 1195                 1200             


Ala Ser  Ala Ser Cys Ser Cys  Ser Asp Leu Gln Pro  Ser Thr Ala 
    1205                 1210                 1215             


Ile Glu  Glu Ala Pro Gly Lys  Ser Cys Gln Pro Lys  Ala Leu Cys 
    1220                 1225                 1230             


Pro Leu  Thr Val Ser Pro Ser  Leu Pro Arg Ala Pro  Val Ser Ser 
    1235                 1240                 1245             


Ala Gln  Val Pro 
    1250         


<210>  526

<211>  401

<212>  DNA

<213>  Homo sapiens



<400>  526
ctcgaacaac gacagccttc ctttcttcca ggtgtaaaca ggttatggag acgcttttgg     60

cttacactca atgacaactt cacctcccac tttgacaaga gttactcttt tcaagagtgt    120

tcttgaaaaa tctggaccta cagctataac actaagctct gcgttggaaa agataactcc    180

atgtttattc tctgccaaac actgatacat gccagcatct gagaggatca ctattgttat    240

gttgagtggt ccttgctcaa tttgaagtct atcccgaggt agcagaggtt cgccattttt    300

tagccacttg tatgtaggct taggccttcc atttgcttta cattcccaaa agacattatc    360

ttccatggcc acgtgaatat catttatttt ttgaatccaa g                        401


<210>  527

<211>  3777

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (117)..(3251)

<223>  



<400>  527
gaaactggga cattttactt tacagtctat taaaggttat acaaaactta aaagaagcag     60

caattctatt cgcttgttat tggacttgaa actccctttg acctcggaaa ctgaag atg    119
                                                              Met       
                                                              1         

agg ttg cca tgg gaa ctg ctg gta ctg caa tca ttc att ttg tgc ctt      167
Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys Leu         
            5                   10                  15                  

gca ggt tca cag act gac ttc tgg tcc ttg ctg ggg gtg ctg cca gcc      215
Ala Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro Ala         
        20                  25                  30                      

ttg gag gct gat gat tcc aca ctg cat ggc ccg att ttt att caa gaa      263
Leu Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu         
    35                  40                  45                          

cca agt cct gta atg ttc cct ttg gat tct gag gag aaa aaa gtg aag      311
Pro Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys         
50                  55                  60                  65          

ctc aat tgt gaa gtt aaa gga aat cca aaa cct cat atc agg tgg aag      359
Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys         
                70                  75                  80              

tta aat gga aca gat gtt gac act ggt atg gat ttc cgc tac agt gtt      407
Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val         
            85                  90                  95                  

gtt gaa ggg agc ttg ttg atc aat aac ccc aat aaa acc caa gat gct      455
Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala         
        100                 105                 110                     

gga acg tac cag tgc aca gcg aca aac tcg ttt gga aca att gtt agc      503
Gly Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser         
    115                 120                 125                         

aga gaa gca aag ctt cag ttt gct tat ctt gac aac ttt aaa aca aga      551
Arg Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg         
130                 135                 140                 145         

aca aga agc act gtg tct gtc cgt cga ggt caa gga atg gtg cta ctg      599
Thr Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu         
                150                 155                 160             

tgt ggc ccg cca ccc cat tct gga gag ctg agt tat gcc tgg atc ttc      647
Cys Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe         
            165                 170                 175                 

aat gaa tac cct tcc tat cag gat aat cgc cgc ttt gtt tct caa gag      695
Asn Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu         
        180                 185                 190                     

act ggg aat ctg tat att gcc aaa gta gaa aaa tca gat gtt ggg aat      743
Thr Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn         
    195                 200                 205                         

tat acc tgt gtg gtt acc aat acc gtg aca aac cac aag gtc ctg ggg      791
Tyr Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly         
210                 215                 220                 225         

cca cct aca cca cta ata ttg aga aat gat gga gtg atg ggt gaa tat      839
Pro Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr         
                230                 235                 240             

gag ccc aaa ata gaa gtg cag ttc cca gaa aca gtt ccg act gca aaa      887
Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys         
            245                 250                 255                 

gga gca acg gtg aag ctg gaa tgc ttt gct tta gga aat cca gta cca      935
Gly Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro         
        260                 265                 270                     

act att atc tgg cga aga gct gat gga aag cca ata gca agg aaa gcc      983
Thr Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala         
    275                 280                 285                         

aga aga cac aag tca aat gga att ctt gag atc cct aat ttt cag cag     1031
Arg Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln         
290                 295                 300                 305         

gag gat gct ggt tta tat gaa tgt gta gct gaa aat tcc aga ggg aaa     1079
Glu Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys         
                310                 315                 320             

aat gta gca agg gga cag cta act ttc tat gct caa cct aat tgg att     1127
Asn Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile         
            325                 330                 335                 

caa aaa ata aat gat att cac gtg gcc atg gaa gaa aat gtc ttt tgg     1175
Gln Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp         
        340                 345                 350                     

gaa tgt aaa gca aat gga agg cct aag cct aca tac aag tgg cta aaa     1223
Glu Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys         
    355                 360                 365                         

aat ggc gaa cct ctg cta act cgg gat aga att caa att gag caa gga     1271
Asn Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly         
370                 375                 380                 385         

aca ctc aac ata aca ata gtg aac ctc tca gat gct ggc atg tat cag     1319
Thr Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln         
                390                 395                 400             

tgt ttg gca gag aat aaa cat gga gtt atc ttt tcc aac gca gag ctt     1367
Cys Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu         
            405                 410                 415                 

agt gtt ata gct gta ggt cca gat ttt tca aga aca ctc ttg aaa aga     1415
Ser Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg         
        420                 425                 430                     

gta act ctt gtc aaa gtg gga ggt gaa gtt gtc att gag tgt aag cca     1463
Val Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro         
    435                 440                 445                         

aaa gcg tct cca aaa cct gtt tac acc tgg aag aaa gga agg gat ata     1511
Lys Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile         
450                 455                 460                 465         

tta aaa gaa aat gaa aga att acc att tct gaa gat gga aac ctc aga     1559
Leu Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg         
                470                 475                 480             

atc atc aac gtt act aaa tca gac gct ggg agt tat acc tgt ata gcc     1607
Ile Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala         
            485                 490                 495                 

act aac cat ttt gga act gct agc agt act gga aac ttg gta gtg aaa     1655
Thr Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys         
        500                 505                 510                     

gat cca aca agg gta atg gta ccc cct tcc agt atg gat gtc act gtt     1703
Asp Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val         
    515                 520                 525                         

gga gag agt att gtt tta ccg tgc cag gta acg cat gat cac tcg cta     1751
Gly Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu         
530                 535                 540                 545         

gac atc gtg ttt act tgg tca ttt aat gga cac ctg ata gac ttt gac     1799
Asp Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp         
                550                 555                 560             

aga gat ggg gac cac ttt gaa aga gtt gga ggg cag gat tca gct ggt     1847
Arg Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly         
            565                 570                 575                 

gat ttg atg atc cga aac atc caa ctg aag cat gct ggg aaa tat gtc     1895
Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val         
        580                 585                 590                     

tgc atg gtc caa aca agt gtg gac agg cta tct gct gct gca gac ctg     1943
Cys Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu         
    595                 600                 605                         

att gta aga ggt cct cca ggt ccc cca gag gct gtg aca ata gac gaa     1991
Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu         
610                 615                 620                 625         

atc aca gat acc act gct cag ctc tcc tgg aga ccc ggg cct gac aat     2039
Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn         
                630                 635                 640             

cac agc ccc atc acc atg tat gtc att caa gcc agg act ccg ttc tcc     2087
His Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser         
            645                 650                 655                 

gtg ggc tgg caa gca gtc agt aca gtc cca gaa ctc att gat ggg aag     2135
Val Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys         
        660                 665                 670                     

aca ttc aca gcg acc gtg gtg ggt ttg aac cct tgg gtt gaa tat gaa     2183
Thr Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu         
    675                 680                 685                         

ttc cgc aca gtt gca gcc aac gtg att ggg att ggg gag ccc agc cgc     2231
Phe Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg         
690                 695                 700                 705         

ccc tca gag aaa cgg aga aca gaa gaa gct ctc ccc gaa gtc aca cca     2279
Pro Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro         
                710                 715                 720             

gcg aat gtc agt ggt ggc gga ggc agc aaa tct gaa ctg gtt ata acc     2327
Ala Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr         
            725                 730                 735                 

tgg gag acg gtc cct gag gaa tta cag aat ggt cga ggc ttt ggt tat     2375
Trp Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr         
        740                 745                 750                     

gtg gtg gcc ttc cgg ccc tac ggt aaa atg atc tgg atg ctg aca gtg     2423
Val Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val         
    755                 760                 765                         

ctg gcc tca gct gac gcc tct aga tac gtg ttc agg aat gag agc gtg     2471
Leu Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val         
770                 775                 780                 785         

cac ccc ttc tct ccc ttt gag gtt aaa gta ggt gtc ttc aac aac aaa     2519
His Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys         
                790                 795                 800             

gga gaa ggc cct ttc agt ccc acc acg gtg gtg tat tct gca gaa gaa     2567
Gly Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu         
            805                 810                 815                 

gaa ccc acc aaa cca cca gcc agt atc ttt gcc aga agt ctt tct gcc     2615
Glu Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala         
        820                 825                 830                     

aca gat att gaa gtt ttc tgg gcc tcc cca ctg gag aag aat aga gga     2663
Thr Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly         
    835                 840                 845                         

cga ata caa ggt tat gag gtt aaa tat tgg aga cat gaa gac aaa gaa     2711
Arg Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu         
850                 855                 860                 865         

gaa aat gct aga aaa ata cga aca gtt gga aat cag aca tca aca aaa     2759
Glu Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys         
                870                 875                 880             

atc acg aac tta aaa ggc agt gtg ctg tat cac tta gct gtc aag gca     2807
Ile Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala         
            885                 890                 895                 

tat aat tct gct ggg aca ggc ccc tct agt gca aca gtc aat gtg aca     2855
Tyr Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr         
        900                 905                 910                     

acc cga aag cca cca cca agt caa ccc ccc gga aac atc ata tgg aat     2903
Thr Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn         
    915                 920                 925                         

tca tca gac tcc aaa att atc ctg aat tgg gat caa gtg aag gcc ctg     2951
Ser Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu         
930                 935                 940                 945         

gat aat gag tcg gaa gta aaa gga tac aaa gtc ttg tac aga tgg aac     2999
Asp Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn         
                950                 955                 960             

aga caa agc agc aca tct gtc att gaa aca aat aaa aca tcg gtg gag     3047
Arg Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu         
            965                 970                 975                 

ctt tct ttg cct ttc gat gaa gat tat ata ata gaa att aag cca ttc     3095
Leu Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe         
        980                 985                 990                     

agc gac gga gga gat ggc agc  agc agt gaa caa att  cga att cca aag   3143
Ser Asp Gly Gly Asp Gly Ser  Ser Ser Glu Gln Ile  Arg Ile Pro Lys       
    995                 1000                 1005                       

ata  tca aat gcc tac gcg  aga gga tct ggg gct  tcc act tcg aat      3188
Ile  Ser Asn Ala Tyr Ala  Arg Gly Ser Gly Ala  Ser Thr Ser Asn          
1010                 1015                 1020                          

gca  tgt acg ctg tca gcc  atc agt aca ata atg  att tcc ctc aca      3233
Ala  Cys Thr Leu Ser Ala  Ile Ser Thr Ile Met  Ile Ser Leu Thr          
1025                 1030                 1035                          

gct  agg tcc agt tta tga caaaagttat ctgaaggact tgctgtttat           3281
Ala  Arg Ser Ser Leu                                                    
1040                                                                    

aatataagca acatttagct agttgttttg aagacaccca gtactaagta atattgttgt   3341

tcaagtacat cttattactg gaataaaaat gttttttgct tctttaggaa tggcattata   3401

caagtacttc ctcaaagcaa atctagcttt gtctgaagtt tctttggaaa ctctgcaatg   3461

ccactgaagg acatctggta atatgatgtt caacaaaagc cagtttacat tattgtccct   3521

ttaatattgc atatctttta ctcatatatt taagaggtta aatcacgaat ctattcacaa   3581

cgttcaacct atcacatgta cgcatattta acatctctta ccatcggact ggtacaaacg   3641

cgtatgggcc caccaaccaa tcatgaccat tactaattcg gaaaaataca ttccttcaag   3701

cgcacagagt ctggacacat catattggga taaataaaat gacacctact acgctaacgg   3761

tatacaacgg cattca                                                   3777


<210>  528

<211>  1044

<212>  PRT

<213>  Homo sapiens



<400>  528

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro 
            20                  25                  30          


Ala Leu Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln 
        35                  40                  45              


Glu Pro Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val 
    50                  55                  60                  


Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp 
65                  70                  75                  80  


Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser 
                85                  90                  95      


Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp 
            100                 105                 110         


Ala Gly Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val 
        115                 120                 125             


Ser Arg Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr 
    130                 135                 140                 


Arg Thr Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu 
145                 150                 155                 160 


Leu Cys Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile 
                165                 170                 175     


Phe Asn Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln 
            180                 185                 190         


Glu Thr Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu 
    210                 215                 220                 


Gly Pro Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu 
225                 230                 235                 240 


Tyr Glu Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala 
                245                 250                 255     


Lys Gly Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val 
            260                 265                 270         


Pro Thr Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys 
        275                 280                 285             


Ala Arg Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln 
    290                 295                 300                 


Gln Glu Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly 
305                 310                 315                 320 


Lys Asn Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp 
                325                 330                 335     


Ile Gln Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe 
            340                 345                 350         


Trp Glu Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu 
        355                 360                 365             


Lys Asn Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln 
    370                 375                 380                 


Gly Thr Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr 
385                 390                 395                 400 


Gln Cys Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu 
                405                 410                 415     


Leu Ser Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys 
            420                 425                 430         


Arg Val Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys 
        435                 440                 445             


Pro Lys Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp 
    450                 455                 460                 


Ile Leu Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu 
465                 470                 475                 480 


Arg Ile Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile 
                485                 490                 495     


Ala Thr Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val 
            500                 505                 510         


Lys Asp Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr 
        515                 520                 525             


Val Gly Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser 
    530                 535                 540                 


Leu Asp Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe 
545                 550                 555                 560 


Asp Arg Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala 
                565                 570                 575     


Gly Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr 
            580                 585                 590         


Val Cys Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp 
        595                 600                 605             


Leu Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp 
    610                 615                 620                 


Glu Ile Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp 
625                 630                 635                 640 


Asn His Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe 
                645                 650                 655     


Ser Val Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly 
            660                 665                 670         


Lys Thr Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr 
        675                 680                 685             


Glu Phe Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser 
    690                 695                 700                 


Arg Pro Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr 
705                 710                 715                 720 


Pro Ala Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile 
                725                 730                 735     


Thr Trp Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly 
            740                 745                 750         


Tyr Val Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr 
        755                 760                 765             


Val Leu Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser 
    770                 775                 780                 


Val His Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn 
785                 790                 795                 800 


Lys Gly Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu 
                805                 810                 815     


Glu Glu Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser 
            820                 825                 830         


Ala Thr Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg 
        835                 840                 845             


Gly Arg Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys 
    850                 855                 860                 


Glu Glu Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr 
865                 870                 875                 880 


Lys Ile Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys 
                885                 890                 895     


Ala Tyr Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val 
            900                 905                 910         


Thr Thr Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp 
        915                 920                 925             


Asn Ser Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala 
    930                 935                 940                 


Leu Asp Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp 
945                 950                 955                 960 


Asn Arg Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val 
                965                 970                 975     


Glu Leu Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro 
            980                 985                 990         


Phe Ser Asp Gly Gly Asp Gly Ser  Ser Ser Glu Gln Ile  Arg Ile Pro 
        995                 1000                 1005             


Lys Ile  Ser Asn Ala Tyr Ala  Arg Gly Ser Gly Ala  Ser Thr Ser 
    1010                 1015                 1020             


Asn Ala  Cys Thr Leu Ser Ala  Ile Ser Thr Ile Met  Ile Ser Leu 
    1025                 1030                 1035             


Thr Ala  Arg Ser Ser Leu 
    1040                 


<210>  529

<211>  3135

<212>  DNA

<213>  Homo sapiens



<400>  529
atgaggttgc catgggaact gctggtactg caatcattca ttttgtgcct tgcaggttca     60

cagactgact tctggtcctt gctgggggtg ctgccagcct tggaggctga tgattccaca    120

ctgcatggcc cgatttttat tcaagaacca agtcctgtaa tgttcccttt ggattctgag    180

gagaaaaaag tgaagctcaa ttgtgaagtt aaaggaaatc caaaacctca tatcaggtgg    240

aagttaaatg gaacagatgt tgacactggt atggatttcc gctacagtgt tgttgaaggg    300

agcttgttga tcaataaccc caataaaacc caagatgctg gaacgtacca gtgcacagcg    360

acaaactcgt ttggaacaat tgttagcaga gaagcaaagc ttcagtttgc ttatcttgac    420

aactttaaaa caagaacaag aagcactgtg tctgtccgtc gaggtcaagg aatggtgcta    480

ctgtgtggcc cgccacccca ttctggagag ctgagttatg cctggatctt caatgaatac    540

ccttcctatc aggataatcg ccgctttgtt tctcaagaga ctgggaatct gtatattgcc    600

aaagtagaaa aatcagatgt tgggaattat acctgtgtgg ttaccaatac cgtgacaaac    660

cacaaggtcc tggggccacc tacaccacta atattgagaa atgatggagt gatgggtgaa    720

tatgagccca aaatagaagt gcagttccca gaaacagttc cgactgcaaa aggagcaacg    780

gtgaagctgg aatgctttgc tttaggaaat ccagtaccaa ctattatctg gcgaagagct    840

gatggaaagc caatagcaag gaaagccaga agacacaagt caaatggaat tcttgagatc    900

cctaattttc agcaggagga tgctggttta tatgaatgtg tagctgaaaa ttccagaggg    960

aaaaatgtag caaggggaca gctaactttc tatgctcaac ctaattggat tcaaaaaata   1020

aatgatattc acgtggccat ggaagaaaat gtcttttggg aatgtaaagc aaatggaagg   1080

cctaagccta catacaagtg gctaaaaaat ggcgaacctc tgctaactcg ggatagaatt   1140

caaattgagc aaggaacact caacataaca atagtgaacc tctcagatgc tggcatgtat   1200

cagtgtttgg cagagaataa acatggagtt atcttttcca acgcagagct tagtgttata   1260

gctgtaggtc cagatttttc aagaacactc ttgaaaagag taactcttgt caaagtggga   1320

ggtgaagttg tcattgagtg taagccaaaa gcgtctccaa aacctgttta cacctggaag   1380

aaaggaaggg atatattaaa agaaaatgaa agaattacca tttctgaaga tggaaacctc   1440

agaatcatca acgttactaa atcagacgct gggagttata cctgtatagc cactaaccat   1500

tttggaactg ctagcagtac tggaaacttg gtagtgaaag atccaacaag ggtaatggta   1560

cccccttcca gtatggatgt cactgttgga gagagtattg ttttaccgtg ccaggtaacg   1620

catgatcact cgctagacat cgtgtttact tggtcattta atggacacct gatagacttt   1680

gacagagatg gggaccactt tgaaagagtt ggagggcagg attcagctgg tgatttgatg   1740

atccgaaaca tccaactgaa gcatgctggg aaatatgtct gcatggtcca aacaagtgtg   1800

gacaggctat ctgctgctgc agacctgatt gtaagaggtc ctccaggtcc cccagaggct   1860

gtgacaatag acgaaatcac agataccact gctcagctct cctggagacc cgggcctgac   1920

aatcacagcc ccatcaccat gtatgtcatt caagccagga ctccgttctc cgtgggctgg   1980

caagcagtca gtacagtccc agaactcatt gatgggaaga cattcacagc gaccgtggtg   2040

ggtttgaacc cttgggttga atatgaattc cgcacagttg cagccaacgt gattgggatt   2100

ggggagccca gccgcccctc agagaaacgg agaacagaag aagctctccc cgaagtcaca   2160

ccagcgaatg tcagtggtgg cggaggcagc aaatctgaac tggttataac ctgggagacg   2220

gtccctgagg aattacagaa tggtcgaggc tttggttatg tggtggcctt ccggccctac   2280

ggtaaaatga tctggatgct gacagtgctg gcctcagctg acgcctctag atacgtgttc   2340

aggaatgaga gcgtgcaccc cttctctccc tttgaggtta aagtaggtgt cttcaacaac   2400

aaaggagaag gccctttcag tcccaccacg gtggtgtatt ctgcagaaga agaacccacc   2460

aaaccaccag ccagtatctt tgccagaagt ctttctgcca cagatattga agttttctgg   2520

gcctccccac tggagaagaa tagaggacga atacaaggtt atgaggttaa atattggaga   2580

catgaagaca aagaagaaaa tgctagaaaa atacgaacag ttggaaatca gacatcaaca   2640

aaaatcacga acttaaaagg cagtgtgctg tatcacttag ctgtcaaggc atataattct   2700

gctgggacag gcccctctag tgcaacagtc aatgtgacaa cccgaaagcc accaccaagt   2760

caaccccccg gaaacatcat atggaattca tcagactcca aaattatcct gaattgggat   2820

caagtgaagg ccctggataa tgagtcggaa gtaaaaggat acaaagtctt gtacagatgg   2880

aacagacaaa gcagcacatc tgtcattgaa acaaataaaa catcggtgga gctttctttg   2940

cctttcgatg aagattatat aatagaaatt aagccattca gcgacggagg agatggcagc   3000

agcagtgaac aaattcgaat tccaaagata tcaaatgcct acgcgagagg atctggggct   3060

tccacttcga atgcatgtac gctgtcagcc atcagtacaa taatgatttc cctcacagct   3120

aggtccagtt tatga                                                    3135


<210>  530

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  530

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Ile Leu Cys 
1               5                   10                  15      


Leu Ala 
        


<210>  531

<211>  1026

<212>  PRT

<213>  Homo sapiens



<400>  531

Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro Ala Leu 
1               5                   10                  15      


Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  532

<211>  60

<212>  PRT

<213>  Homo sapiens



<400>  532

Glu Lys Lys Val Lys Leu Asn Cys Glu Val Lys Gly Asn Pro Lys Pro 
1               5                   10                  15      


His Ile Arg Trp Lys Leu Asn Gly Thr Asp Val Asp Thr Gly Met Asp 
            20                  25                  30          


Phe Arg Tyr Ser Val Val Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn 
        35                  40                  45              


Lys Thr Gln Asp Ala Gly Thr Tyr Gln Cys Thr Ala 
    50                  55                  60  


<210>  533

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  533

Gly Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro 
1               5                   10                  15      


Thr Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala 
            20                  25                  30          


Arg Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln 
        35                  40                  45              


Glu Asp Ala Gly Leu Tyr Glu Cys Val Ala 
    50                  55              


<210>  534

<211>  58

<212>  PRT

<213>  Homo sapiens



<400>  534

Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys Ala Ser Pro Lys Pro 
1               5                   10                  15      


Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu Lys Glu Asn Glu Arg 
            20                  25                  30          


Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile Ile Asn Val Thr Lys 
        35                  40                  45              


Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala 
    50                  55              


<210>  535

<211>  67

<212>  PRT

<213>  Homo sapiens



<400>  535

Gly Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu 
1               5                   10                  15      


Asp Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp 
            20                  25                  30          


Arg Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly 
        35                  40                  45              


Asp Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val 
    50                  55                  60                  


Cys Met Val 
65          


<210>  536

<211>  90

<212>  PRT

<213>  Homo sapiens



<400>  536

Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile Thr Asp Thr Thr 
1               5                   10                  15      


Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His Ser Pro Ile Thr 
            20                  25                  30          


Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val Gly Trp Gln Ala 
        35                  40                  45              


Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr Phe Thr Ala Thr 
    50                  55                  60                  


Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe Arg Thr Val Ala 
65                  70                  75                  80  


Ala Asn Val Ile Gly Ile Gly Glu Pro Ser 
                85                  90  


<210>  537

<211>  89

<212>  PRT

<213>  Homo sapiens



<400>  537

Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
1               5                   10                  15      


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            20                  25                  30          


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        35                  40                  45              


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    50                  55                  60                  


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
65                  70                  75                  80  


Asn Ser Ala Gly Thr Gly Pro Ser Ser 
                85                  


<210>  538

<211>  18

<212>  PRT

<213>  Homo sapiens



<400>  538

Ser Asn Ala Cys Thr Leu Ser Ala Ile Ser Thr Ile Met Ile Ser Leu 
1               5                   10                  15      


Thr Ala 
        


<210>  539

<211>  1004

<212>  PRT

<213>  Homo sapiens



<400>  539

Gly Ser Gln Thr Asp Phe Trp Ser Leu Leu Gly Val Leu Pro Ala Leu 
1               5                   10                  15      


Glu Ala Asp Asp Ser Thr Leu His Gly Pro Ile Phe Ile Gln Glu Pro 
            20                  25                  30          


Ser Pro Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Asn Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Thr Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ala Gly 
                85                  90                  95      


Thr Tyr Gln Cys Thr Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Asp Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu Tyr Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ser Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Asn His Lys Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Thr Ala Lys Gly 
225                 230                 235                 240 


Ala Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Ile Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Asn Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Leu Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Val Ala Arg Gly Gln Leu Thr Phe Tyr Ala Gln Pro Asn Trp Ile Gln 
305                 310                 315                 320 


Lys Ile Asn Asp Ile His Val Ala Met Glu Glu Asn Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Lys Trp Leu Lys Asn 
            340                 345                 350         


Gly Glu Pro Leu Leu Thr Arg Asp Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Leu Ala Glu Asn Lys His Gly Val Ile Phe Ser Asn Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Val Gly Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Lys Pro Val Tyr Thr Trp Lys Lys Gly Arg Asp Ile Leu 
        435                 440                 445             


Lys Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Leu Val Val Lys Asp 
                485                 490                 495     


Pro Thr Arg Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Ser Phe Asn Gly His Leu Ile Asp Phe Asp Arg 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Arg Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Ile Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro Tyr Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val His 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Val Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Leu Glu Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Glu Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Ser Val Leu Tyr His Leu Ala Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Thr Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ala Tyr Ala Arg Gly Ser  Gly Ala Ser Thr 
        995                 1000                 


<210>  540

<211>  1026

<212>  PRT

<213>  Rattus norvegicus



<400>  540

Met Arg Leu Pro Trp Glu Leu Leu Val Leu Gln Ser Phe Met Leu Cys 
1               5                   10                  15      


Leu Ala Asp Asp Tyr Thr Leu His Gly Pro Val Phe Val Gln Glu Pro 
            20                  25                  30          


Ser His Val Met Phe Pro Leu Asp Ser Glu Glu Lys Lys Val Lys Leu 
        35                  40                  45              


Ser Cys Glu Val Lys Gly Asn Pro Lys Pro His Ile Arg Trp Lys Leu 
    50                  55                  60                  


Asn Gly Thr Asp Val Asp Ile Gly Met Asp Phe Arg Tyr Ser Val Val 
65                  70                  75                  80  


Glu Gly Ser Leu Leu Ile Asn Asn Pro Asn Lys Thr Gln Asp Ser Gly 
                85                  90                  95      


Thr Tyr Gln Cys Ile Ala Thr Asn Ser Phe Gly Thr Ile Val Ser Arg 
            100                 105                 110         


Glu Ala Lys Leu Gln Phe Ala Tyr Leu Glu Asn Phe Lys Thr Arg Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Arg Gly Gln Gly Met Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Ser Gly Glu Leu Ser Tyr Ala Trp Ile Phe Asn 
145                 150                 155                 160 


Glu His Pro Ser Tyr Gln Asp Asn Arg Arg Phe Val Ser Gln Glu Thr 
                165                 170                 175     


Gly Asn Leu Tyr Ile Ala Lys Val Glu Lys Ala Asp Val Gly Asn Tyr 
            180                 185                 190         


Thr Cys Val Val Thr Asn Thr Val Thr Ser His Gln Val Leu Gly Pro 
        195                 200                 205             


Pro Thr Pro Leu Ile Leu Arg Asn Asp Gly Val Met Gly Glu Tyr Glu 
    210                 215                 220                 


Pro Lys Ile Glu Val Gln Phe Pro Glu Thr Val Pro Ala Glu Lys Gly 
225                 230                 235                 240 


Ser Thr Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val Pro Thr 
                245                 250                 255     


Ile Leu Trp Arg Arg Ala Asp Gly Lys Pro Ile Ala Arg Lys Ala Arg 
            260                 265                 270         


Arg His Lys Ser Ser Gly Ile Leu Glu Ile Pro Asn Phe Gln Gln Glu 
        275                 280                 285             


Asp Ala Gly Ser Tyr Glu Cys Val Ala Glu Asn Ser Arg Gly Lys Asn 
    290                 295                 300                 


Ile Ala Lys Gly Gln Val Thr Phe Tyr Ala Gln Pro Asn Trp Val Gln 
305                 310                 315                 320 


Ile Ile Asn Asp Ile His Val Ala Met Glu Glu Ser Val Phe Trp Glu 
                325                 330                 335     


Cys Lys Ala Asn Gly Arg Pro Lys Pro Thr Tyr Arg Trp Leu Lys Asn 
            340                 345                 350         


Gly Asp Pro Leu Leu Thr Arg Glu Arg Ile Gln Ile Glu Gln Gly Thr 
        355                 360                 365             


Leu Asn Ile Thr Ile Val Asn Leu Ser Asp Ala Gly Met Tyr Gln Cys 
    370                 375                 380                 


Val Ala Glu Asn Lys His Gly Val Ile Tyr Ala Ser Ala Glu Leu Ser 
385                 390                 395                 400 


Val Ile Ala Glu Ser Pro Asp Phe Ser Arg Thr Leu Leu Lys Arg Val 
                405                 410                 415     


Thr Leu Val Lys Val Gly Gly Glu Val Val Ile Glu Cys Lys Pro Lys 
            420                 425                 430         


Ala Ser Pro Arg Pro Val Tyr Thr Trp Arg Lys Gly Arg Glu Ile Leu 
        435                 440                 445             


Arg Glu Asn Glu Arg Ile Thr Ile Ser Glu Asp Gly Asn Leu Arg Ile 
    450                 455                 460                 


Ile Asn Val Thr Lys Ser Asp Ala Gly Ser Tyr Thr Cys Ile Ala Thr 
465                 470                 475                 480 


Asn His Phe Gly Thr Ala Ser Ser Thr Gly Asn Val Val Val Lys Asp 
                485                 490                 495     


Pro Thr Lys Val Met Val Pro Pro Ser Ser Met Asp Val Thr Val Gly 
            500                 505                 510         


Glu Ser Ile Val Leu Pro Cys Gln Val Thr His Asp His Ser Leu Asp 
        515                 520                 525             


Ile Val Phe Thr Trp Thr Phe Asn Gly His Leu Ile Asp Phe Asp Lys 
    530                 535                 540                 


Asp Gly Asp His Phe Glu Arg Val Gly Gly Gln Asp Ser Ala Gly Asp 
545                 550                 555                 560 


Leu Met Ile Arg Asn Ile Gln Leu Lys His Ala Gly Lys Tyr Val Cys 
                565                 570                 575     


Met Val Gln Thr Ser Val Asp Lys Leu Ser Ala Ala Ala Asp Leu Ile 
            580                 585                 590         


Val Arg Gly Pro Pro Gly Pro Pro Glu Ala Val Thr Ile Asp Glu Ile 
        595                 600                 605             


Thr Asp Thr Thr Ala Gln Leu Ser Trp Arg Pro Gly Pro Asp Asn His 
    610                 615                 620                 


Ser Pro Ile Thr Met Tyr Val Ile Gln Ala Arg Thr Pro Phe Ser Val 
625                 630                 635                 640 


Gly Trp Gln Ala Val Ser Thr Val Pro Glu Leu Val Asp Gly Lys Thr 
                645                 650                 655     


Phe Thr Ala Thr Val Val Gly Leu Asn Pro Trp Val Glu Tyr Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Ala Asn Val Ile Gly Ile Gly Glu Pro Ser Arg Pro 
        675                 680                 685             


Ser Glu Lys Arg Arg Thr Glu Glu Ala Leu Pro Glu Val Thr Pro Ala 
    690                 695                 700                 


Asn Val Ser Gly Gly Gly Gly Ser Lys Ser Glu Leu Val Ile Thr Trp 
705                 710                 715                 720 


Glu Thr Val Pro Glu Glu Leu Gln Asn Gly Arg Gly Phe Gly Tyr Val 
                725                 730                 735     


Val Ala Phe Arg Pro His Gly Lys Met Ile Trp Met Leu Thr Val Leu 
            740                 745                 750         


Ala Ser Ala Asp Ala Ser Arg Tyr Val Phe Arg Asn Glu Ser Val Arg 
        755                 760                 765             


Pro Phe Ser Pro Phe Glu Val Lys Val Gly Val Phe Asn Asn Lys Gly 
    770                 775                 780                 


Glu Gly Pro Phe Ser Pro Thr Thr Leu Val Tyr Ser Ala Glu Glu Glu 
785                 790                 795                 800 


Pro Thr Lys Pro Pro Ala Ser Ile Phe Ala Arg Ser Leu Ser Ala Thr 
                805                 810                 815     


Asp Ile Glu Val Phe Trp Ala Ser Pro Ile Gly Lys Asn Arg Gly Arg 
            820                 825                 830         


Ile Gln Gly Tyr Glu Val Lys Tyr Trp Arg His Asp Asp Lys Glu Glu 
        835                 840                 845             


Asn Ala Arg Lys Ile Arg Thr Val Gly Asn Gln Thr Ser Thr Lys Ile 
    850                 855                 860                 


Thr Asn Leu Lys Gly Asn Ala Leu Tyr His Leu Ser Val Lys Ala Tyr 
865                 870                 875                 880 


Asn Ser Ala Gly Thr Gly Pro Ser Ser Ala Ala Val Asn Val Thr Thr 
                885                 890                 895     


Arg Lys Pro Pro Pro Ser Gln Pro Pro Gly Asn Ile Ile Trp Asn Ser 
            900                 905                 910         


Ser Asp Ser Lys Ile Ile Leu Asn Trp Asp Gln Val Lys Ala Leu Asp 
        915                 920                 925             


Asn Glu Ser Glu Val Lys Gly Tyr Lys Val Leu Tyr Arg Trp Asn Arg 
    930                 935                 940                 


Gln Ser Ser Thr Ser Val Ile Glu Thr Asn Lys Thr Ser Val Glu Leu 
945                 950                 955                 960 


Ser Leu Pro Phe Asp Glu Asp Tyr Ile Ile Glu Ile Lys Pro Phe Ser 
                965                 970                 975     


Asp Gly Gly Asp Gly Ser Ser Ser Glu Gln Ile Arg Ile Pro Lys Ile 
            980                 985                 990         


Ser Asn Ser Tyr Ala Arg Gly Ser  Gly Ala Ser Thr Ser  Asn Ala Cys 
        995                 1000                 1005             


Thr Leu  Ser Ala Ile Ser Thr  Ile Met Ile Ser Leu  Thr Ala Arg 
    1010                 1015                 1020             


Ser Ser  Leu 
    1025     


<210>  541

<211>  840

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (17)..(790)

<223>  



<400>  541
gaagagcagt gtcata atg caa atg gga aga ttt ctt ctc tta gta att tta     52
                  Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu       
                  1               5                   10                

ttt ctg cca cgt gag atg aca agt tct gtt tta act gtg aat ggt aaa      100
Phe Leu Pro Arg Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys         
        15                  20                  25                      

act gag aac tac atc ctg gat act aca cct ggc tcc caa gca tct ctg      148
Thr Glu Asn Tyr Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu         
    30                  35                  40                          

ata tgt gct gtt caa aac cac acc aga gag gaa gaa ctg ctc tgg tac      196
Ile Cys Ala Val Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr         
45                  50                  55                  60          

cga gag gag ggg aga gtg gat ttg aaa tct gga aac aaa atc aat tcc      244
Arg Glu Glu Gly Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser         
                65                  70                  75              

agc tct gtc tgt gtc tct tcc atc agt gaa aat gac aac gga atc agc      292
Ser Ser Val Cys Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser         
            80                  85                  90                  

ttt acc tgc agg ctg ggg agg gat cag tcc gtg tcc gtt tcg gtg gtg      340
Phe Thr Cys Arg Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val Val         
        95                  100                 105                     

ctg aat gtt act ttt cct cct ctc cta agt gga aac gac ttc caa aca      388
Leu Asn Val Thr Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln Thr         
    110                 115                 120                         

gtt gag gaa ggc agt aat ctg aag ttg gtt tgc aat gtg aaa gcc aac      436
Val Glu Glu Gly Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn         
125                 130                 135                 140         

ccc cag gct caa atg atg tgg tac aaa aac agt agt ctc ctc gat tta      484
Pro Gln Ala Gln Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu         
                145                 150                 155             

gag aaa agc cgt cac caa atc caa cag aca agt gag tct ttt cag ctg      532
Glu Lys Ser Arg His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu         
            160                 165                 170                 

tca atc acc aaa gtc gag aag cct gac aac gga acc tac agt tgt atg      580
Ser Ile Thr Lys Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met         
        175                 180                 185                     

gca aag tca tct ctg aaa acg gag agc ttg gac ttt cac ctg att gtt      628
Ala Lys Ser Ser Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val         
    190                 195                 200                         

aaa gat aaa act gtg ggt gta cca ata gag ccc att att gct gca tgt      676
Lys Asp Lys Thr Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys         
205                 210                 215                 220         

gtt gtg atc ttt ctg aca ttg tgc tca ttg tgc ttt gga ctg att gct      724
Val Val Ile Phe Leu Thr Leu Cys Ser Leu Cys Phe Gly Leu Ile Ala         
                225                 230                 235             

aga aga aag aac ata atg aag ctc tgc ttg aag gat aaa gac cct cac      772
Arg Arg Lys Asn Ile Met Lys Leu Cys Leu Lys Asp Lys Asp Pro His         
            240                 245                 250                 

agt gaa aca gct cta tga gaaagctgag atgccatcga ataacgagag             820
Ser Glu Thr Ala Leu                                                     
        255                                                             

agtttgcatc aggacctcca                                                840


<210>  542

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  542

Met Gln Met Gly Arg Phe Leu Leu Leu Val Ile Leu Phe Leu Pro Arg 
1               5                   10                  15      


Glu Met Thr Ser Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr 
            20                  25                  30          


Ile Leu Asp Thr Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val 
        35                  40                  45              


Gln Asn His Thr Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly 
    50                  55                  60                  


Arg Val Asp Leu Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys 
65                  70                  75                  80  


Val Ser Ser Ile Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg 
                85                  90                  95      


Leu Gly Arg Asp Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr 
            100                 105                 110         


Phe Pro Pro Leu Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly 
        115                 120                 125             


Ser Asn Leu Lys Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln 
    130                 135                 140                 


Met Met Trp Tyr Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg 
145                 150                 155                 160 


His Gln Ile Gln Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys 
                165                 170                 175     


Val Glu Lys Pro Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser 
            180                 185                 190         


Leu Lys Thr Glu Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr 
        195                 200                 205             


Val Gly Val Pro Ile Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe 
    210                 215                 220                 


Leu Thr Leu Cys Ser Leu Cys Phe Gly Leu Ile Ala Arg Arg Lys Asn 
225                 230                 235                 240 


Ile Met Lys Leu Cys Leu Lys Asp Lys Asp Pro His Ser Glu Thr Ala 
                245                 250                 255     


Leu 
    


<210>  543

<211>  710

<212>  DNA

<213>  Homo sapiens



<400>  543
atgcaaatgg gaagatttct tctcttagta attttatttc tgccacgtga gatgacaagt     60

tctgttttaa ctgtgaatgg taaaactgag aactacatcc tggatactac acctggctcc    120

caagcatctc tgatatgtgc tgttcaaaac cacaccagag aggaagaact gctctggtac    180

cgagaggagg ggagagtgga tttgaaatct ggaaacaaaa tcaattccag ctctgtctgt    240

gtctcttcca tcagtgaaaa tgacaacgga atcagcttta cctgcaggct ggggagggat    300

cagtccgtgt ccgtttcggt ggtgctgaat gttacttttc ctcctctcct aagtggaaac    360

gacttccaaa cagttgagga aggcagtaat ctgaagttgg tttgcaatgt gaaagccaac    420

ccccaggctc aaatgatgtg gtacaaaaac agtagtctcc tcgatttaga gaaaagccgt    480

caccaaatcc aacagacaag tgagtctttt cagctgtcaa tcaccaaagt cgagaagcct    540

gacaacggaa cctacagttg tatggcaaag tcatctctga aaacggagag cttggacttt    600

cacctgattg ttaaagataa aactgtgggt gtaccaatag agcccattat tgctgcatgt    660

gttgtgatct ttctgacatt gtgctcattg tgctttggac tgattgctag               710


<210>  544

<211>  236

<212>  PRT

<213>  Homo sapiens



<400>  544

Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr Ile Leu Asp Thr Thr 
1               5                   10                  15      


Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln Asn His Thr Arg 
            20                  25                  30          


Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg Val Asp Leu Lys 
        35                  40                  45              


Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile Ser 
    50                  55                  60                  


Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu Gly Arg Asp Gln 
65                  70                  75                  80  


Ser Val Ser Val Ser Val Val Leu Asn Val Thr Phe Pro Pro Leu Leu 
                85                  90                  95      


Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly Ser Asn Leu Lys Leu 
            100                 105                 110         


Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln Met Met Trp Tyr Lys 
        115                 120                 125             


Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg His Gln Ile Gln Gln 
    130                 135                 140                 


Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys Val Glu Lys Pro Asp 
145                 150                 155                 160 


Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser Leu Lys Thr Glu Ser 
                165                 170                 175     


Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr Val Gly Val Pro Ile 
            180                 185                 190         


Glu Pro Ile Ile Ala Ala Cys Val Val Ile Phe Leu Thr Leu Cys Ser 
        195                 200                 205             


Leu Cys Phe Gly Leu Ile Ala Arg Arg Lys Asn Ile Met Lys Leu Cys 
    210                 215                 220                 


Leu Lys Asp Lys Asp Pro His Ser Glu Thr Ala Leu 
225                 230                 235     


<210>  545

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  545

Ile Ala Ala Cys Val Val Ile Phe Leu Thr Leu Cys Ser Leu Cys Phe 
1               5                   10                  15      


Gly Leu Ile Ala Arg Arg Lys Asn Ile Met Lys 
            20                  25          


<210>  546

<211>  196

<212>  PRT

<213>  Homo sapiens



<400>  546

Ser Val Leu Thr Val Asn Gly Lys Thr Glu Asn Tyr Ile Leu Asp Thr 
1               5                   10                  15      


Thr Pro Gly Ser Gln Ala Ser Leu Ile Cys Ala Val Gln Asn His Thr 
            20                  25                  30          


Arg Glu Glu Glu Leu Leu Trp Tyr Arg Glu Glu Gly Arg Val Asp Leu 
        35                  40                  45              


Lys Ser Gly Asn Lys Ile Asn Ser Ser Ser Val Cys Val Ser Ser Ile 
    50                  55                  60                  


Ser Glu Asn Asp Asn Gly Ile Ser Phe Thr Cys Arg Leu Gly Arg Asp 
65                  70                  75                  80  


Gln Ser Val Ser Val Ser Val Val Leu Asn Val Thr Phe Pro Pro Leu 
                85                  90                  95      


Leu Ser Gly Asn Asp Phe Gln Thr Val Glu Glu Gly Ser Asn Leu Lys 
            100                 105                 110         


Leu Val Cys Asn Val Lys Ala Asn Pro Gln Ala Gln Met Met Trp Tyr 
        115                 120                 125             


Lys Asn Ser Ser Leu Leu Asp Leu Glu Lys Ser Arg His Gln Ile Gln 
    130                 135                 140                 


Gln Thr Ser Glu Ser Phe Gln Leu Ser Ile Thr Lys Val Glu Lys Pro 
145                 150                 155                 160 


Asp Asn Gly Thr Tyr Ser Cys Met Ala Lys Ser Ser Leu Lys Thr Glu 
                165                 170                 175     


Ser Leu Asp Phe His Leu Ile Val Lys Asp Lys Thr Val Gly Val Pro 
            180                 185                 190         


Ile Glu Pro Ile 
        195     


<210>  547

<211>  1239

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (58)..(579)

<223>  



<400>  547
cggcacgagc gactccccgc accactcagg gtcctgtgga cagctcacct agcggca        57

atg gct gca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      105
Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu         
1               5                   10                  15              

tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccc tta      153
Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu         
            20                  25                  30                  

tcc agg ctt ttt aaa gag gct atg ctc caa gcc cat cgc gca cac cag      201
Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln         
        35                  40                  45                      

ctg gcc att gac acc tac cag gag ttt ata agc tct tgg gga atg ggt      249
Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Gly         
    50                  55                  60                          

gcg ggt cag ggg tgg caa gaa ggg gtg act ttc ccc cac tgg gga agt      297
Ala Gly Gln Gly Trp Gln Glu Gly Val Thr Phe Pro His Trp Gly Ser         
65                  70                  75                  80          

aat ggg agg aga cta agg agc tca ggg ttg ttt tct gaa gcg aaa atg      345
Asn Gly Arg Arg Leu Arg Ser Ser Gly Leu Phe Ser Glu Ala Lys Met         
                85                  90                  95              

cag gca gat gag cat agg ctg agc cag gtt ccc aga aga gta aca gtg      393
Gln Ala Asp Glu His Arg Leu Ser Gln Val Pro Arg Arg Val Thr Val         
            100                 105                 110                 

gga gct ggt ctc cag cat aga aag cag tgg tcc ttc ttg gtg ggg ggt      441
Gly Ala Gly Leu Gln His Arg Lys Gln Trp Ser Phe Leu Val Gly Gly         
        115                 120                 125                     

cct tcc cct agg aag aag cct ata tca caa agg aac aga agt att cat      489
Pro Ser Pro Arg Lys Lys Pro Ile Ser Gln Arg Asn Arg Ser Ile His         
    130                 135                 140                         

tcc tgc atg act ccc aga cct cct tct gct tct cag act cta ttc cga      537
Ser Cys Met Thr Pro Arg Pro Pro Ser Ala Ser Gln Thr Leu Phe Arg         
145                 150                 155                 160         

cat cct cca aca tgg agg aaa cgc agc aga aat cca act tag              579
His Pro Pro Thr Trp Arg Lys Arg Ser Arg Asn Pro Thr                     
                165                 170                                 

agctgctcca catctccctg ctgctcatcg agtcgcggct ggagcccgtg cggttcctca    639

ggagtacctt caccaacaac ctggtgtatg acacctcgga cagcgatgac tatcacctcc    699

taaaggacct agaggaaggc atccaaatgc tgatgggggt gagggtggca ccaggggtcc    759

ccaatcctgg aagcccactg gcttcgaggg ctgggggaga gaaacactgc tgccctcttt    819

tcagcagtca ggcgctgacc caagagaact caccttattc ttcatttccc ctcgtgaatc    879

ctccaggcct ttctctacac cctgaagggg aaggaggaaa atggataaat gagagaggga    939

gggaacagtg cccaagcgct tggtctctcc ttctcttgct tcactttgca gaggctggaa    999

gacggcagcc acctgactgg gcagaccctc aagcagacct acagcaagtt tgacacaaac   1059

tcgcacaacc atgacgcact gctcaagaac tacgggctgc tccactgctt caggaaggac   1119

atggacaagg tcgagacatt cctgcgcatg gtgcagtgcc gctctgtgga gggcagctgt   1179

ggcttctagg ggcccgcgtg gcatcctgtg accccccccc agcccccccc tcgccctgca   1239


<210>  548

<211>  173

<212>  PRT

<213>  Homo sapiens



<400>  548

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Gly 
    50                  55                  60                  


Ala Gly Gln Gly Trp Gln Glu Gly Val Thr Phe Pro His Trp Gly Ser 
65                  70                  75                  80  


Asn Gly Arg Arg Leu Arg Ser Ser Gly Leu Phe Ser Glu Ala Lys Met 
                85                  90                  95      


Gln Ala Asp Glu His Arg Leu Ser Gln Val Pro Arg Arg Val Thr Val 
            100                 105                 110         


Gly Ala Gly Leu Gln His Arg Lys Gln Trp Ser Phe Leu Val Gly Gly 
        115                 120                 125             


Pro Ser Pro Arg Lys Lys Pro Ile Ser Gln Arg Asn Arg Ser Ile His 
    130                 135                 140                 


Ser Cys Met Thr Pro Arg Pro Pro Ser Ala Ser Gln Thr Leu Phe Arg 
145                 150                 155                 160 


His Pro Pro Thr Trp Arg Lys Arg Ser Arg Asn Pro Thr 
                165                 170             


<210>  549

<211>  522

<212>  DNA

<213>  Homo sapiens



<400>  549
atggctgcag gctcccggac gtccctgctc ctggcttttg ccctgctctg cctgccctgg     60

cttcaagagg ctggtgccgt ccaaaccgtt cccttatcca ggctttttaa agaggctatg    120

ctccaagccc atcgcgcaca ccagctggcc attgacacct accaggagtt tataagctct    180

tggggaatgg gtgcgggtca ggggtggcaa gaaggggtga ctttccccca ctggggaagt    240

aatgggagga gactaaggag ctcagggttg ttttctgaag cgaaaatgca ggcagatgag    300

cataggctga gccaggttcc cagaagagta acagtgggag ctggtctcca gcatagaaag    360

cagtggtcct tcttggtggg gggtccttcc cctaggaaga agcctatatc acaaaggaac    420

agaagtattc attcctgcat gactcccaga cctccttctg cttctcagac tctattccga    480

catcctccaa catggaggaa acgcagcaga aatccaactt ag                       522


<210>  550

<211>  49

<212>  PRT

<213>  Homo sapiens



<400>  550

Leu Leu Leu Ala Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala 
1               5                   10                  15      


Gly Ala Val Gln Thr Val Pro Leu Ser Arg Leu Phe Lys Glu Ala Met 
            20                  25                  30          


Leu Gln Ala His Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu 
        35                  40                  45              


Phe 
    


<210>  551

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  551

Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln Leu Ala 
1               5                   10                  15      


Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp 
            20                  25          


<210>  552

<211>  26

<212>  PRT

<213>  Homo sapiens



<400>  552

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala 
            20                  25      


<210>  553

<211>  147

<212>  PRT

<213>  Homo sapiens



<400>  553

Val Gln Thr Val Pro Leu Ser Arg Leu Phe Lys Glu Ala Met Leu Gln 
1               5                   10                  15      


Ala His Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile 
            20                  25                  30          


Ser Ser Trp Gly Met Gly Ala Gly Gln Gly Trp Gln Glu Gly Val Thr 
        35                  40                  45              


Phe Pro His Trp Gly Ser Asn Gly Arg Arg Leu Arg Ser Ser Gly Leu 
    50                  55                  60                  


Phe Ser Glu Ala Lys Met Gln Ala Asp Glu His Arg Leu Ser Gln Val 
65                  70                  75                  80  


Pro Arg Arg Val Thr Val Gly Ala Gly Leu Gln His Arg Lys Gln Trp 
                85                  90                  95      


Ser Phe Leu Val Gly Gly Pro Ser Pro Arg Lys Lys Pro Ile Ser Gln 
            100                 105                 110         


Arg Asn Arg Ser Ile His Ser Cys Met Thr Pro Arg Pro Pro Ser Ala 
        115                 120                 125             


Ser Gln Thr Leu Phe Arg His Pro Pro Thr Trp Arg Lys Arg Ser Arg 
    130                 135                 140                 


Asn Pro Thr 
145         


<210>  554

<211>  222

<212>  PRT

<213>  Homo sapiens



<400>  554

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Glu 
    50                  55                  60                  


Ala Tyr Ile Thr Lys Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln 
65                  70                  75                  80  


Thr Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu 
                85                  90                  95      


Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu 
            100                 105                 110         


Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe 
        115                 120                 125             


Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu 
    130                 135                 140                 


Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met Gly Arg Leu Glu 
145                 150                 155                 160 


Asp Gly Ser His Leu Thr Gly Gln Thr Leu Lys Gln Thr Tyr Ser Lys 
                165                 170                 175     


Phe Asp Thr Asn Ser His Asn His Asp Ala Leu Leu Lys Asn Tyr Gly 
            180                 185                 190         


Leu Leu His Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu 
        195                 200                 205             


Arg Met Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215                 220         


<210>  555

<211>  199

<212>  PRT

<213>  Homo sapiens



<400>  555

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Ile Ser Ser Trp Gly Met Asp 
    50                  55                  60                  


Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys Ser Asn 
65                  70                  75                  80  


Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg Leu Glu 
                85                  90                  95      


Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val Tyr Asp 
            100                 105                 110         


Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu Glu Gly 
        115                 120                 125             


Ile Gln Met Leu Met Gly Arg Leu Glu Asp Gly Ser His Leu Thr Gly 
    130                 135                 140                 


Gln Thr Leu Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn 
145                 150                 155                 160 


His Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu His Cys Phe Arg Lys 
                165                 170                 175     


Asp Met Asp Lys Val Glu Thr Phe Leu Arg Met Val Gln Cys Arg Ser 
            180                 185                 190         


Val Glu Gly Ser Cys Gly Phe 
        195                 


<210>  556

<211>  1015

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (58)..(828)

<223>  



<400>  556
cggcacgagc gactccccgc accactcagg gtcctgtgga cagctcacct agcggca        57

atg gct gca ggc tcc cgg acg tcc ctg ctc ctg gct ttt gcc ctg ctc      105
Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu         
1               5                   10                  15              

tgc ctg ccc tgg ctt caa gag gct ggt gcc gtc caa acc gtt ccc tta      153
Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu         
            20                  25                  30                  

tcc agg ctt ttt aaa gag gct atg ctc caa gcc cat cgc gca cac cag      201
Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln         
        35                  40                  45                      

ctg gcc att gac acc tac cag gag ttt gaa gaa gcc tat atc aca aag      249
Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Thr Lys         
    50                  55                  60                          

gaa cag aag tat tca ttc ctg cat gac tcc cag acc tcc ttc tgc ttc      297
Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe         
65                  70                  75                  80          

tca gac tct att ccg aca tcc tcc aac atg gag gaa acg cag cag aaa      345
Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys         
                85                  90                  95              

tcc aac tta gag ctg ctc cac atc tcc ctg ctg ctc atc gag tcg cgg      393
Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg         
            100                 105                 110                 

ctg gag ccc gtg cgg ttc ctc agg agt acc ttc acc aac aac ctg gtg      441
Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val         
        115                 120                 125                     

tat gac acc tcg gac agc gat gac tat cac ctc cta aag gac cta gag      489
Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu         
    130                 135                 140                         

gaa ggc atc caa atg ctg atg ggg gtg agg gtg gca cca ggg gtc ccc      537
Glu Gly Ile Gln Met Leu Met Gly Val Arg Val Ala Pro Gly Val Pro         
145                 150                 155                 160         

aat cct gga agc cca ctg gct tcg agg gct ggg gga gag aaa cac tgc      585
Asn Pro Gly Ser Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys His Cys         
                165                 170                 175             

tgc cct ctt ttc agc agt cag gcg ctg acc caa gag aac tca cct tat      633
Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr         
            180                 185                 190                 

tct tca ttt ccc ctc gtg aat cct cca ggc ctt tct cta cac cct gaa      681
Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu         
        195                 200                 205                     

ggg gaa gga gga aaa tgg ata aat gag aga ggg agg gaa cag tgc cca      729
Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro         
    210                 215                 220                         

agc gct tgg tct ctc ctt ctc ttg ctt cac ttt gca gag gct gga aga      777
Ser Ala Trp Ser Leu Leu Leu Leu Leu His Phe Ala Glu Ala Gly Arg         
225                 230                 235                 240         

cgg cag cca cct gac tgg gca gac cct caa gca gac cta cag caa gtt      825
Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val         
                245                 250                 255             

tga cacaaactcg cacaaccatg acgcactgct caagaactac gggctgctcc           878

actgcttcag gaaggacatg gacaaggtcg agacattcct gcgcatggtg cagtgccgct    938

ctgtggaggg cagctgtggc ttctaggggc ccgcgtggca tcctgtgacc cccccccagc    998

ccccccctcg ccctgca                                                  1015


<210>  557

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  557

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Thr Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Thr Phe Thr Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Met Leu Met Gly Val Arg Val Ala Pro Gly Val Pro 
145                 150                 155                 160 


Asn Pro Gly Ser Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys His Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Ser Leu Leu Leu Leu Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val 
                245                 250                 255     


<210>  558

<211>  771

<212>  DNA

<213>  Homo sapiens



<400>  558
atggctgcag gctcccggac gtccctgctc ctggcttttg ccctgctctg cctgccctgg     60

cttcaagagg ctggtgccgt ccaaaccgtt cccttatcca ggctttttaa agaggctatg    120

ctccaagccc atcgcgcaca ccagctggcc attgacacct accaggagtt tgaagaagcc    180

tatatcacaa aggaacagaa gtattcattc ctgcatgact cccagacctc cttctgcttc    240

tcagactcta ttccgacatc ctccaacatg gaggaaacgc agcagaaatc caacttagag    300

ctgctccaca tctccctgct gctcatcgag tcgcggctgg agcccgtgcg gttcctcagg    360

agtaccttca ccaacaacct ggtgtatgac acctcggaca gcgatgacta tcacctccta    420

aaggacctag aggaaggcat ccaaatgctg atgggggtga gggtggcacc aggggtcccc    480

aatcctggaa gcccactggc ttcgagggct gggggagaga aacactgctg ccctcttttc    540

agcagtcagg cgctgaccca agagaactca ccttattctt catttcccct cgtgaatcct    600

ccaggccttt ctctacaccc tgaaggggaa ggaggaaaat ggataaatga gagagggagg    660

gaacagtgcc caagcgcttg gtctctcctt ctcttgcttc actttgcaga ggctggaaga    720

cggcagccac ctgactgggc agaccctcaa gcagacctac agcaagtttg a             771


<210>  559

<211>  143

<212>  PRT

<213>  Homo sapiens



<400>  559

Leu Leu Leu Ala Phe Ala Leu Leu Cys Leu Pro Trp Leu Gln Glu Ala 
1               5                   10                  15      


Gly Ala Val Gln Thr Val Pro Leu Ser Arg Leu Phe Lys Glu Ala Met 
            20                  25                  30          


Leu Gln Ala His Arg Ala His Gln Leu Ala Ile Asp Thr Tyr Gln Glu 
        35                  40                  45              


Phe Glu Glu Ala Tyr Ile Thr Lys Glu Gln Lys Tyr Ser Phe Leu His 
    50                  55                  60                  


Asp Ser Gln Thr Ser Phe Cys Phe Ser Asp Ser Ile Pro Thr Ser Ser 
65                  70                  75                  80  


Asn Met Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu His Ile 
                85                  90                  95      


Ser Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val Arg Phe Leu Arg 
            100                 105                 110         


Ser Thr Phe Thr Asn Asn Leu Val Tyr Asp Thr Ser Asp Ser Asp Asp 
        115                 120                 125             


Tyr His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu Met 
    130                 135                 140             


<210>  560

<211>  38

<212>  PRT

<213>  Homo sapiens



<400>  560

Cys Phe Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu Thr Gln 
1               5                   10                  15      


Gln Lys Ser Asn Leu Glu Leu Leu His Ile Ser Leu Leu Leu Ile Glu 
            20                  25                  30          


Ser Arg Leu Glu Pro Val 
        35              


<210>  561

<211>  27

<212>  PRT

<213>  Homo sapiens



<400>  561

Leu Phe Lys Glu Ala Met Leu Gln Ala His Arg Ala His Gln Leu Ala 
1               5                   10                  15      


Ile Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr 
            20                  25          


<210>  562

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  562

Cys Phe Ser Asp Ser Ile Pro Thr Ser Ser Asn Met Glu Glu 
1               5                   10                  


<210>  563

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  563

Pro Gly Leu Ser Leu His Pro Glu Gly Glu Gly Gly Lys Trp Ile Asn 
1               5                   10                  15      


Glu Arg Gly Arg Glu Gln Cys Pro 
            20                  


<210>  564

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  564

Leu Leu His Ile Ser Leu Leu Leu Ile Glu Ser Arg Leu Glu Pro Val 
1               5                   10                  15      


Arg Phe Leu 
            


<210>  565

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  565

Asp Asp Tyr His Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Met Leu 
1               5                   10                  15      


Met 
    


<210>  566

<211>  26

<212>  PRT

<213>  Homo sapiens



<400>  566

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala 
            20                  25      


<210>  567

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  567

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Thr 
145                 150                 155                 160 


Asn Pro Gly Thr Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Lys Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val 
                245                 250                 255     


<210>  568

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  568

Met Ala Pro Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Ala Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Ala Gly Ala Val Gln Thr Val Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp His Ala Met Leu Gln Ala His Arg Ala His Gln 
        35                  40                  45              


Leu Ala Ile Asp Thr Tyr Gln Glu Phe Glu Glu Thr Tyr Ile Pro Lys 
    50                  55                  60                  


Asp Gln Lys Tyr Ser Phe Leu His Asp Ser Gln Thr Ser Phe Cys Phe 
65                  70                  75                  80  


Ser Asp Ser Ile Pro Thr Pro Ser Asn Met Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Arg Phe Leu Arg Ser Met Phe Ala Asn Asn Leu Val 
        115                 120                 125             


Tyr Asp Thr Ser Asp Ser Asp Asp Tyr His Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Val Arg Val Ala Pro Gly Val Thr 
145                 150                 155                 160 


Asn Pro Gly Thr Pro Leu Ala Ser Arg Ala Gly Gly Glu Lys Tyr Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Lys Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Arg Leu Val Asn Pro Pro Gly Leu Ser Leu His Pro Glu 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Ile Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Arg Gln Pro Pro Asp Trp Ala Asp Pro Gln Ala Asp Leu Gln Gln Val 
                245                 250                 255     


<210>  569

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  569

Met Ala Ala Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Ser Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala Arg Arg Leu Tyr Gln 
        35                  40                  45              


Leu Ala Tyr Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Leu Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Val Lys Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Leu Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Arg His Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Trp Val Arg Val Ala Pro Gly Ile Pro 
145                 150                 155                 160 


Asn Pro Gly Ala Pro Leu Ala Ser Arg Asp Trp Gly Glu Lys His Cys 
                165                 170                 175     


Cys Pro Leu Phe Ser Ser Gln Ala Leu Thr Gln Glu Asn Ser Pro Tyr 
            180                 185                 190         


Ser Ser Phe Pro Leu Val Asn Pro Pro Gly Leu Ser Leu Gln Pro Gly 
        195                 200                 205             


Gly Glu Gly Gly Lys Trp Met Asn Glu Arg Gly Arg Glu Gln Cys Pro 
    210                 215                 220                 


Ser Ala Trp Pro Leu Leu Leu Phe Leu His Phe Ala Glu Ala Gly Arg 
225                 230                 235                 240 


Trp Gln Pro Pro Asp Trp Ala Asp Leu Gln Ser Val Leu Gln Gln Val 
                245                 250                 255     


<210>  570

<211>  412

<212>  DNA

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (412)..(412)

<223>  n = g, a, t, or c



<400>  570
tttcgtccca gcgcccagga ccgtgtctgg gaaaaggtct ttgcccggag agtgggaaga     60

gagaggggag ggtgagcaga ggacaggccg ggagttttcc gggaacggag gaagagcagt    120

ggaggctgcc aggatgaggc tgctgtgtgg cctgtggctg tggctctcct tgctgaaagt    180

cctgcaggcc cagaccccaa cccccctgcc actcccgccc ccgatgcaga gcttccaagg    240

aaaccagttc cagggggaat ggttcgtcct gggcctggcg ggcaacagct tcaggccgga    300

gcacagggcg ctgctgaacg ctttcaccgc aacttttgag ctaagtgatg atggccgctt    360

tgaggtgtgg aatgcgatga ctcggtgagt ggctgtccct gccgttccaa gn            412


<210>  571

<211>  910

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (192)..(662)

<223>  



<220>

<221>  misc_feature

<222>  (31)..(31)

<223>  n = g, a, t, or c



<400>  571
aagggtcaaa attgaggctg tcgcctgcgg naccggaccg gaattcccgg gtcgacgatt     60

tcgtcccagc gcccaggacc gtgtctggga aaaggtcttt gcccggagag tgggaagaga    120

gaggggaggg tgagcagagg acaggccggg agttttccgg gaacggagga agagcagtgg    180

aggctgccag g atg agg ctg ctg tgt ggc ctg tgg ctg tgg ctc tcc ttg     230
             Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu        
             1               5                   10                     

ctg aaa gtc ctg cag gcc cag acc cca acc ccc ctg cca ctc ccg ccc      278
Leu Lys Val Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro         
    15                  20                  25                          

ccg atg cag agc ttc caa gga aac cag ttc cag ggg gaa tgg ttc gtc      326
Pro Met Gln Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val         
30                  35                  40                  45          

ctg ggc ctg gcg ggc aac agc ttc agg ccg gag cac agg gcg ctg ctg      374
Leu Gly Leu Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu         
                50                  55                  60              

aac gct ttc acc gca act ttt gag cta agt gat gat ggc cgc ttt gag      422
Asn Ala Phe Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu         
            65                  70                  75                  

gtg tgg aat gcg atg act cga ggc cag cac tgt gac aca tgg tct tat      470
Val Trp Asn Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr         
        80                  85                  90                      

gtg ctg ata ccg gca gcc cag cct ggg cag ttc act gtg gac cac ggt      518
Val Leu Ile Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly         
    95                  100                 105                         

gtg gac aca cga gca ggc tgg ccg tcc tca gga tca gcc tgc tgg gca      566
Val Asp Thr Arg Ala Gly Trp Pro Ser Ser Gly Ser Ala Cys Trp Ala         
110                 115                 120                 125         

gga gct ggt tgc tgc ctc ccg gga cgc tgg acc agt tca tct gcc tgg      614
Gly Ala Gly Cys Cys Leu Pro Gly Arg Trp Thr Ser Ser Ser Ala Trp         
                130                 135                 140             

gca gag ctc agg gcc tct cgg atg aca aca ttg tct tcc cag atg tga      662
Ala Glu Leu Arg Ala Ser Arg Met Thr Thr Leu Ser Ser Gln Met             
            145                 150                 155                 

ctggaggtgc cctggacctc agcagcctgc cctgggtggc agccccagcc tgaccactca    722

gacagccgcg gcccccaagg cctgactctt cttgtgggag ggcgaggctg gtcaccccag    782

gccagcgtct gttgaaggat gaagcagctc ctgtccggcc cagccctgcc tcacagctgt    842

gcgagctctg ccctcctcag ctctcaaacc tgaataaatg caccaagccc agaaaaaaaa    902

aaaaaaac                                                             910


<210>  572

<211>  156

<212>  PRT

<213>  Homo sapiens



<220>

<221>  misc_feature

<222>  (31)..(31)

<223>  n = g, a, t, or c

<400>  572

Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val 
1               5                   10                  15      


Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln 
            20                  25                  30          


Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu 
        35                  40                  45              


Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe 
    50                  55                  60                  


Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn 
65                  70                  75                  80  


Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile 
                85                  90                  95      


Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Asp Thr 
            100                 105                 110         


Arg Ala Gly Trp Pro Ser Ser Gly Ser Ala Cys Trp Ala Gly Ala Gly 
        115                 120                 125             


Cys Cys Leu Pro Gly Arg Trp Thr Ser Ser Ser Ala Trp Ala Glu Leu 
    130                 135                 140                 


Arg Ala Ser Arg Met Thr Thr Leu Ser Ser Gln Met 
145                 150                 155     


<210>  573

<211>  471

<212>  DNA

<213>  Homo sapiens



<400>  573
atgaggctgc tgtgtggcct gtggctgtgg ctctccttgc tgaaagtcct gcaggcccag     60

accccaaccc ccctgccact cccgcccccg atgcagagct tccaaggaaa ccagttccag    120

ggggaatggt tcgtcctggg cctggcgggc aacagcttca ggccggagca cagggcgctg    180

ctgaacgctt tcaccgcaac ttttgagcta agtgatgatg gccgctttga ggtgtggaat    240

gcgatgactc gaggccagca ctgtgacaca tggtcttatg tgctgatacc ggcagcccag    300

cctgggcagt tcactgtgga ccacggtgtg gacacacgag caggctggcc gtcctcagga    360

tcagcctgct gggcaggagc tggttgctgc ctcccgggac gctggaccag ttcatctgcc    420

tgggcagagc tcagggcctc tcggatgaca acattgtctt cccagatgtg a             471


<210>  574

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  574

Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val 
1               5                   10                  15      


Leu Gln Ala 
            


<210>  575

<211>  137

<212>  PRT

<213>  Homo sapiens



<400>  575

Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln Ser Phe Gln 
1               5                   10                  15      


Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu Ala Gly Asn 
            20                  25                  30          


Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe Thr Ala Thr 
        35                  40                  45              


Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn Ala Met Thr 
    50                  55                  60                  


Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile Pro Ala Ala 
65                  70                  75                  80  


Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Asp Thr Arg Ala Gly 
                85                  90                  95      


Trp Pro Ser Ser Gly Ser Ala Cys Trp Ala Gly Ala Gly Cys Cys Leu 
            100                 105                 110         


Pro Gly Arg Trp Thr Ser Ser Ser Ala Trp Ala Glu Leu Arg Ala Ser 
        115                 120                 125             


Arg Met Thr Thr Leu Ser Ser Gln Met 
    130                 135         


<210>  576

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  576

Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu Ala Gly Asn 
1               5                   10                  15  


<210>  577

<211>  442

<212>  DNA

<213>  Homo sapiens



<400>  577
tccggaattc ccggtgtcag gctggggctg ccacccaggg caggctgctg aggtccaggg     60

cacctccagt cacatctggg aagacaatgt tgtcatccga gaggccctga gctctgccca    120

ggcagatgaa ctggtccagc gtcccgggag gcagcaacca gctcctgccc agcaggctga    180

tcctgaggac ggacagcctg ctcgtgtgtc tgcgggacag catcagggcg aactgggtgt    240

agtcgctgtc caccacccgg gtctcctctc tgtccgcccc gggctccaca ccgtggtcca    300

cagtgaactg cccaggctgg gctgccggta tcagcacata agaccatgtg tcacagtgct    360

ggcctcgagt catcgcattc cacacctcaa agcggccatc atcacttagc tcagaagttg    420

cggtgaaagc gttcagcagc gc                                             442


<210>  578

<211>  918

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (128)..(727)

<223>  



<400>  578
cccagcgccc aggaccgtgt ctgggaaaag gtctttgccc ggagagtggg aagagagagg     60

ggagggtgag cagaggacag gccgggagtt ttccgggaac ggaggaagag cagtggaggc    120

tgccagg atg agg ctg ctg tgt ggc ctg tgg ctg tgg ctc tcc ttg ctg      169
        Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu         
        1               5                   10                          

aaa gtc ctg cag gcc cag acc cca acc ccc ctg cca ctc ccg ccc ccg      217
Lys Val Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro         
15                  20                  25                  30          

atg cag agc ttc caa gga aac cag ttc cag ggg gaa tgg ttc gtc ctg      265
Met Gln Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu         
                35                  40                  45              

ggc ctg gcg ggc aac agc ttc agg ccg gag cac agg gcg ctg ctg aac      313
Gly Leu Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn         
            50                  55                  60                  

gct ttc acc gca act ttt gag cta agt gat gat ggc cgc ttt gag gtg      361
Ala Phe Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val         
        65                  70                  75                      

tgg aat gcg atg act cga ggc cag cac tgt gac aca tgg tct tat gtg      409
Trp Asn Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val         
    80                  85                  90                          

ctg ata ccg gca gcc cag cct ggg cag ttc act gtg gac cac ggt gtg      457
Leu Ile Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val         
95                  100                 105                 110         

gag ccc ggg gcg gac aga gag gag acc cgg gtg gtg gac agc gac tac      505
Glu Pro Gly Ala Asp Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr         
                115                 120                 125             

acc cag ttc gcc ctg atg ctg tcc cgc aga cac acg agc agg ctg gcc      553
Thr Gln Phe Ala Leu Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala         
            130                 135                 140                 

gtc ctc agg atc agc ctg ctg ggc agg agc tgg ttg ctg cct ccc ggg      601
Val Leu Arg Ile Ser Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly         
        145                 150                 155                     

acg ctg gac cag ttc atc tgc ctg ggc aga gct cag ggc ctc tcg gat      649
Thr Leu Asp Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp         
    160                 165                 170                         

gac aac att gtc ttc cca gat gtg act gga ggt gcc ctg gac ctc agc      697
Asp Asn Ile Val Phe Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser         
175                 180                 185                 190         

agc ctg ccc tgg gtg gca gcc cca gct tga ccactcagac agccgcggcc        747
Ser Leu Pro Trp Val Ala Ala Pro Ala                                     
                195                                                     

cccaaggcct gactcttctt gtgggagggc gaggctggtc accccaggcc agcgtctgtt    807

gaaggatgaa gcagctcctg tccggcccag ccctgcctca cagctgtgcg agctctgccc    867

tcctcagctc tcaaacctga ataaatgcac caagcccaga aaaaaaaaaa a             918


<210>  579

<211>  199

<212>  PRT

<213>  Homo sapiens



<400>  579

Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val 
1               5                   10                  15      


Leu Gln Ala Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln 
            20                  25                  30          


Ser Phe Gln Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu 
        35                  40                  45              


Ala Gly Asn Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe 
    50                  55                  60                  


Thr Ala Thr Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn 
65                  70                  75                  80  


Ala Met Thr Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile 
                85                  90                  95      


Pro Ala Ala Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Glu Pro 
            100                 105                 110         


Gly Ala Asp Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr Thr Gln 
        115                 120                 125             


Phe Ala Leu Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala Val Leu 
    130                 135                 140                 


Arg Ile Ser Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly Thr Leu 
145                 150                 155                 160 


Asp Gln Phe Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp Asp Asn 
                165                 170                 175     


Ile Val Phe Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser Ser Leu 
            180                 185                 190         


Pro Trp Val Ala Ala Pro Ala 
        195                 


<210>  580

<211>  600

<212>  DNA

<213>  Homo sapiens



<400>  580
atgaggctgc tgtgtggcct gtggctgtgg ctctccttgc tgaaagtcct gcaggcccag     60

accccaaccc ccctgccact cccgcccccg atgcagagct tccaaggaaa ccagttccag    120

ggggaatggt tcgtcctggg cctggcgggc aacagcttca ggccggagca cagggcgctg    180

ctgaacgctt tcaccgcaac ttttgagcta agtgatgatg gccgctttga ggtgtggaat    240

gcgatgactc gaggccagca ctgtgacaca tggtcttatg tgctgatacc ggcagcccag    300

cctgggcagt tcactgtgga ccacggtgtg gagcccgggg cggacagaga ggagacccgg    360

gtggtggaca gcgactacac ccagttcgcc ctgatgctgt cccgcagaca cacgagcagg    420

ctggccgtcc tcaggatcag cctgctgggc aggagctggt tgctgcctcc cgggacgctg    480

gaccagttca tctgcctggg cagagctcag ggcctctcgg atgacaacat tgtcttccca    540

gatgtgactg gaggtgccct ggacctcagc agcctgccct gggtggcagc cccagcttga    600


<210>  581

<211>  19

<212>  PRT

<213>  Homo sapiens



<400>  581

Met Arg Leu Leu Cys Gly Leu Trp Leu Trp Leu Ser Leu Leu Lys Val 
1               5                   10                  15      


Leu Gln Ala 
            


<210>  582

<211>  180

<212>  PRT

<213>  Homo sapiens



<400>  582

Gln Thr Pro Thr Pro Leu Pro Leu Pro Pro Pro Met Gln Ser Phe Gln 
1               5                   10                  15      


Gly Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu Ala Gly Asn 
            20                  25                  30          


Ser Phe Arg Pro Glu His Arg Ala Leu Leu Asn Ala Phe Thr Ala Thr 
        35                  40                  45              


Phe Glu Leu Ser Asp Asp Gly Arg Phe Glu Val Trp Asn Ala Met Thr 
    50                  55                  60                  


Arg Gly Gln His Cys Asp Thr Trp Ser Tyr Val Leu Ile Pro Ala Ala 
65                  70                  75                  80  


Gln Pro Gly Gln Phe Thr Val Asp His Gly Val Glu Pro Gly Ala Asp 
                85                  90                  95      


Arg Glu Glu Thr Arg Val Val Asp Ser Asp Tyr Thr Gln Phe Ala Leu 
            100                 105                 110         


Met Leu Ser Arg Arg His Thr Ser Arg Leu Ala Val Leu Arg Ile Ser 
        115                 120                 125             


Leu Leu Gly Arg Ser Trp Leu Leu Pro Pro Gly Thr Leu Asp Gln Phe 
    130                 135                 140                 


Ile Cys Leu Gly Arg Ala Gln Gly Leu Ser Asp Asp Asn Ile Val Phe 
145                 150                 155                 160 


Pro Asp Val Thr Gly Gly Ala Leu Asp Leu Ser Ser Leu Pro Trp Val 
                165                 170                 175     


Ala Ala Pro Ala 
            180 


<210>  583

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  583

Asn Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu Ala Gly 
1               5                   10                  


<210>  584

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  584

Val Asp Ser Asp Tyr Thr Gln Phe Ala Leu Met Leu Ser 
1               5                   10              


<210>  585

<211>  157

<212>  PRT

<213>  Mus musculus



<400>  585

Met Gln Phe Gln Gly Glu Trp Phe Val Leu Gly Leu Ala Asp Asn Thr 
1               5                   10                  15      


Phe Arg Arg Glu His Arg Ala Leu Leu Asn Phe Phe Thr Thr Leu Phe 
            20                  25                  30          


Glu Leu Lys Glu Lys Ser Gln Phe Gln Val Thr Asn Ser Met Thr Arg 
        35                  40                  45              


Gly Lys His Cys Asn Thr Trp Ser Tyr Thr Leu Ile Pro Ala Thr Lys 
    50                  55                  60                  


Pro Gly Gln Phe Thr Arg Asp Asn Arg Gly Ser Gly Pro Gly Ala Asp 
65                  70                  75                  80  


Arg Glu Asn Ile Gln Val Ile Glu Thr Asp Tyr Ile Thr Phe Ala Leu 
                85                  90                  95      


Val Leu Ser Leu Arg Gln Thr Ser Ser Gln Asn Ile Thr Arg Val Ser 
            100                 105                 110         


Leu Leu Gly Arg Asn Trp Arg Leu Ser His Lys Thr Ile Asp Lys Phe 
        115                 120                 125             


Ile Cys Leu Thr Arg Thr Gln Asn Leu Thr Lys Asp Asn Phe Leu Phe 
    130                 135                 140                 


Pro Asp Leu Ser Asp Trp Leu Pro Asp Pro Gln Val Cys 
145                 150                 155         


<210>  586

<211>  198

<212>  PRT

<213>  Homo sapiens



<400>  586

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  587

<211>  1640

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1629)

<223>  



<400>  587
atg gca cat cgt gat tct gag atg aaa gaa gaa tgt cta agg gaa gac       48
Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp         
1               5                   10                  15              

ctg aag ttt tac ttc atg agc cct tgt gaa aaa tac cga gcc aga cgc       96
Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg         
            20                  25                  30                  

cag att ccg tgg aaa ctg ggt ttg cag att ttg aag ata gtc atg gtc      144
Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val         
        35                  40                  45                      

acc aca cag ctt gtt cgt ttt ggt tta agt aac cag ctg gtg gtt gct      192
Thr Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala         
    50                  55                  60                          

ttc aaa gaa gat aac act gtt gct ttt aag cac ttg ttt ttg aaa gga      240
Phe Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly         
65                  70                  75                  80          

tat tct ggt aca gat gaa gat gac tac agc tgc agt gta tat act caa      288
Tyr Ser Gly Thr Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln         
                85                  90                  95              

gag gat gcc tat gag agc atc ttt ttt gct att aat cag tat cat cag      336
Glu Asp Ala Tyr Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln         
            100                 105                 110                 

cta aag gac att acc ctg ggg acc ctt ggt tat gga gaa aat gaa gac      384
Leu Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp         
        115                 120                 125                     

aat aga att ggc tta aaa gtc tgt aag cag cat tac aag aaa ggg acc      432
Asn Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr         
    130                 135                 140                         

atg ttt cct tct aat gag aca ctg aat att gac aac gac gtt gag ctc      480
Met Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu         
145                 150                 155                 160         

gat tgt gtt caa tta gac ctt cag gac ctc tcc aag aag cct ccg gac      528
Asp Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp         
                165                 170                 175             

tgg aag aac tca tca ttc ttc aga ctg gaa ttt tat cgg ctc tta cag      576
Trp Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln         
            180                 185                 190                 

gtt gaa atc tcc ttt cat ctt aaa ggc att gac cta cag aca att cat      624
Val Glu Ile Ser Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His         
        195                 200                 205                     

tcc cgt gag tta cca gac tgt tat gtc ttt cag aat acg gca agt atc      672
Ser Arg Glu Leu Pro Asp Cys Tyr Val Phe Gln Asn Thr Ala Ser Ile         
    210                 215                 220                         

ttt att atc ttt gac aat aaa gct cac agt ggc aaa atc aaa atc tat      720
Phe Ile Ile Phe Asp Asn Lys Ala His Ser Gly Lys Ile Lys Ile Tyr         
225                 230                 235                 240         

ttt gac agt gat gcc aaa att gaa gaa tgt aaa gac ttg aac ata ttt      768
Phe Asp Ser Asp Ala Lys Ile Glu Glu Cys Lys Asp Leu Asn Ile Phe         
                245                 250                 255             

gga tct act cag aaa aat gct cag tat gtc ctg gtg ttt gat gca ttt      816
Gly Ser Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe         
            260                 265                 270                 

gtc att gtg att tgc ttg gca tct ctt att ctg tgt aca aga tcc att      864
Val Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile         
        275                 280                 285                     

gtt ctt gct cta agg tta cgg aag aga ttt cta aat ttc ttc ctg gag      912
Val Leu Ala Leu Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu         
    290                 295                 300                         

aag tac aag cgg cct gtg tgt gac acc gac cag tgg gag ttc atc aac      960
Lys Tyr Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn         
305                 310                 315                 320         

ggc tgg tat gtc ctg gtg att atc agc gac cta atg aca atc att ggc     1008
Gly Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly         
                325                 330                 335             

tcc ata tta aaa atg gaa atc aaa gca aag aat ctc aca aac tat gat     1056
Ser Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp         
            340                 345                 350                 

ctc tgc agc att ttt ctt gga acc tct acg ctc ttg gtt tgg gtt gga     1104
Leu Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly         
        355                 360                 365                     

gtc atc aga tac ctg ggt tat ttc cag gca tat aat gtg ctg att tta     1152
Val Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu         
    370                 375                 380                         

aca atg cag gcc tca ctg cca aaa gtt ctt cgg ttt tgt gct tgt gct     1200
Thr Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala         
385                 390                 395                 400         

ggt atg att tat ctg ggt tac aca ttc tgt ggc tgg att gtc tta gga     1248
Gly Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly         
                405                 410                 415             

cca tac cat gac aag ttt gaa aat ctg aac aca gtt gct gag tgt ctg     1296
Pro Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu         
            420                 425                 430                 

ttt tct ctg gtc aac ggt gat gac atg ttt gca acc ttt gcc caa atc     1344
Phe Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile         
        435                 440                 445                     

cag cag aag agc atc ttg gtg tgg ctg ttc agt cgt ctg tat tta tat     1392
Gln Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr         
    450                 455                 460                         

tcc ttc atc agc ctt ttt ata tat atg att ctc agt ctt ttt att gca     1440
Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala         
465                 470                 475                 480         

ctt att aca gat tct tat gac acc att aag aaa ttc caa cag aat ggg     1488
Leu Ile Thr Asp Ser Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly         
                485                 490                 495             

ttt cct gaa acg gat ttg cag gaa ttc ctg aag gaa tgc agt agc aaa     1536
Phe Pro Glu Thr Asp Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys         
            500                 505                 510                 

gaa gag tat cag aaa gag tcc tca gcc ttc ctg tcc tgc atc tgc tgt     1584
Glu Glu Tyr Gln Lys Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys         
        515                 520                 525                     

cgg agg agg aaa aga agt gat gat cac ttg ata cct att agc taa         1629
Arg Arg Arg Lys Arg Ser Asp Asp His Leu Ile Pro Ile Ser                 
    530                 535                 540                         

agttctgcta a                                                        1640


<210>  588

<211>  542

<212>  PRT

<213>  Homo sapiens



<400>  588

Met Ala His Arg Asp Ser Glu Met Lys Glu Glu Cys Leu Arg Glu Asp 
1               5                   10                  15      


Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg 
            20                  25                  30          


Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val 
        35                  40                  45              


Thr Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala 
    50                  55                  60                  


Phe Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly 
65                  70                  75                  80  


Tyr Ser Gly Thr Asp Glu Asp Asp Tyr Ser Cys Ser Val Tyr Thr Gln 
                85                  90                  95      


Glu Asp Ala Tyr Glu Ser Ile Phe Phe Ala Ile Asn Gln Tyr His Gln 
            100                 105                 110         


Leu Lys Asp Ile Thr Leu Gly Thr Leu Gly Tyr Gly Glu Asn Glu Asp 
        115                 120                 125             


Asn Arg Ile Gly Leu Lys Val Cys Lys Gln His Tyr Lys Lys Gly Thr 
    130                 135                 140                 


Met Phe Pro Ser Asn Glu Thr Leu Asn Ile Asp Asn Asp Val Glu Leu 
145                 150                 155                 160 


Asp Cys Val Gln Leu Asp Leu Gln Asp Leu Ser Lys Lys Pro Pro Asp 
                165                 170                 175     


Trp Lys Asn Ser Ser Phe Phe Arg Leu Glu Phe Tyr Arg Leu Leu Gln 
            180                 185                 190         


Val Glu Ile Ser Phe His Leu Lys Gly Ile Asp Leu Gln Thr Ile His 
        195                 200                 205             


Ser Arg Glu Leu Pro Asp Cys Tyr Val Phe Gln Asn Thr Ala Ser Ile 
    210                 215                 220                 


Phe Ile Ile Phe Asp Asn Lys Ala His Ser Gly Lys Ile Lys Ile Tyr 
225                 230                 235                 240 


Phe Asp Ser Asp Ala Lys Ile Glu Glu Cys Lys Asp Leu Asn Ile Phe 
                245                 250                 255     


Gly Ser Thr Gln Lys Asn Ala Gln Tyr Val Leu Val Phe Asp Ala Phe 
            260                 265                 270         


Val Ile Val Ile Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile 
        275                 280                 285             


Val Leu Ala Leu Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu 
    290                 295                 300                 


Lys Tyr Lys Arg Pro Val Cys Asp Thr Asp Gln Trp Glu Phe Ile Asn 
305                 310                 315                 320 


Gly Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly 
                325                 330                 335     


Ser Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp 
            340                 345                 350         


Leu Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
        355                 360                 365             


Val Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu 
    370                 375                 380                 


Thr Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala 
385                 390                 395                 400 


Gly Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly 
                405                 410                 415     


Pro Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu 
            420                 425                 430         


Phe Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile 
        435                 440                 445             


Gln Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr 
    450                 455                 460                 


Ser Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala 
465                 470                 475                 480 


Leu Ile Thr Asp Ser Tyr Asp Thr Ile Lys Lys Phe Gln Gln Asn Gly 
                485                 490                 495     


Phe Pro Glu Thr Asp Leu Gln Glu Phe Leu Lys Glu Cys Ser Ser Lys 
            500                 505                 510         


Glu Glu Tyr Gln Lys Glu Ser Ser Ala Phe Leu Ser Cys Ile Cys Cys 
        515                 520                 525             


Arg Arg Arg Lys Arg Ser Asp Asp His Leu Ile Pro Ile Ser 
    530                 535                 540         


<210>  589

<211>  1629

<212>  DNA

<213>  Homo sapiens



<400>  589
atggcacatc gtgattctga gatgaaagaa gaatgtctaa gggaagacct gaagttttac     60

ttcatgagcc cttgtgaaaa ataccgagcc agacgccaga ttccgtggaa actgggtttg    120

cagattttga agatagtcat ggtcaccaca cagcttgttc gttttggttt aagtaaccag    180

ctggtggttg ctttcaaaga agataacact gttgctttta agcacttgtt tttgaaagga    240

tattctggta cagatgaaga tgactacagc tgcagtgtat atactcaaga ggatgcctat    300

gagagcatct tttttgctat taatcagtat catcagctaa aggacattac cctggggacc    360

cttggttatg gagaaaatga agacaataga attggcttaa aagtctgtaa gcagcattac    420

aagaaaggga ccatgtttcc ttctaatgag acactgaata ttgacaacga cgttgagctc    480

gattgtgttc aattagacct tcaggacctc tccaagaagc ctccggactg gaagaactca    540

tcattcttca gactggaatt ttatcggctc ttacaggttg aaatctcctt tcatcttaaa    600

ggcattgacc tacagacaat tcattcccgt gagttaccag actgttatgt ctttcagaat    660

acggcaagta tctttattat ctttgacaat aaagctcaca gtggcaaaat caaaatctat    720

tttgacagtg atgccaaaat tgaagaatgt aaagacttga acatatttgg atctactcag    780

aaaaatgctc agtatgtcct ggtgtttgat gcatttgtca ttgtgatttg cttggcatct    840

cttattctgt gtacaagatc cattgttctt gctctaaggt tacggaagag atttctaaat    900

ttcttcctgg agaagtacaa gcggcctgtg tgtgacaccg accagtggga gttcatcaac    960

ggctggtatg tcctggtgat tatcagcgac ctaatgacaa tcattggctc catattaaaa   1020

atggaaatca aagcaaagaa tctcacaaac tatgatctct gcagcatttt tcttggaacc   1080

tctacgctct tggtttgggt tggagtcatc agatacctgg gttatttcca ggcatataat   1140

gtgctgattt taacaatgca ggcctcactg ccaaaagttc ttcggttttg tgcttgtgct   1200

ggtatgattt atctgggtta cacattctgt ggctggattg tcttaggacc ataccatgac   1260

aagtttgaaa atctgaacac agttgctgag tgtctgtttt ctctggtcaa cggtgatgac   1320

atgtttgcaa cctttgccca aatccagcag aagagcatct tggtgtggct gttcagtcgt   1380

ctgtatttat attccttcat cagccttttt atatatatga ttctcagtct ttttattgca   1440

cttattacag attcttatga caccattaag aaattccaac agaatgggtt tcctgaaacg   1500

gatttgcagg aattcctgaa ggaatgcagt agcaaagaag agtatcagaa agagtcctca   1560

gccttcctgt cctgcatctg ctgtcggagg aggaaaagaa gtgatgatca cttgatacct   1620

attagctaa                                                           1629


<210>  590

<211>  161

<212>  PRT

<213>  Homo sapiens



<400>  590

Trp Tyr Val Leu Val Ile Ile Ser Asp Leu Met Thr Ile Ile Gly Ser 
1               5                   10                  15      


Ile Leu Lys Met Glu Ile Lys Ala Lys Asn Leu Thr Asn Tyr Asp Leu 
            20                  25                  30          


Cys Ser Ile Phe Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly Val 
        35                  40                  45              


Ile Arg Tyr Leu Gly Tyr Phe Gln Ala Tyr Asn Val Leu Ile Leu Thr 
    50                  55                  60                  


Met Gln Ala Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly 
65                  70                  75                  80  


Met Ile Tyr Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro 
                85                  90                  95      


Tyr His Asp Lys Phe Glu Asn Leu Asn Thr Val Ala Glu Cys Leu Phe 
            100                 105                 110         


Ser Leu Val Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln 
        115                 120                 125             


Gln Lys Ser Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser 
    130                 135                 140                 


Phe Ile Ser Leu Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu 
145                 150                 155                 160 


Ile 
    


<210>  591

<211>  538

<212>  PRT

<213>  Mus musculus



<400>  591

Met Ala Ser Leu Asp Ser Glu Val Arg Glu Glu Cys Leu Arg Glu Asp 
1               5                   10                  15      


Leu Lys Phe Tyr Phe Met Ser Pro Cys Glu Lys Tyr Arg Ala Arg Arg 
            20                  25                  30          


Gln Ile Pro Trp Lys Leu Gly Leu Gln Ile Leu Lys Ile Val Met Val 
        35                  40                  45              


Thr Thr Gln Leu Val Arg Phe Gly Leu Ser Asn Gln Leu Val Val Ala 
    50                  55                  60                  


Phe Lys Glu Asp Asn Thr Val Ala Phe Lys His Leu Phe Leu Lys Gly 
65                  70                  75                  80  


Phe Ser Gly Val Asp Glu Asp Asp Tyr Ser Cys Ser Ile Tyr Thr Gln 
                85                  90                  95      


Glu Asn Thr Tyr Glu Ser Ile Phe Phe Ala Ile Lys Gln Tyr Arg His 
            100                 105                 110         


Leu Lys Asn Ile Ser Leu Ala Thr Leu Gly Tyr Gly Glu Ser Glu Asp 
        115                 120                 125             


Asn Arg Thr Gly Leu Lys Val Cys Lys Gln His Tyr Lys Thr Gly Ala 
    130                 135                 140                 


Met Phe Ser Ser Asn Glu Thr Leu Asn Ile Asp Ser Asp Ile Glu Thr 
145                 150                 155                 160 


Asp Cys Ile His Leu Asp Leu Gln Val Leu Thr Thr Glu Pro Glu Asp 
                165                 170                 175     


Trp Ala Gln Thr Ser Phe Phe Arg Leu Asp Phe Tyr Arg Leu Val Gln 
            180                 185                 190         


Val Asp Ile Ser Phe Ala Leu Lys Gly Ile Asp Leu Gln Ala Val His 
        195                 200                 205             


Ser Arg Glu Ile Pro Asp Cys Tyr Leu Phe Gln Asn Thr Ile Thr Phe 
    210                 215                 220                 


Asp Asn Thr Ala His Ser Gly Lys Ile Lys Ile Tyr Leu Asn Ser Glu 
225                 230                 235                 240 


Ala Asn Ile Glu Glu Cys Lys Asn Met Asn Ile Ser Gly Ser Thr Gln 
                245                 250                 255     


Arg Ser Thr His Tyr Leu Leu Val Phe Asp Val Phe Val Ile Met Ile 
            260                 265                 270         


Cys Leu Ala Ser Leu Ile Leu Cys Thr Arg Ser Ile Val Leu Ala Leu 
        275                 280                 285             


Arg Leu Arg Lys Arg Phe Leu Asn Phe Phe Leu Glu Lys Tyr Lys Gln 
    290                 295                 300                 


Arg Val Cys Gly Ala Asp Gln Trp Glu Phe Val Asn Gly Trp Tyr Val 
305                 310                 315                 320 


Leu Val Thr Ile Ser Asp Leu Met Thr Ile Ile Gly Ser Ile Leu Lys 
                325                 330                 335     


Met Glu Ile Lys Ala Lys Lys Leu Thr Asn Tyr Asp Val Cys Ser Ile 
            340                 345                 350         


Leu Leu Gly Thr Ser Thr Leu Phe Val Trp Val Gly Val Ile Arg Tyr 
        355                 360                 365             


Leu Gly Tyr Phe Gln Thr Tyr Asn Val Leu Ile Leu Thr Met Gln Ala 
    370                 375                 380                 


Ser Leu Pro Lys Val Leu Arg Phe Cys Ala Cys Ala Gly Met Ile Tyr 
385                 390                 395                 400 


Leu Gly Tyr Thr Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Glu 
                405                 410                 415     


Lys Phe Glu Asn Leu Asn Ile Val Ala Glu Cys Leu Phe Ser Leu Val 
            420                 425                 430         


Asn Gly Asp Asp Met Phe Ala Thr Phe Ala Gln Ile Gln Gln Lys Ser 
        435                 440                 445             


Ile Leu Val Trp Leu Phe Ser Arg Leu Tyr Leu Tyr Ser Phe Ile Ser 
    450                 455                 460                 


Leu Phe Ile Tyr Met Val Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp 
465                 470                 475                 480 


Ser Tyr His Thr Ile Lys Lys Tyr Gln Gln His Gly Phe Pro Glu Thr 
                485                 490                 495     


Asp Leu Gln Lys Phe Leu Lys Glu Ser Gly Ser Lys Asp Gly Tyr Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Leu Leu Ser Cys Leu Cys Cys Leu Arg Arg Arg 
        515                 520                 525             


Arg Ser Asn Asp His Leu Ile Leu Ile Asp 
    530                 535             


<210>  592

<211>  580

<212>  PRT

<213>  Homo sapiens



<400>  592

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Ser Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  593

<211>  497

<212>  PRT

<213>  Homo sapiens



<400>  593

Met Ala Asp Pro Glu Val Val Val Cys Ser Cys Ser Ser His Glu Glu 
1               5                   10                  15      


Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu 
            20                  25                  30          


Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn 
        35                  40                  45              


Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala 
    50                  55                  60                  


Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Tyr Leu Gln Leu 
65                  70                  75                  80  


Tyr Asn Val Ser Val Gly Asn His Ala Tyr Glu Asn Lys Gly Thr Lys 
                85                  90                  95      


Gln Ser Ala Met Ala Ile Cys Gln His Phe Tyr Lys Arg Gly Asn Ile 
            100                 105                 110         


Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp Pro Glu Ile Glu Thr Glu 
        115                 120                 125             


Cys Phe Phe Val Glu Pro Asp Glu Pro Phe His Ile Gly Thr Pro Ala 
    130                 135                 140                 


Glu Asn Lys Leu Asn Leu Thr Leu Asp Phe His Arg Leu Leu Thr Val 
145                 150                 155                 160 


Glu Leu Gln Phe Lys Leu Lys Ala Ile Asn Leu Gln Thr Val Arg His 
                165                 170                 175     


Gln Glu Leu Pro Asp Cys Tyr Asp Phe Thr Leu Thr Ile Thr Phe Asp 
            180                 185                 190         


Asn Lys Ala His Ser Gly Arg Ile Lys Ile Ser Leu Asp Asn Asp Ile 
        195                 200                 205             


Ser Ile Arg Glu Cys Lys Asp Trp His Val Ser Gly Ser Ile Gln Lys 
    210                 215                 220                 


Asn Thr His Tyr Met Met Ile Phe Asp Ala Phe Val Ile Leu Thr Cys 
225                 230                 235                 240 


Leu Val Ser Leu Ile Leu Cys Ile Arg Ser Val Ile Arg Gly Leu Gln 
                245                 250                 255     


Leu Gln Gln Glu Phe Val Asn Phe Phe Leu Leu His Tyr Lys Lys Glu 
            260                 265                 270         


Val Ser Val Ser Asp Gln Met Glu Phe Val Asn Gly Trp Tyr Ile Met 
        275                 280                 285             


Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile Gly Ser Ile Leu Lys Met 
    290                 295                 300                 


Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr Asp Val Cys Ser Ile Leu 
305                 310                 315                 320 


Leu Gly Thr Ser Thr Met Leu Val Trp Leu Gly Val Ile Arg Tyr Leu 
                325                 330                 335     


Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile Leu Thr Leu Gln Ala Ala 
            340                 345                 350         


Leu Pro Asn Val Ile Arg Phe Cys Cys Cys Ala Ala Met Ile Tyr Leu 
        355                 360                 365             


Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys 
    370                 375                 380                 


Phe Arg Ser Leu Asn Met Val Ser Glu Cys Leu Phe Ser Leu Ile Asn 
385                 390                 395                 400 


Gly Asp Asp Met Phe Ala Thr Phe Ala Lys Met Gln Gln Lys Ser Tyr 
                405                 410                 415     


Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu Tyr Ser Phe Ile Ser Leu 
            420                 425                 430         


Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Thr 
        435                 440                 445             


Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp Gly Phe Pro Glu Thr Glu 
    450                 455                 460                 


Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp Leu Pro Asn Ser Gly Lys 
465                 470                 475                 480 


Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser Leu Phe Cys Cys Cys Lys 
                485                 490                 495     


Lys 
    


<210>  594

<211>  580

<212>  PRT

<213>  Homo sapiens



<400>  594

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Pro Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  595

<211>  671

<212>  PRT

<213>  Caenorhabditis elegans



<400>  595

Ala Ala Ser Met Ser Arg Arg Ser Thr Thr Asp Arg Ser Asp Phe Asn 
1               5                   10                  15      


Asp Asn Ala Ser Asn Ala Ser Ser Asn Ala Ser Arg Arg Pro Thr Ile 
            20                  25                  30          


Asn Phe Gln Glu Ile Met Glu Asp Leu Pro His His Glu Arg Glu Thr 
        35                  40                  45              


Gly Glu Arg Leu Arg Arg His Leu Gln Phe Phe Phe Met Asn Pro Met 
    50                  55                  60                  


Glu Lys Trp Lys Val Arg His Gln Leu Pro Tyr Lys Leu Val Leu Gln 
65                  70                  75                  80  


Val Leu Lys Ile Val Phe Val Thr Met Gln Leu Ile Leu Phe Ala Glu 
                85                  90                  95      


Met Arg Met Ser His Val Asp Phe Leu Glu Asp Thr Thr Thr Val Met 
            100                 105                 110         


Arg His Arg Phe Leu Lys Glu Trp Asn Asp Asp Arg Asp Ala Leu Gln 
        115                 120                 125             


Tyr Pro Pro Ala Glu Gly Arg Tyr Ser Val Tyr Asp Asp Gln Gly Leu 
    130                 135                 140                 


Ser Glu His Leu Ser Phe Leu Ile Asn Ser Tyr Tyr Ser Ile Arg Asn 
145                 150                 155                 160 


Asp Ser Phe Ala Ser Phe Ser Tyr Asp Val Val Ser His Pro Ser Gly 
                165                 170                 175     


Asn Leu Gly Ala Gln Ile Ser Phe Glu Ser Ile Pro Pro Ile Glu Val 
            180                 185                 190         


Leu Ile Asp Arg Ile Ser Asn Val Thr Val Asn Asn Asn Thr Tyr Asn 
        195                 200                 205             


Phe Asp Ile Arg Glu Val Lys Asp Thr Lys Arg Leu Asn Leu Thr Glu 
    210                 215                 220                 


Thr Glu Val Phe Gln Ile Gly Gln Ser Asp Asp Ala Val Arg Asp Ile 
225                 230                 235                 240 


Leu Ala Thr Arg Gly Ile Thr Phe Leu Pro Glu Asp Ala Leu Lys Ile 
                245                 250                 255     


Ser Thr Val Gln Phe Lys Phe Arg Leu Arg Thr Ile His Tyr Ser Pro 
            260                 265                 270         


Thr Ala Gly Asp Gln Lys Pro Glu Cys Tyr Lys Ile Ser Val Ser Ile 
        275                 280                 285             


Lys Phe Asp Asn Ser Arg His Thr Gly Gln Val His Val Thr Leu Ser 
    290                 295                 300                 


Thr Val Val Ser Tyr Val Asn Val Cys Asn Gly Arg Ile Ile Lys Gly 
305                 310                 315                 320 


Gln Val Ser Gly Val Gly Trp Ser Phe Asp Thr Leu Leu Ile Gly Gly 
                325                 330                 335     


Thr Asp Ile Phe Val Leu Ile Leu Cys Ile Leu Ser Leu Ile Leu Cys 
            340                 345                 350         


Cys Arg Ala Leu Ile Lys Ala His Leu Leu Gln Ile Lys Thr Ser Asp 
        355                 360                 365             


Tyr Phe Glu Asn Val Leu Lys Asn Lys Ile Thr Val Thr Asp Gln Leu 
    370                 375                 380                 


Asp Phe Leu Asn Leu Trp Tyr Val Met Ile Val Val Asn Asp Ala Leu 
385                 390                 395                 400 


Ile Ile Ile Gly Thr Val Ala Lys Ile Ser Ile Glu Phe Gln Asp Phe 
                405                 410                 415     


Asp Asn Ser Leu Phe Thr Leu Thr Ser Ile Phe Leu Gly Met Gly Ala 
            420                 425                 430         


Leu Leu Val Tyr Val Gly Val Leu Arg Tyr Phe Gly Phe Phe Ser Gln 
        435                 440                 445             


Tyr Asn Ile Leu Met Leu Thr Leu Lys Arg Ser Ala Pro Asn Ile Met 
    450                 455                 460                 


Arg Phe Met Thr Cys Ala Ile Val Leu Tyr Ala Gly Phe Leu Ile Ala 
465                 470                 475                 480 


Gly Trp Val Ile Ile Gly Pro Tyr Ser Met Lys Phe Arg Thr Leu Ala 
                485                 490                 495     


Glu Ser Ser Glu Ala Leu Phe Ser Leu Leu Asn Gly Asp Asp Met Phe 
            500                 505                 510         


Ala Thr Phe Tyr Thr Ile Asn Asp Ser Asn Thr Val Ile Lys Val Phe 
        515                 520                 525             


Gly Thr Val Tyr Ile Tyr Leu Phe Val Ser Leu Phe Ile Tyr Val Val 
    530                 535                 540                 


Leu Ser Leu Phe Ile Ala Ile Ile Met Asp Ala Tyr Glu Val Val Lys 
545                 550                 555                 560 


Asp Arg Tyr Ser Asp Gly Leu Arg Ala Ile Glu Lys Arg Gly Cys Leu 
                565                 570                 575     


Arg Asp Phe Val Glu Ser Asn Pro Pro Pro Ser Glu Leu Gly Ser Pro 
            580                 585                 590         


Thr Thr Arg Ser Ala Tyr Ala Pro Ser Asn Leu Leu Asn Leu Ala Ala 
        595                 600                 605             


Gly Asn Asp Ser Ser Arg Ala Leu Arg Ala Leu His Ala Ile Asp Asn 
    610                 615                 620                 


Ala Arg Asp Trp Leu Ser Ser Leu Arg Asp Gly Thr Arg Phe Gln Ser 
625                 630                 635                 640 


Phe Ser Asn Pro Leu Asn Asp Ser Asn Glu Asp Val Leu Ala Asp Gln 
                645                 650                 655     


Asn Ala Asn Gly Asn Asp Pro His Asn Ser Arg Pro Ser Asn Val 
            660                 665                 670     


<210>  596

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  596

Lys His Leu Phe Leu Lys Gly Tyr Ser Gly Thr Asp Glu Asp Asp Tyr 
1               5                   10                  15      


Ser 
    


<210>  597

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  597

Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly Ala Asp Asp Thr 
1               5                   10                  15  


<210>  598

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  598

Asp Asn Val His Leu Leu Gly Tyr Ser Leu Gly Ala Met Ala Ala 
1               5                   10                  15  


<210>  599

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  599

Ser His Val His Leu Ile Gly Tyr Ser Leu Gly Ala Met Ala Ala 
1               5                   10                  15  


<210>  600

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  600

Lys Pro Val Phe Leu Ile Gly His Ser Leu Gly Cys Leu His Leu 
1               5                   10                  15  


<210>  601

<211>  4962

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (261)..(4784)

<223>  



<400>  601
atgcatcaag aagggtacgg aggtcgaata cactacaacc gccccccagt gtgttggaat     60

tcgcctttaa gcagtggtat ccctgcagag tacgcgggga gtccagcagc caccatcacc    120

accactgcgg ttgctgctgc agctgcagct gctgctctcc ctccggctgc ttcttcgcgt    180

ggccagcagc gaatggagcg atggagccca gactgttctg ctggaccact ctctttctcc    240

tggccgggtg gtgcctgcca ggg ttg ccc tgc ccc agc cgg tgc ctt tgc ttt    293
                      Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe       
                      1               5                   10            

aag agc acc gtc cgc tgc atg cac ttg atg ctg gac cac att cct cag      341
Lys Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln         
            15                  20                  25                  

gta cca cag cag acc aca gtt cta gac ttg agg ttt aac aga ata aga      389
Val Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg         
        30                  35                  40                      

gaa att cca ggg agc gcc ttc aag aaa ctc aag aat ttg aac aca ctt      437
Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu         
    45                  50                  55                          

tac ctg tat aag aac cac atc aga aag att tcc aga aat gct ttt gaa      485
Tyr Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu         
60                  65                  70                  75          

gga ctt gaa aat ttg cta tat ctg tat att cat ttc aac caa cta gaa      533
Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu         
                80                  85                  90              

atg cta cag cca gag acc ttt gga gac ctt ctg aga tta gag cga cta      581
Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu         
            95                  100                 105                 

ttt ttg cat aac aac aaa tta tct aaa att cca gct ggg agc ttt tct      629
Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser         
        110                 115                 120                     

aat ctg gat tca tta aaa aga ttg cgt ctg gat tcc aac gcc ctg gtt      677
Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val         
    125                 130                 135                         

tgt gac tgt gat ctg atg tgg ctg ggg gag ctt tta caa ggc ttt gcc      725
Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala         
140                 145                 150                 155         

caa cac ggc cac acc cag gct gcg gct acc tgc gaa tat ccc agg aga      773
Gln His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg         
                160                 165                 170             

ctc cat ggg cgt gca gtt gct tca gta aca gta gag gaa ttc aat tgc      821
Leu His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys         
            175                 180                 185                 

cag agc ccc cga att act ttt gag ccg cag gat gtg gag gta cca tca      869
Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser         
        190                 195                 200                     

gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga aac ccc aaa cct      917
Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro         
    205                 210                 215                         

gag att att tgg ata cac aac aac cac tca ttg gat ttg gaa gat gat      965
Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp         
220                 225                 230                 235         

act cga ctt aat gtg ttt gat gat ggc aca ctc atg atc cga aac acc     1013
Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr         
                240                 245                 250             

aga gag tca gac caa ggt gtc tat cag tgc atg gcc aga aat tcc gct     1061
Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala         
            255                 260                 265                 

ggg gaa gcc aag aca cag agt gcc atg ctc aga tac tcc agt ctt cca     1109
Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro         
        270                 275                 280                     

gcc aaa cca ggc ttt gta atc cag cct cag gac aca gag gtt tta act     1157
Ala Lys Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Thr         
    285                 290                 295                         

ggc acc agc aca act ttg gaa tgt atg gcc aca ggc cac cca cac cct     1205
Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro         
300                 305                 310                 315         

ctt atc act tgg acc agg gac aat gga ttg gag ttg gat gga tcc agg     1253
Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg         
                320                 325                 330             

cat gtg gca acg tcc agt gga ctt tac tta cag aac atc aca caa cgg     1301
His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg         
            335                 340                 345                 

gat cat ggt cga ttt acc tgt cat gcc aac aat agc cac ggc act gtt     1349
Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val         
        350                 355                 360                     

caa gct gca gca aac ata att gta caa gct cct cca caa ttt aca gta     1397
Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val         
    365                 370                 375                         

acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct gta gag tgg ctc     1445
Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu         
380                 385                 390                 395         

tgt gaa gct gac ggc aac cca cct cct gtt att gtc tgg aca aaa aca     1493
Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr         
                400                 405                 410             

ggt att aga aca tct gca gga ggg cag ctc cct gtg gaa ggc cag cat     1541
Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln His         
            415                 420                 425                 

aca gtt ctc tcc tct ggc act ttg aga att gac cgt gca gca cag cac     1589
Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His         
        430                 435                 440                     

gat caa ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg aaa     1637
Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys         
    445                 450                 455                         

aag gtg tct gtg cag ctg act gta aaa ccc aaa ggc cct agc agc aac     1685
Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser Asn         
460                 465                 470                 475         

act aag aca gct gga aaa gcc ccc tta ata ccc tgc tgt gtt ttc agg     1733
Thr Lys Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe Arg         
                480                 485                 490             

ccc ttc ctg gtc tca gct ctt gca gtg ttt act caa ctt cct cag gat     1781
Pro Phe Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp         
            495                 500                 505                 

aca agt gtc gag gtt gga aag aat ata aac att tca tgt cat gct caa     1829
Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln         
        510                 515                 520                     

gga gaa cca cag ccc ata att act tgg aat aag gaa ggt gtg aag att     1877
Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys Ile         
    525                 530                 535                         

act gag agt ggt aaa ttc cat gtg gat gat gaa ggc acg ttg act atc     1925
Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile         
540                 545                 550                 555         

tac gac gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct cgg     1973
Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg         
                560                 565                 570             

aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg ggc     2021
Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Gly         
            575                 580                 585                 

tgt gac cag tat tgg ggg ttg ggg acc tct gtc ata gga tct tcg aac     2069
Cys Asp Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser Asn         
        590                 595                 600                     

ctc agt gag gag cac gga ttt att ctg aag gcg ctg ggg ttg gga acc     2117
Leu Ser Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly Thr         
    605                 610                 615                         

cct ggt cta gct ata cag ggt aga caa gct ggc gat gac ttt gtt gaa     2165
Pro Gly Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu         
620                 625                 630                 635         

tct tcc att ctt gat gct gta cag aga gtt gac agt gca att aac tcc     2213
Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser         
                640                 645                 650             

aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt gac ctg     2261
Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu         
            655                 660                 665                 

ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg gca     2309
Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala         
        670                 675                 680                     

aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa cgt     2357
Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg         
    685                 690                 695                         

gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg tac     2405
Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr         
700                 705                 710                 715         

aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta tct     2453
Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser         
                720                 725                 730             

gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt ttc     2501
Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe         
            735                 740                 745                 

cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag cag     2549
His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln         
        750                 755                 760                     

ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag cca     2597
Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro         
    765                 770                 775                         

gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct gtg     2645
Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val         
780                 785                 790                 795         

ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg tgg     2693
Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp         
                800                 805                 810             

gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg ctc     2741
Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu         
            815                 820                 825                 

atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg cct     2789
Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro         
        830                 835                 840                     

gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc gtc     2837
Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val         
    845                 850                 855                         

tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc gac     2885
Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp         
860                 865                 870                 875         

ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc ccc     2933
Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro         
                880                 885                 890             

gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat gca     2981
Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala         
            895                 900                 905                 

cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac gtt     3029
Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val         
        910                 915                 920                     

tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg gtg     3077
Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val         
    925                 930                 935                         

cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc gga aag     3125
Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys         
940                 945                 950                 955         

ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg cga cag     3173
Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln         
                960                 965                 970             

gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc aac gag     3221
Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu         
            975                 980                 985                 

cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg  gaa cac aac    3269
His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg  Glu His Asn        
        990                 995                 1000                    

agg gtg  gcc acg gag ctg tcc  gcc ctg aac ccc cac  tgg gag gga      3314
Arg Val  Ala Thr Glu Leu Ser  Ala Leu Asn Pro His  Trp Glu Gly          
    1005                 1010                 1015                      

aac acg  gtt tac cag gaa gcc  agg aag atc gtg ggc  gcg gag ctg      3359
Asn Thr  Val Tyr Gln Glu Ala  Arg Lys Ile Val Gly  Ala Glu Leu          
    1020                 1025                 1030                      

cag cac  atc acc tac agc cac  tgg ctg cct aag gtc  ctg ggg gac      3404
Gln His  Ile Thr Tyr Ser His  Trp Leu Pro Lys Val  Leu Gly Asp          
    1035                 1040                 1045                      

cct ggc  act agg atg ctg agg  ggt tac cga ggc tac  aac ccc aac      3449
Pro Gly  Thr Arg Met Leu Arg  Gly Tyr Arg Gly Tyr  Asn Pro Asn          
    1050                 1055                 1060                      

gtg aat  gca ggc atc att aac  tct ttt gct act gca  gcc ttt aga      3494
Val Asn  Ala Gly Ile Ile Asn  Ser Phe Ala Thr Ala  Ala Phe Arg          
    1065                 1070                 1075                      

ttt ggc  cac aca tta atc aat  cct att ctt tac cga  ctg aat gcc      3539
Phe Gly  His Thr Leu Ile Asn  Pro Ile Leu Tyr Arg  Leu Asn Ala          
    1080                 1085                 1090                      

acc tta  ggt gaa att tcc gaa  ggc cac ctt ccg ttc  cat aaa gcg      3584
Thr Leu  Gly Glu Ile Ser Glu  Gly His Leu Pro Phe  His Lys Ala          
    1095                 1100                 1105                      

ctc ttt  tca ccg tcc aga ata  atc aag gaa ggt ggg  ata gac ccg      3629
Leu Phe  Ser Pro Ser Arg Ile  Ile Lys Glu Gly Gly  Ile Asp Pro          
    1110                 1115                 1120                      

gtt ctc  cgg ggg ctg ttt ggc  gtg gct gct aaa tgg  cgg gca ccc      3674
Val Leu  Arg Gly Leu Phe Gly  Val Ala Ala Lys Trp  Arg Ala Pro          
    1125                 1130                 1135                      

tcc tac  ctt ctc agt cct gag  ctg acc cag agg ctc  ttc tcc gcg      3719
Ser Tyr  Leu Leu Ser Pro Glu  Leu Thr Gln Arg Leu  Phe Ser Ala          
    1140                 1145                 1150                      

gct tat  tct gcg gcc gtg gat  tcg gct gcc acc atc  att caa agg      3764
Ala Tyr  Ser Ala Ala Val Asp  Ser Ala Ala Thr Ile  Ile Gln Arg          
    1155                 1160                 1165                      

ggt aga  gac cac ggg atc cca  cca tat gtt gac ttc  aga gtt ttc      3809
Gly Arg  Asp His Gly Ile Pro  Pro Tyr Val Asp Phe  Arg Val Phe          
    1170                 1175                 1180                      

tgt aat  ttg act tca gtt aag  aac ttt gag gat ctt  caa aat gaa      3854
Cys Asn  Leu Thr Ser Val Lys  Asn Phe Glu Asp Leu  Gln Asn Glu          
    1185                 1190                 1195                      

att aaa  gat tca gag att aga  caa aaa ctg aga aag  ttg tac ggc      3899
Ile Lys  Asp Ser Glu Ile Arg  Gln Lys Leu Arg Lys  Leu Tyr Gly          
    1200                 1205                 1210                      

tct cca  ggt gac att gac ctc  tgg ccc gcc ctt atg  gtt gaa gac      3944
Ser Pro  Gly Asp Ile Asp Leu  Trp Pro Ala Leu Met  Val Glu Asp          
    1215                 1220                 1225                      

ctg att  cct ggt aca aga gtg  gga cca aca ctt atg  tgc ctg ttt      3989
Leu Ile  Pro Gly Thr Arg Val  Gly Pro Thr Leu Met  Cys Leu Phe          
    1230                 1235                 1240                      

gtt acc  cag ttt cag cgg cta  aga gat gga gat agg  ttc tgg tat      4034
Val Thr  Gln Phe Gln Arg Leu  Arg Asp Gly Asp Arg  Phe Trp Tyr          
    1245                 1250                 1255                      

gaa aac  cct gga gta ttt acc  ccg gca caa ctc act  cag ctg aag      4079
Glu Asn  Pro Gly Val Phe Thr  Pro Ala Gln Leu Thr  Gln Leu Lys          
    1260                 1265                 1270                      

cag gcg  tcc ctg agc cgg gtg  ctt tgt gac aat ggt  gac agc att      4124
Gln Ala  Ser Leu Ser Arg Val  Leu Cys Asp Asn Gly  Asp Ser Ile          
    1275                 1280                 1285                      

cag caa  gtg cag gct gat gtc  ttt gta aag gca gaa  tac cca cag      4169
Gln Gln  Val Gln Ala Asp Val  Phe Val Lys Ala Glu  Tyr Pro Gln          
    1290                 1295                 1300                      

gat tac  ctg aac tgc agc gag  atc ccg aag gtg gac  ctg cga gtg      4214
Asp Tyr  Leu Asn Cys Ser Glu  Ile Pro Lys Val Asp  Leu Arg Val          
    1305                 1310                 1315                      

tgg caa  gac tgc tgt gca gac  tgt agg agt aga gga  cag ttc aga      4259
Trp Gln  Asp Cys Cys Ala Asp  Cys Arg Ser Arg Gly  Gln Phe Arg          
    1320                 1325                 1330                      

gca gtg  acg caa gag tct caa  aag aaa cgc tca gct  caa tac agc      4304
Ala Val  Thr Gln Glu Ser Gln  Lys Lys Arg Ser Ala  Gln Tyr Ser          
    1335                 1340                 1345                      

tat cct  gtt gat aag gat atg  gag tta agt cat cta  aga agt agg      4349
Tyr Pro  Val Asp Lys Asp Met  Glu Leu Ser His Leu  Arg Ser Arg          
    1350                 1355                 1360                      

caa caa  gat aaa ata tat gtg  ggt gaa gat gct aga  aat gtg aca      4394
Gln Gln  Asp Lys Ile Tyr Val  Gly Glu Asp Ala Arg  Asn Val Thr          
    1365                 1370                 1375                      

gtt ctg  gca aaa aca aag ttc  tcc caa gat ttc agc  acg ttt gca      4439
Val Leu  Ala Lys Thr Lys Phe  Ser Gln Asp Phe Ser  Thr Phe Ala          
    1380                 1385                 1390                      

gcg gaa  att cag gaa acc atc  aca gca ctc aga gag  cag ata aac      4484
Ala Glu  Ile Gln Glu Thr Ile  Thr Ala Leu Arg Glu  Gln Ile Asn          
    1395                 1400                 1405                      

aag ctg  gag gca cgc ctg agg  cag gca ggg tgt aca  gat gtt aga      4529
Lys Leu  Glu Ala Arg Leu Arg  Gln Ala Gly Cys Thr  Asp Val Arg          
    1410                 1415                 1420                      

ggg gtt  cca agg aag gcc gag  gag cgc tgg atg aaa  gaa gac tgc      4574
Gly Val  Pro Arg Lys Ala Glu  Glu Arg Trp Met Lys  Glu Asp Cys          
    1425                 1430                 1435                      

act cac  tgc att tgt gag agt  ggc cag gtc acc tgt  gtg gtg gag      4619
Thr His  Cys Ile Cys Glu Ser  Gly Gln Val Thr Cys  Val Val Glu          
    1440                 1445                 1450                      

att tgt  ccc ccg gct ccc tgt  ccc agt cct gaa ttg  gtg aaa gga      4664
Ile Cys  Pro Pro Ala Pro Cys  Pro Ser Pro Glu Leu  Val Lys Gly          
    1455                 1460                 1465                      

acc tgc  tgt cca gtt tgc aga  gac cga gga atg cca  agt gat tcc      4709
Thr Cys  Cys Pro Val Cys Arg  Asp Arg Gly Met Pro  Ser Asp Ser          
    1470                 1475                 1480                      

cca gag  aag cgc taa taa aag ttt tgt  gct gtt gag ccc caa  atg      4754
Pro Glu  Lys Arg         Lys Phe Cys  Ala Val Glu Pro Gln  Met          
    1485                         1490                 1495              

gga aat ttc tca  gga aga gac att tag gac  ttcagaactt ttaacttgta     4804
Gly Asn Phe Ser  Gly Arg Asp Ile     Asp                                
            1500                     1505                               

gtcacattgt tgatatggaa accactgact taagcaactt agttcatcta atcttacata   4864

tacttacgat cttttatttt ttcattttct aacatacctt gaaataattc aaaactaaaa   4924

gcaataaagt gcatatgaag tgtttgatca taagaaat                           4962


<210>  602

<211>  1487

<212>  PRT

<213>  Homo sapiens



<400>  602

Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg 
1               5                   10                  15      


Cys Met His Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr 
            20                  25                  30          


Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser 
        35                  40                  45              


Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn 
    50                  55                  60                  


His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu 
65                  70                  75                  80  


Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu 
                85                  90                  95      


Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn 
            100                 105                 110         


Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu 
        115                 120                 125             


Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu 
    130                 135                 140                 


Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr 
145                 150                 155                 160 


Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala 
                165                 170                 175     


Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile 
            180                 185                 190         


Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr 
        195                 200                 205             


Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile 
    210                 215                 220                 


His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val 
225                 230                 235                 240 


Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln 
                245                 250                 255     


Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr 
            260                 265                 270         


Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Gly Phe 
        275                 280                 285             


Val Ile Gln Pro Gln Asp Thr Glu Val Leu Thr Gly Thr Ser Thr Thr 
    290                 295                 300                 


Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr 
305                 310                 315                 320 


Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser 
                325                 330                 335     


Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe 
            340                 345                 350         


Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn 
        355                 360                 365             


Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln 
    370                 375                 380                 


Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly Ile Arg Thr Ser 
                405                 410                 415     


Ala Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser 
            420                 425                 430         


Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr 
        435                 440                 445             


Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln 
    450                 455                 460                 


Leu Thr Val Lys Pro Lys Gly Pro Ser Ser Asn Thr Lys Thr Ala Gly 
465                 470                 475                 480 


Lys Ala Pro Leu Ile Pro Cys Cys Val Phe Arg Pro Phe Leu Val Ser 
                485                 490                 495     


Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val 
            500                 505                 510         


Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro 
        515                 520                 525             


Ile Ile Thr Trp Asn Lys Glu Gly Val Lys Ile Thr Glu Ser Gly Lys 
    530                 535                 540                 


Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe 
545                 550                 555                 560 


Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu 
                565                 570                 575     


Ala Val Thr Asn Met Phe Leu Thr Val Thr Gly Cys Asp Gln Tyr Trp 
            580                 585                 590         


Gly Leu Gly Thr Ser Val Ile Gly Ser Ser Asn Leu Ser Glu Glu His 
        595                 600                 605             


Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly Thr Pro Gly Leu Ala Ile 
    610                 615                 620                 


Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp 
625                 630                 635                 640 


Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu 
                645                 650                 655     


Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His 
            660                 665                 670         


Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile 
        675                 680                 685             


Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu 
    690                 695                 700                 


Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser 
705                 710                 715                 720 


Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg 
                725                 730                 735     


Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg 
            740                 745                 750         


Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala 
        755                 760                 765             


Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly 
    770                 775                 780                 


Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro 
785                 790                 795                 800 


Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala 
                805                 810                 815     


Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp 
            820                 825                 830         


Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala 
        835                 840                 845             


Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro 
    850                 855                 860                 


Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His 
865                 870                 875                 880 


Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly 
                885                 890                 895     


Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn 
            900                 905                 910         


Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu 
        915                 920                 925             


Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu 
    930                 935                 940                 


Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe 
945                 950                 955                 960 


Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro 
                965                 970                 975     


Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala 
            980                 985                 990         


Ala Met His Thr Leu Trp Phe Arg  Glu His Asn Arg Val  Ala Thr Glu 
        995                 1000                 1005             


Leu Ser  Ala Leu Asn Pro His  Trp Glu Gly Asn Thr  Val Tyr Gln 
    1010                 1015                 1020             


Glu Ala  Arg Lys Ile Val Gly  Ala Glu Leu Gln His  Ile Thr Tyr 
    1025                 1030                 1035             


Ser His  Trp Leu Pro Lys Val  Leu Gly Asp Pro Gly  Thr Arg Met 
    1040                 1045                 1050             


Leu Arg  Gly Tyr Arg Gly Tyr  Asn Pro Asn Val Asn  Ala Gly Ile 
    1055                 1060                 1065             


Ile Asn  Ser Phe Ala Thr Ala  Ala Phe Arg Phe Gly  His Thr Leu 
    1070                 1075                 1080             


Ile Asn  Pro Ile Leu Tyr Arg  Leu Asn Ala Thr Leu  Gly Glu Ile 
    1085                 1090                 1095             


Ser Glu  Gly His Leu Pro Phe  His Lys Ala Leu Phe  Ser Pro Ser 
    1100                 1105                 1110             


Arg Ile  Ile Lys Glu Gly Gly  Ile Asp Pro Val Leu  Arg Gly Leu 
    1115                 1120                 1125             


Phe Gly  Val Ala Ala Lys Trp  Arg Ala Pro Ser Tyr  Leu Leu Ser 
    1130                 1135                 1140             


Pro Glu  Leu Thr Gln Arg Leu  Phe Ser Ala Ala Tyr  Ser Ala Ala 
    1145                 1150                 1155             


Val Asp  Ser Ala Ala Thr Ile  Ile Gln Arg Gly Arg  Asp His Gly 
    1160                 1165                 1170             


Ile Pro  Pro Tyr Val Asp Phe  Arg Val Phe Cys Asn  Leu Thr Ser 
    1175                 1180                 1185             


Val Lys  Asn Phe Glu Asp Leu  Gln Asn Glu Ile Lys  Asp Ser Glu 
    1190                 1195                 1200             


Ile Arg  Gln Lys Leu Arg Lys  Leu Tyr Gly Ser Pro  Gly Asp Ile 
    1205                 1210                 1215             


Asp Leu  Trp Pro Ala Leu Met  Val Glu Asp Leu Ile  Pro Gly Thr 
    1220                 1225                 1230             


Arg Val  Gly Pro Thr Leu Met  Cys Leu Phe Val Thr  Gln Phe Gln 
    1235                 1240                 1245             


Arg Leu  Arg Asp Gly Asp Arg  Phe Trp Tyr Glu Asn  Pro Gly Val 
    1250                 1255                 1260             


Phe Thr  Pro Ala Gln Leu Thr  Gln Leu Lys Gln Ala  Ser Leu Ser 
    1265                 1270                 1275             


Arg Val  Leu Cys Asp Asn Gly  Asp Ser Ile Gln Gln  Val Gln Ala 
    1280                 1285                 1290             


Asp Val  Phe Val Lys Ala Glu  Tyr Pro Gln Asp Tyr  Leu Asn Cys 
    1295                 1300                 1305             


Ser Glu  Ile Pro Lys Val Asp  Leu Arg Val Trp Gln  Asp Cys Cys 
    1310                 1315                 1320             


Ala Asp  Cys Arg Ser Arg Gly  Gln Phe Arg Ala Val  Thr Gln Glu 
    1325                 1330                 1335             


Ser Gln  Lys Lys Arg Ser Ala  Gln Tyr Ser Tyr Pro  Val Asp Lys 
    1340                 1345                 1350             


Asp Met  Glu Leu Ser His Leu  Arg Ser Arg Gln Gln  Asp Lys Ile 
    1355                 1360                 1365             


Tyr Val  Gly Glu Asp Ala Arg  Asn Val Thr Val Leu  Ala Lys Thr 
    1370                 1375                 1380             


Lys Phe  Ser Gln Asp Phe Ser  Thr Phe Ala Ala Glu  Ile Gln Glu 
    1385                 1390                 1395             


Thr Ile  Thr Ala Leu Arg Glu  Gln Ile Asn Lys Leu  Glu Ala Arg 
    1400                 1405                 1410             


Leu Arg  Gln Ala Gly Cys Thr  Asp Val Arg Gly Val  Pro Arg Lys 
    1415                 1420                 1425             


Ala Glu  Glu Arg Trp Met Lys  Glu Asp Cys Thr His  Cys Ile Cys 
    1430                 1435                 1440             


Glu Ser  Gly Gln Val Thr Cys  Val Val Glu Ile Cys  Pro Pro Ala 
    1445                 1450                 1455             


Pro Cys  Pro Ser Pro Glu Leu  Val Lys Gly Thr Cys  Cys Pro Val 
    1460                 1465                 1470             


Cys Arg  Asp Arg Gly Met Pro  Ser Asp Ser Pro Glu  Lys Arg 
    1475                 1480                 1485         



<210>  603

<211>  4524

<212>  DNA

<213>  Homo sapiens



<400>  603
atggagccca gactgttctg ctggaccact ctctttctcc tggccgggtg gtgcctgcca     60

gggttgccct gccccagccg gtgcctttgc tttaagagca ccgtccgctg catgcacttg    120

atgctggacc acattcctca ggtaccacag cagaccacag ttctagactt gaggtttaac    180

agaataagag aaattccagg gagcgccttc aagaaactca agaatttgaa cacactttac    240

ctgtataaga accacatcag aaagatttcc agaaatgctt ttgaaggact tgaaaatttg    300

ctatatctgt atattcattt caaccaacta gaaatgctac agccagagac ctttggagac    360

cttctgagat tagagcgact atttttgcat aacaacaaat tatctaaaat tccagctggg    420

agcttttcta atctggattc attaaaaaga ttgcgtctgg attccaacgc cctggtttgt    480

gactgtgatc tgatgtggct gggggagctt ttacaaggct ttgcccaaca cggccacacc    540

caggctgcgg ctacctgcga atatcccagg agactccatg ggcgtgcagt tgcttcagta    600

acagtagagg aattcaattg ccagagcccc cgaattactt ttgagccgca ggatgtggag    660

gtaccatcag gaaataccgt ctacttcacc tgccgggcgg aaggaaaccc caaacctgag    720

attatttgga tacacaacaa ccactcattg gatttggaag atgatactcg acttaatgtg    780

tttgatgatg gcacactcat gatccgaaac accagagagt cagaccaagg tgtctatcag    840

tgcatggcca gaaattccgc tggggaagcc aagacacaga gtgccatgct cagatactcc    900

agtcttccag ccaaaccagg ctttgtaatc cagcctcagg acacagaggt tttaactggc    960

accagcacaa ctttggaatg tatggccaca ggccacccac accctcttat cacttggacc   1020

agggacaatg gattggagtt ggatggatcc aggcatgtgg caacgtccag tggactttac   1080

ttacagaaca tcacacaacg ggatcatggt cgatttacct gtcatgccaa caatagccac   1140

ggcactgttc aagctgcagc aaacataatt gtacaagctc ctccacaatt tacagtaacc   1200

cccaaggatc aagtggtgct ggaagaacat gctgtagagt ggctctgtga agctgacggc   1260

aacccacctc ctgttattgt ctggacaaaa acaggtatta gaacatctgc aggagggcag   1320

ctccctgtgg aaggccagca tacagttctc tcctctggca ctttgagaat tgaccgtgca   1380

gcacagcacg atcaaggcca atatgaatgt caagcagtca gttcgttggg ggtgaaaaag   1440

gtgtctgtgc agctgactgt aaaacccaaa ggccctagca gcaacactaa gacagctgga   1500

aaagccccct taataccctg ctgtgttttc aggcccttcc tggtctcagc tcttgcagtg   1560

tttactcaac ttcctcagga tacaagtgtc gaggttggaa agaatataaa catttcatgt   1620

catgctcaag gagaaccaca gcccataatt acttggaata aggaaggtgt gaagattact   1680

gagagtggta aattccatgt ggatgatgaa ggcacgttga ctatctacga cgcagggttc   1740

cctgaccagg gaagatatga atgtgtggct cggaattctt ttggccttgc tgtgaccaac   1800

atgtttctta cagtcacggg ctgtgaccag tattgggggt tggggacctc tgtcatagga   1860

tcttcgaacc tcagtgagga gcacggattt attctgaagg cgctggggtt gggaacccct   1920

ggtctagcta tacagggtag acaagctggc gatgactttg ttgaatcttc cattcttgat   1980

gctgtacaga gagttgacag tgcaattaac tccacacgaa gacatttgtt ttcacaaaaa   2040

cctcacacct ccagtgacct gctggctcaa tttcattacc cgcgtgaccc actgattgtg   2100

gaaatggcaa gagcagggga gatttttgag cacacgctgc agctgatacg ggaacgtgtg   2160

aagcaggggc tcactgtgga cttggaaggc aaagaattcc ggtacaatga cttggtgtcc   2220

ccgcgctccc tcagcctcat cgccaattta tctggatgca cagctcgcag gcctctgcca   2280

aactgctcca accggtgttt ccatgcgaag taccgcgccc acgacggcac gtgcaacaac   2340

ctgcagcagc ccacgtgggg cgcggcgctg accgccttcg cgcgcctgct gcagccagcc   2400

taccgggacg gcatccgcgc gccccgcggg ctcggccttc ctgtgggctc ccgccagccc   2460

ctcccgccgc cccggctggt cgccacagtg tgggcgcgcg cggcggccgt cacccccgac   2520

cacagctaca cgcgcatgct catgcactgg ggctggtttc tagagcacga cttggaccac   2580

acagtgcctg cgctgagcac agcccgcttc tcggatgggc ggccgtgcag ctccgtctgc   2640

accaacgacc ctccttgttt ccccatgaac acccggcacg ccgacccccg gggcacccac   2700

gcgccctgca tgctcttcgc gcgctccagc cccgcgtgtg ccagcggccg tccctctgcg   2760

acggtggatt cagtctatgc acgagagcag atcaaccagc aaacagccta catcgatggc   2820

tccaacgttt acgggagctc ggagcgggaa tcccaggctc tcagagaccc ttcggtgcct   2880

cggggtctcc tgaagacagg ctttccttgg cctccctccg gaaagccctt attgcccttt   2940

tctacaggcc cacccaccga gtgcgcgcga caggagcagg agagcccctg tttcctggcc   3000

ggggaccacc gggccaacga gcatctggct ctggccgcca tgcacaccct gtggttccgg   3060

gaacacaaca gggtggccac ggagctgtcc gccctgaacc cccactggga gggaaacacg   3120

gtttaccagg aagccaggaa gatcgtgggc gcggagctgc agcacatcac ctacagccac   3180

tggctgccta aggtcctggg ggaccctggc actaggatgc tgaggggtta ccgaggctac   3240

aaccccaacg tgaatgcagg catcattaac tcttttgcta ctgcagcctt tagatttggc   3300

cacacattaa tcaatcctat tctttaccga ctgaatgcca ccttaggtga aatttccgaa   3360

ggccaccttc cgttccataa agcgctcttt tcaccgtcca gaataatcaa ggaaggtggg   3420

atagacccgg ttctccgggg gctgtttggc gtggctgcta aatggcgggc accctcctac   3480

cttctcagtc ctgagctgac ccagaggctc ttctccgcgg cttattctgc ggccgtggat   3540

tcggctgcca ccatcattca aaggggtaga gaccacggga tcccaccata tgttgacttc   3600

agagttttct gtaatttgac ttcagttaag aactttgagg atcttcaaaa tgaaattaaa   3660

gattcagaga ttagacaaaa actgagaaag ttgtacggct ctccaggtga cattgacctc   3720

tggcccgccc ttatggttga agacctgatt cctggtacaa gagtgggacc aacacttatg   3780

tgcctgtttg ttacccagtt tcagcggcta agagatggag ataggttctg gtatgaaaac   3840

cctggagtat ttaccccggc acaactcact cagctgaagc aggcgtccct gagccgggtg   3900

ctttgtgaca atggtgacag cattcagcaa gtgcaggctg atgtctttgt aaaggcagaa   3960

tacccacagg attacctgaa ctgcagcgag atcccgaagg tggacctgcg agtgtggcaa   4020

gactgctgtg cagactgtag gagtagagga cagttcagag cagtgacgca agagtctcaa   4080

aagaaacgct cagctcaata cagctatcct gttgataagg atatggagtt aagtcatcta   4140

agaagtaggc aacaagataa aatatatgtg ggtgaagatg ctagaaatgt gacagttctg   4200

gcaaaaacaa agttctccca agatttcagc acgtttgcag cggaaattca ggaaaccatc   4260

acagcactca gagagcagat aaacaagctg gaggcacgcc tgaggcaggc agggtgtaca   4320

gatgttagag gggttccaag gaaggccgag gagcgctgga tgaaagaaga ctgcactcac   4380

tgcatttgtg agagtggcca ggtcacctgt gtggtggaga tttgtccccc ggctccctgt   4440

cccagtcctg aattggtgaa aggaacctgc tgtccagttt gcagagaccg aggaatgcca   4500

agtgattccc cagagaagcg ctaa                                          4524


<210>  604

<211>  23

<212>  PRT

<213>  Homo sapiens



<400>  604

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro 
            20              


<210>  605

<211>  1484

<212>  PRT

<213>  Homo sapiens



<400>  605

Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His 
1               5                   10                  15      


Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu 
            20                  25                  30          


Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys 
        35                  40                  45              


Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn His Ile Arg 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu 
65                  70                  75                  80  


Tyr Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly 
                85                  90                  95      


Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser 
            100                 105                 110         


Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu 
        115                 120                 125             


Arg Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu 
    130                 135                 140                 


Gly Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala 
145                 150                 155                 160 


Ala Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser 
                165                 170                 175     


Val Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu 
            180                 185                 190         


Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys 
        195                 200                 205             


Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn 
    210                 215                 220                 


His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp 
225                 230                 235                 240 


Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr 
                245                 250                 255     


Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala 
            260                 265                 270         


Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Gly Phe Val Ile Gln 
        275                 280                 285             


Pro Gln Asp Thr Glu Val Leu Thr Gly Thr Ser Thr Thr Leu Glu Cys 
    290                 295                 300                 


Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn 
305                 310                 315                 320 


Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu 
                325                 330                 335     


Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His 
            340                 345                 350         


Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val 
        355                 360                 365             


Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu 
    370                 375                 380                 


Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro 
385                 390                 395                 400 


Pro Val Ile Val Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly 
                405                 410                 415     


Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu 
            420                 425                 430         


Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln 
        435                 440                 445             


Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val 
    450                 455                 460                 


Lys Pro Lys Gly Pro Ser Ser Asn Thr Lys Thr Ala Gly Lys Ala Pro 
465                 470                 475                 480 


Leu Ile Pro Cys Cys Val Phe Arg Pro Phe Leu Val Ser Ala Leu Ala 
                485                 490                 495     


Val Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn 
            500                 505                 510         


Ile Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr 
        515                 520                 525             


Trp Asn Lys Glu Gly Val Lys Ile Thr Glu Ser Gly Lys Phe His Val 
    530                 535                 540                 


Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln 
545                 550                 555                 560 


Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr 
                565                 570                 575     


Asn Met Phe Leu Thr Val Thr Gly Cys Asp Gln Tyr Trp Gly Leu Gly 
            580                 585                 590         


Thr Ser Val Ile Gly Ser Ser Asn Leu Ser Glu Glu His Gly Phe Ile 
        595                 600                 605             


Leu Lys Ala Leu Gly Leu Gly Thr Pro Gly Leu Ala Ile Gln Gly Arg 
    610                 615                 620                 


Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln 
625                 630                 635                 640 


Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln 
                645                 650                 655     


Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg 
            660                 665                 670         


Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His 
        675                 680                 685             


Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp 
    690                 695                 700                 


Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser 
705                 710                 715                 720 


Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu 
                725                 730                 735     


Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp 
            740                 745                 750         


Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr 
        755                 760                 765             


Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala 
    770                 775                 780                 


Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro 
785                 790                 795                 800 


Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro 
                805                 810                 815     


Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu 
            820                 825                 830         


His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser 
        835                 840                 845             


Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe 
    850                 855                 860                 


Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys 
865                 870                 875                 880 


Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser 
                885                 890                 895     


Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr 
            900                 905                 910         


Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser 
        915                 920                 925             


Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly 
    930                 935                 940                 


Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly 
945                 950                 955                 960 


Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu 
                965                 970                 975     


Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His 
            980                 985                 990         


Thr Leu Trp Phe Arg Glu His Asn  Arg Val Ala Thr Glu  Leu Ser Ala 
        995                 1000                 1005             


Leu Asn  Pro His Trp Glu Gly  Asn Thr Val Tyr Gln  Glu Ala Arg 
    1010                 1015                 1020             


Lys Ile  Val Gly Ala Glu Leu  Gln His Ile Thr Tyr  Ser His Trp 
    1025                 1030                 1035             


Leu Pro  Lys Val Leu Gly Asp  Pro Gly Thr Arg Met  Leu Arg Gly 
    1040                 1045                 1050             


Tyr Arg  Gly Tyr Asn Pro Asn  Val Asn Ala Gly Ile  Ile Asn Ser 
    1055                 1060                 1065             


Phe Ala  Thr Ala Ala Phe Arg  Phe Gly His Thr Leu  Ile Asn Pro 
    1070                 1075                 1080             


Ile Leu  Tyr Arg Leu Asn Ala  Thr Leu Gly Glu Ile  Ser Glu Gly 
    1085                 1090                 1095             


His Leu  Pro Phe His Lys Ala  Leu Phe Ser Pro Ser  Arg Ile Ile 
    1100                 1105                 1110             


Lys Glu  Gly Gly Ile Asp Pro  Val Leu Arg Gly Leu  Phe Gly Val 
    1115                 1120                 1125             


Ala Ala  Lys Trp Arg Ala Pro  Ser Tyr Leu Leu Ser  Pro Glu Leu 
    1130                 1135                 1140             


Thr Gln  Arg Leu Phe Ser Ala  Ala Tyr Ser Ala Ala  Val Asp Ser 
    1145                 1150                 1155             


Ala Ala  Thr Ile Ile Gln Arg  Gly Arg Asp His Gly  Ile Pro Pro 
    1160                 1165                 1170             


Tyr Val  Asp Phe Arg Val Phe  Cys Asn Leu Thr Ser  Val Lys Asn 
    1175                 1180                 1185             


Phe Glu  Asp Leu Gln Asn Glu  Ile Lys Asp Ser Glu  Ile Arg Gln 
    1190                 1195                 1200             


Lys Leu  Arg Lys Leu Tyr Gly  Ser Pro Gly Asp Ile  Asp Leu Trp 
    1205                 1210                 1215             


Pro Ala  Leu Met Val Glu Asp  Leu Ile Pro Gly Thr  Arg Val Gly 
    1220                 1225                 1230             


Pro Thr  Leu Met Cys Leu Phe  Val Thr Gln Phe Gln  Arg Leu Arg 
    1235                 1240                 1245             


Asp Gly  Asp Arg Phe Trp Tyr  Glu Asn Pro Gly Val  Phe Thr Pro 
    1250                 1255                 1260             


Ala Gln  Leu Thr Gln Leu Lys  Gln Ala Ser Leu Ser  Arg Val Leu 
    1265                 1270                 1275             


Cys Asp  Asn Gly Asp Ser Ile  Gln Gln Val Gln Ala  Asp Val Phe 
    1280                 1285                 1290             


Val Lys  Ala Glu Tyr Pro Gln  Asp Tyr Leu Asn Cys  Ser Glu Ile 
    1295                 1300                 1305             


Pro Lys  Val Asp Leu Arg Val  Trp Gln Asp Cys Cys  Ala Asp Cys 
    1310                 1315                 1320             


Arg Ser  Arg Gly Gln Phe Arg  Ala Val Thr Gln Glu  Ser Gln Lys 
    1325                 1330                 1335             


Lys Arg  Ser Ala Gln Tyr Ser  Tyr Pro Val Asp Lys  Asp Met Glu 
    1340                 1345                 1350             


Leu Ser  His Leu Arg Ser Arg  Gln Gln Asp Lys Ile  Tyr Val Gly 
    1355                 1360                 1365             


Glu Asp  Ala Arg Asn Val Thr  Val Leu Ala Lys Thr  Lys Phe Ser 
    1370                 1375                 1380             


Gln Asp  Phe Ser Thr Phe Ala  Ala Glu Ile Gln Glu  Thr Ile Thr 
    1385                 1390                 1395             


Ala Leu  Arg Glu Gln Ile Asn  Lys Leu Glu Ala Arg  Leu Arg Gln 
    1400                 1405                 1410             


Ala Gly  Cys Thr Asp Val Arg  Gly Val Pro Arg Lys  Ala Glu Glu 
    1415                 1420                 1425             


Arg Trp  Met Lys Glu Asp Cys  Thr His Cys Ile Cys  Glu Ser Gly 
    1430                 1435                 1440             


Gln Val  Thr Cys Val Val Glu  Ile Cys Pro Pro Ala  Pro Cys Pro 
    1445                 1450                 1455             


Ser Pro  Glu Leu Val Lys Gly  Thr Cys Cys Pro Val  Cys Arg Asp 
    1460                 1465                 1470             


Arg Gly  Met Pro Ser Asp Ser  Pro Glu Lys Arg 
    1475                 1480                 


<210>  606

<211>  4842

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (145)..(4536)

<223>  



<400>  606
cagtggtaac aacgcatagt gcgggggctc ccaaacttgg ctcagtccag cagccaccat     60

caccaccact gcggttgctg ctgcagctgc agctgctgct ctccctccgg ctgcttcttc    120

gcgtggccag cagcgaatgg agcg atg gag ccc aga ctg ttc tgc tgg acc       171
                           Met Glu Pro Arg Leu Phe Cys Trp Thr          
                           1               5                            

act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc      219
Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro         
10                  15                  20                  25          

agc cgg tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg      267
Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met         
                30                  35                  40              

ctg gac cac att cct cag gta cca cag cag acc aca gtt cta gac ttg      315
Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu         
            45                  50                  55                  

agg ttt aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc      363
Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu         
        60                  65                  70                      

aag aat ttg aac aca ctt ctg ctg aac aac aac cac atc aga aag att      411
Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn His Ile Arg Lys Ile         
    75                  80                  85                          

tcc aga aat gct ttt gaa gga ctt gaa aat ttg cta tat ctg tac ctg      459
Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Leu         
90                  95                  100                 105         

tat aag aat gaa atc cat gca cta gat aag caa aca ttt aaa gga ctc      507
Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys Gly Leu         
                110                 115                 120             

ata tct ttg gaa cat ctg tat att cat ttc aac caa cta gaa atg cta      555
Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu Met Leu         
            125                 130                 135                 

cag cca gag acc ttt gga gac ctt ctg aga tta gag cga cta ttt ttg      603
Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu         
        140                 145                 150                     

cat aac aac aaa tta tct aaa att ccg gct ggg agc ttt tct aat ctg      651
His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu         
    155                 160                 165                         

gat tca tta aaa aga ttg cgt ctg gat tcc aac gcc ctg gtt tgt gac      699
Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys Asp         
170                 175                 180                 185         

tgt gat ctg atg tgg ctg ggg gag ctt tta caa ggc ttt gcc caa cac      747
Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln His         
                190                 195                 200             

ggc cac acc cag gct gcg gct acc tgc gaa tat ccc agg aga ctc cat      795
Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu His         
            205                 210                 215                 

ggg cgt gca gtt gct tca gta aca gta gag gaa ttc aat tgc cag agc      843
Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln Ser         
        220                 225                 230                     

ccc cga att act ttt gag ccg cag gat gtg gag gta cca tca gga aat      891
Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly Asn         
    235                 240                 245                         

acc gtc tac ttc acc tgc cgg gcg gaa gga aac ccc aaa cct gag att      939
Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile         
250                 255                 260                 265         

att tgg ata cac aac aac cac tca ttg gat ttg gaa gat gat act cga      987
Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr Arg         
                270                 275                 280             

ctt aat gtg ttt gat gat ggc aca ctc atg atc cga aac acc aga gag     1035
Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg Glu         
            285                 290                 295                 

tca gac caa ggt gtc tat cag tgc atg gcc aga aat tcc gct ggg gaa     1083
Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly Glu         
        300                 305                 310                     

gcc aag aca cag agt gcc atg ctc aga tac tcc agt ctt cca gcc aaa     1131
Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys         
    315                 320                 325                         

cca agc ttt gta atc cag cct cag gac aca gag gtt tta att ggc acc     1179
Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile Gly Thr         
330                 335                 340                 345         

agc aca act ttg gaa tgt atg gcc aca ggc cac cca cac cct ctt atc     1227
Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu Ile         
                350                 355                 360             

act tgg acc agg gac aat gga ttg gag ctg gat gga tcc agg cac gtg     1275
Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His Val         
            365                 370                 375                 

gca acg tcc agt gga ctt tac tta cag aac atc aca caa cgg gat cat     1323
Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp His         
        380                 385                 390                     

ggt cga ttt acc tgt cat gcc aac aat agc cac ggc act gtt caa gct     1371
Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln Ala         
    395                 400                 405                         

gca gca aac ata att gta caa gct cct cca caa ttt aca gta acc ccc     1419
Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr Pro         
410                 415                 420                 425         

aag gat caa gtg gtg ctg gaa gaa cat gct gta gag tgg ctc tgt gaa     1467
Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys Glu         
                430                 435                 440             

gct gac ggc aac cca cct cct gtt att gtc tgg aca aaa aca gga ggg     1515
Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly Gly         
            445                 450                 455                 

cag ctc cct gtg gaa ggc cag cat aca gtt ctc tcc tct ggc act ttg     1563
Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu         
        460                 465                 470                     

aga att gac cgt gca gca cag cac gat caa ggc caa tat gaa tgt caa     1611
Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln         
    475                 480                 485                         

gca gtc agt tcg ttg ggg gtg aaa aag gtg tct gtg cag ctg act gta     1659
Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val         
490                 495                 500                 505         

aaa ccc aaa gct ctt gca gtg ttt act caa ctt cct cag gat aca agt     1707
Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr Ser         
                510                 515                 520             

gtc gag gtt gga aag aat ata aac att tca tgt cat gct caa gga gaa     1755
Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly Glu         
            525                 530                 535                 

cca cag ccc ata att act tgg aat aag gaa ggt gtg cag att act gag     1803
Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile Thr Glu         
        540                 545                 550                     

agt ggt aaa ttc cat gtg gat gat gaa ggc acg ctg act atc tac gac     1851
Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp         
    555                 560                 565                         

gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct cgg aat tct     1899
Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser         
570                 575                 580                 585         

ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg gct ata cag     1947
Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala Ile Gln         
                590                 595                 600             

ggt aga caa gct ggc gat gac ttt gtt gaa tct tcc att ctt gat gct     1995
Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp Ala         
            605                 610                 615                 

gta cag aga gtt gac agt gca att aac tcc aca cga aga cat ttg ttt     2043
Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu Phe         
        620                 625                 630                     

tca caa aaa cct cac acc tcc agt gac ctg ctg gct caa ttt cat tac     2091
Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His Tyr         
    635                 640                 645                         

ccg cgt gac cca ctg att gtg gaa atg gca aga gca ggg gag att ttt     2139
Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile Phe         
650                 655                 660                 665         

gag cac acg ctg cag ctg ata cgg gaa cgt gtg aag cag ggg ctc act     2187
Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu Thr         
                670                 675                 680             

gtg gac ttg gaa ggc aaa gaa ttc cgg tac aat gac ttg gtg tcc ccg     2235
Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro         
            685                 690                 695                 

cgc tcc ctc agc ctc atc gcc aat tta tct gga tgc aca gct cgc agg     2283
Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg         
        700                 705                 710                     

cct ctg cca aac tgc tcc aac cgg tgt ttc cat gcg aag tac cgc gcc     2331
Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg Ala         
    715                 720                 725                         

cac gac ggc acg tgc aac aac ctg cag cag ccc acg tgg ggc gcg gcg     2379
His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala         
730                 735                 740                 745         

ctg acc gcc ttc gcg cgc ctg ctg cag cca gcc tac cgg gac ggc atc     2427
Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile         
                750                 755                 760             

cgc gcg ccc cgc ggg ctc ggc ctt cct gtg ggc tcc cgc cag ccc ctc     2475
Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro Leu         
            765                 770                 775                 

ccg ccg ccc cgg ctg gtc gcc aca gtg tgg gcg cgc gcg gcg gcc gtc     2523
Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala Val         
        780                 785                 790                     

acc ccc gac cac agc tac acg cgc atg ctc atg cac tgg ggc tgg ttt     2571
Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp Phe         
    795                 800                 805                         

cta gag cac gac ttg gac cac aca gtg cct gcg ctg agc aca gcc cgc     2619
Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala Arg         
810                 815                 820                 825         

ttc tcg gat ggg cgg ccg tgc agc tcc gtc tgc acc aac gac cct cct     2667
Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro Pro         
                830                 835                 840             

tgt ttc ccc atg aac acc cgg cac gcc gac ccc cgg ggc acc cac gcg     2715
Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His Ala         
            845                 850                 855                 

ccc tgc atg ctc ttc gcg cgc tcc agc ccc gcg tgt gcc agc ggc cgt     2763
Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg         
        860                 865                 870                     

ccc tct gcg acg gtg gat tca gtc tat gca cga gag cag atc aac cag     2811
Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln         
    875                 880                 885                         

caa aca gcc tac atc gat ggc tcc aac gtt tac ggg agc tcg gag cgg     2859
Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg         
890                 895                 900                 905         

gaa tcc cag gct ctc aga gac cct tcg gtg cct cgg ggt ctc ctg aag     2907
Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu Lys         
                910                 915                 920             

aca ggc ttt cct tgg cct ccc tcc gga aag ccc tta ttg ccc ttt tct     2955
Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser         
            925                 930                 935                 

aca ggc cca ccc acc gag tgc gcg cga cag gag cag gag agc ccc tgt     3003
Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys         
        940                 945                 950                     

ttc ctg gcc ggg gac cac cgg gcc aac gag cat ctg gct ctg gcc gcc     3051
Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala Ala         
    955                 960                 965                         

atg cac acc ctg tgg ttc cgg gaa cac aac agg gtg gcc acg gag ctg     3099
Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr Glu Leu         
970                 975                 980                 985         

tcc gcc ctg aac ccc cac tgg gag gga aac acg gtt tac cag gaa  gcc    3147
Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln Glu  Ala        
                990                 995                 1000            

agg aag atc gtg  ggc gcg gag ctg cag  cac atc acc tac agc  cac      3192
Arg Lys Ile Val  Gly Ala Glu Leu Gln  His Ile Thr Tyr Ser  His          
            1005                 1010                 1015              

tgg ctg cct aag  gtc ctg ggg gac cct  ggc act agg atg ctg  agg      3237
Trp Leu Pro Lys  Val Leu Gly Asp Pro  Gly Thr Arg Met Leu  Arg          
            1020                 1025                 1030              

ggt tac cga ggc  tac aac ccc aac gtg  aat gca ggc atc att  aac      3282
Gly Tyr Arg Gly  Tyr Asn Pro Asn Val  Asn Ala Gly Ile Ile  Asn          
            1035                 1040                 1045              

tct ttt gct act  gca gcc ttt aga ttt  ggc cac aca tta atc  aat      3327
Ser Phe Ala Thr  Ala Ala Phe Arg Phe  Gly His Thr Leu Ile  Asn          
            1050                 1055                 1060              

cct att ctt tac  cga ctg aat gcc acc  tta ggt gaa att tcc  gaa      3372
Pro Ile Leu Tyr  Arg Leu Asn Ala Thr  Leu Gly Glu Ile Ser  Glu          
            1065                 1070                 1075              

ggc cac ctt ccg  ttc cat aaa gcg ctc  ttt tca ccg tcc aga  ata      3417
Gly His Leu Pro  Phe His Lys Ala Leu  Phe Ser Pro Ser Arg  Ile          
            1080                 1085                 1090              

atc aag gaa ggt  ggg ata gac ccg gtt  ctc cgg ggg ctg ttt  ggc      3462
Ile Lys Glu Gly  Gly Ile Asp Pro Val  Leu Arg Gly Leu Phe  Gly          
            1095                 1100                 1105              

gtg gct gct aaa  tgg cgg gca ccc tcc  tac ctt ctc agt cct  gag      3507
Val Ala Ala Lys  Trp Arg Ala Pro Ser  Tyr Leu Leu Ser Pro  Glu          
            1110                 1115                 1120              

ctg acc cag agg  ctc ttc tcc gcg gct  tat tct gcg gcc gtg  gat      3552
Leu Thr Gln Arg  Leu Phe Ser Ala Ala  Tyr Ser Ala Ala Val  Asp          
            1125                 1130                 1135              

tcg gct gcc acc  atc att caa agg ggt  aga gac cac ggg atc  cca      3597
Ser Ala Ala Thr  Ile Ile Gln Arg Gly  Arg Asp His Gly Ile  Pro          
            1140                 1145                 1150              

cca tat gtt gac  ttc aga gtt ttc tgt  aat ttg act tca gtt  aag      3642
Pro Tyr Val Asp  Phe Arg Val Phe Cys  Asn Leu Thr Ser Val  Lys          
            1155                 1160                 1165              

aac ttt gag gat  ctt caa aat gaa att  aaa gat tca gag att  aga      3687
Asn Phe Glu Asp  Leu Gln Asn Glu Ile  Lys Asp Ser Glu Ile  Arg          
            1170                 1175                 1180              

caa aaa ctg aga  aag ttg tac ggc tct  cca ggt gac att gac  ctc      3732
Gln Lys Leu Arg  Lys Leu Tyr Gly Ser  Pro Gly Asp Ile Asp  Leu          
            1185                 1190                 1195              

tgg ccc gcc ctt  atg gtt gaa gac ctg  att cct ggt aca aga  gtg      3777
Trp Pro Ala Leu  Met Val Glu Asp Leu  Ile Pro Gly Thr Arg  Val          
            1200                 1205                 1210              

gga cca aca ctt  atg tgc atg ttc gtt  acc cag ttt cag cgg  cta      3822
Gly Pro Thr Leu  Met Cys Met Phe Val  Thr Gln Phe Gln Arg  Leu          
            1215                 1220                 1225              

aga gat gga gat  agg ttc tgg tat gaa  aac cct gga gta ttt  acc      3867
Arg Asp Gly Asp  Arg Phe Trp Tyr Glu  Asn Pro Gly Val Phe  Thr          
            1230                 1235                 1240              

ccg gca caa ctc  act cag ctg aag cag  gcg tcc ctg agc cgg  gtg      3912
Pro Ala Gln Leu  Thr Gln Leu Lys Gln  Ala Ser Leu Ser Arg  Val          
            1245                 1250                 1255              

ctt tgt gac aat  ggt gac agc att cag  caa gtg cag gct gat  gtc      3957
Leu Cys Asp Asn  Gly Asp Ser Ile Gln  Gln Val Gln Ala Asp  Val          
            1260                 1265                 1270              

ttt gta aag gca  gaa tac cca cag gat  tac ctg aac tgc agc  gag      4002
Phe Val Lys Ala  Glu Tyr Pro Gln Asp  Tyr Leu Asn Cys Ser  Glu          
            1275                 1280                 1285              

atc ccg aag gtg  gac ctg cga gtg tgg  caa gac tgc tgt gca  gac      4047
Ile Pro Lys Val  Asp Leu Arg Val Trp  Gln Asp Cys Cys Ala  Asp          
            1290                 1295                 1300              

tgt agg agt aga  gga cag ttc aga gca  gtg acg caa gag tct  caa      4092
Cys Arg Ser Arg  Gly Gln Phe Arg Ala  Val Thr Gln Glu Ser  Gln          
            1305                 1310                 1315              

aag aaa cgc tca  gct caa tac agc tat  cct gtt gat aag gat  atg      4137
Lys Lys Arg Ser  Ala Gln Tyr Ser Tyr  Pro Val Asp Lys Asp  Met          
            1320                 1325                 1330              

gag tta agt cat  cta aga agt agg caa  caa gat aaa ata tat  gtg      4182
Glu Leu Ser His  Leu Arg Ser Arg Gln  Gln Asp Lys Ile Tyr  Val          
            1335                 1340                 1345              

ggt gaa gat gct  aga aat gtg aca gtt  ctg gca aaa aca aag  ttc      4227
Gly Glu Asp Ala  Arg Asn Val Thr Val  Leu Ala Lys Thr Lys  Phe          
            1350                 1355                 1360              

tcc caa gat ttc  agc acg ttt gca gcg  gaa att cag gaa acc  atc      4272
Ser Gln Asp Phe  Ser Thr Phe Ala Ala  Glu Ile Gln Glu Thr  Ile          
            1365                 1370                 1375              

aca gca ctc aga  gag cag ata aac aag  ctg gag gca cgc ctg  agg      4317
Thr Ala Leu Arg  Glu Gln Ile Asn Lys  Leu Glu Ala Arg Leu  Arg          
            1380                 1385                 1390              

cag gca ggg tgt  aca gat gtt aga ggg  gtt cca agg aag gcc  gag      4362
Gln Ala Gly Cys  Thr Asp Val Arg Gly  Val Pro Arg Lys Ala  Glu          
            1395                 1400                 1405              

gag cgc tgg atg  aaa gaa gac tgc act  cac tgc att tgt gag  agt      4407
Glu Arg Trp Met  Lys Glu Asp Cys Thr  His Cys Ile Cys Glu  Ser          
            1410                 1415                 1420              

ggc cag gtc acc  tgt gtg gtg gag att  tgt ccc ccg gct ccc  tgt      4452
Gly Gln Val Thr  Cys Val Val Glu Ile  Cys Pro Pro Ala Pro  Cys          
            1425                 1430                 1435              

ccc agt cct gaa  ttg gtg aaa gga acc  tgc tgt cca gtt tgc  aga      4497
Pro Ser Pro Glu  Leu Val Lys Gly Thr  Cys Cys Pro Val Cys  Arg          
            1440                 1445                 1450              

gac cga gga atg  cca agt gat tcc cca  gag aag cgc taa taaaagtttt    4546
Asp Arg Gly Met  Pro Ser Asp Ser Pro  Glu Lys Arg                       
            1455                 1460                                   

gtgctgttga gccccaaatg ggaaatttct caggaagaga catttaggac ttcagaactt   4606

ttaacttgta gtcacattgt tgatatggaa accactgact taagcaactt agttcatcta   4666

atcttacata tacttacgat cttttatttt ttcattttct aacatacctt gaaataattc   4726

aaaactaaaa gcaataaagt gcatatgaag tgtttgatca taagaaatat ttcttactgt   4786

aagctgtcag ttttatatgc cacacctgga aataaaaaga atatcatgga atattt       4842


<210>  607

<211>  1463

<212>  PRT

<213>  Homo sapiens



<400>  607

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys 
            20                  25                  30          


Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val 
        35                  40                  45              


Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu 
    50                  55                  60                  


Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu 
65                  70                  75                  80  


Leu Asn Asn Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly 
                85                  90                  95      


Leu Glu Asn Leu Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala 
            100                 105                 110         


Leu Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr 
        115                 120                 125             


Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp 
    130                 135                 140                 


Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys 
145                 150                 155                 160 


Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg 
                165                 170                 175     


Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly 
            180                 185                 190         


Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala 
        195                 200                 205             


Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val 
    210                 215                 220                 


Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro 
225                 230                 235                 240 


Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg 
                245                 250                 255     


Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His 
            260                 265                 270         


Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly 
        275                 280                 285             


Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln 
    290                 295                 300                 


Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met 
305                 310                 315                 320 


Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro 
                325                 330                 335     


Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met 
            340                 345                 350         


Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly 
        355                 360                 365             


Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr 
    370                 375                 380                 


Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala 
385                 390                 395                 400 


Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln 
                405                 410                 415     


Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu 
            420                 425                 430         


Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro 
        435                 440                 445             


Val Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly Gln 
    450                 455                 460                 


His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln 
465                 470                 475                 480 


His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val 
                485                 490                 495     


Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala Val 
            500                 505                 510         


Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile 
        515                 520                 525             


Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp 
    530                 535                 540                 


Asn Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp 
545                 550                 555                 560 


Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly 
                565                 570                 575     


Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn 
            580                 585                 590         


Met Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp 
        595                 600                 605             


Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala 
    610                 615                 620                 


Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser 
625                 630                 635                 640 


Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val 
                645                 650                 655     


Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile 
            660                 665                 670         


Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu 
        675                 680                 685             


Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala 
    690                 695                 700                 


Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn 
705                 710                 715                 720 


Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn 
                725                 730                 735     


Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu 
            740                 745                 750         


Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly 
        755                 760                 765             


Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala 
    770                 775                 780                 


Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr 
785                 790                 795                 800 


Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His 
                805                 810                 815     


Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys 
            820                 825                 830         


Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg 
        835                 840                 845             


His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg 
    850                 855                 860                 


Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser 
865                 870                 875                 880 


Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly 
                885                 890                 895     


Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp 
            900                 905                 910         


Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro 
        915                 920                 925             


Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys 
    930                 935                 940                 


Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg 
945                 950                 955                 960 


Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg 
                965                 970                 975     


Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp 
            980                 985                 990         


Glu Gly Asn Thr Val Tyr Gln Glu  Ala Arg Lys Ile Val  Gly Ala Glu 
        995                 1000                 1005             


Leu Gln  His Ile Thr Tyr Ser  His Trp Leu Pro Lys  Val Leu Gly 
    1010                 1015                 1020             


Asp Pro  Gly Thr Arg Met Leu  Arg Gly Tyr Arg Gly  Tyr Asn Pro 
    1025                 1030                 1035             


Asn Val  Asn Ala Gly Ile Ile  Asn Ser Phe Ala Thr  Ala Ala Phe 
    1040                 1045                 1050             


Arg Phe  Gly His Thr Leu Ile  Asn Pro Ile Leu Tyr  Arg Leu Asn 
    1055                 1060                 1065             


Ala Thr  Leu Gly Glu Ile Ser  Glu Gly His Leu Pro  Phe His Lys 
    1070                 1075                 1080             


Ala Leu  Phe Ser Pro Ser Arg  Ile Ile Lys Glu Gly  Gly Ile Asp 
    1085                 1090                 1095             


Pro Val  Leu Arg Gly Leu Phe  Gly Val Ala Ala Lys  Trp Arg Ala 
    1100                 1105                 1110             


Pro Ser  Tyr Leu Leu Ser Pro  Glu Leu Thr Gln Arg  Leu Phe Ser 
    1115                 1120                 1125             


Ala Ala  Tyr Ser Ala Ala Val  Asp Ser Ala Ala Thr  Ile Ile Gln 
    1130                 1135                 1140             


Arg Gly  Arg Asp His Gly Ile  Pro Pro Tyr Val Asp  Phe Arg Val 
    1145                 1150                 1155             


Phe Cys  Asn Leu Thr Ser Val  Lys Asn Phe Glu Asp  Leu Gln Asn 
    1160                 1165                 1170             


Glu Ile  Lys Asp Ser Glu Ile  Arg Gln Lys Leu Arg  Lys Leu Tyr 
    1175                 1180                 1185             


Gly Ser  Pro Gly Asp Ile Asp  Leu Trp Pro Ala Leu  Met Val Glu 
    1190                 1195                 1200             


Asp Leu  Ile Pro Gly Thr Arg  Val Gly Pro Thr Leu  Met Cys Met 
    1205                 1210                 1215             


Phe Val  Thr Gln Phe Gln Arg  Leu Arg Asp Gly Asp  Arg Phe Trp 
    1220                 1225                 1230             


Tyr Glu  Asn Pro Gly Val Phe  Thr Pro Ala Gln Leu  Thr Gln Leu 
    1235                 1240                 1245             


Lys Gln  Ala Ser Leu Ser Arg  Val Leu Cys Asp Asn  Gly Asp Ser 
    1250                 1255                 1260             


Ile Gln  Gln Val Gln Ala Asp  Val Phe Val Lys Ala  Glu Tyr Pro 
    1265                 1270                 1275             


Gln Asp  Tyr Leu Asn Cys Ser  Glu Ile Pro Lys Val  Asp Leu Arg 
    1280                 1285                 1290             


Val Trp  Gln Asp Cys Cys Ala  Asp Cys Arg Ser Arg  Gly Gln Phe 
    1295                 1300                 1305             


Arg Ala  Val Thr Gln Glu Ser  Gln Lys Lys Arg Ser  Ala Gln Tyr 
    1310                 1315                 1320             


Ser Tyr  Pro Val Asp Lys Asp  Met Glu Leu Ser His  Leu Arg Ser 
    1325                 1330                 1335             


Arg Gln  Gln Asp Lys Ile Tyr  Val Gly Glu Asp Ala  Arg Asn Val 
    1340                 1345                 1350             


Thr Val  Leu Ala Lys Thr Lys  Phe Ser Gln Asp Phe  Ser Thr Phe 
    1355                 1360                 1365             


Ala Ala  Glu Ile Gln Glu Thr  Ile Thr Ala Leu Arg  Glu Gln Ile 
    1370                 1375                 1380             


Asn Lys  Leu Glu Ala Arg Leu  Arg Gln Ala Gly Cys  Thr Asp Val 
    1385                 1390                 1395             


Arg Gly  Val Pro Arg Lys Ala  Glu Glu Arg Trp Met  Lys Glu Asp 
    1400                 1405                 1410             


Cys Thr  His Cys Ile Cys Glu  Ser Gly Gln Val Thr  Cys Val Val 
    1415                 1420                 1425             


Glu Ile  Cys Pro Pro Ala Pro  Cys Pro Ser Pro Glu  Leu Val Lys 
    1430                 1435                 1440             


Gly Thr  Cys Cys Pro Val Cys  Arg Asp Arg Gly Met  Pro Ser Asp 
    1445                 1450                 1455             


Ser Pro  Glu Lys Arg 
    1460             


<210>  608

<211>  4392

<212>  DNA

<213>  Homo sapiens



<400>  608
atggagccca gactgttctg ctggaccact ctctttctcc tggccgggtg gtgcctgcca     60

gggttgccct gccccagccg gtgcctttgc tttaagagca ccgtccgctg catgcacttg    120

atgctggacc acattcctca ggtaccacag cagaccacag ttctagactt gaggtttaac    180

agaataagag aaattccagg gagcgccttc aagaaactca agaatttgaa cacacttctg    240

ctgaacaaca accacatcag aaagatttcc agaaatgctt ttgaaggact tgaaaatttg    300

ctatatctgt acctgtataa gaatgaaatc catgcactag ataagcaaac atttaaagga    360

ctcatatctt tggaacatct gtatattcat ttcaaccaac tagaaatgct acagccagag    420

acctttggag accttctgag attagagcga ctatttttgc ataacaacaa attatctaaa    480

attccggctg ggagcttttc taatctggat tcattaaaaa gattgcgtct ggattccaac    540

gccctggttt gtgactgtga tctgatgtgg ctgggggagc ttttacaagg ctttgcccaa    600

cacggccaca cccaggctgc ggctacctgc gaatatccca ggagactcca tgggcgtgca    660

gttgcttcag taacagtaga ggaattcaat tgccagagcc cccgaattac ttttgagccg    720

caggatgtgg aggtaccatc aggaaatacc gtctacttca cctgccgggc ggaaggaaac    780

cccaaacctg agattatttg gatacacaac aaccactcat tggatttgga agatgatact    840

cgacttaatg tgtttgatga tggcacactc atgatccgaa acaccagaga gtcagaccaa    900

ggtgtctatc agtgcatggc cagaaattcc gctggggaag ccaagacaca gagtgccatg    960

ctcagatact ccagtcttcc agccaaacca agctttgtaa tccagcctca ggacacagag   1020

gttttaattg gcaccagcac aactttggaa tgtatggcca caggccaccc acaccctctt   1080

atcacttgga ccagggacaa tggattggag ctggatggat ccaggcacgt ggcaacgtcc   1140

agtggacttt acttacagaa catcacacaa cgggatcatg gtcgatttac ctgtcatgcc   1200

aacaatagcc acggcactgt tcaagctgca gcaaacataa ttgtacaagc tcctccacaa   1260

tttacagtaa cccccaagga tcaagtggtg ctggaagaac atgctgtaga gtggctctgt   1320

gaagctgacg gcaacccacc tcctgttatt gtctggacaa aaacaggagg gcagctccct   1380

gtggaaggcc agcatacagt tctctcctct ggcactttga gaattgaccg tgcagcacag   1440

cacgatcaag gccaatatga atgtcaagca gtcagttcgt tgggggtgaa aaaggtgtct   1500

gtgcagctga ctgtaaaacc caaagctctt gcagtgttta ctcaacttcc tcaggataca   1560

agtgtcgagg ttggaaagaa tataaacatt tcatgtcatg ctcaaggaga accacagccc   1620

ataattactt ggaataagga aggtgtgcag attactgaga gtggtaaatt ccatgtggat   1680

gatgaaggca cgctgactat ctacgacgca gggttccctg accagggaag atatgaatgt   1740

gtggctcgga attcttttgg ccttgctgtg accaacatgt ttcttacagt cacggctata   1800

cagggtagac aagctggcga tgactttgtt gaatcttcca ttcttgatgc tgtacagaga   1860

gttgacagtg caattaactc cacacgaaga catttgtttt cacaaaaacc tcacacctcc   1920

agtgacctgc tggctcaatt tcattacccg cgtgacccac tgattgtgga aatggcaaga   1980

gcaggggaga tttttgagca cacgctgcag ctgatacggg aacgtgtgaa gcaggggctc   2040

actgtggact tggaaggcaa agaattccgg tacaatgact tggtgtcccc gcgctccctc   2100

agcctcatcg ccaatttatc tggatgcaca gctcgcaggc ctctgccaaa ctgctccaac   2160

cggtgtttcc atgcgaagta ccgcgcccac gacggcacgt gcaacaacct gcagcagccc   2220

acgtggggcg cggcgctgac cgccttcgcg cgcctgctgc agccagccta ccgggacggc   2280

atccgcgcgc cccgcgggct cggccttcct gtgggctccc gccagcccct cccgccgccc   2340

cggctggtcg ccacagtgtg ggcgcgcgcg gcggccgtca cccccgacca cagctacacg   2400

cgcatgctca tgcactgggg ctggtttcta gagcacgact tggaccacac agtgcctgcg   2460

ctgagcacag cccgcttctc ggatgggcgg ccgtgcagct ccgtctgcac caacgaccct   2520

ccttgtttcc ccatgaacac ccggcacgcc gacccccggg gcacccacgc gccctgcatg   2580

ctcttcgcgc gctccagccc cgcgtgtgcc agcggccgtc cctctgcgac ggtggattca   2640

gtctatgcac gagagcagat caaccagcaa acagcctaca tcgatggctc caacgtttac   2700

gggagctcgg agcgggaatc ccaggctctc agagaccctt cggtgcctcg gggtctcctg   2760

aagacaggct ttccttggcc tccctccgga aagcccttat tgcccttttc tacaggccca   2820

cccaccgagt gcgcgcgaca ggagcaggag agcccctgtt tcctggccgg ggaccaccgg   2880

gccaacgagc atctggctct ggccgccatg cacaccctgt ggttccggga acacaacagg   2940

gtggccacgg agctgtccgc cctgaacccc cactgggagg gaaacacggt ttaccaggaa   3000

gccaggaaga tcgtgggcgc ggagctgcag cacatcacct acagccactg gctgcctaag   3060

gtcctggggg accctggcac taggatgctg aggggttacc gaggctacaa ccccaacgtg   3120

aatgcaggca tcattaactc ttttgctact gcagccttta gatttggcca cacattaatc   3180

aatcctattc tttaccgact gaatgccacc ttaggtgaaa tttccgaagg ccaccttccg   3240

ttccataaag cgctcttttc accgtccaga ataatcaagg aaggtgggat agacccggtt   3300

ctccgggggc tgtttggcgt ggctgctaaa tggcgggcac cctcctacct tctcagtcct   3360

gagctgaccc agaggctctt ctccgcggct tattctgcgg ccgtggattc ggctgccacc   3420

atcattcaaa ggggtagaga ccacgggatc ccaccatatg ttgacttcag agttttctgt   3480

aatttgactt cagttaagaa ctttgaggat cttcaaaatg aaattaaaga ttcagagatt   3540

agacaaaaac tgagaaagtt gtacggctct ccaggtgaca ttgacctctg gcccgccctt   3600

atggttgaag acctgattcc tggtacaaga gtgggaccaa cacttatgtg catgttcgtt   3660

acccagtttc agcggctaag agatggagat aggttctggt atgaaaaccc tggagtattt   3720

accccggcac aactcactca gctgaagcag gcgtccctga gccgggtgct ttgtgacaat   3780

ggtgacagca ttcagcaagt gcaggctgat gtctttgtaa aggcagaata cccacaggat   3840

tacctgaact gcagcgagat cccgaaggtg gacctgcgag tgtggcaaga ctgctgtgca   3900

gactgtagga gtagaggaca gttcagagca gtgacgcaag agtctcaaaa gaaacgctca   3960

gctcaataca gctatcctgt tgataaggat atggagttaa gtcatctaag aagtaggcaa   4020

caagataaaa tatatgtggg tgaagatgct agaaatgtga cagttctggc aaaaacaaag   4080

ttctcccaag atttcagcac gtttgcagcg gaaattcagg aaaccatcac agcactcaga   4140

gagcagataa acaagctgga ggcacgcctg aggcaggcag ggtgtacaga tgttagaggg   4200

gttccaagga aggccgagga gcgctggatg aaagaagact gcactcactg catttgtgag   4260

agtggccagg tcacctgtgt ggtggagatt tgtcccccgg ctccctgtcc cagtcctgaa   4320

ttggtgaaag gaacctgctg tccagtttgc agagaccgag gaatgccaag tgattcccca   4380

gagaagcgct aa                                                       4392


<210>  609

<211>  23

<212>  PRT

<213>  Homo sapiens



<400>  609

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro 
            20              


<210>  610

<211>  1440

<212>  PRT

<213>  Homo sapiens



<400>  610

Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His 
1               5                   10                  15      


Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu 
            20                  25                  30          


Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys 
        35                  40                  45              


Lys Leu Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn His Ile Arg 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu 
65                  70                  75                  80  


Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys 
                85                  90                  95      


Gly Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu 
            100                 105                 110         


Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu 
        115                 120                 125             


Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser 
    130                 135                 140                 


Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val 
145                 150                 155                 160 


Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala 
                165                 170                 175     


Gln His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg 
            180                 185                 190         


Leu His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys 
        195                 200                 205             


Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser 
    210                 215                 220                 


Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro 
225                 230                 235                 240 


Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp 
                245                 250                 255     


Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr 
            260                 265                 270         


Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala 
        275                 280                 285             


Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro 
    290                 295                 300                 


Ala Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile 
305                 310                 315                 320 


Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro 
                325                 330                 335     


Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg 
            340                 345                 350         


His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg 
        355                 360                 365             


Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val 
    370                 375                 380                 


Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val 
385                 390                 395                 400 


Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu 
                405                 410                 415     


Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr 
            420                 425                 430         


Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly 
        435                 440                 445             


Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu 
    450                 455                 460                 


Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu 
465                 470                 475                 480 


Thr Val Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp 
                485                 490                 495     


Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln 
            500                 505                 510         


Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile 
        515                 520                 525             


Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile 
    530                 535                 540                 


Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg 
545                 550                 555                 560 


Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala 
                565                 570                 575     


Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu 
            580                 585                 590         


Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His 
        595                 600                 605             


Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe 
    610                 615                 620                 


His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu 
625                 630                 635                 640 


Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly 
                645                 650                 655     


Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val 
            660                 665                 670         


Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala 
        675                 680                 685             


Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr 
    690                 695                 700                 


Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly 
705                 710                 715                 720 


Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp 
                725                 730                 735     


Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln 
            740                 745                 750         


Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala 
        755                 760                 765             


Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly 
    770                 775                 780                 


Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr 
785                 790                 795                 800 


Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp 
                805                 810                 815     


Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr 
            820                 825                 830         


His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser 
        835                 840                 845             


Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile 
    850                 855                 860                 


Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser 
865                 870                 875                 880 


Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu 
                885                 890                 895     


Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro 
            900                 905                 910         


Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser 
        915                 920                 925             


Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu 
    930                 935                 940                 


Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr 
945                 950                 955                 960 


Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln 
                965                 970                 975     


Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr Ser 
            980                 985                 990         


His Trp Leu Pro Lys Val Leu Gly  Asp Pro Gly Thr Arg  Met Leu Arg 
        995                 1000                 1005             


Gly Tyr  Arg Gly Tyr Asn Pro  Asn Val Asn Ala Gly  Ile Ile Asn 
    1010                 1015                 1020             


Ser Phe  Ala Thr Ala Ala Phe  Arg Phe Gly His Thr  Leu Ile Asn 
    1025                 1030                 1035             


Pro Ile  Leu Tyr Arg Leu Asn  Ala Thr Leu Gly Glu  Ile Ser Glu 
    1040                 1045                 1050             


Gly His  Leu Pro Phe His Lys  Ala Leu Phe Ser Pro  Ser Arg Ile 
    1055                 1060                 1065             


Ile Lys  Glu Gly Gly Ile Asp  Pro Val Leu Arg Gly  Leu Phe Gly 
    1070                 1075                 1080             


Val Ala  Ala Lys Trp Arg Ala  Pro Ser Tyr Leu Leu  Ser Pro Glu 
    1085                 1090                 1095             


Leu Thr  Gln Arg Leu Phe Ser  Ala Ala Tyr Ser Ala  Ala Val Asp 
    1100                 1105                 1110             


Ser Ala  Ala Thr Ile Ile Gln  Arg Gly Arg Asp His  Gly Ile Pro 
    1115                 1120                 1125             


Pro Tyr  Val Asp Phe Arg Val  Phe Cys Asn Leu Thr  Ser Val Lys 
    1130                 1135                 1140             


Asn Phe  Glu Asp Leu Gln Asn  Glu Ile Lys Asp Ser  Glu Ile Arg 
    1145                 1150                 1155             


Gln Lys  Leu Arg Lys Leu Tyr  Gly Ser Pro Gly Asp  Ile Asp Leu 
    1160                 1165                 1170             


Trp Pro  Ala Leu Met Val Glu  Asp Leu Ile Pro Gly  Thr Arg Val 
    1175                 1180                 1185             


Gly Pro  Thr Leu Met Cys Met  Phe Val Thr Gln Phe  Gln Arg Leu 
    1190                 1195                 1200             


Arg Asp  Gly Asp Arg Phe Trp  Tyr Glu Asn Pro Gly  Val Phe Thr 
    1205                 1210                 1215             


Pro Ala  Gln Leu Thr Gln Leu  Lys Gln Ala Ser Leu  Ser Arg Val 
    1220                 1225                 1230             


Leu Cys  Asp Asn Gly Asp Ser  Ile Gln Gln Val Gln  Ala Asp Val 
    1235                 1240                 1245             


Phe Val  Lys Ala Glu Tyr Pro  Gln Asp Tyr Leu Asn  Cys Ser Glu 
    1250                 1255                 1260             


Ile Pro  Lys Val Asp Leu Arg  Val Trp Gln Asp Cys  Cys Ala Asp 
    1265                 1270                 1275             


Cys Arg  Ser Arg Gly Gln Phe  Arg Ala Val Thr Gln  Glu Ser Gln 
    1280                 1285                 1290             


Lys Lys  Arg Ser Ala Gln Tyr  Ser Tyr Pro Val Asp  Lys Asp Met 
    1295                 1300                 1305             


Glu Leu  Ser His Leu Arg Ser  Arg Gln Gln Asp Lys  Ile Tyr Val 
    1310                 1315                 1320             


Gly Glu  Asp Ala Arg Asn Val  Thr Val Leu Ala Lys  Thr Lys Phe 
    1325                 1330                 1335             


Ser Gln  Asp Phe Ser Thr Phe  Ala Ala Glu Ile Gln  Glu Thr Ile 
    1340                 1345                 1350             


Thr Ala  Leu Arg Glu Gln Ile  Asn Lys Leu Glu Ala  Arg Leu Arg 
    1355                 1360                 1365             


Gln Ala  Gly Cys Thr Asp Val  Arg Gly Val Pro Arg  Lys Ala Glu 
    1370                 1375                 1380             


Glu Arg  Trp Met Lys Glu Asp  Cys Thr His Cys Ile  Cys Glu Ser 
    1385                 1390                 1395             


Gly Gln  Val Thr Cys Val Val  Glu Ile Cys Pro Pro  Ala Pro Cys 
    1400                 1405                 1410             


Pro Ser  Pro Glu Leu Val Lys  Gly Thr Cys Cys Pro  Val Cys Arg 
    1415                 1420                 1425             


Asp Arg  Gly Met Pro Ser Asp  Ser Pro Glu Lys Arg  
    1430                 1435                 1440 


<210>  611

<211>  4767

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (145)..(4464)

<223>  



<400>  611
cagtggtaac aacgcatagt gcgggggctc ccaaacttgg ctcagtccag cagccaccat     60

caccaccact gcggttgctg ctgcagctgc agctgctgct ctccctccgg ctgcttcttc    120

gcgtggccag cagcgaatgg agcg atg gag ccc aga ctg ttc tgc tgg acc       171
                           Met Glu Pro Arg Leu Phe Cys Trp Thr          
                           1               5                            

act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc      219
Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro         
10                  15                  20                  25          

agc cgg tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg      267
Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met         
                30                  35                  40              

ctg gac cac att cct cag gta cca cag cag acc aca gtt cta gac ttg      315
Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu         
            45                  50                  55                  

agg ttt aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc      363
Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu         
        60                  65                  70                      

aag aat ttg aac aca ctg tac ctg tat aag aat gaa atc cat gca cta      411
Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu         
    75                  80                  85                          

gat aag caa aca ttt aaa gga ctc ata tct ttg gaa cat ctg tat att      459
Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr Ile         
90                  95                  100                 105         

cat ttc aac caa cta gaa atg cta cag cca gag acc ttt gga gac ctt      507
His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu         
                110                 115                 120             

ctg aga tta gag cga cta ttt ttg cat aac aac aaa tta tct aaa att      555
Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile         
            125                 130                 135                 

ccg gct ggg agc ttt tct aat ctg gat tca tta aaa aga ttg cgt ctg      603
Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu         
        140                 145                 150                     

gat tcc aac gcc ctg gtt tgt gac tgt gat ctg atg tgg ctg ggg gag      651
Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu         
    155                 160                 165                         

ctt tta caa ggc ttt gcc caa cac ggc cac acc cag gct gcg gct acc      699
Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala Thr         
170                 175                 180                 185         

tgc gaa tat ccc agg aga ctc cat ggg cgt gca gtt gct tca gta aca      747
Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val Thr         
                190                 195                 200             

gta gag gaa ttc aat tgc cag agc ccc cga att act ttt gag ccg cag      795
Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln         
            205                 210                 215                 

gat gtg gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg      843
Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala         
        220                 225                 230                     

gaa gga aac ccc aaa cct gag att att tgg ata cac aac aac cac tca      891
Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser         
    235                 240                 245                         

ttg gat ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca      939
Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr         
250                 255                 260                 265         

ctc atg atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc      987
Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys         
                270                 275                 280             

atg gcc aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc     1035
Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu         
            285                 290                 295                 

aga tac tcc agt ctt cca gcc aaa cca agc ttt gta atc cag cct cag     1083
Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln         
        300                 305                 310                     

gac aca gag gtt tta att ggc acc agc aca act ttg gaa tgt atg gcc     1131
Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala         
    315                 320                 325                         

aca ggc cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg     1179
Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu         
330                 335                 340                 345         

gag ctg gat gga tcc agg cac gtg gca acg tcc agt gga ctt tac tta     1227
Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu         
                350                 355                 360             

cag aac atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac     1275
Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn         
            365                 370                 375                 

aat agc cac ggc act gtt caa gct gca gca aac ata att gta caa gct     1323
Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala         
        380                 385                 390                     

cct cca caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa     1371
Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu         
    395                 400                 405                         

cat gct gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt     1419
His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val         
410                 415                 420                 425         

att gtc tgg aca aaa aca gga ggg cag ctc cct gtg gaa ggc cag cat     1467
Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly Gln His         
                430                 435                 440             

aca gtt ctc tcc tct ggc act ttg aga att gac cgt gca gca cag cac     1515
Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His         
            445                 450                 455                 

gat caa ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg aaa     1563
Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys         
        460                 465                 470                     

aag gtg tct gtg cag ctg act gta aaa ccc aaa gct ctt gca gtg ttt     1611
Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala Val Phe         
    475                 480                 485                         

act caa ctt cct cag gat aca agt gtc gag gtt gga aag aat ata aac     1659
Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn         
490                 495                 500                 505         

att tca tgt cat gct caa gga gaa cca cag ccc ata att act tgg aat     1707
Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn         
                510                 515                 520             

aag gaa ggt gtg cag att act gag agt ggt aaa ttc cat gtg gat gat     1755
Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp         
            525                 530                 535                 

gaa ggc acg ctg act atc tac gac gca ggg ttc cct gac cag gga aga     1803
Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg         
        540                 545                 550                     

tat gaa tgt gtg gct cgg aat tct ttt ggc ctt gct gtg acc aac atg     1851
Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met         
    555                 560                 565                         

ttt ctt aca gtc acg gct ata cag ggt aga caa gct ggc gat gac ttt     1899
Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe         
570                 575                 580                 585         

gtt gaa tct tcc att ctt gat gct gta cag aga gtt gac agt gca att     1947
Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile         
                590                 595                 600             

aac tcc aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt     1995
Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser         
            605                 610                 615                 

gac ctg ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa     2043
Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu         
        620                 625                 630                     

atg gca aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg     2091
Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg         
    635                 640                 645                         

gaa cgt gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc     2139
Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe         
650                 655                 660                 665         

cgg tac aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat     2187
Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn         
                670                 675                 680             

tta tct gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg     2235
Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg         
            685                 690                 695                 

tgt ttc cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg     2283
Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu         
        700                 705                 710                     

cag cag ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg     2331
Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu         
    715                 720                 725                         

cag cca gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt     2379
Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu         
730                 735                 740                 745         

cct gtg ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca     2427
Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr         
                750                 755                 760             

gtg tgg gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc     2475
Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg         
            765                 770                 775                 

atg ctc atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca     2523
Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr         
        780                 785                 790                     

gtg cct gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc     2571
Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser         
    795                 800                 805                         

tcc gtc tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac     2619
Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His         
810                 815                 820                 825         

gcc gac ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc     2667
Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser         
                830                 835                 840             

agc ccc gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc     2715
Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val         
            845                 850                 855                 

tat gca cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc     2763
Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser         
        860                 865                 870                     

aac gtt tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct     2811
Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro         
    875                 880                 885                         

tcg gtg cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc     2859
Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser         
890                 895                 900                 905         

gga aag ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg     2907
Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala         
                910                 915                 920             

cga cag gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc     2955
Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala         
            925                 930                 935                 

aac gag cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa     3003
Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu         
        940                 945                 950                     

cac aac agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag     3051
His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu         
    955                 960                 965                         

gga aac acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg     3099
Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu         
970                 975                 980                 985         

cag cac atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac  cct    3147
Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp  Pro        
                990                 995                 1000            

ggc act agg atg  ctg agg ggt tac cga  ggc tac aac ccc aac  gtg      3192
Gly Thr Arg Met  Leu Arg Gly Tyr Arg  Gly Tyr Asn Pro Asn  Val          
            1005                 1010                 1015              

aat gca ggc atc  att aac tct ttt gct  act gca gcc ttt aga  ttt      3237
Asn Ala Gly Ile  Ile Asn Ser Phe Ala  Thr Ala Ala Phe Arg  Phe          
            1020                 1025                 1030              

ggc cac aca tta  atc aat cct att ctt  tac cga ctg aat gcc  acc      3282
Gly His Thr Leu  Ile Asn Pro Ile Leu  Tyr Arg Leu Asn Ala  Thr          
            1035                 1040                 1045              

tta ggt gaa att  tcc gaa ggc cac ctt  ccg ttc cat aaa gcg  ctc      3327
Leu Gly Glu Ile  Ser Glu Gly His Leu  Pro Phe His Lys Ala  Leu          
            1050                 1055                 1060              

ttt tca ccg tcc  aga ata atc aag gaa  ggt ggg ata gac ccg  gtt      3372
Phe Ser Pro Ser  Arg Ile Ile Lys Glu  Gly Gly Ile Asp Pro  Val          
            1065                 1070                 1075              

ctc cgg ggg ctg  ttt ggc gtg gct gct  aaa tgg cgg gca ccc  tcc      3417
Leu Arg Gly Leu  Phe Gly Val Ala Ala  Lys Trp Arg Ala Pro  Ser          
            1080                 1085                 1090              

tac ctt ctc agt  cct gag ctg acc cag  agg ctc ttc tcc gcg  gct      3462
Tyr Leu Leu Ser  Pro Glu Leu Thr Gln  Arg Leu Phe Ser Ala  Ala          
            1095                 1100                 1105              

tat tct gcg gcc  gtg gat tcg gct gcc  acc atc att caa agg  ggt      3507
Tyr Ser Ala Ala  Val Asp Ser Ala Ala  Thr Ile Ile Gln Arg  Gly          
            1110                 1115                 1120              

aga gac cac ggg  atc cca cca tat gtt  gac ttc aga gtt ttc  tgt      3552
Arg Asp His Gly  Ile Pro Pro Tyr Val  Asp Phe Arg Val Phe  Cys          
            1125                 1130                 1135              

aat ttg act tca  gtt aag aac ttt gag  gat ctt caa aat gaa  att      3597
Asn Leu Thr Ser  Val Lys Asn Phe Glu  Asp Leu Gln Asn Glu  Ile          
            1140                 1145                 1150              

aaa gat tca gag  att aga caa aaa ctg  aga aag ttg tac ggc  tct      3642
Lys Asp Ser Glu  Ile Arg Gln Lys Leu  Arg Lys Leu Tyr Gly  Ser          
            1155                 1160                 1165              

cca ggt gac att  gac ctc tgg ccc gcc  ctt atg gtt gaa gac  ctg      3687
Pro Gly Asp Ile  Asp Leu Trp Pro Ala  Leu Met Val Glu Asp  Leu          
            1170                 1175                 1180              

att cct ggt aca  aga gtg gga cca aca  ctt atg tgc atg ttc  gtt      3732
Ile Pro Gly Thr  Arg Val Gly Pro Thr  Leu Met Cys Met Phe  Val          
            1185                 1190                 1195              

acc cag ttt cag  cgg cta aga gat gga  gat agg ttc tgg tat  gaa      3777
Thr Gln Phe Gln  Arg Leu Arg Asp Gly  Asp Arg Phe Trp Tyr  Glu          
            1200                 1205                 1210              

aac cct gga gta  ttt acc ccg gca caa  ctc act cag ctg aag  cag      3822
Asn Pro Gly Val  Phe Thr Pro Ala Gln  Leu Thr Gln Leu Lys  Gln          
            1215                 1220                 1225              

gcg tcc ctg agc  cgg gtg ctt tgt gac  aat ggt gac agc att  cag      3867
Ala Ser Leu Ser  Arg Val Leu Cys Asp  Asn Gly Asp Ser Ile  Gln          
            1230                 1235                 1240              

caa gtg cag gct  gat gtc ttt gta aag  gca gaa tac cca cag  gat      3912
Gln Val Gln Ala  Asp Val Phe Val Lys  Ala Glu Tyr Pro Gln  Asp          
            1245                 1250                 1255              

tac ctg aac tgc  agc gag atc ccg aag  gtg gac ctg cga gtg  tgg      3957
Tyr Leu Asn Cys  Ser Glu Ile Pro Lys  Val Asp Leu Arg Val  Trp          
            1260                 1265                 1270              

caa gac tgc tgt  gca gac tgt agg agt  aga gga cag ttc aga  gca      4002
Gln Asp Cys Cys  Ala Asp Cys Arg Ser  Arg Gly Gln Phe Arg  Ala          
            1275                 1280                 1285              

gtg acg caa gag  tct caa aag aaa cgc  tca gct caa tac agc  tat      4047
Val Thr Gln Glu  Ser Gln Lys Lys Arg  Ser Ala Gln Tyr Ser  Tyr          
            1290                 1295                 1300              

cct gtt gat aag  gat atg gag tta agt  cat cta aga agt agg  caa      4092
Pro Val Asp Lys  Asp Met Glu Leu Ser  His Leu Arg Ser Arg  Gln          
            1305                 1310                 1315              

caa gat aaa ata  tat gtg ggt gaa gat  gct aga aat gtg aca  gtt      4137
Gln Asp Lys Ile  Tyr Val Gly Glu Asp  Ala Arg Asn Val Thr  Val          
            1320                 1325                 1330              

ctg gca aaa aca  aag ttc tcc caa gat  ttc agc acg ttt gca  gcg      4182
Leu Ala Lys Thr  Lys Phe Ser Gln Asp  Phe Ser Thr Phe Ala  Ala          
            1335                 1340                 1345              

gaa att cag gaa  acc atc aca gca ctc  aga gag cag ata aac  aag      4227
Glu Ile Gln Glu  Thr Ile Thr Ala Leu  Arg Glu Gln Ile Asn  Lys          
            1350                 1355                 1360              

ctg gag gca cgc  ctg agg cag gca ggg  tgt aca gat gtt aga  ggg      4272
Leu Glu Ala Arg  Leu Arg Gln Ala Gly  Cys Thr Asp Val Arg  Gly          
            1365                 1370                 1375              

gtt cca agg aag  gcc gag gag cgc tgg  atg aaa gaa gac tgc  act      4317
Val Pro Arg Lys  Ala Glu Glu Arg Trp  Met Lys Glu Asp Cys  Thr          
            1380                 1385                 1390              

cac tgc att tgt  gag agt ggc cag gtc  acc tgt gtg gtg gag  att      4362
His Cys Ile Cys  Glu Ser Gly Gln Val  Thr Cys Val Val Glu  Ile          
            1395                 1400                 1405              

tgt ccc ccg gct  ccc tgt ccc agt cct  gaa ttg gtg aaa gga  acc      4407
Cys Pro Pro Ala  Pro Cys Pro Ser Pro  Glu Leu Val Lys Gly  Thr          
            1410                 1415                 1420              

tgc tgt cca gtt  tgc aga gac cga gga  atg cca agt gat tcc  cca      4452
Cys Cys Pro Val  Cys Arg Asp Arg Gly  Met Pro Ser Asp Ser  Pro          
            1425                 1430                 1435              

gag aag cgc taa taaaagtttt gtgctgttga gccccaaatg ggaaatttct         4504
Glu Lys Arg                                                             
                                                                        

caggaagaga catttaggac ttcagaactt ttaacttgta gtcacattgt tgatatggaa   4564

accactgact taagcaactt agttcatcta atcttacata tacttacgat cttttatttt   4624

ttcattttct aacatacctt gaaataattc aaaactaaaa gcaataaagt gcatatgaag   4684

tgtttgatca taagaaatat ttcttactgt aagctgtcag ttttatatgc cacacctgga   4744

aataaaaaga atatcatgga ata                                           4767


<210>  612

<211>  1439

<212>  PRT

<213>  Homo sapiens



<400>  612

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys 
            20                  25                  30          


Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val 
        35                  40                  45              


Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu 
    50                  55                  60                  


Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys Gly 
                85                  90                  95      


Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu Met 
            100                 105                 110         


Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe 
        115                 120                 125             


Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn 
    130                 135                 140                 


Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys 
145                 150                 155                 160 


Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln 
                165                 170                 175     


His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu 
            180                 185                 190         


His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln 
        195                 200                 205             


Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly 
    210                 215                 220                 


Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu 
225                 230                 235                 240 


Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr 
                245                 250                 255     


Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg 
            260                 265                 270         


Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly 
        275                 280                 285             


Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala 
    290                 295                 300                 


Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile Gly 
305                 310                 315                 320 


Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu 
                325                 330                 335     


Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His 
            340                 345                 350         


Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp 
        355                 360                 365             


His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln 
    370                 375                 380                 


Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr 
385                 390                 395                 400 


Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys 
                405                 410                 415     


Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly 
            420                 425                 430         


Gly Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr 
        435                 440                 445             


Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys 
    450                 455                 460                 


Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr 
465                 470                 475                 480 


Val Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr 
                485                 490                 495     


Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly 
            500                 505                 510         


Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile Thr 
        515                 520                 525             


Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr 
    530                 535                 540                 


Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn 
545                 550                 555                 560 


Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala Ile 
                565                 570                 575     


Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp 
            580                 585                 590         


Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu 
        595                 600                 605             


Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His 
    610                 615                 620                 


Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile 
625                 630                 635                 640 


Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu 
                645                 650                 655     


Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser 
            660                 665                 670         


Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg 
        675                 680                 685             


Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg 
    690                 695                 700                 


Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala 
705                 710                 715                 720 


Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly 
                725                 730                 735     


Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro 
            740                 745                 750         


Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala 
        755                 760                 765             


Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp 
    770                 775                 780                 


Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala 
785                 790                 795                 800 


Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro 
                805                 810                 815     


Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His 
            820                 825                 830         


Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly 
        835                 840                 845             


Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn 
    850                 855                 860                 


Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu 
865                 870                 875                 880 


Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu 
                885                 890                 895     


Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe 
            900                 905                 910         


Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro 
        915                 920                 925             


Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala 
    930                 935                 940                 


Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr Glu 
945                 950                 955                 960 


Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln Glu 
                965                 970                 975     


Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr Ser His 
            980                 985                 990         


Trp Leu Pro Lys Val Leu Gly Asp  Pro Gly Thr Arg Met  Leu Arg Gly 
        995                 1000                 1005             


Tyr Arg  Gly Tyr Asn Pro Asn  Val Asn Ala Gly Ile  Ile Asn Ser 
    1010                 1015                 1020             


Phe Ala  Thr Ala Ala Phe Arg  Phe Gly His Thr Leu  Ile Asn Pro 
    1025                 1030                 1035             


Ile Leu  Tyr Arg Leu Asn Ala  Thr Leu Gly Glu Ile  Ser Glu Gly 
    1040                 1045                 1050             


His Leu  Pro Phe His Lys Ala  Leu Phe Ser Pro Ser  Arg Ile Ile 
    1055                 1060                 1065             


Lys Glu  Gly Gly Ile Asp Pro  Val Leu Arg Gly Leu  Phe Gly Val 
    1070                 1075                 1080             


Ala Ala  Lys Trp Arg Ala Pro  Ser Tyr Leu Leu Ser  Pro Glu Leu 
    1085                 1090                 1095             


Thr Gln  Arg Leu Phe Ser Ala  Ala Tyr Ser Ala Ala  Val Asp Ser 
    1100                 1105                 1110             


Ala Ala  Thr Ile Ile Gln Arg  Gly Arg Asp His Gly  Ile Pro Pro 
    1115                 1120                 1125             


Tyr Val  Asp Phe Arg Val Phe  Cys Asn Leu Thr Ser  Val Lys Asn 
    1130                 1135                 1140             


Phe Glu  Asp Leu Gln Asn Glu  Ile Lys Asp Ser Glu  Ile Arg Gln 
    1145                 1150                 1155             


Lys Leu  Arg Lys Leu Tyr Gly  Ser Pro Gly Asp Ile  Asp Leu Trp 
    1160                 1165                 1170             


Pro Ala  Leu Met Val Glu Asp  Leu Ile Pro Gly Thr  Arg Val Gly 
    1175                 1180                 1185             


Pro Thr  Leu Met Cys Met Phe  Val Thr Gln Phe Gln  Arg Leu Arg 
    1190                 1195                 1200             


Asp Gly  Asp Arg Phe Trp Tyr  Glu Asn Pro Gly Val  Phe Thr Pro 
    1205                 1210                 1215             


Ala Gln  Leu Thr Gln Leu Lys  Gln Ala Ser Leu Ser  Arg Val Leu 
    1220                 1225                 1230             


Cys Asp  Asn Gly Asp Ser Ile  Gln Gln Val Gln Ala  Asp Val Phe 
    1235                 1240                 1245             


Val Lys  Ala Glu Tyr Pro Gln  Asp Tyr Leu Asn Cys  Ser Glu Ile 
    1250                 1255                 1260             


Pro Lys  Val Asp Leu Arg Val  Trp Gln Asp Cys Cys  Ala Asp Cys 
    1265                 1270                 1275             


Arg Ser  Arg Gly Gln Phe Arg  Ala Val Thr Gln Glu  Ser Gln Lys 
    1280                 1285                 1290             


Lys Arg  Ser Ala Gln Tyr Ser  Tyr Pro Val Asp Lys  Asp Met Glu 
    1295                 1300                 1305             


Leu Ser  His Leu Arg Ser Arg  Gln Gln Asp Lys Ile  Tyr Val Gly 
    1310                 1315                 1320             


Glu Asp  Ala Arg Asn Val Thr  Val Leu Ala Lys Thr  Lys Phe Ser 
    1325                 1330                 1335             


Gln Asp  Phe Ser Thr Phe Ala  Ala Glu Ile Gln Glu  Thr Ile Thr 
    1340                 1345                 1350             


Ala Leu  Arg Glu Gln Ile Asn  Lys Leu Glu Ala Arg  Leu Arg Gln 
    1355                 1360                 1365             


Ala Gly  Cys Thr Asp Val Arg  Gly Val Pro Arg Lys  Ala Glu Glu 
    1370                 1375                 1380             


Arg Trp  Met Lys Glu Asp Cys  Thr His Cys Ile Cys  Glu Ser Gly 
    1385                 1390                 1395             


Gln Val  Thr Cys Val Val Glu  Ile Cys Pro Pro Ala  Pro Cys Pro 
    1400                 1405                 1410             


Ser Pro  Glu Leu Val Lys Gly  Thr Cys Cys Pro Val  Cys Arg Asp 
    1415                 1420                 1425             


Arg Gly  Met Pro Ser Asp Ser  Pro Glu Lys Arg 
    1430                 1435                 


<210>  613

<211>  4320

<212>  DNA

<213>  Homo sapiens



<400>  613
atggagccca gactgttctg ctggaccact ctctttctcc tggccgggtg gtgcctgcca     60

gggttgccct gccccagccg gtgcctttgc tttaagagca ccgtccgctg catgcacttg    120

atgctggacc acattcctca ggtaccacag cagaccacag ttctagactt gaggtttaac    180

agaataagag aaattccagg gagcgccttc aagaaactca agaatttgaa cacactgtac    240

ctgtataaga atgaaatcca tgcactagat aagcaaacat ttaaaggact catatctttg    300

gaacatctgt atattcattt caaccaacta gaaatgctac agccagagac ctttggagac    360

cttctgagat tagagcgact atttttgcat aacaacaaat tatctaaaat tccggctggg    420

agcttttcta atctggattc attaaaaaga ttgcgtctgg attccaacgc cctggtttgt    480

gactgtgatc tgatgtggct gggggagctt ttacaaggct ttgcccaaca cggccacacc    540

caggctgcgg ctacctgcga atatcccagg agactccatg ggcgtgcagt tgcttcagta    600

acagtagagg aattcaattg ccagagcccc cgaattactt ttgagccgca ggatgtggag    660

gtaccatcag gaaataccgt ctacttcacc tgccgggcgg aaggaaaccc caaacctgag    720

attatttgga tacacaacaa ccactcattg gatttggaag atgatactcg acttaatgtg    780

tttgatgatg gcacactcat gatccgaaac accagagagt cagaccaagg tgtctatcag    840

tgcatggcca gaaattccgc tggggaagcc aagacacaga gtgccatgct cagatactcc    900

agtcttccag ccaaaccaag ctttgtaatc cagcctcagg acacagaggt tttaattggc    960

accagcacaa ctttggaatg tatggccaca ggccacccac accctcttat cacttggacc   1020

agggacaatg gattggagct ggatggatcc aggcacgtgg caacgtccag tggactttac   1080

ttacagaaca tcacacaacg ggatcatggt cgatttacct gtcatgccaa caatagccac   1140

ggcactgttc aagctgcagc aaacataatt gtacaagctc ctccacaatt tacagtaacc   1200

cccaaggatc aagtggtgct ggaagaacat gctgtagagt ggctctgtga agctgacggc   1260

aacccacctc ctgttattgt ctggacaaaa acaggagggc agctccctgt ggaaggccag   1320

catacagttc tctcctctgg cactttgaga attgaccgtg cagcacagca cgatcaaggc   1380

caatatgaat gtcaagcagt cagttcgttg ggggtgaaaa aggtgtctgt gcagctgact   1440

gtaaaaccca aagctcttgc agtgtttact caacttcctc aggatacaag tgtcgaggtt   1500

ggaaagaata taaacatttc atgtcatgct caaggagaac cacagcccat aattacttgg   1560

aataaggaag gtgtgcagat tactgagagt ggtaaattcc atgtggatga tgaaggcacg   1620

ctgactatct acgacgcagg gttccctgac cagggaagat atgaatgtgt ggctcggaat   1680

tcttttggcc ttgctgtgac caacatgttt cttacagtca cggctataca gggtagacaa   1740

gctggcgatg actttgttga atcttccatt cttgatgctg tacagagagt tgacagtgca   1800

attaactcca cacgaagaca tttgttttca caaaaacctc acacctccag tgacctgctg   1860

gctcaatttc attacccgcg tgacccactg attgtggaaa tggcaagagc aggggagatt   1920

tttgagcaca cgctgcagct gatacgggaa cgtgtgaagc aggggctcac tgtggacttg   1980

gaaggcaaag aattccggta caatgacttg gtgtccccgc gctccctcag cctcatcgcc   2040

aatttatctg gatgcacagc tcgcaggcct ctgccaaact gctccaaccg gtgtttccat   2100

gcgaagtacc gcgcccacga cggcacgtgc aacaacctgc agcagcccac gtggggcgcg   2160

gcgctgaccg ccttcgcgcg cctgctgcag ccagcctacc gggacggcat ccgcgcgccc   2220

cgcgggctcg gccttcctgt gggctcccgc cagcccctcc cgccgccccg gctggtcgcc   2280

acagtgtggg cgcgcgcggc ggccgtcacc cccgaccaca gctacacgcg catgctcatg   2340

cactggggct ggtttctaga gcacgacttg gaccacacag tgcctgcgct gagcacagcc   2400

cgcttctcgg atgggcggcc gtgcagctcc gtctgcacca acgaccctcc ttgtttcccc   2460

atgaacaccc ggcacgccga cccccggggc acccacgcgc cctgcatgct cttcgcgcgc   2520

tccagccccg cgtgtgccag cggccgtccc tctgcgacgg tggattcagt ctatgcacga   2580

gagcagatca accagcaaac agcctacatc gatggctcca acgtttacgg gagctcggag   2640

cgggaatccc aggctctcag agacccttcg gtgcctcggg gtctcctgaa gacaggcttt   2700

ccttggcctc cctccggaaa gcccttattg cccttttcta caggcccacc caccgagtgc   2760

gcgcgacagg agcaggagag cccctgtttc ctggccgggg accaccgggc caacgagcat   2820

ctggctctgg ccgccatgca caccctgtgg ttccgggaac acaacagggt ggccacggag   2880

ctgtccgccc tgaaccccca ctgggaggga aacacggttt accaggaagc caggaagatc   2940

gtgggcgcgg agctgcagca catcacctac agccactggc tgcctaaggt cctgggggac   3000

cctggcacta ggatgctgag gggttaccga ggctacaacc ccaacgtgaa tgcaggcatc   3060

attaactctt ttgctactgc agcctttaga tttggccaca cattaatcaa tcctattctt   3120

taccgactga atgccacctt aggtgaaatt tccgaaggcc accttccgtt ccataaagcg   3180

ctcttttcac cgtccagaat aatcaaggaa ggtgggatag acccggttct ccgggggctg   3240

tttggcgtgg ctgctaaatg gcgggcaccc tcctaccttc tcagtcctga gctgacccag   3300

aggctcttct ccgcggctta ttctgcggcc gtggattcgg ctgccaccat cattcaaagg   3360

ggtagagacc acgggatccc accatatgtt gacttcagag ttttctgtaa tttgacttca   3420

gttaagaact ttgaggatct tcaaaatgaa attaaagatt cagagattag acaaaaactg   3480

agaaagttgt acggctctcc aggtgacatt gacctctggc ccgcccttat ggttgaagac   3540

ctgattcctg gtacaagagt gggaccaaca cttatgtgca tgttcgttac ccagtttcag   3600

cggctaagag atggagatag gttctggtat gaaaaccctg gagtatttac cccggcacaa   3660

ctcactcagc tgaagcaggc gtccctgagc cgggtgcttt gtgacaatgg tgacagcatt   3720

cagcaagtgc aggctgatgt ctttgtaaag gcagaatacc cacaggatta cctgaactgc   3780

agcgagatcc cgaaggtgga cctgcgagtg tggcaagact gctgtgcaga ctgtaggagt   3840

agaggacagt tcagagcagt gacgcaagag tctcaaaaga aacgctcagc tcaatacagc   3900

tatcctgttg ataaggatat ggagttaagt catctaagaa gtaggcaaca agataaaata   3960

tatgtgggtg aagatgctag aaatgtgaca gttctggcaa aaacaaagtt ctcccaagat   4020

ttcagcacgt ttgcagcgga aattcaggaa accatcacag cactcagaga gcagataaac   4080

aagctggagg cacgcctgag gcaggcaggg tgtacagatg ttagaggggt tccaaggaag   4140

gccgaggagc gctggatgaa agaagactgc actcactgca tttgtgagag tggccaggtc   4200

acctgtgtgg tggagatttg tcccccggct ccctgtccca gtcctgaatt ggtgaaagga   4260

acctgctgtc cagtttgcag agaccgagga atgccaagtg attccccaga gaagcgctaa   4320


<210>  614

<211>  23

<212>  PRT

<213>  Homo sapiens



<400>  614

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro 
            20              


<210>  615

<211>  1416

<212>  PRT

<213>  Homo sapiens



<400>  615

Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His 
1               5                   10                  15      


Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu 
            20                  25                  30          


Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys 
        35                  40                  45              


Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn Glu Ile His 
    50                  55                  60                  


Ala Leu Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu 
65                  70                  75                  80  


Tyr Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly 
                85                  90                  95      


Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser 
            100                 105                 110         


Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu 
        115                 120                 125             


Arg Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu 
    130                 135                 140                 


Gly Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala 
145                 150                 155                 160 


Ala Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser 
                165                 170                 175     


Val Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu 
            180                 185                 190         


Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys 
        195                 200                 205             


Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn 
    210                 215                 220                 


His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp 
225                 230                 235                 240 


Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr 
                245                 250                 255     


Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala 
            260                 265                 270         


Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln 
        275                 280                 285             


Pro Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys 
    290                 295                 300                 


Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn 
305                 310                 315                 320 


Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu 
                325                 330                 335     


Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His 
            340                 345                 350         


Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val 
        355                 360                 365             


Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu 
    370                 375                 380                 


Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro 
385                 390                 395                 400 


Pro Val Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly 
                405                 410                 415     


Gln His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala 
            420                 425                 430         


Gln His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly 
        435                 440                 445             


Val Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala 
    450                 455                 460                 


Val Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn 
465                 470                 475                 480 


Ile Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr 
                485                 490                 495     


Trp Asn Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val 
            500                 505                 510         


Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln 
        515                 520                 525             


Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr 
    530                 535                 540                 


Asn Met Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp 
545                 550                 555                 560 


Asp Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser 
                565                 570                 575     


Ala Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr 
            580                 585                 590         


Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile 
        595                 600                 605             


Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu 
    610                 615                 620                 


Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys 
625                 630                 635                 640 


Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile 
                645                 650                 655     


Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser 
            660                 665                 670         


Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn 
        675                 680                 685             


Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg 
    690                 695                 700                 


Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu 
705                 710                 715                 720 


Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val 
                725                 730                 735     


Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr 
            740                 745                 750         


Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp 
        755                 760                 765             


His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro 
    770                 775                 780                 


Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr 
785                 790                 795                 800 


Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala 
                805                 810                 815     


Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp 
            820                 825                 830         


Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp 
        835                 840                 845             


Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg 
    850                 855                 860                 


Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro 
865                 870                 875                 880 


Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu 
                885                 890                 895     


Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His 
            900                 905                 910         


Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe 
        915                 920                 925             


Arg Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His 
    930                 935                 940                 


Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala 
945                 950                 955                 960 


Glu Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly 
                965                 970                 975     


Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn 
            980                 985                 990         


Val Asn Ala Gly Ile Ile Asn Ser  Phe Ala Thr Ala Ala  Phe Arg Phe 
        995                 1000                 1005             


Gly His  Thr Leu Ile Asn Pro  Ile Leu Tyr Arg Leu  Asn Ala Thr 
    1010                 1015                 1020             


Leu Gly  Glu Ile Ser Glu Gly  His Leu Pro Phe His  Lys Ala Leu 
    1025                 1030                 1035             


Phe Ser  Pro Ser Arg Ile Ile  Lys Glu Gly Gly Ile  Asp Pro Val 
    1040                 1045                 1050             


Leu Arg  Gly Leu Phe Gly Val  Ala Ala Lys Trp Arg  Ala Pro Ser 
    1055                 1060                 1065             


Tyr Leu  Leu Ser Pro Glu Leu  Thr Gln Arg Leu Phe  Ser Ala Ala 
    1070                 1075                 1080             


Tyr Ser  Ala Ala Val Asp Ser  Ala Ala Thr Ile Ile  Gln Arg Gly 
    1085                 1090                 1095             


Arg Asp  His Gly Ile Pro Pro  Tyr Val Asp Phe Arg  Val Phe Cys 
    1100                 1105                 1110             


Asn Leu  Thr Ser Val Lys Asn  Phe Glu Asp Leu Gln  Asn Glu Ile 
    1115                 1120                 1125             


Lys Asp  Ser Glu Ile Arg Gln  Lys Leu Arg Lys Leu  Tyr Gly Ser 
    1130                 1135                 1140             


Pro Gly  Asp Ile Asp Leu Trp  Pro Ala Leu Met Val  Glu Asp Leu 
    1145                 1150                 1155             


Ile Pro  Gly Thr Arg Val Gly  Pro Thr Leu Met Cys  Met Phe Val 
    1160                 1165                 1170             


Thr Gln  Phe Gln Arg Leu Arg  Asp Gly Asp Arg Phe  Trp Tyr Glu 
    1175                 1180                 1185             


Asn Pro  Gly Val Phe Thr Pro  Ala Gln Leu Thr Gln  Leu Lys Gln 
    1190                 1195                 1200             


Ala Ser  Leu Ser Arg Val Leu  Cys Asp Asn Gly Asp  Ser Ile Gln 
    1205                 1210                 1215             


Gln Val  Gln Ala Asp Val Phe  Val Lys Ala Glu Tyr  Pro Gln Asp 
    1220                 1225                 1230             


Tyr Leu  Asn Cys Ser Glu Ile  Pro Lys Val Asp Leu  Arg Val Trp 
    1235                 1240                 1245             


Gln Asp  Cys Cys Ala Asp Cys  Arg Ser Arg Gly Gln  Phe Arg Ala 
    1250                 1255                 1260             


Val Thr  Gln Glu Ser Gln Lys  Lys Arg Ser Ala Gln  Tyr Ser Tyr 
    1265                 1270                 1275             


Pro Val  Asp Lys Asp Met Glu  Leu Ser His Leu Arg  Ser Arg Gln 
    1280                 1285                 1290             


Gln Asp  Lys Ile Tyr Val Gly  Glu Asp Ala Arg Asn  Val Thr Val 
    1295                 1300                 1305             


Leu Ala  Lys Thr Lys Phe Ser  Gln Asp Phe Ser Thr  Phe Ala Ala 
    1310                 1315                 1320             


Glu Ile  Gln Glu Thr Ile Thr  Ala Leu Arg Glu Gln  Ile Asn Lys 
    1325                 1330                 1335             


Leu Glu  Ala Arg Leu Arg Gln  Ala Gly Cys Thr Asp  Val Arg Gly 
    1340                 1345                 1350             


Val Pro  Arg Lys Ala Glu Glu  Arg Trp Met Lys Glu  Asp Cys Thr 
    1355                 1360                 1365             


His Cys  Ile Cys Glu Ser Gly  Gln Val Thr Cys Val  Val Glu Ile 
    1370                 1375                 1380             


Cys Pro  Pro Ala Pro Cys Pro  Ser Pro Glu Leu Val  Lys Gly Thr 
    1385                 1390                 1395             


Cys Cys  Pro Val Cys Arg Asp  Arg Gly Met Pro Ser  Asp Ser Pro 
    1400                 1405                 1410             


Glu Lys  Arg 
    1415     


<210>  616

<211>  1496

<212>  PRT

<213>  Homo sapiens



<400>  616

Ser Arg Pro Trp Trp Leu Arg Ala Ser Glu Arg Pro Ser Ala Pro Ser 
1               5                   10                  15      


Ala Met Ala Lys Arg Ser Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala 
            20                  25                  30          


Leu Val Leu Phe Cys Ala Trp Gly Thr Leu Ala Val Val Ala Gln Lys 
        35                  40                  45              


Pro Gly Ala Gly Cys Pro Ser Arg Cys Leu Cys Phe Arg Thr Thr Val 
    50                  55                  60                  


Arg Cys Met His Leu Leu Leu Glu Ala Val Pro Ala Val Ala Pro Gln 
65                  70                  75                  80  


Thr Ser Ile Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro 
                85                  90                  95      


Gly Ala Phe Arg Arg Leu Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn 
            100                 105                 110         


Asn Gln Ile Lys Arg Ile Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn 
        115                 120                 125             


Leu Lys Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg 
    130                 135                 140                 


Gln Ala Phe Lys Gly Leu Ala Ser Leu Glu Gln Leu Tyr Leu His Phe 
145                 150                 155                 160 


Asn Gln Ile Glu Thr Leu Asp Pro Asp Ser Phe Gln His Leu Pro Lys 
                165                 170                 175     


Leu Glu Arg Leu Phe Leu His Asn Asn Arg Ile Thr His Leu Val Pro 
            180                 185                 190         


Gly Thr Phe Asn His Leu Glu Ser Met Lys Arg Leu Arg Leu Asp Ser 
        195                 200                 205             


Asn Thr Leu His Cys Asp Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu 
    210                 215                 220                 


Lys Thr Tyr Ala Glu Ser Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu 
225                 230                 235                 240 


Tyr Pro Arg Arg Ile Gln Gly Arg Ser Val Ala Thr Ile Thr Pro Glu 
                245                 250                 255     


Glu Leu Asn Cys Glu Arg Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala 
            260                 265                 270         


Asp Val Thr Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly 
        275                 280                 285             


Asn Pro Lys Pro Glu Ile Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser 
    290                 295                 300                 


Met Lys Thr Asp Ser Arg Leu Asn Leu Leu Asp Asp Gly Thr Leu Met 
305                 310                 315                 320 


Ile Gln Asn Thr Gln Glu Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala 
                325                 330                 335     


Lys Asn Val Ala Gly Glu Val Lys Thr Gln Glu Val Thr Leu Arg Tyr 
            340                 345                 350         


Phe Gly Ser Pro Ala Arg Pro Thr Phe Val Ile Gln Pro Gln Asn Thr 
        355                 360                 365             


Glu Val Leu Val Gly Glu Ser Val Thr Leu Glu Cys Ser Ala Thr Gly 
    370                 375                 380                 


His Pro Pro Pro Arg Ile Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu 
385                 390                 395                 400 


Pro Val Asp Pro Arg Val Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile 
                405                 410                 415     


Gln Asn Val Val Gln Gly Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr 
            420                 425                 430         


Asn Asn Ile Asp Ser Val His Ala Thr Ala Phe Ile Ile Val Gln Ala 
        435                 440                 445             


Leu Pro Gln Phe Thr Val Thr Pro Gln Asp Arg Val Val Ile Glu Gly 
    450                 455                 460                 


Gln Thr Val Asp Phe Gln Cys Glu Ala Lys Gly Asn Pro Pro Pro Val 
465                 470                 475                 480 


Ile Ala Trp Thr Lys Gly Gly Ser Gln Leu Ser Val Asp Arg Arg His 
                485                 490                 495     


Leu Val Leu Ser Ser Gly Thr Leu Arg Ile Ser Gly Val Ala Leu His 
            500                 505                 510         


Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Asn Ile Ile Gly Ser Gln 
        515                 520                 525             


Lys Val Val Ala His Leu Thr Val Gln Pro Arg Val Thr Pro Val Phe 
    530                 535                 540                 


Ala Ser Ile Pro Ser Asp Thr Thr Val Glu Val Gly Ala Asn Val Gln 
545                 550                 555                 560 


Leu Pro Cys Ser Ser Gln Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn 
                565                 570                 575     


Lys Asp Gly Val Gln Val Thr Glu Ser Gly Lys Phe His Ile Ser Pro 
            580                 585                 590         


Glu Gly Phe Leu Thr Ile Asn Asp Val Gly Pro Ala Asp Ala Gly Arg 
        595                 600                 605             


Tyr Glu Cys Val Ala Arg Asn Thr Ile Gly Ser Ala Ser Val Ser Met 
    610                 615                 620                 


Val Leu Ser Val Asn Val Pro Asp Val Ser Arg Asn Gly Asp Pro Phe 
625                 630                 635                 640 


Val Ala Thr Ser Ile Val Glu Ala Ile Ala Thr Val Asp Arg Ala Ile 
                645                 650                 655     


Asn Ser Thr Arg Thr His Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn 
            660                 665                 670         


Asp Leu Leu Ala Leu Phe Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu 
        675                 680                 685             


Gln Ala Arg Ala Gly Glu Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln 
    690                 695                 700                 


Glu His Val Gln His Gly Leu Met Val Asp Leu Asn Gly Thr Ser Tyr 
705                 710                 715                 720 


His Tyr Asn Asp Leu Val Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn 
                725                 730                 735     


Leu Ser Gly Cys Thr Ala His Arg Arg Val Asn Asn Cys Ser Asp Met 
            740                 745                 750         


Cys Phe His Gln Lys Tyr Arg Thr His Asp Gly Thr Cys Asn Asn Leu 
        755                 760                 765             


Gln His Pro Met Trp Gly Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu 
    770                 775                 780                 


Lys Ser Val Tyr Glu Asn Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro 
785                 790                 795                 800 


His Arg Leu Tyr Asn Gly His Ala Leu Pro Met Pro Arg Leu Val Ser 
                805                 810                 815     


Thr Thr Leu Ile Gly Thr Glu Thr Val Thr Pro Asp Glu Gln Phe Thr 
            820                 825                 830         


His Met Leu Met Gln Trp Gly Gln Phe Leu Asp His Asp Leu Asp Ser 
        835                 840                 845             


Thr Val Val Ala Leu Ser Gln Ala Arg Phe Ser Asp Gly Gln His Cys 
    850                 855                 860                 


Ser Asn Val Cys Ser Asn Asp Pro Pro Cys Phe Ser Val Met Ile Pro 
865                 870                 875                 880 


Pro Asn Asp Ser Arg Ala Arg Ser Gly Ala Arg Cys Met Phe Phe Val 
                885                 890                 895     


Arg Ser Ser Pro Val Cys Gly Ser Gly Met Thr Ser Leu Leu Met Asn 
            900                 905                 910         


Ser Val Tyr Pro Arg Glu Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp 
        915                 920                 925             


Ala Ser Asn Val Tyr Gly Ser Thr Glu His Glu Ala Arg Ser Ile Arg 
    930                 935                 940                 


Asp Leu Ala Ser His Arg Gly Leu Leu Arg Gln Gly Ile Val Gln Arg 
945                 950                 955                 960 


Ser Gly Lys Pro Leu Leu Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys 
                965                 970                 975     


Met Arg Asp Glu Asn Glu Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp 
            980                 985                 990         


His Arg Ala Asn Glu Gln Leu Gly  Leu Thr Ser Met His  Thr Leu Trp 
        995                 1000                 1005             


Phe Arg  Glu His Asn Arg Ile  Ala Thr Glu Leu Leu  Lys Leu Asn 
    1010                 1015                 1020             


Pro His  Trp Asp Gly Asp Thr  Ile Tyr Tyr Glu Thr  Arg Lys Ile 
    1025                 1030                 1035             


Val Gly  Ala Glu Ile Gln His  Ile Thr Tyr Gln His  Trp Leu Pro 
    1040                 1045                 1050             


Lys Ile  Leu Gly Glu Val Gly  Met Arg Thr Leu Gly  Glu Tyr His 
    1055                 1060                 1065             


Gly Tyr  Asp Pro Gly Ile Asn  Ala Gly Ile Phe Asn  Ala Phe Ala 
    1070                 1075                 1080             


Thr Ala  Ala Phe Arg Phe Gly  His Thr Leu Val Asn  Pro Leu Leu 
    1085                 1090                 1095             


Tyr Arg  Leu Asp Glu Asn Phe  Gln Pro Ile Ala Gln  Asp His Leu 
    1100                 1105                 1110             


Pro Leu  His Lys Ala Phe Phe  Ser Pro Phe Arg Ile  Val Asn Glu 
    1115                 1120                 1125             


Gly Gly  Ile Asp Pro Leu Leu  Arg Gly Leu Phe Gly  Val Ala Gly 
    1130                 1135                 1140             


Lys Met  Arg Val Pro Ser Gln  Leu Leu Asn Thr Glu  Leu Thr Glu 
    1145                 1150                 1155             


Arg Leu  Phe Ser Met Ala His  Thr Val Ala Leu Asp  Leu Ala Ala 
    1160                 1165                 1170             


Ile Asn  Ile Gln Arg Gly Arg  Asp His Gly Ile Pro  Pro Tyr His 
    1175                 1180                 1185             


Asp Tyr  Arg Val Tyr Cys Asn  Leu Ser Ala Ala His  Thr Phe Glu 
    1190                 1195                 1200             


Asp Leu  Lys Asn Glu Ile Lys  Asn Pro Glu Ile Arg  Glu Lys Leu 
    1205                 1210                 1215             


Lys Arg  Leu Tyr Gly Ser Thr  Leu Asn Ile Asp Leu  Phe Pro Ala 
    1220                 1225                 1230             


Leu Val  Val Glu Asp Leu Val  Pro Gly Ser Arg Leu  Gly Pro Thr 
    1235                 1240                 1245             


Leu Met  Cys Leu Leu Ser Thr  Gln Phe Lys Arg Leu  Arg Asp Gly 
    1250                 1255                 1260             


Asp Arg  Leu Trp Tyr Glu Asn  Pro Gly Val Phe Ser  Pro Ala Gln 
    1265                 1270                 1275             


Leu Thr  Gln Ile Lys Gln Thr  Ser Leu Ala Arg Ile  Leu Cys Asp 
    1280                 1285                 1290             


Asn Ala  Asp Asn Ile Thr Arg  Val Gln Ser Asp Val  Phe Arg Val 
    1295                 1300                 1305             


Ala Glu  Phe Pro His Gly Tyr  Gly Ser Cys Asp Glu  Ile Pro Arg 
    1310                 1315                 1320             


Val Asp  Leu Arg Val Trp Gln  Asp Cys Cys Glu Asp  Cys Arg Thr 
    1325                 1330                 1335             


Arg Gly  Gln Phe Asn Ala Phe  Ser Tyr His Phe Arg  Gly Arg Arg 
    1340                 1345                 1350             


Ser Leu  Glu Phe Ser Tyr Gln  Glu Asp Lys Pro Thr  Lys Lys Thr 
    1355                 1360                 1365             


Arg Pro  Arg Lys Ile Pro Ser  Val Gly Arg Gln Gly  Glu His Leu 
    1370                 1375                 1380             


Ser Asn  Ser Thr Ser Ala Phe  Ser Thr Arg Ser Asp  Ala Ser Gly 
    1385                 1390                 1395             


Thr Asn  Asp Phe Arg Glu Phe  Val Leu Glu Met Gln  Lys Thr Ile 
    1400                 1405                 1410             


Thr Asp  Leu Arg Thr Gln Ile  Lys Lys Leu Glu Ser  Arg Leu Ser 
    1415                 1420                 1425             


Thr Thr  Glu Cys Val Asp Ala  Gly Gly Glu Ser His  Ala Asn Asn 
    1430                 1435                 1440             


Thr Lys  Trp Lys Lys Asp Ala  Cys Thr Ile Cys Glu  Cys Lys Asp 
    1445                 1450                 1455             


Gly Gln  Val Thr Cys Phe Val  Glu Ala Cys Pro Pro  Ala Thr Cys 
    1460                 1465                 1470             


Ala Val  Pro Val Asn Ile Pro  Gly Ala Cys Cys Pro  Val Cys Leu 
    1475                 1480                 1485             


Gln Lys  Arg Ala Glu Glu Lys  Pro 
    1490                 1495     


<210>  617

<211>  4866

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (12)..(4628)

<223>  



<400>  617
cggcgccagg g atg gat atc tgc aga acc tgc ctt cgt aga cga ctc act      50
             Met Asp Ile Cys Arg Thr Cys Leu Arg Arg Arg Leu Thr        
             1               5                   10                     

ata tgc tgc tct ccc tcc ggc tgc ttc ttc gcg tgg cca gca gcg aat       98
Ile Cys Cys Ser Pro Ser Gly Cys Phe Phe Ala Trp Pro Ala Ala Asn         
    15                  20                  25                          

gga gcg atg gag ccc aga ctg ttc tgc tgg acc act ctc ttt ctc ctg      146
Gly Ala Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu         
30                  35                  40                  45          

gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc agc cgg tgc ctt tgc      194
Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys         
                50                  55                  60              

ttt aag agc acc gtc cgc tgc atg cac ttg atg ctg gac cac att cct      242
Phe Lys Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro         
            65                  70                  75                  

cag gta cca cag cag acc aca gtt cta gac ttg agg ttt aac aga ata      290
Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile         
        80                  85                  90                      

aga gaa att cca ggg agc gcc ttc aag aaa ctc aag aat ttg aac aca      338
Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr         
    95                  100                 105                         

ctt tac ctg tat aag aac cac atc aga aag att tcc aga aat gct ttt      386
Leu Tyr Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe         
110                 115                 120                 125         

gaa gga ctt gaa aat ttg cta tat ctg tat att cat ttc aac caa cta      434
Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu         
                130                 135                 140             

gaa atg cta cag cca gag acc ttt gga gac ctt ctg aga tta gag cga      482
Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg         
            145                 150                 155                 

cta ttt ttg cat aac aac aaa tta tct aaa att cca gct ggg agc ttt      530
Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe         
        160                 165                 170                     

tct aat ctg gat tca tta aaa aga ttg cgt ctg gat tcc aac gcc ctg      578
Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu         
    175                 180                 185                         

gtt tgt gac tgt gat ctg atg tgg ctg ggg gag ctt tta caa ggc ttt      626
Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe         
190                 195                 200                 205         

gcc caa cac ggc cac acc cag gct gcg gct acc tgc gaa tat ccc agg      674
Ala Gln His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg         
                210                 215                 220             

aga ctc cat ggg cgt gca gtt gct tca gta aca gta gag gaa ttc aat      722
Arg Leu His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn         
            225                 230                 235                 

tgc cag agc ccc cga att act ttt gag ccg cag gat gtg gag gta cca      770
Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro         
        240                 245                 250                     

tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga aac ccc aaa      818
Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys         
    255                 260                 265                         

cct gag att att tgg ata cac aac aac cac tca ttg gat ttg gaa gat      866
Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp         
270                 275                 280                 285         

gat act cga ctt aat gtg ttt gat gat ggc aca ctc atg atc cga aac      914
Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn         
                290                 295                 300             

acc aga gag tca gac caa ggt gtc tat cag tgc atg gcc aga aat tcc      962
Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser         
            305                 310                 315                 

gct ggg gaa gcc aag aca cag agt gcc atg ctc aga tac tcc agt ctt     1010
Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu         
        320                 325                 330                     

cca gcc aaa cca ggc ttt gta atc cag cct cag gac aca gag gtt tta     1058
Pro Ala Lys Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu         
    335                 340                 345                         

act ggc acc agc aca act ttg gaa tgt atg gcc aca ggc cac cca cac     1106
Thr Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His         
350                 355                 360                 365         

cct ctt atc act tgg acc agg gac aat gga ttg gag ttg gat gga tcc     1154
Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser         
                370                 375                 380             

agg cat gtg gca acg tcc agt gga ctt tac tta cag aac atc aca caa     1202
Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln         
            385                 390                 395                 

cgg gat cat ggt cga ttt acc tgt cat gcc aac aat agc cac ggc act     1250
Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr         
        400                 405                 410                     

gtt caa gct gca gca aac ata att gta caa gct cct cca caa ttt aca     1298
Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr         
    415                 420                 425                         

gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct gta gag tgg     1346
Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp         
430                 435                 440                 445         

ctc tgt gaa gct gac ggc aac cca cct cct gtt att gtc tgg aca aaa     1394
Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys         
                450                 455                 460             

aca ggt att aga aca tct gca gga ggg cag ctc cct gtg gaa ggc cag     1442
Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln         
            465                 470                 475                 

cat aca gtt ctc tcc tct ggc act ttg aga att gac cgt gca gca cag     1490
His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln         
        480                 485                 490                     

cac gat caa ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg     1538
His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val         
    495                 500                 505                         

aaa aag gtg tct gtg cag ctg act gta aaa ccc aaa ggc cct agc agc     1586
Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser         
510                 515                 520                 525         

aac act aag aca gct gga aaa gcc ccc tta ata ccc tgc tgt gtt ttc     1634
Asn Thr Lys Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe         
                530                 535                 540             

agg ccc ttc ctg gtc tca gct ctt gca gtg ttt act caa ctt cct cag     1682
Arg Pro Phe Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln         
            545                 550                 555                 

gat aca agt gtc gag gtt gga aag aat ata aac att tca tgt cat gct     1730
Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala         
        560                 565                 570                     

caa gga gaa cca cag ccc ata att act tgg aat aag gaa ggt gtg aag     1778
Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys         
    575                 580                 585                         

att act gag agt ggt aaa ttc cat gtg gat gat gaa ggc acg ttg act     1826
Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr         
590                 595                 600                 605         

atc tac gac gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct     1874
Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala         
                610                 615                 620             

cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg     1922
Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr         
            625                 630                 635                 

ggc tgt gac cag tat tgg ggg ttg ggg acc tct gtc ata gga tct tcg     1970
Gly Cys Asp Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser         
        640                 645                 650                     

aac ctc agt gag gag cac gga ttt att ctg aag gcg ctg ggg ttg gga     2018
Asn Leu Ser Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly         
    655                 660                 665                         

acc cct ggt cta gct ata cag ggt aga caa gct ggc gat gac ttt gtt     2066
Thr Pro Gly Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val         
670                 675                 680                 685         

gaa tct tcc att ctt gat gct gta cag aga gtt gac agt gca att aac     2114
Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn         
                690                 695                 700             

tcc aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt gac     2162
Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp         
            705                 710                 715                 

ctg ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg     2210
Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met         
        720                 725                 730                     

gca aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa     2258
Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu         
    735                 740                 745                         

cgt gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg     2306
Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg         
750                 755                 760                 765         

tac aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta     2354
Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu         
                770                 775                 780             

tct gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt     2402
Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys         
            785                 790                 795                 

ttc cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag     2450
Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln         
        800                 805                 810                     

cag ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag     2498
Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln         
    815                 820                 825                         

cca gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct     2546
Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro         
830                 835                 840                 845         

gtg ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg     2594
Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val         
                850                 855                 860             

tgg gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg     2642
Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met         
            865                 870                 875                 

ctc atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg     2690
Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val         
        880                 885                 890                     

cct gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc     2738
Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser         
    895                 900                 905                         

gtc tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc     2786
Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala         
910                 915                 920                 925         

gac ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc     2834
Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser         
                930                 935                 940             

ccc gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat     2882
Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr         
            945                 950                 955                 

gca cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac     2930
Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn         
        960                 965                 970                     

gtt tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg     2978
Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser         
    975                 980                 985                         

gtg cct cgg ggt ctc ctg aag aca ggc ttt cct  tgg cct ccc tcc gga    3026
Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro  Trp Pro Pro Ser Gly        
990                 995                 1000                 1005       

aag ccc tta ttg ccc  ttt tct aca ggc cca  ccc acc gag tgc gcg       3071
Lys Pro Leu Leu Pro  Phe Ser Thr Gly Pro  Pro Thr Glu Cys Ala           
                1010                 1015                 1020          

cga cag gag cag gag  agc ccc tgt ttc ctg  gcc ggg gac cac cgg       3116
Arg Gln Glu Gln Glu  Ser Pro Cys Phe Leu  Ala Gly Asp His Arg           
                1025                 1030                 1035          

gcc aac gag cat ctg  gct ctg gcc gcc atg  cac acc ctg tgg ttc       3161
Ala Asn Glu His Leu  Ala Leu Ala Ala Met  His Thr Leu Trp Phe           
                1040                 1045                 1050          

cgg gaa cac aac agg  gtg gcc acg gag ctg  tcc gcc ctg aac ccc       3206
Arg Glu His Asn Arg  Val Ala Thr Glu Leu  Ser Ala Leu Asn Pro           
                1055                 1060                 1065          

cac tgg gag gga aac  acg gtt tac cag gaa  gcc agg aag atc gtg       3251
His Trp Glu Gly Asn  Thr Val Tyr Gln Glu  Ala Arg Lys Ile Val           
                1070                 1075                 1080          

ggc gcg gag ctg cag  cac atc acc tac agc  cac tgg ctg cct aag       3296
Gly Ala Glu Leu Gln  His Ile Thr Tyr Ser  His Trp Leu Pro Lys           
                1085                 1090                 1095          

gtc ctg ggg gac cct  ggc act agg atg ctg  agg ggt tac cga ggc       3341
Val Leu Gly Asp Pro  Gly Thr Arg Met Leu  Arg Gly Tyr Arg Gly           
                1100                 1105                 1110          

tac aac ccc aac gtg  aat gca ggc atc att  aac tct ttt gct act       3386
Tyr Asn Pro Asn Val  Asn Ala Gly Ile Ile  Asn Ser Phe Ala Thr           
                1115                 1120                 1125          

gca gcc ttt aga ttt  ggc cac aca tta atc  aat cct att ctt tac       3431
Ala Ala Phe Arg Phe  Gly His Thr Leu Ile  Asn Pro Ile Leu Tyr           
                1130                 1135                 1140          

cga ctg aat gcc acc  tta ggt gaa att tcc  gaa ggc cac ctt ccg       3476
Arg Leu Asn Ala Thr  Leu Gly Glu Ile Ser  Glu Gly His Leu Pro           
                1145                 1150                 1155          

ttc cat aaa gcg ctc  ttt tca ccg tcc aga  ata atc aag gaa ggt       3521
Phe His Lys Ala Leu  Phe Ser Pro Ser Arg  Ile Ile Lys Glu Gly           
                1160                 1165                 1170          

ggg ata gac ccg gtt  ctc cgg ggg ctg ttt  ggc gtg gct gct aaa       3566
Gly Ile Asp Pro Val  Leu Arg Gly Leu Phe  Gly Val Ala Ala Lys           
                1175                 1180                 1185          

tgg cgg gca ccc tcc  tac ctt ctc agt cct  gag ctg acc cag agg       3611
Trp Arg Ala Pro Ser  Tyr Leu Leu Ser Pro  Glu Leu Thr Gln Arg           
                1190                 1195                 1200          

ctc ttc tcc gcg gct  tat tct gcg gcc gtg  gat tcg gct gcc acc       3656
Leu Phe Ser Ala Ala  Tyr Ser Ala Ala Val  Asp Ser Ala Ala Thr           
                1205                 1210                 1215          

atc att caa agg ggt  aga gac cac ggg atc  cca cca tat gtt gac       3701
Ile Ile Gln Arg Gly  Arg Asp His Gly Ile  Pro Pro Tyr Val Asp           
                1220                 1225                 1230          

ttc aga gtt ttc tgt  aat ttg act tca gtt  aag aac ttt gag gat       3746
Phe Arg Val Phe Cys  Asn Leu Thr Ser Val  Lys Asn Phe Glu Asp           
                1235                 1240                 1245          

ctt caa aat gaa att  aaa gat tca gag att  aga caa aaa ctg aga       3791
Leu Gln Asn Glu Ile  Lys Asp Ser Glu Ile  Arg Gln Lys Leu Arg           
                1250                 1255                 1260          

aag ttg tac ggc tct  cca ggt gac att gac  ctc tgg ccc gcc ctt       3836
Lys Leu Tyr Gly Ser  Pro Gly Asp Ile Asp  Leu Trp Pro Ala Leu           
                1265                 1270                 1275          

atg gtt gaa gac ctg  att cct ggt aca aga  gtg gga cca aca ctt       3881
Met Val Glu Asp Leu  Ile Pro Gly Thr Arg  Val Gly Pro Thr Leu           
                1280                 1285                 1290          

atg tgc ctg ttt gtt  acc cag ttt cag cgg  cta aga gat gga gat       3926
Met Cys Leu Phe Val  Thr Gln Phe Gln Arg  Leu Arg Asp Gly Asp           
                1295                 1300                 1305          

agg ttc tgg tat gaa  aac cct gga gta ttt  acc ccg gca caa ctc       3971
Arg Phe Trp Tyr Glu  Asn Pro Gly Val Phe  Thr Pro Ala Gln Leu           
                1310                 1315                 1320          

act cag ctg aag cag  gcg tcc ctg agc cgg  gtg ctt tgt gac aat       4016
Thr Gln Leu Lys Gln  Ala Ser Leu Ser Arg  Val Leu Cys Asp Asn           
                1325                 1330                 1335          

ggt gac agc att cag  caa gtg cag gct gat  gtc ttt gta aag gca       4061
Gly Asp Ser Ile Gln  Gln Val Gln Ala Asp  Val Phe Val Lys Ala           
                1340                 1345                 1350          

gaa tac cca cag gat  tac ctg aac tgc agc  gag atc ccg aag gtg       4106
Glu Tyr Pro Gln Asp  Tyr Leu Asn Cys Ser  Glu Ile Pro Lys Val           
                1355                 1360                 1365          

gac ctg cga gtg tgg  caa gac tgc tgt gca  gac tgt agg agt aga       4151
Asp Leu Arg Val Trp  Gln Asp Cys Cys Ala  Asp Cys Arg Ser Arg           
                1370                 1375                 1380          

gga cag ttc aga gca  gtg acg caa gag tct  caa aag aaa cgc tca       4196
Gly Gln Phe Arg Ala  Val Thr Gln Glu Ser  Gln Lys Lys Arg Ser           
                1385                 1390                 1395          

gct caa tac agc tat  cct gtt gat aag gat  atg gag tta agt cat       4241
Ala Gln Tyr Ser Tyr  Pro Val Asp Lys Asp  Met Glu Leu Ser His           
                1400                 1405                 1410          

cta aga agt agg caa  caa gat aaa ata tat  gtg ggt gaa gat gct       4286
Leu Arg Ser Arg Gln  Gln Asp Lys Ile Tyr  Val Gly Glu Asp Ala           
                1415                 1420                 1425          

aga aat gtg aca gtt  ctg gca aaa aca aag  ttc tcc caa gat ttc       4331
Arg Asn Val Thr Val  Leu Ala Lys Thr Lys  Phe Ser Gln Asp Phe           
                1430                 1435                 1440          

agc acg ttt gca gcg  gaa att cag gaa acc  atc aca gca ctc aga       4376
Ser Thr Phe Ala Ala  Glu Ile Gln Glu Thr  Ile Thr Ala Leu Arg           
                1445                 1450                 1455          

gag cag ata aac aag  ctg gag gca cgc ctg  agg cag gca ggg tgt       4421
Glu Gln Ile Asn Lys  Leu Glu Ala Arg Leu  Arg Gln Ala Gly Cys           
                1460                 1465                 1470          

aca gat gtt aga ggg  gtt cca agg aag gcc  gag gag cgc tgg atg       4466
Thr Asp Val Arg Gly  Val Pro Arg Lys Ala  Glu Glu Arg Trp Met           
                1475                 1480                 1485          

aaa gaa gac tgc act  cac tgc att tgt gag  agt ggc cag gtc acc       4511
Lys Glu Asp Cys Thr  His Cys Ile Cys Glu  Ser Gly Gln Val Thr           
                1490                 1495                 1500          

tgt gtg gtg gag att  tgt ccc ccg gct ccc  tgt ccc agt cct gaa       4556
Cys Val Val Glu Ile  Cys Pro Pro Ala Pro  Cys Pro Ser Pro Glu           
                1505                 1510                 1515          

ttg gtg aaa gga acc  tgc tgt cca gtt tgc  aga gac cga gga atg       4601
Leu Val Lys Gly Thr  Cys Cys Pro Val Cys  Arg Asp Arg Gly Met           
                1520                 1525                 1530          

cca agt gat tcc cca  gag aag cgc taa taaaagtttt gtgctgttga          4648
Pro Ser Asp Ser Pro  Glu Lys Arg                                        
                1535                                                    

gccccaaatg ggaaatttct caggaagaga catttaggac ttcagaactt ttaacttgta   4708

gtcacattgt tgatatggaa accactgact taagcaactt agttcatcta atcttacata   4768

tacttacgat cttttatttt ttcattttct aacatacctt gaaataattc aaaactaaaa   4828

gcaataaagt gcatatgaag tgtttgatca taagaaat                           4866


<210>  618

<211>  1538

<212>  PRT

<213>  Homo sapiens



<400>  618

Met Asp Ile Cys Arg Thr Cys Leu Arg Arg Arg Leu Thr Ile Cys Cys 
1               5                   10                  15      


Ser Pro Ser Gly Cys Phe Phe Ala Trp Pro Ala Ala Asn Gly Ala Met 
            20                  25                  30          


Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly Trp 
        35                  40                  45              


Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser 
    50                  55                  60                  


Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val Pro 
65                  70                  75                  80  


Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile 
                85                  90                  95      


Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu 
            100                 105                 110         


Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu 
        115                 120                 125             


Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu Met Leu 
    130                 135                 140                 


Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu 
145                 150                 155                 160 


His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu 
                165                 170                 175     


Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys Asp 
            180                 185                 190         


Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln His 
        195                 200                 205             


Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu His 
    210                 215                 220                 


Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln Ser 
225                 230                 235                 240 


Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly Asn 
                245                 250                 255     


Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile 
            260                 265                 270         


Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr Arg 
        275                 280                 285             


Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg Glu 
    290                 295                 300                 


Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly Glu 
305                 310                 315                 320 


Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys 
                325                 330                 335     


Pro Gly Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Thr Gly Thr 
            340                 345                 350         


Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu Ile 
        355                 360                 365             


Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His Val 
    370                 375                 380                 


Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp His 
385                 390                 395                 400 


Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln Ala 
                405                 410                 415     


Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr Pro 
            420                 425                 430         


Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys Glu 
        435                 440                 445             


Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly Ile 
    450                 455                 460                 


Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr Val 
465                 470                 475                 480 


Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln 
                485                 490                 495     


Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val 
            500                 505                 510         


Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Ser Ser Asn Thr Lys 
        515                 520                 525             


Thr Ala Gly Lys Ala Pro Leu Ile Pro Cys Cys Val Phe Arg Pro Phe 
    530                 535                 540                 


Leu Val Ser Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr Ser 
545                 550                 555                 560 


Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly Glu 
                565                 570                 575     


Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Lys Ile Thr Glu 
            580                 585                 590         


Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp 
        595                 600                 605             


Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser 
    610                 615                 620                 


Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Gly Cys Asp 
625                 630                 635                 640 


Gln Tyr Trp Gly Leu Gly Thr Ser Val Ile Gly Ser Ser Asn Leu Ser 
                645                 650                 655     


Glu Glu His Gly Phe Ile Leu Lys Ala Leu Gly Leu Gly Thr Pro Gly 
            660                 665                 670         


Leu Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser 
        675                 680                 685             


Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg 
    690                 695                 700                 


Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala 
705                 710                 715                 720 


Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala 
                725                 730                 735     


Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys 
            740                 745                 750         


Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp 
        755                 760                 765             


Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys 
    770                 775                 780                 


Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala 
785                 790                 795                 800 


Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr 
                805                 810                 815     


Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr 
            820                 825                 830         


Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser 
        835                 840                 845             


Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg 
    850                 855                 860                 


Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His 
865                 870                 875                 880 


Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu 
                885                 890                 895     


Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr 
            900                 905                 910         


Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg 
        915                 920                 925             


Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys 
    930                 935                 940                 


Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu 
945                 950                 955                 960 


Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly 
                965                 970                 975     


Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg 
            980                 985                 990         


Gly Leu Leu Lys Thr Gly Phe Pro  Trp Pro Pro Ser Gly  Lys Pro Leu 
        995                 1000                 1005             


Leu Pro  Phe Ser Thr Gly Pro  Pro Thr Glu Cys Ala  Arg Gln Glu 
    1010                 1015                 1020             


Gln Glu  Ser Pro Cys Phe Leu  Ala Gly Asp His Arg  Ala Asn Glu 
    1025                 1030                 1035             


His Leu  Ala Leu Ala Ala Met  His Thr Leu Trp Phe  Arg Glu His 
    1040                 1045                 1050             


Asn Arg  Val Ala Thr Glu Leu  Ser Ala Leu Asn Pro  His Trp Glu 
    1055                 1060                 1065             


Gly Asn  Thr Val Tyr Gln Glu  Ala Arg Lys Ile Val  Gly Ala Glu 
    1070                 1075                 1080             


Leu Gln  His Ile Thr Tyr Ser  His Trp Leu Pro Lys  Val Leu Gly 
    1085                 1090                 1095             


Asp Pro  Gly Thr Arg Met Leu  Arg Gly Tyr Arg Gly  Tyr Asn Pro 
    1100                 1105                 1110             


Asn Val  Asn Ala Gly Ile Ile  Asn Ser Phe Ala Thr  Ala Ala Phe 
    1115                 1120                 1125             


Arg Phe  Gly His Thr Leu Ile  Asn Pro Ile Leu Tyr  Arg Leu Asn 
    1130                 1135                 1140             


Ala Thr  Leu Gly Glu Ile Ser  Glu Gly His Leu Pro  Phe His Lys 
    1145                 1150                 1155             


Ala Leu  Phe Ser Pro Ser Arg  Ile Ile Lys Glu Gly  Gly Ile Asp 
    1160                 1165                 1170             


Pro Val  Leu Arg Gly Leu Phe  Gly Val Ala Ala Lys  Trp Arg Ala 
    1175                 1180                 1185             


Pro Ser  Tyr Leu Leu Ser Pro  Glu Leu Thr Gln Arg  Leu Phe Ser 
    1190                 1195                 1200             


Ala Ala  Tyr Ser Ala Ala Val  Asp Ser Ala Ala Thr  Ile Ile Gln 
    1205                 1210                 1215             


Arg Gly  Arg Asp His Gly Ile  Pro Pro Tyr Val Asp  Phe Arg Val 
    1220                 1225                 1230             


Phe Cys  Asn Leu Thr Ser Val  Lys Asn Phe Glu Asp  Leu Gln Asn 
    1235                 1240                 1245             


Glu Ile  Lys Asp Ser Glu Ile  Arg Gln Lys Leu Arg  Lys Leu Tyr 
    1250                 1255                 1260             


Gly Ser  Pro Gly Asp Ile Asp  Leu Trp Pro Ala Leu  Met Val Glu 
    1265                 1270                 1275             


Asp Leu  Ile Pro Gly Thr Arg  Val Gly Pro Thr Leu  Met Cys Leu 
    1280                 1285                 1290             


Phe Val  Thr Gln Phe Gln Arg  Leu Arg Asp Gly Asp  Arg Phe Trp 
    1295                 1300                 1305             


Tyr Glu  Asn Pro Gly Val Phe  Thr Pro Ala Gln Leu  Thr Gln Leu 
    1310                 1315                 1320             


Lys Gln  Ala Ser Leu Ser Arg  Val Leu Cys Asp Asn  Gly Asp Ser 
    1325                 1330                 1335             


Ile Gln  Gln Val Gln Ala Asp  Val Phe Val Lys Ala  Glu Tyr Pro 
    1340                 1345                 1350             


Gln Asp  Tyr Leu Asn Cys Ser  Glu Ile Pro Lys Val  Asp Leu Arg 
    1355                 1360                 1365             


Val Trp  Gln Asp Cys Cys Ala  Asp Cys Arg Ser Arg  Gly Gln Phe 
    1370                 1375                 1380             


Arg Ala  Val Thr Gln Glu Ser  Gln Lys Lys Arg Ser  Ala Gln Tyr 
    1385                 1390                 1395             


Ser Tyr  Pro Val Asp Lys Asp  Met Glu Leu Ser His  Leu Arg Ser 
    1400                 1405                 1410             


Arg Gln  Gln Asp Lys Ile Tyr  Val Gly Glu Asp Ala  Arg Asn Val 
    1415                 1420                 1425             


Thr Val  Leu Ala Lys Thr Lys  Phe Ser Gln Asp Phe  Ser Thr Phe 
    1430                 1435                 1440             


Ala Ala  Glu Ile Gln Glu Thr  Ile Thr Ala Leu Arg  Glu Gln Ile 
    1445                 1450                 1455             


Asn Lys  Leu Glu Ala Arg Leu  Arg Gln Ala Gly Cys  Thr Asp Val 
    1460                 1465                 1470             


Arg Gly  Val Pro Arg Lys Ala  Glu Glu Arg Trp Met  Lys Glu Asp 
    1475                 1480                 1485             


Cys Thr  His Cys Ile Cys Glu  Ser Gly Gln Val Thr  Cys Val Val 
    1490                 1495                 1500             


Glu Ile  Cys Pro Pro Ala Pro  Cys Pro Ser Pro Glu  Leu Val Lys 
    1505                 1510                 1515             


Gly Thr  Cys Cys Pro Val Cys  Arg Asp Arg Gly Met  Pro Ser Asp 
    1520                 1525                 1530             


Ser Pro  Glu Lys Arg 
    1535             


<210>  619

<211>  4617

<212>  DNA

<213>  Homo sapiens



<400>  619
atggatatct gcagaacctg ccttcgtaga cgactcacta tatgctgctc tccctccggc     60

tgcttcttcg cgtggccagc agcgaatgga gcgatggagc ccagactgtt ctgctggacc    120

actctctttc tcctggccgg gtggtgcctg ccagggttgc cctgccccag ccggtgcctt    180

tgctttaaga gcaccgtccg ctgcatgcac ttgatgctgg accacattcc tcaggtacca    240

cagcagacca cagttctaga cttgaggttt aacagaataa gagaaattcc agggagcgcc    300

ttcaagaaac tcaagaattt gaacacactt tacctgtata agaaccacat cagaaagatt    360

tccagaaatg cttttgaagg acttgaaaat ttgctatatc tgtatattca tttcaaccaa    420

ctagaaatgc tacagccaga gacctttgga gaccttctga gattagagcg actatttttg    480

cataacaaca aattatctaa aattccagct gggagctttt ctaatctgga ttcattaaaa    540

agattgcgtc tggattccaa cgccctggtt tgtgactgtg atctgatgtg gctgggggag    600

cttttacaag gctttgccca acacggccac acccaggctg cggctacctg cgaatatccc    660

aggagactcc atgggcgtgc agttgcttca gtaacagtag aggaattcaa ttgccagagc    720

ccccgaatta cttttgagcc gcaggatgtg gaggtaccat caggaaatac cgtctacttc    780

acctgccggg cggaaggaaa ccccaaacct gagattattt ggatacacaa caaccactca    840

ttggatttgg aagatgatac tcgacttaat gtgtttgatg atggcacact catgatccga    900

aacaccagag agtcagacca aggtgtctat cagtgcatgg ccagaaattc cgctggggaa    960

gccaagacac agagtgccat gctcagatac tccagtcttc cagccaaacc aggctttgta   1020

atccagcctc aggacacaga ggttttaact ggcaccagca caactttgga atgtatggcc   1080

acaggccacc cacaccctct tatcacttgg accagggaca atggattgga gttggatgga   1140

tccaggcatg tggcaacgtc cagtggactt tacttacaga acatcacaca acgggatcat   1200

ggtcgattta cctgtcatgc caacaatagc cacggcactg ttcaagctgc agcaaacata   1260

attgtacaag ctcctccaca atttacagta acccccaagg atcaagtggt gctggaagaa   1320

catgctgtag agtggctctg tgaagctgac ggcaacccac ctcctgttat tgtctggaca   1380

aaaacaggta ttagaacatc tgcaggaggg cagctccctg tggaaggcca gcatacagtt   1440

ctctcctctg gcactttgag aattgaccgt gcagcacagc acgatcaagg ccaatatgaa   1500

tgtcaagcag tcagttcgtt gggggtgaaa aaggtgtctg tgcagctgac tgtaaaaccc   1560

aaaggcccta gcagcaacac taagacagct ggaaaagccc ccttaatacc ctgctgtgtt   1620

ttcaggccct tcctggtctc agctcttgca gtgtttactc aacttcctca ggatacaagt   1680

gtcgaggttg gaaagaatat aaacatttca tgtcatgctc aaggagaacc acagcccata   1740

attacttgga ataaggaagg tgtgaagatt actgagagtg gtaaattcca tgtggatgat   1800

gaaggcacgt tgactatcta cgacgcaggg ttccctgacc agggaagata tgaatgtgtg   1860

gctcggaatt cttttggcct tgctgtgacc aacatgtttc ttacagtcac gggctgtgac   1920

cagtattggg ggttggggac ctctgtcata ggatcttcga acctcagtga ggagcacgga   1980

tttattctga aggcgctggg gttgggaacc cctggtctag ctatacaggg tagacaagct   2040

ggcgatgact ttgttgaatc ttccattctt gatgctgtac agagagttga cagtgcaatt   2100

aactccacac gaagacattt gttttcacaa aaacctcaca cctccagtga cctgctggct   2160

caatttcatt acccgcgtga cccactgatt gtggaaatgg caagagcagg ggagattttt   2220

gagcacacgc tgcagctgat acgggaacgt gtgaagcagg ggctcactgt ggacttggaa   2280

ggcaaagaat tccggtacaa tgacttggtg tccccgcgct ccctcagcct catcgccaat   2340

ttatctggat gcacagctcg caggcctctg ccaaactgct ccaaccggtg tttccatgcg   2400

aagtaccgcg cccacgacgg cacgtgcaac aacctgcagc agcccacgtg gggcgcggcg   2460

ctgaccgcct tcgcgcgcct gctgcagcca gcctaccggg acggcatccg cgcgccccgc   2520

gggctcggcc ttcctgtggg ctcccgccag cccctcccgc cgccccggct ggtcgccaca   2580

gtgtgggcgc gcgcggcggc cgtcaccccc gaccacagct acacgcgcat gctcatgcac   2640

tggggctggt ttctagagca cgacttggac cacacagtgc ctgcgctgag cacagcccgc   2700

ttctcggatg ggcggccgtg cagctccgtc tgcaccaacg accctccttg tttccccatg   2760

aacacccggc acgccgaccc ccggggcacc cacgcgccct gcatgctctt cgcgcgctcc   2820

agccccgcgt gtgccagcgg ccgtccctct gcgacggtgg attcagtcta tgcacgagag   2880

cagatcaacc agcaaacagc ctacatcgat ggctccaacg tttacgggag ctcggagcgg   2940

gaatcccagg ctctcagaga cccttcggtg cctcggggtc tcctgaagac aggctttcct   3000

tggcctccct ccggaaagcc cttattgccc ttttctacag gcccacccac cgagtgcgcg   3060

cgacaggagc aggagagccc ctgtttcctg gccggggacc accgggccaa cgagcatctg   3120

gctctggccg ccatgcacac cctgtggttc cgggaacaca acagggtggc cacggagctg   3180

tccgccctga acccccactg ggagggaaac acggtttacc aggaagccag gaagatcgtg   3240

ggcgcggagc tgcagcacat cacctacagc cactggctgc ctaaggtcct gggggaccct   3300

ggcactagga tgctgagggg ttaccgaggc tacaacccca acgtgaatgc aggcatcatt   3360

aactcttttg ctactgcagc ctttagattt ggccacacat taatcaatcc tattctttac   3420

cgactgaatg ccaccttagg tgaaatttcc gaaggccacc ttccgttcca taaagcgctc   3480

ttttcaccgt ccagaataat caaggaaggt gggatagacc cggttctccg ggggctgttt   3540

ggcgtggctg ctaaatggcg ggcaccctcc taccttctca gtcctgagct gacccagagg   3600

ctcttctccg cggcttattc tgcggccgtg gattcggctg ccaccatcat tcaaaggggt   3660

agagaccacg ggatcccacc atatgttgac ttcagagttt tctgtaattt gacttcagtt   3720

aagaactttg aggatcttca aaatgaaatt aaagattcag agattagaca aaaactgaga   3780

aagttgtacg gctctccagg tgacattgac ctctggcccg cccttatggt tgaagacctg   3840

attcctggta caagagtggg accaacactt atgtgcctgt ttgttaccca gtttcagcgg   3900

ctaagagatg gagataggtt ctggtatgaa aaccctggag tatttacccc ggcacaactc   3960

actcagctga agcaggcgtc cctgagccgg gtgctttgtg acaatggtga cagcattcag   4020

caagtgcagg ctgatgtctt tgtaaaggca gaatacccac aggattacct gaactgcagc   4080

gagatcccga aggtggacct gcgagtgtgg caagactgct gtgcagactg taggagtaga   4140

ggacagttca gagcagtgac gcaagagtct caaaagaaac gctcagctca atacagctat   4200

cctgttgata aggatatgga gttaagtcat ctaagaagta ggcaacaaga taaaatatat   4260

gtgggtgaag atgctagaaa tgtgacagtt ctggcaaaaa caaagttctc ccaagatttc   4320

agcacgtttg cagcggaaat tcaggaaacc atcacagcac tcagagagca gataaacaag   4380

ctggaggcac gcctgaggca ggcagggtgt acagatgtta gaggggttcc aaggaaggcc   4440

gaggagcgct ggatgaaaga agactgcact cactgcattt gtgagagtgg ccaggtcacc   4500

tgtgtggtgg agatttgtcc cccggctccc tgtcccagtc ctgaattggt gaaaggaacc   4560

tgctgtccag tttgcagaga ccgaggaatg ccaagtgatt ccccagagaa gcgctaa      4617


<210>  620

<211>  54

<212>  PRT

<213>  Homo sapiens



<400>  620

Met Asp Ile Cys Arg Thr Cys Leu Arg Arg Arg Leu Thr Ile Cys Cys 
1               5                   10                  15      


Ser Pro Ser Gly Cys Phe Phe Ala Trp Pro Ala Ala Asn Gly Ala Met 
            20                  25                  30          


Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly Trp 
        35                  40                  45              


Cys Leu Pro Gly Leu Pro 
    50                  


<210>  621

<211>  4543

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (103)..(4305)

<223>  



<400>  621
gagtccagca gccaccatca ccaccactgc ggttgctgct gcagctgcag ctgctgctct     60

ccctccggct gcttcttcgc gtggccagca gcgaatggag cg atg gag ccc aga       114
                                               Met Glu Pro Arg          
                                               1                        

ctg ttc tgc tgg acc act ctc ttt ctc ctg gcc ggg tgg tgc ctg cca      162
Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly Trp Cys Leu Pro         
5                   10                  15                  20          

ggg ttg ccc tgc ccc agc cgg tgc ctt tgc ttt aag agc acc gtc cgc      210
Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg         
                25                  30                  35              

tgc atg cac ttg atg ctg gac cac att cct cag gta cca cag cag acc      258
Cys Met His Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr         
            40                  45                  50                  

aca gtt cta gac ttg agg ttt aac aga ata aga gaa att cca ggg agc      306
Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser         
        55                  60                  65                      

gcc ttc aag aaa ctc aag aat ttg aac aca ctt ctg ctg aac aac aac      354
Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn         
    70                  75                  80                          

cac atc aga aag att tcc aga aat gct ttt gaa gga ctt gaa aat ttg      402
His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu         
85                  90                  95                  100         

cta tat ctg tac ctg tat aag aat gaa atc cat gca cta gat aag caa      450
Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln         
                105                 110                 115             

aca ttt aaa gga ctc ata tct ttg gaa cat ctg tat att cat ttc aac      498
Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn         
            120                 125                 130                 

caa cta gaa atg cta cag cca gag acc ttt gga gac ctt ctg aga tta      546
Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu         
        135                 140                 145                     

gag cga ctg gat gaa gcc cac ttg atc atg gtg gat aag ctt ttt gat      594
Glu Arg Leu Asp Glu Ala His Leu Ile Met Val Asp Lys Leu Phe Asp         
    150                 155                 160                         

gtg ctg ctg gat tcg gtt tgc cag tat ttt att gag gat ttt tgc atc      642
Val Leu Leu Asp Ser Val Cys Gln Tyr Phe Ile Glu Asp Phe Cys Ile         
165                 170                 175                 180         

gat gtt cat cag gag agc ccc cga att act ttt gag ccg cag gat gtg      690
Asp Val His Gln Glu Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val         
                185                 190                 195             

gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga      738
Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly         
            200                 205                 210                 

aac ccc aaa cct gag att att tgg ata cac aac aac cac tca ttg gat      786
Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp         
        215                 220                 225                     

ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca ctc atg      834
Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met         
    230                 235                 240                         

atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc atg gcc      882
Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala         
245                 250                 255                 260         

aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc aga tac      930
Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr         
                265                 270                 275             

tcc agt ctt cca gcc aaa cca agc ttt gta atc cag cct cag gac aca      978
Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr         
            280                 285                 290                 

gag gtt tta att ggc acc agc aca act ttg gaa tgt atg gcc aca ggc     1026
Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly         
        295                 300                 305                     

cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg gag ctg     1074
His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu         
    310                 315                 320                         

gat gga tcc agg cac gtg gca acg tcc agt gga ctt tac tta cag aac     1122
Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn         
325                 330                 335                 340         

atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac aat agc     1170
Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser         
                345                 350                 355             

cac ggc act gtt caa gct gca gca aac ata att gta caa gct cct cca     1218
His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro         
            360                 365                 370                 

caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct     1266
Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala         
        375                 380                 385                     

gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt att gtc     1314
Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val         
    390                 395                 400                         

tgg aca aaa aca ggt att aga aca tct gca gga ggg cag ctc cct gtg     1362
Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val         
405                 410                 415                 420         

gaa ggc cag cat aca gtt ctc tcc tct ggc act ttg aga att gac cgt     1410
Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg         
                425                 430                 435             

gca gca cag cac gat caa ggc caa tat gaa tgt caa gca gtc agt tcg     1458
Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser         
            440                 445                 450                 

ttg ggg gtg aaa aag gtg tct gtg cag ctg act gta aaa ccc aaa ggt     1506
Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly         
        455                 460                 465                     

cca ttt atg caa atg aag gat tca aac ttg ctg agt tct gat tgg ttg     1554
Pro Phe Met Gln Met Lys Asp Ser Asn Leu Leu Ser Ser Asp Trp Leu         
    470                 475                 480                         

gtt cag gta agc tct gaa ggt ctt gaa gtt aaa aag gaa ggt gtg cag     1602
Val Gln Val Ser Ser Glu Gly Leu Glu Val Lys Lys Glu Gly Val Gln         
485                 490                 495                 500         

att act gag agt ggt aaa ttc cat gtg gat gat gaa ggc acg ctg act     1650
Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr         
                505                 510                 515             

atc tac gac gca ggg ttc cct gac cag gga aga tat gaa tgt gtg gct     1698
Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala         
            520                 525                 530                 

cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt aca gtc acg     1746
Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr         
        535                 540                 545                     

gtc tct gaa aaa aca gtg gag ctc tcc agg gca atg aat tgg ttt cca     1794
Val Ser Glu Lys Thr Val Glu Leu Ser Arg Ala Met Asn Trp Phe Pro         
    550                 555                 560                         

tgt tta atg atg caa agt gat gaa aaa cct cac acc tcc agt gac ctg     1842
Cys Leu Met Met Gln Ser Asp Glu Lys Pro His Thr Ser Ser Asp Leu         
565                 570                 575                 580         

ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg gca     1890
Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala         
                585                 590                 595             

aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa cgt     1938
Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg         
            600                 605                 610                 

gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg tac     1986
Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr         
        615                 620                 625                     

aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta tct     2034
Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser         
    630                 635                 640                         

gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt ttc     2082
Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe         
645                 650                 655                 660         

cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag cag     2130
His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln         
                665                 670                 675             

ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag cca     2178
Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro         
            680                 685                 690                 

gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct gtg     2226
Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val         
        695                 700                 705                     

ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg tgg     2274
Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp         
    710                 715                 720                         

gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg ctc     2322
Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu         
725                 730                 735                 740         

atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg cct     2370
Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro         
                745                 750                 755             

gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc gtc     2418
Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val         
            760                 765                 770                 

tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc gac     2466
Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp         
        775                 780                 785                     

ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc ccc     2514
Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro         
    790                 795                 800                         

gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat gca     2562
Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala         
805                 810                 815                 820         

cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac gtt     2610
Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val         
                825                 830                 835             

tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg gtg     2658
Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val         
            840                 845                 850                 

cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc gga aag     2706
Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys         
        855                 860                 865                     

ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg cga cag     2754
Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln         
    870                 875                 880                         

gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc aac gag     2802
Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu         
885                 890                 895                 900         

cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa cac aac     2850
His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn         
                905                 910                 915             

agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag gga aac     2898
Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn         
            920                 925                 930                 

acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg cag cac     2946
Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His         
        935                 940                 945                     

atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac cct ggc act     2994
Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr         
    950                 955                 960                         

agg atg ctg agg ggt tac cga ggc tac aac ccc aac gtg aat gca ggc     3042
Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly         
965                 970                 975                 980         

atc att aac tct ttt gct act gca gcc ttt aga ttt ggc cac aca tta     3090
Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu         
                985                 990                 995             

atc aat cct att  ctt tac cga ctg aat  gcc acc tta ggt gaa  att      3135
Ile Asn Pro Ile  Leu Tyr Arg Leu Asn  Ala Thr Leu Gly Glu  Ile          
            1000                 1005                 1010              

tcc gaa ggc cac  ctt ccg ttc cat aaa  gcg ctc ttt tca ccg  tcc      3180
Ser Glu Gly His  Leu Pro Phe His Lys  Ala Leu Phe Ser Pro  Ser          
            1015                 1020                 1025              

aga ata atc aag  gaa ggt ggg ata gac  ccg gtt ctc cgg ggg  ctg      3225
Arg Ile Ile Lys  Glu Gly Gly Ile Asp  Pro Val Leu Arg Gly  Leu          
            1030                 1035                 1040              

ttt ggc gtg gct  gct aaa tgg cgg gca  ccc tcc tac ctt ctc  agt      3270
Phe Gly Val Ala  Ala Lys Trp Arg Ala  Pro Ser Tyr Leu Leu  Ser          
            1045                 1050                 1055              

cct gag ctg acc  cag agg ctc ttc tcc  gcg gct tat tct gcg  gcc      3315
Pro Glu Leu Thr  Gln Arg Leu Phe Ser  Ala Ala Tyr Ser Ala  Ala          
            1060                 1065                 1070              

gtg gat tcg gct  gcc acc atc att caa  agg ggt aga gac cac  ggg      3360
Val Asp Ser Ala  Ala Thr Ile Ile Gln  Arg Gly Arg Asp His  Gly          
            1075                 1080                 1085              

atc cca cca tat  gtt gac ttc aga gtt  ttc tgt aat ttg act  tca      3405
Ile Pro Pro Tyr  Val Asp Phe Arg Val  Phe Cys Asn Leu Thr  Ser          
            1090                 1095                 1100              

gtt aag aac ttt  gag gat ctt caa aat  gaa att aaa gat tca  gag      3450
Val Lys Asn Phe  Glu Asp Leu Gln Asn  Glu Ile Lys Asp Ser  Glu          
            1105                 1110                 1115              

att aga caa aaa  ctg aga aag ttg tac  ggc tct cca ggt gac  att      3495
Ile Arg Gln Lys  Leu Arg Lys Leu Tyr  Gly Ser Pro Gly Asp  Ile          
            1120                 1125                 1130              

gac ctc tgg ccc  gcc ctt atg gtt gaa  gac ctg att cct ggt  aca      3540
Asp Leu Trp Pro  Ala Leu Met Val Glu  Asp Leu Ile Pro Gly  Thr          
            1135                 1140                 1145              

aga gtg gga cca  aca ctt atg tgc ctg  ttt gtt acc cag ttt  cag      3585
Arg Val Gly Pro  Thr Leu Met Cys Leu  Phe Val Thr Gln Phe  Gln          
            1150                 1155                 1160              

cgg cta aga gat  gga gat agg ttc tgg  tat gaa aac cct gga  gta      3630
Arg Leu Arg Asp  Gly Asp Arg Phe Trp  Tyr Glu Asn Pro Gly  Val          
            1165                 1170                 1175              

ttt acc ccg gca  caa ctc act cag ctg  aag cag gcg tcc ctg  agc      3675
Phe Thr Pro Ala  Gln Leu Thr Gln Leu  Lys Gln Ala Ser Leu  Ser          
            1180                 1185                 1190              

cgg gtg ctt tgt  gac aat ggt gac agc  att cag caa gtg cag  gct      3720
Arg Val Leu Cys  Asp Asn Gly Asp Ser  Ile Gln Gln Val Gln  Ala          
            1195                 1200                 1205              

gat gtc ttt gta  aag gca gaa tac cca  cag gat tac ctg aac  tgc      3765
Asp Val Phe Val  Lys Ala Glu Tyr Pro  Gln Asp Tyr Leu Asn  Cys          
            1210                 1215                 1220              

agc gag atc ccg  aag gtg gac ctg cga  gtg tgg caa gac tgc  tgt      3810
Ser Glu Ile Pro  Lys Val Asp Leu Arg  Val Trp Gln Asp Cys  Cys          
            1225                 1230                 1235              

gca gac tgt agg  agt aga gga cag ttc  aga gca gtg acg caa  gag      3855
Ala Asp Cys Arg  Ser Arg Gly Gln Phe  Arg Ala Val Thr Gln  Glu          
            1240                 1245                 1250              

tct caa aag aaa  cgc tca gct caa tac  agc tat cct gtt gat  aag      3900
Ser Gln Lys Lys  Arg Ser Ala Gln Tyr  Ser Tyr Pro Val Asp  Lys          
            1255                 1260                 1265              

gat atg gag tta  agt cat cta aga agt  agg caa caa gat aaa  ata      3945
Asp Met Glu Leu  Ser His Leu Arg Ser  Arg Gln Gln Asp Lys  Ile          
            1270                 1275                 1280              

tat gtg ggt gaa  gat gct aga aat gtg  aca gtt ctg gca aaa  aca      3990
Tyr Val Gly Glu  Asp Ala Arg Asn Val  Thr Val Leu Ala Lys  Thr          
            1285                 1290                 1295              

aag ttc tcc caa  gat ttc agc acg ttt  gca gcg gaa att cag  gaa      4035
Lys Phe Ser Gln  Asp Phe Ser Thr Phe  Ala Ala Glu Ile Gln  Glu          
            1300                 1305                 1310              

acc atc aca gca  ctc aga gag cag ata  aac aag ctg gag gca  cgc      4080
Thr Ile Thr Ala  Leu Arg Glu Gln Ile  Asn Lys Leu Glu Ala  Arg          
            1315                 1320                 1325              

ctg agg cag gca  ggg tgt aca gat gtt  aga ggg gtt cca agg  aag      4125
Leu Arg Gln Ala  Gly Cys Thr Asp Val  Arg Gly Val Pro Arg  Lys          
            1330                 1335                 1340              

gcc gag gag cgc  tgg atg aaa gaa gac  tgc act cac tgc att  tgt      4170
Ala Glu Glu Arg  Trp Met Lys Glu Asp  Cys Thr His Cys Ile  Cys          
            1345                 1350                 1355              

gag agt ggc cag  gtc acc tgt gtg gtg  gag att tgt ccc ccg  gct      4215
Glu Ser Gly Gln  Val Thr Cys Val Val  Glu Ile Cys Pro Pro  Ala          
            1360                 1365                 1370              

ccc tgt ccc agt  cct gaa ttg gtg aaa  gga acc tgc tgt cca  gtt      4260
Pro Cys Pro Ser  Pro Glu Leu Val Lys  Gly Thr Cys Cys Pro  Val          
            1375                 1380                 1385              

tgc aga gac cga  gga atg cca agt gat  tcc cca gag aag cgc  taa      4305
Cys Arg Asp Arg  Gly Met Pro Ser Asp  Ser Pro Glu Lys Arg               
            1390                 1395                 1400              

taaaagtttt gtgctgttga gccccaaatg ggaaatttct caggaagaga catttaggac   4365

ttcagaactt ttaacttgta gtcacattgt tgatatggaa accactgact taagcaactt   4425

agttcatcta atcttacata tacttacgat cttttatttt ttcattttct aacatacctt   4485

gaaataattc aaaactaaaa gcaataaagt gcatatgaag tgtttgatca taagaaat     4543


<210>  622

<211>  1400

<212>  PRT

<213>  Homo sapiens



<400>  622

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys 
            20                  25                  30          


Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val 
        35                  40                  45              


Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu 
    50                  55                  60                  


Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Leu 
65                  70                  75                  80  


Leu Asn Asn Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly 
                85                  90                  95      


Leu Glu Asn Leu Leu Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile His Ala 
            100                 105                 110         


Leu Asp Lys Gln Thr Phe Lys Gly Leu Ile Ser Leu Glu His Leu Tyr 
        115                 120                 125             


Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp 
    130                 135                 140                 


Leu Leu Arg Leu Glu Arg Leu Asp Glu Ala His Leu Ile Met Val Asp 
145                 150                 155                 160 


Lys Leu Phe Asp Val Leu Leu Asp Ser Val Cys Gln Tyr Phe Ile Glu 
                165                 170                 175     


Asp Phe Cys Ile Asp Val His Gln Glu Ser Pro Arg Ile Thr Phe Glu 
            180                 185                 190         


Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys 
        195                 200                 205             


Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn 
    210                 215                 220                 


His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp 
225                 230                 235                 240 


Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr 
                245                 250                 255     


Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala 
            260                 265                 270         


Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln 
        275                 280                 285             


Pro Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys 
    290                 295                 300                 


Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn 
305                 310                 315                 320 


Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu 
                325                 330                 335     


Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His 
            340                 345                 350         


Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val 
        355                 360                 365             


Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu 
    370                 375                 380                 


Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro 
385                 390                 395                 400 


Pro Val Ile Val Trp Thr Lys Thr Gly Ile Arg Thr Ser Ala Gly Gly 
                405                 410                 415     


Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr Leu 
            420                 425                 430         


Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys Gln 
        435                 440                 445             


Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr Val 
    450                 455                 460                 


Lys Pro Lys Gly Pro Phe Met Gln Met Lys Asp Ser Asn Leu Leu Ser 
465                 470                 475                 480 


Ser Asp Trp Leu Val Gln Val Ser Ser Glu Gly Leu Glu Val Lys Lys 
                485                 490                 495     


Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu 
            500                 505                 510         


Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr 
        515                 520                 525             


Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe 
    530                 535                 540                 


Leu Thr Val Thr Val Ser Glu Lys Thr Val Glu Leu Ser Arg Ala Met 
545                 550                 555                 560 


Asn Trp Phe Pro Cys Leu Met Met Gln Ser Asp Glu Lys Pro His Thr 
                565                 570                 575     


Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile 
            580                 585                 590         


Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu 
        595                 600                 605             


Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys 
    610                 615                 620                 


Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile 
625                 630                 635                 640 


Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser 
                645                 650                 655     


Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn 
            660                 665                 670         


Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg 
        675                 680                 685             


Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu 
    690                 695                 700                 


Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val 
705                 710                 715                 720 


Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr 
                725                 730                 735     


Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp 
            740                 745                 750         


His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro 
        755                 760                 765             


Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr 
    770                 775                 780                 


Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala 
785                 790                 795                 800 


Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp 
                805                 810                 815     


Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp 
            820                 825                 830         


Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg 
        835                 840                 845             


Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro 
    850                 855                 860                 


Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu 
865                 870                 875                 880 


Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His 
                885                 890                 895     


Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe 
            900                 905                 910         


Arg Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His 
        915                 920                 925             


Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala 
    930                 935                 940                 


Glu Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly 
945                 950                 955                 960 


Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn 
                965                 970                 975     


Val Asn Ala Gly Ile Ile Asn Ser Phe Ala Thr Ala Ala Phe Arg Phe 
            980                 985                 990         


Gly His Thr Leu Ile Asn Pro Ile  Leu Tyr Arg Leu Asn  Ala Thr Leu 
        995                 1000                 1005             


Gly Glu  Ile Ser Glu Gly His  Leu Pro Phe His Lys  Ala Leu Phe 
    1010                 1015                 1020             


Ser Pro  Ser Arg Ile Ile Lys  Glu Gly Gly Ile Asp  Pro Val Leu 
    1025                 1030                 1035             


Arg Gly  Leu Phe Gly Val Ala  Ala Lys Trp Arg Ala  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Ser Pro Glu Leu Thr  Gln Arg Leu Phe Ser  Ala Ala Tyr 
    1055                 1060                 1065             


Ser Ala  Ala Val Asp Ser Ala  Ala Thr Ile Ile Gln  Arg Gly Arg 
    1070                 1075                 1080             


Asp His  Gly Ile Pro Pro Tyr  Val Asp Phe Arg Val  Phe Cys Asn 
    1085                 1090                 1095             


Leu Thr  Ser Val Lys Asn Phe  Glu Asp Leu Gln Asn  Glu Ile Lys 
    1100                 1105                 1110             


Asp Ser  Glu Ile Arg Gln Lys  Leu Arg Lys Leu Tyr  Gly Ser Pro 
    1115                 1120                 1125             


Gly Asp  Ile Asp Leu Trp Pro  Ala Leu Met Val Glu  Asp Leu Ile 
    1130                 1135                 1140             


Pro Gly  Thr Arg Val Gly Pro  Thr Leu Met Cys Leu  Phe Val Thr 
    1145                 1150                 1155             


Gln Phe  Gln Arg Leu Arg Asp  Gly Asp Arg Phe Trp  Tyr Glu Asn 
    1160                 1165                 1170             


Pro Gly  Val Phe Thr Pro Ala  Gln Leu Thr Gln Leu  Lys Gln Ala 
    1175                 1180                 1185             


Ser Leu  Ser Arg Val Leu Cys  Asp Asn Gly Asp Ser  Ile Gln Gln 
    1190                 1195                 1200             


Val Gln  Ala Asp Val Phe Val  Lys Ala Glu Tyr Pro  Gln Asp Tyr 
    1205                 1210                 1215             


Leu Asn  Cys Ser Glu Ile Pro  Lys Val Asp Leu Arg  Val Trp Gln 
    1220                 1225                 1230             


Asp Cys  Cys Ala Asp Cys Arg  Ser Arg Gly Gln Phe  Arg Ala Val 
    1235                 1240                 1245             


Thr Gln  Glu Ser Gln Lys Lys  Arg Ser Ala Gln Tyr  Ser Tyr Pro 
    1250                 1255                 1260             


Val Asp  Lys Asp Met Glu Leu  Ser His Leu Arg Ser  Arg Gln Gln 
    1265                 1270                 1275             


Asp Lys  Ile Tyr Val Gly Glu  Asp Ala Arg Asn Val  Thr Val Leu 
    1280                 1285                 1290             


Ala Lys  Thr Lys Phe Ser Gln  Asp Phe Ser Thr Phe  Ala Ala Glu 
    1295                 1300                 1305             


Ile Gln  Glu Thr Ile Thr Ala  Leu Arg Glu Gln Ile  Asn Lys Leu 
    1310                 1315                 1320             


Glu Ala  Arg Leu Arg Gln Ala  Gly Cys Thr Asp Val  Arg Gly Val 
    1325                 1330                 1335             


Pro Arg  Lys Ala Glu Glu Arg  Trp Met Lys Glu Asp  Cys Thr His 
    1340                 1345                 1350             


Cys Ile  Cys Glu Ser Gly Gln  Val Thr Cys Val Val  Glu Ile Cys 
    1355                 1360                 1365             


Pro Pro  Ala Pro Cys Pro Ser  Pro Glu Leu Val Lys  Gly Thr Cys 
    1370                 1375                 1380             


Cys Pro  Val Cys Arg Asp Arg  Gly Met Pro Ser Asp  Ser Pro Glu 
    1385                 1390                 1395             


Lys Arg  
    1400 


<210>  623

<211>  4203

<212>  DNA

<213>  Homo sapiens



<400>  623
atggagccca gactgttctg ctggaccact ctctttctcc tggccgggtg gtgcctgcca     60

gggttgccct gccccagccg gtgcctttgc tttaagagca ccgtccgctg catgcacttg    120

atgctggacc acattcctca ggtaccacag cagaccacag ttctagactt gaggtttaac    180

agaataagag aaattccagg gagcgccttc aagaaactca agaatttgaa cacacttctg    240

ctgaacaaca accacatcag aaagatttcc agaaatgctt ttgaaggact tgaaaatttg    300

ctatatctgt acctgtataa gaatgaaatc catgcactag ataagcaaac atttaaagga    360

ctcatatctt tggaacatct gtatattcat ttcaaccaac tagaaatgct acagccagag    420

acctttggag accttctgag attagagcga ctggatgaag cccacttgat catggtggat    480

aagctttttg atgtgctgct ggattcggtt tgccagtatt ttattgagga tttttgcatc    540

gatgttcatc aggagagccc ccgaattact tttgagccgc aggatgtgga ggtaccatca    600

ggaaataccg tctacttcac ctgccgggcg gaaggaaacc ccaaacctga gattatttgg    660

atacacaaca accactcatt ggatttggaa gatgatactc gacttaatgt gtttgatgat    720

ggcacactca tgatccgaaa caccagagag tcagaccaag gtgtctatca gtgcatggcc    780

agaaattccg ctggggaagc caagacacag agtgccatgc tcagatactc cagtcttcca    840

gccaaaccaa gctttgtaat ccagcctcag gacacagagg ttttaattgg caccagcaca    900

actttggaat gtatggccac aggccaccca caccctctta tcacttggac cagggacaat    960

ggattggagc tggatggatc caggcacgtg gcaacgtcca gtggacttta cttacagaac   1020

atcacacaac gggatcatgg tcgatttacc tgtcatgcca acaatagcca cggcactgtt   1080

caagctgcag caaacataat tgtacaagct cctccacaat ttacagtaac ccccaaggat   1140

caagtggtgc tggaagaaca tgctgtagag tggctctgtg aagctgacgg caacccacct   1200

cctgttattg tctggacaaa aacaggtatt agaacatctg caggagggca gctccctgtg   1260

gaaggccagc atacagttct ctcctctggc actttgagaa ttgaccgtgc agcacagcac   1320

gatcaaggcc aatatgaatg tcaagcagtc agttcgttgg gggtgaaaaa ggtgtctgtg   1380

cagctgactg taaaacccaa aggtccattt atgcaaatga aggattcaaa cttgctgagt   1440

tctgattggt tggttcaggt aagctctgaa ggtcttgaag ttaaaaagga aggtgtgcag   1500

attactgaga gtggtaaatt ccatgtggat gatgaaggca cgctgactat ctacgacgca   1560

gggttccctg accagggaag atatgaatgt gtggctcgga attcttttgg ccttgctgtg   1620

accaacatgt ttcttacagt cacggtctct gaaaaaacag tggagctctc cagggcaatg   1680

aattggtttc catgtttaat gatgcaaagt gatgaaaaac ctcacacctc cagtgacctg   1740

ctggctcaat ttcattaccc gcgtgaccca ctgattgtgg aaatggcaag agcaggggag   1800

atttttgagc acacgctgca gctgatacgg gaacgtgtga agcaggggct cactgtggac   1860

ttggaaggca aagaattccg gtacaatgac ttggtgtccc cgcgctccct cagcctcatc   1920

gccaatttat ctggatgcac agctcgcagg cctctgccaa actgctccaa ccggtgtttc   1980

catgcgaagt accgcgccca cgacggcacg tgcaacaacc tgcagcagcc cacgtggggc   2040

gcggcgctga ccgccttcgc gcgcctgctg cagccagcct accgggacgg catccgcgcg   2100

ccccgcgggc tcggccttcc tgtgggctcc cgccagcccc tcccgccgcc ccggctggtc   2160

gccacagtgt gggcgcgcgc ggcggccgtc acccccgacc acagctacac gcgcatgctc   2220

atgcactggg gctggtttct agagcacgac ttggaccaca cagtgcctgc gctgagcaca   2280

gcccgcttct cggatgggcg gccgtgcagc tccgtctgca ccaacgaccc tccttgtttc   2340

cccatgaaca cccggcacgc cgacccccgg ggcacccacg cgccctgcat gctcttcgcg   2400

cgctccagcc ccgcgtgtgc cagcggccgt ccctctgcga cggtggattc agtctatgca   2460

cgagagcaga tcaaccagca aacagcctac atcgatggct ccaacgttta cgggagctcg   2520

gagcgggaat cccaggctct cagagaccct tcggtgcctc ggggtctcct gaagacaggc   2580

tttccttggc ctccctccgg aaagccctta ttgccctttt ctacaggccc acccaccgag   2640

tgcgcgcgac aggagcagga gagcccctgt ttcctggccg gggaccaccg ggccaacgag   2700

catctggctc tggccgccat gcacaccctg tggttccggg aacacaacag ggtggccacg   2760

gagctgtccg ccctgaaccc ccactgggag ggaaacacgg tttaccagga agccaggaag   2820

atcgtgggcg cggagctgca gcacatcacc tacagccact ggctgcctaa ggtcctgggg   2880

gaccctggca ctaggatgct gaggggttac cgaggctaca accccaacgt gaatgcaggc   2940

atcattaact cttttgctac tgcagccttt agatttggcc acacattaat caatcctatt   3000

ctttaccgac tgaatgccac cttaggtgaa atttccgaag gccaccttcc gttccataaa   3060

gcgctctttt caccgtccag aataatcaag gaaggtggga tagacccggt tctccggggg   3120

ctgtttggcg tggctgctaa atggcgggca ccctcctacc ttctcagtcc tgagctgacc   3180

cagaggctct tctccgcggc ttattctgcg gccgtggatt cggctgccac catcattcaa   3240

aggggtagag accacgggat cccaccatat gttgacttca gagttttctg taatttgact   3300

tcagttaaga actttgagga tcttcaaaat gaaattaaag attcagagat tagacaaaaa   3360

ctgagaaagt tgtacggctc tccaggtgac attgacctct ggcccgccct tatggttgaa   3420

gacctgattc ctggtacaag agtgggacca acacttatgt gcctgtttgt tacccagttt   3480

cagcggctaa gagatggaga taggttctgg tatgaaaacc ctggagtatt taccccggca   3540

caactcactc agctgaagca ggcgtccctg agccgggtgc tttgtgacaa tggtgacagc   3600

attcagcaag tgcaggctga tgtctttgta aaggcagaat acccacagga ttacctgaac   3660

tgcagcgaga tcccgaaggt ggacctgcga gtgtggcaag actgctgtgc agactgtagg   3720

agtagaggac agttcagagc agtgacgcaa gagtctcaaa agaaacgctc agctcaatac   3780

agctatcctg ttgataagga tatggagtta agtcatctaa gaagtaggca acaagataaa   3840

atatatgtgg gtgaagatgc tagaaatgtg acagttctgg caaaaacaaa gttctcccaa   3900

gatttcagca cgtttgcagc ggaaattcag gaaaccatca cagcactcag agagcagata   3960

aacaagctgg aggcacgcct gaggcaggca gggtgtacag atgttagagg ggttccaagg   4020

aaggccgagg agcgctggat gaaagaagac tgcactcact gcatttgtga gagtggccag   4080

gtcacctgtg tggtggagat ttgtcccccg gctccctgtc ccagtcctga attggtgaaa   4140

ggaacctgct gtccagtttg cagagaccga ggaatgccaa gtgattcccc agagaagcgc   4200

taa                                                                 4203


<210>  624

<211>  1377

<212>  PRT

<213>  Homo sapiens



<400>  624

Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His 
1               5                   10                  15      


Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu 
            20                  25                  30          


Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys 
        35                  40                  45              


Lys Leu Lys Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn His Ile Arg 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu 
65                  70                  75                  80  


Tyr Leu Tyr Lys Asn Glu Ile His Ala Leu Asp Lys Gln Thr Phe Lys 
                85                  90                  95      


Gly Leu Ile Ser Leu Glu His Leu Tyr Ile His Phe Asn Gln Leu Glu 
            100                 105                 110         


Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu 
        115                 120                 125             


Asp Glu Ala His Leu Ile Met Val Asp Lys Leu Phe Asp Val Leu Leu 
    130                 135                 140                 


Asp Ser Val Cys Gln Tyr Phe Ile Glu Asp Phe Cys Ile Asp Val His 
145                 150                 155                 160 


Gln Glu Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro 
                165                 170                 175     


Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys 
            180                 185                 190         


Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp 
        195                 200                 205             


Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn 
    210                 215                 220                 


Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser 
225                 230                 235                 240 


Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu 
                245                 250                 255     


Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu 
            260                 265                 270         


Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His 
        275                 280                 285             


Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser 
    290                 295                 300                 


Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln 
305                 310                 315                 320 


Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr 
                325                 330                 335     


Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr 
            340                 345                 350         


Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp 
        355                 360                 365             


Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys 
    370                 375                 380                 


Thr Gly Ile Arg Thr Ser Ala Gly Gly Gln Leu Pro Val Glu Gly Gln 
385                 390                 395                 400 


His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln 
                405                 410                 415     


His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val 
            420                 425                 430         


Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Gly Pro Phe Met 
        435                 440                 445             


Gln Met Lys Asp Ser Asn Leu Leu Ser Ser Asp Trp Leu Val Gln Val 
    450                 455                 460                 


Ser Ser Glu Gly Leu Glu Val Lys Lys Glu Gly Val Gln Ile Thr Glu 
465                 470                 475                 480 


Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp 
                485                 490                 495     


Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser 
            500                 505                 510         


Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Val Ser Glu 
        515                 520                 525             


Lys Thr Val Glu Leu Ser Arg Ala Met Asn Trp Phe Pro Cys Leu Met 
    530                 535                 540                 


Met Gln Ser Asp Glu Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln 
545                 550                 555                 560 


Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly 
                565                 570                 575     


Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln 
            580                 585                 590         


Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu 
        595                 600                 605             


Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr 
    610                 615                 620                 


Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys 
625                 630                 635                 640 


Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp 
                645                 650                 655     


Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg 
            660                 665                 670         


Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg 
        675                 680                 685             


Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala 
    690                 695                 700                 


Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp 
705                 710                 715                 720 


Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser 
                725                 730                 735     


Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn 
            740                 745                 750         


Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly 
        755                 760                 765             


Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala 
    770                 775                 780                 


Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln 
785                 790                 795                 800 


Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser 
                805                 810                 815     


Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly 
            820                 825                 830         


Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu 
        835                 840                 845             


Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu 
    850                 855                 860                 


Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala 
865                 870                 875                 880 


Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala 
                885                 890                 895     


Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr 
            900                 905                 910         


Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr 
        915                 920                 925             


Ser His Trp Leu Pro Lys Val Leu Gly Asp Pro Gly Thr Arg Met Leu 
    930                 935                 940                 


Arg Gly Tyr Arg Gly Tyr Asn Pro Asn Val Asn Ala Gly Ile Ile Asn 
945                 950                 955                 960 


Ser Phe Ala Thr Ala Ala Phe Arg Phe Gly His Thr Leu Ile Asn Pro 
                965                 970                 975     


Ile Leu Tyr Arg Leu Asn Ala Thr Leu Gly Glu Ile Ser Glu Gly His 
            980                 985                 990         


Leu Pro Phe His Lys Ala Leu Phe  Ser Pro Ser Arg Ile  Ile Lys Glu 
        995                 1000                 1005             


Gly Gly  Ile Asp Pro Val Leu  Arg Gly Leu Phe Gly  Val Ala Ala 
    1010                 1015                 1020             


Lys Trp  Arg Ala Pro Ser Tyr  Leu Leu Ser Pro Glu  Leu Thr Gln 
    1025                 1030                 1035             


Arg Leu  Phe Ser Ala Ala Tyr  Ser Ala Ala Val Asp  Ser Ala Ala 
    1040                 1045                 1050             


Thr Ile  Ile Gln Arg Gly Arg  Asp His Gly Ile Pro  Pro Tyr Val 
    1055                 1060                 1065             


Asp Phe  Arg Val Phe Cys Asn  Leu Thr Ser Val Lys  Asn Phe Glu 
    1070                 1075                 1080             


Asp Leu  Gln Asn Glu Ile Lys  Asp Ser Glu Ile Arg  Gln Lys Leu 
    1085                 1090                 1095             


Arg Lys  Leu Tyr Gly Ser Pro  Gly Asp Ile Asp Leu  Trp Pro Ala 
    1100                 1105                 1110             


Leu Met  Val Glu Asp Leu Ile  Pro Gly Thr Arg Val  Gly Pro Thr 
    1115                 1120                 1125             


Leu Met  Cys Leu Phe Val Thr  Gln Phe Gln Arg Leu  Arg Asp Gly 
    1130                 1135                 1140             


Asp Arg  Phe Trp Tyr Glu Asn  Pro Gly Val Phe Thr  Pro Ala Gln 
    1145                 1150                 1155             


Leu Thr  Gln Leu Lys Gln Ala  Ser Leu Ser Arg Val  Leu Cys Asp 
    1160                 1165                 1170             


Asn Gly  Asp Ser Ile Gln Gln  Val Gln Ala Asp Val  Phe Val Lys 
    1175                 1180                 1185             


Ala Glu  Tyr Pro Gln Asp Tyr  Leu Asn Cys Ser Glu  Ile Pro Lys 
    1190                 1195                 1200             


Val Asp  Leu Arg Val Trp Gln  Asp Cys Cys Ala Asp  Cys Arg Ser 
    1205                 1210                 1215             


Arg Gly  Gln Phe Arg Ala Val  Thr Gln Glu Ser Gln  Lys Lys Arg 
    1220                 1225                 1230             


Ser Ala  Gln Tyr Ser Tyr Pro  Val Asp Lys Asp Met  Glu Leu Ser 
    1235                 1240                 1245             


His Leu  Arg Ser Arg Gln Gln  Asp Lys Ile Tyr Val  Gly Glu Asp 
    1250                 1255                 1260             


Ala Arg  Asn Val Thr Val Leu  Ala Lys Thr Lys Phe  Ser Gln Asp 
    1265                 1270                 1275             


Phe Ser  Thr Phe Ala Ala Glu  Ile Gln Glu Thr Ile  Thr Ala Leu 
    1280                 1285                 1290             


Arg Glu  Gln Ile Asn Lys Leu  Glu Ala Arg Leu Arg  Gln Ala Gly 
    1295                 1300                 1305             


Cys Thr  Asp Val Arg Gly Val  Pro Arg Lys Ala Glu  Glu Arg Trp 
    1310                 1315                 1320             


Met Lys  Glu Asp Cys Thr His  Cys Ile Cys Glu Ser  Gly Gln Val 
    1325                 1330                 1335             


Thr Cys  Val Val Glu Ile Cys  Pro Pro Ala Pro Cys  Pro Ser Pro 
    1340                 1345                 1350             


Glu Leu  Val Lys Gly Thr Cys  Cys Pro Val Cys Arg  Asp Arg Gly 
    1355                 1360                 1365             


Met Pro  Ser Asp Ser Pro Glu  Lys Arg 
    1370                 1375         


<210>  625

<211>  4886

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (261)..(4580)

<223>  



<400>  625
aaaaagttat atccattagt acggcaagat agtgaggtgg cattatacaa taatcaaggt     60

atgcatcaag aagggtacgg aggtcgaata cactacaacc gccccccagt gtgttggaat    120

tcgcctttaa gcagtggtat ccctgcagag tacgcgggga gtccagcagc caccatcacc    180

accactgcgg ttgctgctgc agctgcagct gctgctctcc ctccggctgc ttcttcgcgt    240

ggccagcagc gaatggagcg atg gag ccc aga ctg ttc tgc tgg acc act ctc    293
                      Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu       
                      1               5                   10            

ttt ctc ctg gcc ggg tgg tgc ctg cca ggg ttg ccc tgc ccc agc cgg      341
Phe Leu Leu Ala Gly Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg         
            15                  20                  25                  

tgc ctt tgc ttt aag agc acc gtc cgc tgc atg cac ttg atg ctg gac      389
Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His Leu Met Leu Asp         
        30                  35                  40                      

cac att cct cag gta cca cag cag acc aca gtt cta gac ttg agg ttt      437
His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe         
    45                  50                  55                          

aac aga ata aga gaa att cca ggg agc gcc ttc aag aaa ctc aag aat      485
Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn         
60                  65                  70                  75          

ttg aac aca ctt tac ctg tat aag aac cac atc aga aag att tcc aga      533
Leu Asn Thr Leu Tyr Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg         
                80                  85                  90              

aat gct ttt gaa gga ctt gaa aat ttg cta tat ctg tat att cat ttc      581
Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe         
            95                  100                 105                 

aac caa cta gaa atg cta cag cca gag acc ttt gga gac ctt ctg aga      629
Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg         
        110                 115                 120                     

tta gag cga cta ttt ttg cat aac aac aaa tta tct aaa att cca gct      677
Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala         
    125                 130                 135                         

ggg agc ttt tct aat ctg gat tca tta aaa aga ttg cgt ctg gat tcc      725
Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser         
140                 145                 150                 155         

aac gcc ctg gtt tgt gac tgt gat ctg atg tgg ctg ggg gag ctt tta      773
Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu         
                160                 165                 170             

caa ggc ttt gcc caa cac ggc cac acc cag gct gcg gct acc tgc gaa      821
Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala Ala Thr Cys Glu         
            175                 180                 185                 

tat ccc agg aga ctc cat ggg cgt gca gtt gct tca gta aca gta gag      869
Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser Val Thr Val Glu         
        190                 195                 200                     

gaa ttc aat tgc cag agc ccc cga att act ttt gag ccg cag gat gtg      917
Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val         
    205                 210                 215                         

gag gta cca tca gga aat acc gtc tac ttc acc tgc cgg gcg gaa gga      965
Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly         
220                 225                 230                 235         

aac ccc aaa cct gag att att tgg ata cac aac aac cac tca ttg gat     1013
Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn His Ser Leu Asp         
                240                 245                 250             

ttg gaa gat gat act cga ctt aat gtg ttt gat gat ggc aca ctc atg     1061
Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met         
            255                 260                 265                 

atc cga aac acc aga gag tca gac caa ggt gtc tat cag tgc atg gcc     1109
Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala         
        270                 275                 280                     

aga aat tcc gct ggg gaa gcc aag aca cag agt gcc atg ctc aga tac     1157
Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr         
    285                 290                 295                         

tcc agt ctt cca gcc aaa cca agc ttt gta atc cag cct cag gac aca     1205
Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr         
300                 305                 310                 315         

gag gtt tta att ggc acc agc aca act ttg gaa tgt atg gcc aca ggc     1253
Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly         
                320                 325                 330             

cac cca cac cct ctt atc act tgg acc agg gac aat gga ttg gag ctg     1301
His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu         
            335                 340                 345                 

gat gga tcc agg cac gtg gca acg tcc agt gga ctt tac tta cag aac     1349
Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn         
        350                 355                 360                     

atc aca caa cgg gat cat ggt cga ttt acc tgt cat gcc aac aat agc     1397
Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His Ala Asn Asn Ser         
    365                 370                 375                         

cac ggc act gtt caa gct gca gca aac ata att gta caa gct cct cca     1445
His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro         
380                 385                 390                 395         

caa ttt aca gta acc ccc aag gat caa gtg gtg ctg gaa gaa cat gct     1493
Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu Glu Glu His Ala         
                400                 405                 410             

gta gag tgg ctc tgt gaa gct gac ggc aac cca cct cct gtt att gtc     1541
Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val         
            415                 420                 425                 

tgg aca aaa aca gga ggg cag ctc cct gtg gaa ggc cag cat aca gtt     1589
Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly Gln His Thr Val         
        430                 435                 440                     

ctc tcc tct ggc act ttg aga att gac cgt gca gca cag cac gat caa     1637
Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln         
    445                 450                 455                         

ggc caa tat gaa tgt caa gca gtc agt tcg ttg ggg gtg aaa aag gtg     1685
Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val         
460                 465                 470                 475         

tct gtg cag ctg act gta aaa ccc aaa gct ctt gca gtg ttt act caa     1733
Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala Val Phe Thr Gln         
                480                 485                 490             

ctt cct cag gat aca agt gtc gag gtt gga aag aat ata aac att tca     1781
Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser         
            495                 500                 505                 

tgt cat gct caa gga gaa cca cag ccc ata att act tgg aat aag gaa     1829
Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu         
        510                 515                 520                     

ggt gtg cag att act gag agt ggt aaa ttc cat gtg gat gat gaa ggc     1877
Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly         
    525                 530                 535                         

acg ctg act atc tac gac gca ggg ttc cct gac cag gga aga tat gaa     1925
Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu         
540                 545                 550                 555         

tgt gtg gct cgg aat tct ttt ggc ctt gct gtg acc aac atg ttt ctt     1973
Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu         
                560                 565                 570             

aca gtc acg gct ata cag ggt aga caa gct ggc gat gac ttt gtt gaa     2021
Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu         
            575                 580                 585                 

tct tcc att ctt gat gct gta cag aga gtt gac agt gca att aac tcc     2069
Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser         
        590                 595                 600                     

aca cga aga cat ttg ttt tca caa aaa cct cac acc tcc agt gac ctg     2117
Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu         
    605                 610                 615                         

ctg gct caa ttt cat tac ccg cgt gac cca ctg att gtg gaa atg gca     2165
Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala         
620                 625                 630                 635         

aga gca ggg gag att ttt gag cac acg ctg cag ctg ata cgg gaa cgt     2213
Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg         
                640                 645                 650             

gtg aag cag ggg ctc act gtg gac ttg gaa ggc aaa gaa ttc cgg tac     2261
Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr         
            655                 660                 665                 

aat gac ttg gtg tcc ccg cgc tcc ctc agc ctc atc gcc aat tta tct     2309
Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser         
        670                 675                 680                     

gga tgc aca gct cgc agg cct ctg cca aac tgc tcc aac cgg tgt ttc     2357
Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe         
    685                 690                 695                         

cat gcg aag tac cgc gcc cac gac ggc acg tgc aac aac ctg cag cag     2405
His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln         
700                 705                 710                 715         

ccc acg tgg ggc gcg gcg ctg acc gcc ttc gcg cgc ctg ctg cag cca     2453
Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro         
                720                 725                 730             

gcc tac cgg gac ggc atc cgc gcg ccc cgc ggg ctc ggc ctt cct gtg     2501
Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val         
            735                 740                 745                 

ggc tcc cgc cag ccc ctc ccg ccg ccc cgg ctg gtc gcc aca gtg tgg     2549
Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp         
        750                 755                 760                     

gcg cgc gcg gcg gcc gtc acc ccc gac cac agc tac acg cgc atg ctc     2597
Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu         
    765                 770                 775                         

atg cac tgg ggc tgg ttt cta gag cac gac ttg gac cac aca gtg cct     2645
Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp His Thr Val Pro         
780                 785                 790                 795         

gcg ctg agc aca gcc cgc ttc tcg gat ggg cgg ccg tgc agc tcc gtc     2693
Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val         
                800                 805                 810             

tgc acc aac gac cct cct tgt ttc ccc atg aac acc cgg cac gcc gac     2741
Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp         
            815                 820                 825                 

ccc cgg ggc acc cac gcg ccc tgc atg ctc ttc gcg cgc tcc agc ccc     2789
Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro         
        830                 835                 840                     

gcg tgt gcc agc ggc cgt ccc tct gcg acg gtg gat tca gtc tat gca     2837
Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala         
    845                 850                 855                         

cga gag cag atc aac cag caa aca gcc tac atc gat ggc tcc aac gtt     2885
Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val         
860                 865                 870                 875         

tac ggg agc tcg gag cgg gaa tcc cag gct ctc aga gac cct tcg gtg     2933
Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val         
                880                 885                 890             

cct cgg ggt ctc ctg aag aca ggc ttt cct tgg cct ccc tcc gga aag     2981
Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys         
            895                 900                 905                 

ccc tta ttg ccc ttt tct aca ggc cca ccc acc gag tgc gcg cga cag     3029
Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln         
        910                 915                 920                     

gag cag gag agc ccc tgt ttc ctg gcc ggg gac cac cgg gcc aac gag     3077
Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu         
    925                 930                 935                         

cat ctg gct ctg gcc gcc atg cac acc ctg tgg ttc cgg gaa cac aac     3125
His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe Arg Glu His Asn         
940                 945                 950                 955         

agg gtg gcc acg gag ctg tcc gcc ctg aac ccc cac tgg gag gga aac     3173
Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn         
                960                 965                 970             

acg gtt tac cag gaa gcc agg aag atc gtg ggc gcg gag ctg cag cac     3221
Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His         
            975                 980                 985                 

atc acc tac agc cac tgg ctg cct aag gtc ctg ggg gac  cct ggc act    3269
Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly Asp  Pro Gly Thr        
        990                 995                 1000                    

agg atg  ctg agg ggt tac cga  ggc tac aac ccc aac  gtg aat gca      3314
Arg Met  Leu Arg Gly Tyr Arg  Gly Tyr Asn Pro Asn  Val Asn Ala          
    1005                 1010                 1015                      

ggc atc  att aac tct ttt gct  act gca gcc ttt aga  ttt ggc cac      3359
Gly Ile  Ile Asn Ser Phe Ala  Thr Ala Ala Phe Arg  Phe Gly His          
    1020                 1025                 1030                      

aca tta  atc aat cct att ctt  tac cga ctg aat gcc  acc tta ggt      3404
Thr Leu  Ile Asn Pro Ile Leu  Tyr Arg Leu Asn Ala  Thr Leu Gly          
    1035                 1040                 1045                      

gaa att  tcc gaa ggc cac ctt  ccg ttc cat aaa gcg  ctc ttt tca      3449
Glu Ile  Ser Glu Gly His Leu  Pro Phe His Lys Ala  Leu Phe Ser          
    1050                 1055                 1060                      

ccg tcc  aga ata atc aag gaa  ggt ggg ata gac ccg  gtt ctc cgg      3494
Pro Ser  Arg Ile Ile Lys Glu  Gly Gly Ile Asp Pro  Val Leu Arg          
    1065                 1070                 1075                      

ggg ctg  ttt ggc gtg gct gct  aaa tgg cgg gca ccc  tcc tac ctt      3539
Gly Leu  Phe Gly Val Ala Ala  Lys Trp Arg Ala Pro  Ser Tyr Leu          
    1080                 1085                 1090                      

ctc agt  cct gag ctg acc cag  agg ctc ttc tcc gcg  gct tat tct      3584
Leu Ser  Pro Glu Leu Thr Gln  Arg Leu Phe Ser Ala  Ala Tyr Ser          
    1095                 1100                 1105                      

gcg gcc  gtg gat tcg gct gcc  acc atc att caa agg  ggt aga gac      3629
Ala Ala  Val Asp Ser Ala Ala  Thr Ile Ile Gln Arg  Gly Arg Asp          
    1110                 1115                 1120                      

cac ggg  atc cca cca tat gtt  gac ttc aga gtt ttc  tgt aat ttg      3674
His Gly  Ile Pro Pro Tyr Val  Asp Phe Arg Val Phe  Cys Asn Leu          
    1125                 1130                 1135                      

act tca  gtt aag aac ttt gag  gat ctt caa aat gaa  att aaa gat      3719
Thr Ser  Val Lys Asn Phe Glu  Asp Leu Gln Asn Glu  Ile Lys Asp          
    1140                 1145                 1150                      

tca gag  att aga caa aaa ctg  aga aag ttg tac ggc  tct cca ggt      3764
Ser Glu  Ile Arg Gln Lys Leu  Arg Lys Leu Tyr Gly  Ser Pro Gly          
    1155                 1160                 1165                      

gac att  gac ctc tgg ccc gcc  ctt atg gtt gaa gac  ctg att cct      3809
Asp Ile  Asp Leu Trp Pro Ala  Leu Met Val Glu Asp  Leu Ile Pro          
    1170                 1175                 1180                      

ggt aca  aga gtg gga cca aca  ctt atg tgc atg ttc  gtt acc cag      3854
Gly Thr  Arg Val Gly Pro Thr  Leu Met Cys Met Phe  Val Thr Gln          
    1185                 1190                 1195                      

ttt cag  cgg cta aga gat gga  gat agg ttc tgg tat  gaa aac cct      3899
Phe Gln  Arg Leu Arg Asp Gly  Asp Arg Phe Trp Tyr  Glu Asn Pro          
    1200                 1205                 1210                      

gga gta  ttt acc ccg gca caa  ctc act cag ctg aag  cag gcg tcc      3944
Gly Val  Phe Thr Pro Ala Gln  Leu Thr Gln Leu Lys  Gln Ala Ser          
    1215                 1220                 1225                      

ctg agc  cgg gtg ctt tgt gac  aat ggt gac agc att  cag caa gtg      3989
Leu Ser  Arg Val Leu Cys Asp  Asn Gly Asp Ser Ile  Gln Gln Val          
    1230                 1235                 1240                      

cag gct  gat gtc ttt gta aag  gca gaa tac cca cag  gat tac ctg      4034
Gln Ala  Asp Val Phe Val Lys  Ala Glu Tyr Pro Gln  Asp Tyr Leu          
    1245                 1250                 1255                      

aac tgc  agc gag atc ccg aag  gtg gac ctg cga gtg  tgg caa gac      4079
Asn Cys  Ser Glu Ile Pro Lys  Val Asp Leu Arg Val  Trp Gln Asp          
    1260                 1265                 1270                      

tgc tgt  gca gac tgt agg agt  aga gga cag ttc aga  gca gtg acg      4124
Cys Cys  Ala Asp Cys Arg Ser  Arg Gly Gln Phe Arg  Ala Val Thr          
    1275                 1280                 1285                      

caa gag  tct caa aag aaa cgc  tca gct caa tac agc  tat cct gtt      4169
Gln Glu  Ser Gln Lys Lys Arg  Ser Ala Gln Tyr Ser  Tyr Pro Val          
    1290                 1295                 1300                      

gat aag  gat atg gag tta agt  cat cta aga agt agg  caa caa gat      4214
Asp Lys  Asp Met Glu Leu Ser  His Leu Arg Ser Arg  Gln Gln Asp          
    1305                 1310                 1315                      

aaa ata  tat gtg ggt gaa gat  gct aga aat gtg aca  gtt ctg gca      4259
Lys Ile  Tyr Val Gly Glu Asp  Ala Arg Asn Val Thr  Val Leu Ala          
    1320                 1325                 1330                      

aaa aca  aag ttc tcc caa gat  ttc agc acg ttt gca  gcg gaa att      4304
Lys Thr  Lys Phe Ser Gln Asp  Phe Ser Thr Phe Ala  Ala Glu Ile          
    1335                 1340                 1345                      

cag gaa  acc atc aca gca ctc  aga gag cag ata aac  aag ctg gag      4349
Gln Glu  Thr Ile Thr Ala Leu  Arg Glu Gln Ile Asn  Lys Leu Glu          
    1350                 1355                 1360                      

gca cgc  ctg agg cag gca ggg  tgt aca gat gtt aga  ggg gtt cca      4394
Ala Arg  Leu Arg Gln Ala Gly  Cys Thr Asp Val Arg  Gly Val Pro          
    1365                 1370                 1375                      

agg aag  gcc gag gag cgc tgg  atg aaa gaa gac tgc  act cac tgc      4439
Arg Lys  Ala Glu Glu Arg Trp  Met Lys Glu Asp Cys  Thr His Cys          
    1380                 1385                 1390                      

att tgt  gag agt ggc cag gtc  acc tgt gtg gtg gag  att tgt ccc      4484
Ile Cys  Glu Ser Gly Gln Val  Thr Cys Val Val Glu  Ile Cys Pro          
    1395                 1400                 1405                      

ccg gct  ccc tgt ccc agt cct  gaa ttg gtg aaa gga  acc tgc tgt      4529
Pro Ala  Pro Cys Pro Ser Pro  Glu Leu Val Lys Gly  Thr Cys Cys          
    1410                 1415                 1420                      

cca gtt  tgc aga gac cga gga  atg cca agt gat tcc  cca gag aag      4574
Pro Val  Cys Arg Asp Arg Gly  Met Pro Ser Asp Ser  Pro Glu Lys          
    1425                 1430                 1435                      

cgc taa taaaagtttt gtgctgttga gccccaaatg ggaaatttct caggaagaga      4630
Arg                                                                     
                                                                        

catttaggac ttcagaactt ttaacttgta gtcacattgt tgatatggaa accactgact   4690

taagcaactt agttcatcta atcttacata tacttacgat cttttatttt ttcattttct   4750

aacatacctt gaaataattc aaaactaaaa gcaataaagt gcatatgaag tgtttgatca   4810

taagaaatat ttcttactgt aagctgtcag ttttatatgc cacacctgga aataaaaaga   4870

atatcatgga atattt                                                   4886


<210>  626

<211>  1439

<212>  PRT

<213>  Homo sapiens



<400>  626

Met Glu Pro Arg Leu Phe Cys Trp Thr Thr Leu Phe Leu Leu Ala Gly 
1               5                   10                  15      


Trp Cys Leu Pro Gly Leu Pro Cys Pro Ser Arg Cys Leu Cys Phe Lys 
            20                  25                  30          


Ser Thr Val Arg Cys Met His Leu Met Leu Asp His Ile Pro Gln Val 
        35                  40                  45              


Pro Gln Gln Thr Thr Val Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu 
    50                  55                  60                  


Ile Pro Gly Ser Ala Phe Lys Lys Leu Lys Asn Leu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Tyr Lys Asn His Ile Arg Lys Ile Ser Arg Asn Ala Phe Glu Gly 
                85                  90                  95      


Leu Glu Asn Leu Leu Tyr Leu Tyr Ile His Phe Asn Gln Leu Glu Met 
            100                 105                 110         


Leu Gln Pro Glu Thr Phe Gly Asp Leu Leu Arg Leu Glu Arg Leu Phe 
        115                 120                 125             


Leu His Asn Asn Lys Leu Ser Lys Ile Pro Ala Gly Ser Phe Ser Asn 
    130                 135                 140                 


Leu Asp Ser Leu Lys Arg Leu Arg Leu Asp Ser Asn Ala Leu Val Cys 
145                 150                 155                 160 


Asp Cys Asp Leu Met Trp Leu Gly Glu Leu Leu Gln Gly Phe Ala Gln 
                165                 170                 175     


His Gly His Thr Gln Ala Ala Ala Thr Cys Glu Tyr Pro Arg Arg Leu 
            180                 185                 190         


His Gly Arg Ala Val Ala Ser Val Thr Val Glu Glu Phe Asn Cys Gln 
        195                 200                 205             


Ser Pro Arg Ile Thr Phe Glu Pro Gln Asp Val Glu Val Pro Ser Gly 
    210                 215                 220                 


Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn Pro Lys Pro Glu 
225                 230                 235                 240 


Ile Ile Trp Ile His Asn Asn His Ser Leu Asp Leu Glu Asp Asp Thr 
                245                 250                 255     


Arg Leu Asn Val Phe Asp Asp Gly Thr Leu Met Ile Arg Asn Thr Arg 
            260                 265                 270         


Glu Ser Asp Gln Gly Val Tyr Gln Cys Met Ala Arg Asn Ser Ala Gly 
        275                 280                 285             


Glu Ala Lys Thr Gln Ser Ala Met Leu Arg Tyr Ser Ser Leu Pro Ala 
    290                 295                 300                 


Lys Pro Ser Phe Val Ile Gln Pro Gln Asp Thr Glu Val Leu Ile Gly 
305                 310                 315                 320 


Thr Ser Thr Thr Leu Glu Cys Met Ala Thr Gly His Pro His Pro Leu 
                325                 330                 335     


Ile Thr Trp Thr Arg Asp Asn Gly Leu Glu Leu Asp Gly Ser Arg His 
            340                 345                 350         


Val Ala Thr Ser Ser Gly Leu Tyr Leu Gln Asn Ile Thr Gln Arg Asp 
        355                 360                 365             


His Gly Arg Phe Thr Cys His Ala Asn Asn Ser His Gly Thr Val Gln 
    370                 375                 380                 


Ala Ala Ala Asn Ile Ile Val Gln Ala Pro Pro Gln Phe Thr Val Thr 
385                 390                 395                 400 


Pro Lys Asp Gln Val Val Leu Glu Glu His Ala Val Glu Trp Leu Cys 
                405                 410                 415     


Glu Ala Asp Gly Asn Pro Pro Pro Val Ile Val Trp Thr Lys Thr Gly 
            420                 425                 430         


Gly Gln Leu Pro Val Glu Gly Gln His Thr Val Leu Ser Ser Gly Thr 
        435                 440                 445             


Leu Arg Ile Asp Arg Ala Ala Gln His Asp Gln Gly Gln Tyr Glu Cys 
    450                 455                 460                 


Gln Ala Val Ser Ser Leu Gly Val Lys Lys Val Ser Val Gln Leu Thr 
465                 470                 475                 480 


Val Lys Pro Lys Ala Leu Ala Val Phe Thr Gln Leu Pro Gln Asp Thr 
                485                 490                 495     


Ser Val Glu Val Gly Lys Asn Ile Asn Ile Ser Cys His Ala Gln Gly 
            500                 505                 510         


Glu Pro Gln Pro Ile Ile Thr Trp Asn Lys Glu Gly Val Gln Ile Thr 
        515                 520                 525             


Glu Ser Gly Lys Phe His Val Asp Asp Glu Gly Thr Leu Thr Ile Tyr 
    530                 535                 540                 


Asp Ala Gly Phe Pro Asp Gln Gly Arg Tyr Glu Cys Val Ala Arg Asn 
545                 550                 555                 560 


Ser Phe Gly Leu Ala Val Thr Asn Met Phe Leu Thr Val Thr Ala Ile 
                565                 570                 575     


Gln Gly Arg Gln Ala Gly Asp Asp Phe Val Glu Ser Ser Ile Leu Asp 
            580                 585                 590         


Ala Val Gln Arg Val Asp Ser Ala Ile Asn Ser Thr Arg Arg His Leu 
        595                 600                 605             


Phe Ser Gln Lys Pro His Thr Ser Ser Asp Leu Leu Ala Gln Phe His 
    610                 615                 620                 


Tyr Pro Arg Asp Pro Leu Ile Val Glu Met Ala Arg Ala Gly Glu Ile 
625                 630                 635                 640 


Phe Glu His Thr Leu Gln Leu Ile Arg Glu Arg Val Lys Gln Gly Leu 
                645                 650                 655     


Thr Val Asp Leu Glu Gly Lys Glu Phe Arg Tyr Asn Asp Leu Val Ser 
            660                 665                 670         


Pro Arg Ser Leu Ser Leu Ile Ala Asn Leu Ser Gly Cys Thr Ala Arg 
        675                 680                 685             


Arg Pro Leu Pro Asn Cys Ser Asn Arg Cys Phe His Ala Lys Tyr Arg 
    690                 695                 700                 


Ala His Asp Gly Thr Cys Asn Asn Leu Gln Gln Pro Thr Trp Gly Ala 
705                 710                 715                 720 


Ala Leu Thr Ala Phe Ala Arg Leu Leu Gln Pro Ala Tyr Arg Asp Gly 
                725                 730                 735     


Ile Arg Ala Pro Arg Gly Leu Gly Leu Pro Val Gly Ser Arg Gln Pro 
            740                 745                 750         


Leu Pro Pro Pro Arg Leu Val Ala Thr Val Trp Ala Arg Ala Ala Ala 
        755                 760                 765             


Val Thr Pro Asp His Ser Tyr Thr Arg Met Leu Met His Trp Gly Trp 
    770                 775                 780                 


Phe Leu Glu His Asp Leu Asp His Thr Val Pro Ala Leu Ser Thr Ala 
785                 790                 795                 800 


Arg Phe Ser Asp Gly Arg Pro Cys Ser Ser Val Cys Thr Asn Asp Pro 
                805                 810                 815     


Pro Cys Phe Pro Met Asn Thr Arg His Ala Asp Pro Arg Gly Thr His 
            820                 825                 830         


Ala Pro Cys Met Leu Phe Ala Arg Ser Ser Pro Ala Cys Ala Ser Gly 
        835                 840                 845             


Arg Pro Ser Ala Thr Val Asp Ser Val Tyr Ala Arg Glu Gln Ile Asn 
    850                 855                 860                 


Gln Gln Thr Ala Tyr Ile Asp Gly Ser Asn Val Tyr Gly Ser Ser Glu 
865                 870                 875                 880 


Arg Glu Ser Gln Ala Leu Arg Asp Pro Ser Val Pro Arg Gly Leu Leu 
                885                 890                 895     


Lys Thr Gly Phe Pro Trp Pro Pro Ser Gly Lys Pro Leu Leu Pro Phe 
            900                 905                 910         


Ser Thr Gly Pro Pro Thr Glu Cys Ala Arg Gln Glu Gln Glu Ser Pro 
        915                 920                 925             


Cys Phe Leu Ala Gly Asp His Arg Ala Asn Glu His Leu Ala Leu Ala 
    930                 935                 940                 


Ala Met His Thr Leu Trp Phe Arg Glu His Asn Arg Val Ala Thr Glu 
945                 950                 955                 960 


Leu Ser Ala Leu Asn Pro His Trp Glu Gly Asn Thr Val Tyr Gln Glu 
                965                 970                 975     


Ala Arg Lys Ile Val Gly Ala Glu Leu Gln His Ile Thr Tyr Ser His 
            980                 985                 990         


Trp Leu Pro Lys Val Leu Gly Asp  Pro Gly Thr Arg Met  Leu Arg Gly 
        995                 1000                 1005             


Tyr Arg  Gly Tyr Asn Pro Asn  Val Asn Ala Gly Ile  Ile Asn Ser 
    1010                 1015                 1020             


Phe Ala  Thr Ala Ala Phe Arg  Phe Gly His Thr Leu  Ile Asn Pro 
    1025                 1030                 1035             


Ile Leu  Tyr Arg Leu Asn Ala  Thr Leu Gly Glu Ile  Ser Glu Gly 
    1040                 1045                 1050             


His Leu  Pro Phe His Lys Ala  Leu Phe Ser Pro Ser  Arg Ile Ile 
    1055                 1060                 1065             


Lys Glu  Gly Gly Ile Asp Pro  Val Leu Arg Gly Leu  Phe Gly Val 
    1070                 1075                 1080             


Ala Ala  Lys Trp Arg Ala Pro  Ser Tyr Leu Leu Ser  Pro Glu Leu 
    1085                 1090                 1095             


Thr Gln  Arg Leu Phe Ser Ala  Ala Tyr Ser Ala Ala  Val Asp Ser 
    1100                 1105                 1110             


Ala Ala  Thr Ile Ile Gln Arg  Gly Arg Asp His Gly  Ile Pro Pro 
    1115                 1120                 1125             


Tyr Val  Asp Phe Arg Val Phe  Cys Asn Leu Thr Ser  Val Lys Asn 
    1130                 1135                 1140             


Phe Glu  Asp Leu Gln Asn Glu  Ile Lys Asp Ser Glu  Ile Arg Gln 
    1145                 1150                 1155             


Lys Leu  Arg Lys Leu Tyr Gly  Ser Pro Gly Asp Ile  Asp Leu Trp 
    1160                 1165                 1170             


Pro Ala  Leu Met Val Glu Asp  Leu Ile Pro Gly Thr  Arg Val Gly 
    1175                 1180                 1185             


Pro Thr  Leu Met Cys Met Phe  Val Thr Gln Phe Gln  Arg Leu Arg 
    1190                 1195                 1200             


Asp Gly  Asp Arg Phe Trp Tyr  Glu Asn Pro Gly Val  Phe Thr Pro 
    1205                 1210                 1215             


Ala Gln  Leu Thr Gln Leu Lys  Gln Ala Ser Leu Ser  Arg Val Leu 
    1220                 1225                 1230             


Cys Asp  Asn Gly Asp Ser Ile  Gln Gln Val Gln Ala  Asp Val Phe 
    1235                 1240                 1245             


Val Lys  Ala Glu Tyr Pro Gln  Asp Tyr Leu Asn Cys  Ser Glu Ile 
    1250                 1255                 1260             


Pro Lys  Val Asp Leu Arg Val  Trp Gln Asp Cys Cys  Ala Asp Cys 
    1265                 1270                 1275             


Arg Ser  Arg Gly Gln Phe Arg  Ala Val Thr Gln Glu  Ser Gln Lys 
    1280                 1285                 1290             


Lys Arg  Ser Ala Gln Tyr Ser  Tyr Pro Val Asp Lys  Asp Met Glu 
    1295                 1300                 1305             


Leu Ser  His Leu Arg Ser Arg  Gln Gln Asp Lys Ile  Tyr Val Gly 
    1310                 1315                 1320             


Glu Asp  Ala Arg Asn Val Thr  Val Leu Ala Lys Thr  Lys Phe Ser 
    1325                 1330                 1335             


Gln Asp  Phe Ser Thr Phe Ala  Ala Glu Ile Gln Glu  Thr Ile Thr 
    1340                 1345                 1350             


Ala Leu  Arg Glu Gln Ile Asn  Lys Leu Glu Ala Arg  Leu Arg Gln 
    1355                 1360                 1365             


Ala Gly  Cys Thr Asp Val Arg  Gly Val Pro Arg Lys  Ala Glu Glu 
    1370                 1375                 1380             


Arg Trp  Met Lys Glu Asp Cys  Thr His Cys Ile Cys  Glu Ser Gly 
    1385                 1390                 1395             


Gln Val  Thr Cys Val Val Glu  Ile Cys Pro Pro Ala  Pro Cys Pro 
    1400                 1405                 1410             


Ser Pro  Glu Leu Val Lys Gly  Thr Cys Cys Pro Val  Cys Arg Asp 
    1415                 1420                 1425             


Arg Gly  Met Pro Ser Asp Ser  Pro Glu Lys Arg 
    1430                 1435                 


<210>  627

<211>  4320

<212>  DNA

<213>  Homo sapiens



<400>  627
atggagccca gactgttctg ctggaccact ctctttctcc tggccgggtg gtgcctgcca     60

gggttgccct gccccagccg gtgcctttgc tttaagagca ccgtccgctg catgcacttg    120

atgctggacc acattcctca ggtaccacag cagaccacag ttctagactt gaggtttaac    180

agaataagag aaattccagg gagcgccttc aagaaactca agaatttgaa cacactttac    240

ctgtataaga accacatcag aaagatttcc agaaatgctt ttgaaggact tgaaaatttg    300

ctatatctgt atattcattt caaccaacta gaaatgctac agccagagac ctttggagac    360

cttctgagat tagagcgact atttttgcat aacaacaaat tatctaaaat tccagctggg    420

agcttttcta atctggattc attaaaaaga ttgcgtctgg attccaacgc cctggtttgt    480

gactgtgatc tgatgtggct gggggagctt ttacaaggct ttgcccaaca cggccacacc    540

caggctgcgg ctacctgcga atatcccagg agactccatg ggcgtgcagt tgcttcagta    600

acagtagagg aattcaattg ccagagcccc cgaattactt ttgagccgca ggatgtggag    660

gtaccatcag gaaataccgt ctacttcacc tgccgggcgg aaggaaaccc caaacctgag    720

attatttgga tacacaacaa ccactcattg gatttggaag atgatactcg acttaatgtg    780

tttgatgatg gcacactcat gatccgaaac accagagagt cagaccaagg tgtctatcag    840

tgcatggcca gaaattccgc tggggaagcc aagacacaga gtgccatgct cagatactcc    900

agtcttccag ccaaaccaag ctttgtaatc cagcctcagg acacagaggt tttaattggc    960

accagcacaa ctttggaatg tatggccaca ggccacccac accctcttat cacttggacc   1020

agggacaatg gattggagct ggatggatcc aggcacgtgg caacgtccag tggactttac   1080

ttacagaaca tcacacaacg ggatcatggt cgatttacct gtcatgccaa caatagccac   1140

ggcactgttc aagctgcagc aaacataatt gtacaagctc ctccacaatt tacagtaacc   1200

cccaaggatc aagtggtgct ggaagaacat gctgtagagt ggctctgtga agctgacggc   1260

aacccacctc ctgttattgt ctggacaaaa acaggagggc agctccctgt ggaaggccag   1320

catacagttc tctcctctgg cactttgaga attgaccgtg cagcacagca cgatcaaggc   1380

caatatgaat gtcaagcagt cagttcgttg ggggtgaaaa aggtgtctgt gcagctgact   1440

gtaaaaccca aagctcttgc agtgtttact caacttcctc aggatacaag tgtcgaggtt   1500

ggaaagaata taaacatttc atgtcatgct caaggagaac cacagcccat aattacttgg   1560

aataaggaag gtgtgcagat tactgagagt ggtaaattcc atgtggatga tgaaggcacg   1620

ctgactatct acgacgcagg gttccctgac cagggaagat atgaatgtgt ggctcggaat   1680

tcttttggcc ttgctgtgac caacatgttt cttacagtca cggctataca gggtagacaa   1740

gctggcgatg actttgttga atcttccatt cttgatgctg tacagagagt tgacagtgca   1800

attaactcca cacgaagaca tttgttttca caaaaacctc acacctccag tgacctgctg   1860

gctcaatttc attacccgcg tgacccactg attgtggaaa tggcaagagc aggggagatt   1920

tttgagcaca cgctgcagct gatacgggaa cgtgtgaagc aggggctcac tgtggacttg   1980

gaaggcaaag aattccggta caatgacttg gtgtccccgc gctccctcag cctcatcgcc   2040

aatttatctg gatgcacagc tcgcaggcct ctgccaaact gctccaaccg gtgtttccat   2100

gcgaagtacc gcgcccacga cggcacgtgc aacaacctgc agcagcccac gtggggcgcg   2160

gcgctgaccg ccttcgcgcg cctgctgcag ccagcctacc gggacggcat ccgcgcgccc   2220

cgcgggctcg gccttcctgt gggctcccgc cagcccctcc cgccgccccg gctggtcgcc   2280

acagtgtggg cgcgcgcggc ggccgtcacc cccgaccaca gctacacgcg catgctcatg   2340

cactggggct ggtttctaga gcacgacttg gaccacacag tgcctgcgct gagcacagcc   2400

cgcttctcgg atgggcggcc gtgcagctcc gtctgcacca acgaccctcc ttgtttcccc   2460

atgaacaccc ggcacgccga cccccggggc acccacgcgc cctgcatgct cttcgcgcgc   2520

tccagccccg cgtgtgccag cggccgtccc tctgcgacgg tggattcagt ctatgcacga   2580

gagcagatca accagcaaac agcctacatc gatggctcca acgtttacgg gagctcggag   2640

cgggaatccc aggctctcag agacccttcg gtgcctcggg gtctcctgaa gacaggcttt   2700

ccttggcctc cctccggaaa gcccttattg cccttttcta caggcccacc caccgagtgc   2760

gcgcgacagg agcaggagag cccctgtttc ctggccgggg accaccgggc caacgagcat   2820

ctggctctgg ccgccatgca caccctgtgg ttccgggaac acaacagggt ggccacggag   2880

ctgtccgccc tgaaccccca ctgggaggga aacacggttt accaggaagc caggaagatc   2940

gtgggcgcgg agctgcagca catcacctac agccactggc tgcctaaggt cctgggggac   3000

cctggcacta ggatgctgag gggttaccga ggctacaacc ccaacgtgaa tgcaggcatc   3060

attaactctt ttgctactgc agcctttaga tttggccaca cattaatcaa tcctattctt   3120

taccgactga atgccacctt aggtgaaatt tccgaaggcc accttccgtt ccataaagcg   3180

ctcttttcac cgtccagaat aatcaaggaa ggtgggatag acccggttct ccgggggctg   3240

tttggcgtgg ctgctaaatg gcgggcaccc tcctaccttc tcagtcctga gctgacccag   3300

aggctcttct ccgcggctta ttctgcggcc gtggattcgg ctgccaccat cattcaaagg   3360

ggtagagacc acgggatccc accatatgtt gacttcagag ttttctgtaa tttgacttca   3420

gttaagaact ttgaggatct tcaaaatgaa attaaagatt cagagattag acaaaaactg   3480

agaaagttgt acggctctcc aggtgacatt gacctctggc ccgcccttat ggttgaagac   3540

ctgattcctg gtacaagagt gggaccaaca cttatgtgca tgttcgttac ccagtttcag   3600

cggctaagag atggagatag gttctggtat gaaaaccctg gagtatttac cccggcacaa   3660

ctcactcagc tgaagcaggc gtccctgagc cgggtgcttt gtgacaatgg tgacagcatt   3720

cagcaagtgc aggctgatgt ctttgtaaag gcagaatacc cacaggatta cctgaactgc   3780

agcgagatcc cgaaggtgga cctgcgagtg tggcaagact gctgtgcaga ctgtaggagt   3840

agaggacagt tcagagcagt gacgcaagag tctcaaaaga aacgctcagc tcaatacagc   3900

tatcctgttg ataaggatat ggagttaagt catctaagaa gtaggcaaca agataaaata   3960

tatgtgggtg aagatgctag aaatgtgaca gttctggcaa aaacaaagtt ctcccaagat   4020

ttcagcacgt ttgcagcgga aattcaggaa accatcacag cactcagaga gcagataaac   4080

aagctggagg cacgcctgag gcaggcaggg tgtacagatg ttagaggggt tccaaggaag   4140

gccgaggagc gctggatgaa agaagactgc actcactgca tttgtgagag tggccaggtc   4200

acctgtgtgg tggagatttg tcccccggct ccctgtccca gtcctgaatt ggtgaaagga   4260

acctgctgtc cagtttgcag agaccgagga atgccaagtg attccccaga gaagcgctaa   4320


<210>  628

<211>  1416

<212>  PRT

<213>  Homo sapiens



<400>  628

Cys Pro Ser Arg Cys Leu Cys Phe Lys Ser Thr Val Arg Cys Met His 
1               5                   10                  15      


Leu Met Leu Asp His Ile Pro Gln Val Pro Gln Gln Thr Thr Val Leu 
            20                  25                  30          


Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Pro Gly Ser Ala Phe Lys 
        35                  40                  45              


Lys Leu Lys Asn Leu Asn Thr Leu Tyr Leu Tyr Lys Asn His Ile Arg 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ala Phe Glu Gly Leu Glu Asn Leu Leu Tyr Leu 
65                  70                  75                  80  


Tyr Ile His Phe Asn Gln Leu Glu Met Leu Gln Pro Glu Thr Phe Gly 
                85                  90                  95      


Asp Leu Leu Arg Leu Glu Arg Leu Phe Leu His Asn Asn Lys Leu Ser 
            100                 105                 110         


Lys Ile Pro Ala Gly Ser Phe Ser Asn Leu Asp Ser Leu Lys Arg Leu 
        115                 120                 125             


Arg Leu Asp Ser Asn Ala Leu Val Cys Asp Cys Asp Leu Met Trp Leu 
    130                 135                 140                 


Gly Glu Leu Leu Gln Gly Phe Ala Gln His Gly His Thr Gln Ala Ala 
145                 150                 155                 160 


Ala Thr Cys Glu Tyr Pro Arg Arg Leu His Gly Arg Ala Val Ala Ser 
                165                 170                 175     


Val Thr Val Glu Glu Phe Asn Cys Gln Ser Pro Arg Ile Thr Phe Glu 
            180                 185                 190         


Pro Gln Asp Val Glu Val Pro Ser Gly Asn Thr Val Tyr Phe Thr Cys 
        195                 200                 205             


Arg Ala Glu Gly Asn Pro Lys Pro Glu Ile Ile Trp Ile His Asn Asn 
    210                 215                 220                 


His Ser Leu Asp Leu Glu Asp Asp Thr Arg Leu Asn Val Phe Asp Asp 
225                 230                 235                 240 


Gly Thr Leu Met Ile Arg Asn Thr Arg Glu Ser Asp Gln Gly Val Tyr 
                245                 250                 255     


Gln Cys Met Ala Arg Asn Ser Ala Gly Glu Ala Lys Thr Gln Ser Ala 
            260                 265                 270         


Met Leu Arg Tyr Ser Ser Leu Pro Ala Lys Pro Ser Phe Val Ile Gln 
        275                 280                 285             


Pro Gln Asp Thr Glu Val Leu Ile Gly Thr Ser Thr Thr Leu Glu Cys 
    290                 295                 300                 


Met Ala Thr Gly His Pro His Pro Leu Ile Thr Trp Thr Arg Asp Asn 
305                 310                 315                 320 


Gly Leu Glu Leu Asp Gly Ser Arg His Val Ala Thr Ser Ser Gly Leu 
                325                 330                 335     


Tyr Leu Gln Asn Ile Thr Gln Arg Asp His Gly Arg Phe Thr Cys His 
            340                 345                 350         


Ala Asn Asn Ser His Gly Thr Val Gln Ala Ala Ala Asn Ile Ile Val 
        355                 360                 365             


Gln Ala Pro Pro Gln Phe Thr Val Thr Pro Lys Asp Gln Val Val Leu 
    370                 375                 380                 


Glu Glu His Ala Val Glu Trp Leu Cys Glu Ala Asp Gly Asn Pro Pro 
385                 390                 395                 400 


Pro Val Ile Val Trp Thr Lys Thr Gly Gly Gln Leu Pro Val Glu Gly 
                405                 410                 415     


Gln His Thr Val Leu Ser Ser Gly Thr Leu Arg Ile Asp Arg Ala Ala 
            420                 425                 430         


Gln His Asp Gln Gly Gln Tyr Glu Cys Gln Ala Val Ser Ser Leu Gly 
        435                 440                 445             


Val Lys Lys Val Ser Val Gln Leu Thr Val Lys Pro Lys Ala Leu Ala 
    450                 455                 460                 


Val Phe Thr Gln Leu Pro Gln Asp Thr Ser Val Glu Val Gly Lys Asn 
465                 470                 475                 480 


Ile Asn Ile Ser Cys His Ala Gln Gly Glu Pro Gln Pro Ile Ile Thr 
                485                 490                 495     


Trp Asn Lys Glu Gly Val Gln Ile Thr Glu Ser Gly Lys Phe His Val 
            500                 505                 510         


Asp Asp Glu Gly Thr Leu Thr Ile Tyr Asp Ala Gly Phe Pro Asp Gln 
        515                 520                 525             


Gly Arg Tyr Glu Cys Val Ala Arg Asn Ser Phe Gly Leu Ala Val Thr 
    530                 535                 540                 


Asn Met Phe Leu Thr Val Thr Ala Ile Gln Gly Arg Gln Ala Gly Asp 
545                 550                 555                 560 


Asp Phe Val Glu Ser Ser Ile Leu Asp Ala Val Gln Arg Val Asp Ser 
                565                 570                 575     


Ala Ile Asn Ser Thr Arg Arg His Leu Phe Ser Gln Lys Pro His Thr 
            580                 585                 590         


Ser Ser Asp Leu Leu Ala Gln Phe His Tyr Pro Arg Asp Pro Leu Ile 
        595                 600                 605             


Val Glu Met Ala Arg Ala Gly Glu Ile Phe Glu His Thr Leu Gln Leu 
    610                 615                 620                 


Ile Arg Glu Arg Val Lys Gln Gly Leu Thr Val Asp Leu Glu Gly Lys 
625                 630                 635                 640 


Glu Phe Arg Tyr Asn Asp Leu Val Ser Pro Arg Ser Leu Ser Leu Ile 
                645                 650                 655     


Ala Asn Leu Ser Gly Cys Thr Ala Arg Arg Pro Leu Pro Asn Cys Ser 
            660                 665                 670         


Asn Arg Cys Phe His Ala Lys Tyr Arg Ala His Asp Gly Thr Cys Asn 
        675                 680                 685             


Asn Leu Gln Gln Pro Thr Trp Gly Ala Ala Leu Thr Ala Phe Ala Arg 
    690                 695                 700                 


Leu Leu Gln Pro Ala Tyr Arg Asp Gly Ile Arg Ala Pro Arg Gly Leu 
705                 710                 715                 720 


Gly Leu Pro Val Gly Ser Arg Gln Pro Leu Pro Pro Pro Arg Leu Val 
                725                 730                 735     


Ala Thr Val Trp Ala Arg Ala Ala Ala Val Thr Pro Asp His Ser Tyr 
            740                 745                 750         


Thr Arg Met Leu Met His Trp Gly Trp Phe Leu Glu His Asp Leu Asp 
        755                 760                 765             


His Thr Val Pro Ala Leu Ser Thr Ala Arg Phe Ser Asp Gly Arg Pro 
    770                 775                 780                 


Cys Ser Ser Val Cys Thr Asn Asp Pro Pro Cys Phe Pro Met Asn Thr 
785                 790                 795                 800 


Arg His Ala Asp Pro Arg Gly Thr His Ala Pro Cys Met Leu Phe Ala 
                805                 810                 815     


Arg Ser Ser Pro Ala Cys Ala Ser Gly Arg Pro Ser Ala Thr Val Asp 
            820                 825                 830         


Ser Val Tyr Ala Arg Glu Gln Ile Asn Gln Gln Thr Ala Tyr Ile Asp 
        835                 840                 845             


Gly Ser Asn Val Tyr Gly Ser Ser Glu Arg Glu Ser Gln Ala Leu Arg 
    850                 855                 860                 


Asp Pro Ser Val Pro Arg Gly Leu Leu Lys Thr Gly Phe Pro Trp Pro 
865                 870                 875                 880 


Pro Ser Gly Lys Pro Leu Leu Pro Phe Ser Thr Gly Pro Pro Thr Glu 
                885                 890                 895     


Cys Ala Arg Gln Glu Gln Glu Ser Pro Cys Phe Leu Ala Gly Asp His 
            900                 905                 910         


Arg Ala Asn Glu His Leu Ala Leu Ala Ala Met His Thr Leu Trp Phe 
        915                 920                 925             


Arg Glu His Asn Arg Val Ala Thr Glu Leu Ser Ala Leu Asn Pro His 
    930                 935                 940                 


Trp Glu Gly Asn Thr Val Tyr Gln Glu Ala Arg Lys Ile Val Gly Ala 
945                 950                 955                 960 


Glu Leu Gln His Ile Thr Tyr Ser His Trp Leu Pro Lys Val Leu Gly 
                965                 970                 975     


Asp Pro Gly Thr Arg Met Leu Arg Gly Tyr Arg Gly Tyr Asn Pro Asn 
            980                 985                 990         


Val Asn Ala Gly Ile Ile Asn Ser  Phe Ala Thr Ala Ala  Phe Arg Phe 
        995                 1000                 1005             


Gly His  Thr Leu Ile Asn Pro  Ile Leu Tyr Arg Leu  Asn Ala Thr 
    1010                 1015                 1020             


Leu Gly  Glu Ile Ser Glu Gly  His Leu Pro Phe His  Lys Ala Leu 
    1025                 1030                 1035             


Phe Ser  Pro Ser Arg Ile Ile  Lys Glu Gly Gly Ile  Asp Pro Val 
    1040                 1045                 1050             


Leu Arg  Gly Leu Phe Gly Val  Ala Ala Lys Trp Arg  Ala Pro Ser 
    1055                 1060                 1065             


Tyr Leu  Leu Ser Pro Glu Leu  Thr Gln Arg Leu Phe  Ser Ala Ala 
    1070                 1075                 1080             


Tyr Ser  Ala Ala Val Asp Ser  Ala Ala Thr Ile Ile  Gln Arg Gly 
    1085                 1090                 1095             


Arg Asp  His Gly Ile Pro Pro  Tyr Val Asp Phe Arg  Val Phe Cys 
    1100                 1105                 1110             


Asn Leu  Thr Ser Val Lys Asn  Phe Glu Asp Leu Gln  Asn Glu Ile 
    1115                 1120                 1125             


Lys Asp  Ser Glu Ile Arg Gln  Lys Leu Arg Lys Leu  Tyr Gly Ser 
    1130                 1135                 1140             


Pro Gly  Asp Ile Asp Leu Trp  Pro Ala Leu Met Val  Glu Asp Leu 
    1145                 1150                 1155             


Ile Pro  Gly Thr Arg Val Gly  Pro Thr Leu Met Cys  Met Phe Val 
    1160                 1165                 1170             


Thr Gln  Phe Gln Arg Leu Arg  Asp Gly Asp Arg Phe  Trp Tyr Glu 
    1175                 1180                 1185             


Asn Pro  Gly Val Phe Thr Pro  Ala Gln Leu Thr Gln  Leu Lys Gln 
    1190                 1195                 1200             


Ala Ser  Leu Ser Arg Val Leu  Cys Asp Asn Gly Asp  Ser Ile Gln 
    1205                 1210                 1215             


Gln Val  Gln Ala Asp Val Phe  Val Lys Ala Glu Tyr  Pro Gln Asp 
    1220                 1225                 1230             


Tyr Leu  Asn Cys Ser Glu Ile  Pro Lys Val Asp Leu  Arg Val Trp 
    1235                 1240                 1245             


Gln Asp  Cys Cys Ala Asp Cys  Arg Ser Arg Gly Gln  Phe Arg Ala 
    1250                 1255                 1260             


Val Thr  Gln Glu Ser Gln Lys  Lys Arg Ser Ala Gln  Tyr Ser Tyr 
    1265                 1270                 1275             


Pro Val  Asp Lys Asp Met Glu  Leu Ser His Leu Arg  Ser Arg Gln 
    1280                 1285                 1290             


Gln Asp  Lys Ile Tyr Val Gly  Glu Asp Ala Arg Asn  Val Thr Val 
    1295                 1300                 1305             


Leu Ala  Lys Thr Lys Phe Ser  Gln Asp Phe Ser Thr  Phe Ala Ala 
    1310                 1315                 1320             


Glu Ile  Gln Glu Thr Ile Thr  Ala Leu Arg Glu Gln  Ile Asn Lys 
    1325                 1330                 1335             


Leu Glu  Ala Arg Leu Arg Gln  Ala Gly Cys Thr Asp  Val Arg Gly 
    1340                 1345                 1350             


Val Pro  Arg Lys Ala Glu Glu  Arg Trp Met Lys Glu  Asp Cys Thr 
    1355                 1360                 1365             


His Cys  Ile Cys Glu Ser Gly  Gln Val Thr Cys Val  Val Glu Ile 
    1370                 1375                 1380             


Cys Pro  Pro Ala Pro Cys Pro  Ser Pro Glu Leu Val  Lys Gly Thr 
    1385                 1390                 1395             


Cys Cys  Pro Val Cys Arg Asp  Arg Gly Met Pro Ser  Asp Ser Pro 
    1400                 1405                 1410             


Glu Lys  Arg 
    1415     


<210>  629

<211>  3568

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(2940)

<223>  



<400>  629
atg agg ggt tac cat ggc gac cga ggc agc cat ccc cgc cca gcc cgc       48
Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg         
1               5                   10                  15              

ttt gct gac caa cag cat atg gac gtg ggc cct gct gcc agg gcc cca       96
Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro         
            20                  25                  30                  

tac ctg ctg ggc tcc agg gag gcc ttc tcc acc gag ccc cgc ttc tgt      144
Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys         
        35                  40                  45                      

gcc ccg aga gct ggc ctg gga cac att tct cct gaa ggg ccc ctg agc      192
Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser         
    50                  55                  60                          

ctg agt gag ggg ccg tcg gta ggc cct gag gga ggg cca gcg ggg gcc      240
Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala         
65                  70                  75                  80          

ggg gtt ggg ggg ggt agc agc acc ttc ccc agg atg tac cct ggc cag      288
Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln         
                85                  90                  95              

ggc ccc ttc gac acc tgt gaa gac tgt gtg ggc cac cca cag ggc aag      336
Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys         
            100                 105                 110                 

ggt gcc ccc cgc ctg cct cct aca ctc ctg gat cag ttt gaa aag cag      384
Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln         
        115                 120                 125                     

ttg cca gtt caa caa gat ggc ttc cac aca cta cca tac cag cga ggg      432
Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly         
    130                 135                 140                         

cca gca ggg gca ggg ccc ggg cca gcg cca ggg acg ggc act gcc cca      480
Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro         
145                 150                 155                 160         

gag ccc cgc agt gag agc cct agc cgc atc cgg cac ctg gtt cat tct      528
Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser         
                165                 170                 175             

gtg cag aag ctc ttt gcc aag tcc cac tct ctg gag gcg ccg ggg aag      576
Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys         
            180                 185                 190                 

cgg gac tat aat ggg ccc aag gct gag gga aga ggt ggc tct gga gga      624
Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly         
        195                 200                 205                     

gac agc tac ccc ggc ccg ggc tct gga ggc ccc cac acc tcc cat cac      672
Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His         
    210                 215                 220                         

cac cat cac cac cac cat cac cac cac cac cag tcc cgg cac ggc aag      720
His His His His His His His His His His Gln Ser Arg His Gly Lys         
225                 230                 235                 240         

agg agc aag agc aag gac cgc aag ggg gat ggg cgg cac cag gcc aag      768
Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys         
                245                 250                 255             

tcc aca ggc tgg tgg agt tcc gat gac aac ttg gac agt gat agc ggc      816
Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly         
            260                 265                 270                 

ttc ctg gcg ggt ggg agg ccc cct ggg gag cct ggt ggt ccc ttc tgc      864
Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys         
        275                 280                 285                     

ctg gag ggt cca gat ggg tcc tac cgg gac ttg agc ttc aag ggg cgc      912
Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg         
    290                 295                 300                         

tcg ggc ggg tcg gaa ggc cgc tgc ctt gcc tgc act ggc atg tcc atg      960
Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met         
305                 310                 315                 320         

tca ctg gat gga cag tcg gtc aag cga agt gcc tgg cat acc atg atg     1008
Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met         
                325                 330                 335             

gtc agc cag ggc cgg gat gga tac ccg ggg gcc ggg cca ggc aag ggg     1056
Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly         
            340                 345                 350                 

ctc ctg ggt ccg gag acc aag gcc aaa gcc agg act tat cac tat ctg     1104
Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu         
        355                 360                 365                     

cag gtg ccg caa gat gac tgg ggg ggt tac ccc acc ggt ggc aag gat     1152
Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp         
    370                 375                 380                         

ggg gag atc ccc tgc cgc agg atg cgg agc ggc agc tac atc aaa gcc     1200
Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala         
385                 390                 395                 400         

atg ggg gat gag gag agc gga gac tca gac ggc agc ccc aag aca tct     1248
Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser         
                405                 410                 415             

ccc aaa gca gtc gcc cga cgc ttc acc acc cgt cgc tcc tcc agc gtg     1296
Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val         
            420                 425                 430                 

gac cag gcc agg atc agc tgc tgt gtc cca ccc cgg atc cac ccc cgg     1344
Asp Gln Ala Arg Ile Ser Cys Cys Val Pro Pro Arg Ile His Pro Arg         
        435                 440                 445                     

agc tcc atc cct ggc tac agc cgt tcc ctc acc act gga cag ctc agc     1392
Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser         
    450                 455                 460                         

gat gag ttg aac cag cag ctg gag gcc gtg tgc ggg tcg gtg ttt ggg     1440
Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly         
465                 470                 475                 480         

gag ctg gag tcc cag gcc gtg gac gcc ctg gac ctg ccc ggc tgt ttc     1488
Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe         
                485                 490                 495             

cgc atg cgg agc cac agc tac ctc cgg gcc atc cag gcc ggc tgc tct     1536
Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser         
            500                 505                 510                 

caa gac gac gac tgc ctg ccc ctc ctc gct acc cct gcc gct gtc tca     1584
Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser         
        515                 520                 525                     

ggg agg ccc ggc tcc tcc ttc aac ttc aga aag gcc ccg ccc ccc atc     1632
Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile         
    530                 535                 540                         

ccg ccg gga agc cag gcc ccg ccc cgc atc tcc atc acc gcc cag agc     1680
Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser         
545                 550                 555                 560         

agc acc gac tcc gcg cac gag agc ttc acg gcg gcc gag ggc ccc gcc     1728
Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala         
                565                 570                 575             

cgg cgc tgc agc tcc gcc gac ggg ctg gac ggc ccc gcc atg ggt gcg     1776
Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala         
            580                 585                 590                 

cgc aca ctg gag ttg gcg ccg gtg ccg ccc cgg gcc agc ccc aag ccc     1824
Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro         
        595                 600                 605                     

ccc aca ctc atc atc aag acc atc cct ggc agg gag gag ctg cgg agc     1872
Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser         
    610                 615                 620                         

ctg gcg cgg cag cgg aag tgg cgg ccg tcc att ggg gtg cag gtg gag     1920
Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu         
625                 630                 635                 640         

acg atc tca gat tcg gac acc gag aac agg agc cgg agg gag ttc cac     1968
Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His         
                645                 650                 655             

tct att ggc gtg cag gtg gaa gag gac aag agg cga gca agg ttc aag     2016
Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys         
            660                 665                 670                 

cgc tcc aat agt gtg acg gct ggc gtg cag gca gac ctg gag ctg gag     2064
Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu         
        675                 680                 685                     

ggc ctg gca ggc ctg gcc acg gtg gcc aca gaa gac aag gcc ctg cag     2112
Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln         
    690                 695                 700                         

ttt gga cgc tcc ttc cag agg cac gcc tct gag ccc cag cct ggg ccc     2160
Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro         
705                 710                 715                 720         

cgg gcc ccc acc tac tca gtc ttc cgc acg gtc cac acg cag ggc cag     2208
Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln         
                725                 730                 735             

tgg gcc tac cgc gag ggc tac cca ctg ccg tac gag ccg ccg gcc acc     2256
Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr         
            740                 745                 750                 

gat ggg tcg ccc ggc cct gcc ccc gcc ccc acc ccc tgc cct ggg gcc     2304
Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Cys Pro Gly Ala         
        755                 760                 765                     

ggc cgc cgt gac tcc tgg ata gag cgc ggt tca cgt agc ctc ccc gac     2352
Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp         
    770                 775                 780                         

tca ggc cgc gca tcc ccc tgc cca cgc gac ggc gag tgg ttc atc aag     2400
Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys         
785                 790                 795                 800         

atg ctg cgg gca gag gtg gag aag ctg gag cac tgg tgc cag cag atg     2448
Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met         
                805                 810                 815             

gag cgt gag gcg gag gac tat gag cta ccc gag gag atc ctg gag aag     2496
Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys         
            820                 825                 830                 

atc cgc agt gct gtg ggc agc aca caa ctt ctc ctg tcc cag aag gtt     2544
Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val         
        835                 840                 845                     

cag cag ttc ttc cgg ctg tgt cag caa agc atg gat ccc act gcg ttc     2592
Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe         
    850                 855                 860                         

cct gtg ccc acc ttc cag gac ctg gcg ggt ttc tgg gac ctc cta cag     2640
Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln         
865                 870                 875                 880         

ctc tcc atc gag gat gtg acc ctc aag ttc ctg gag cta cag caa ctc     2688
Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu         
                885                 890                 895             

aag gcc aac agc tgg aaa ctc ctg gag cct aag gag gag aag aag gtc     2736
Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val         
            900                 905                 910                 

cct ccg ccg ata cca aag aag ccc ctg cgg ggc cgg ggc gtg ccg gtg     2784
Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val         
        915                 920                 925                     

aag gag cgc tcc ctg gac tcc gtg gac cgg cag cgg cag gaa gcg cgc     2832
Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg         
    930                 935                 940                         

aag cgg ctc ctg gcg gcc aag cgc gcc gct tcc ttc cgc cac agc tcg     2880
Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser         
945                 950                 955                 960         

gcc acc gag agc gcc gac agc atc gag att tac atc ccc gag gcc cag     2928
Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln         
                965                 970                 975             

acc agg ctg tga ccggtccggc ccgcccagcc cggcccgggc ccgcggttct         2980
Thr Arg Leu                                                             
                                                                        

ccacccgtac tgtacaccca gcgtcgaggt cactgtgaac gcgggccgcc ccgtgcgccc   3040

gccccaccgg caccggacgc cccggccccc gggcccgtca cactctcgtg ggttttttac   3100

cttcctgatc ccacgcgaag gcgcccgggc tgggcagggg gccgtgcctc tccgccctgc   3160

gcccctcacc tggatcccct gcccacctgg tccgacgctt tgtccccacc tcctccccat   3220

gggcaccatc tctgccattc tttcccccac gggccaggcc gggccgggtc cctcatctgg   3280

gctctgcgtc cccccctccc ccaccccgcg gggctgggct tcgtggggat caagcttcgt   3340

ggctttttat gaagaatccc gaaccctgcc taggagcccg ccccaccctc ccaggggctc   3400

catcctcagc cctctgccca ctgggcccag ggaccacagt ggctggacca acccaggacc   3460

agggcgcctg ggcctctccc ctttcccagc ggctggggag gggagatggg ggcttcccct   3520

caccacacct gtggctgttc ccacatcccc ttgaatatcc caggaaaa                3568


<210>  630

<211>  979

<212>  PRT

<213>  Homo sapiens



<400>  630

Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg 
1               5                   10                  15      


Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro 
            20                  25                  30          


Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys 
        35                  40                  45              


Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly Pro Leu Ser 
    50                  55                  60                  


Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro Ala Gly Ala 
65                  70                  75                  80  


Gly Val Gly Gly Gly Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly Gln 
                85                  90                  95      


Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly Lys 
            100                 105                 110         


Gly Ala Pro Arg Leu Pro Pro Thr Leu Leu Asp Gln Phe Glu Lys Gln 
        115                 120                 125             


Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg Gly 
    130                 135                 140                 


Pro Ala Gly Ala Gly Pro Gly Pro Ala Pro Gly Thr Gly Thr Ala Pro 
145                 150                 155                 160 


Glu Pro Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser 
                165                 170                 175     


Val Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys 
            180                 185                 190         


Arg Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly 
        195                 200                 205             


Asp Ser Tyr Pro Gly Pro Gly Ser Gly Gly Pro His Thr Ser His His 
    210                 215                 220                 


His His His His His His His His His His Gln Ser Arg His Gly Lys 
225                 230                 235                 240 


Arg Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Ala Lys 
                245                 250                 255     


Ser Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly 
            260                 265                 270         


Phe Leu Ala Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys 
        275                 280                 285             


Leu Glu Gly Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg 
    290                 295                 300                 


Ser Gly Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met 
305                 310                 315                 320 


Ser Leu Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met 
                325                 330                 335     


Val Ser Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly 
            340                 345                 350         


Leu Leu Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu 
        355                 360                 365             


Gln Val Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp 
    370                 375                 380                 


Gly Glu Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala 
385                 390                 395                 400 


Met Gly Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser 
                405                 410                 415     


Pro Lys Ala Val Ala Arg Arg Phe Thr Thr Arg Arg Ser Ser Ser Val 
            420                 425                 430         


Asp Gln Ala Arg Ile Ser Cys Cys Val Pro Pro Arg Ile His Pro Arg 
        435                 440                 445             


Ser Ser Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser 
    450                 455                 460                 


Asp Glu Leu Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly 
465                 470                 475                 480 


Glu Leu Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe 
                485                 490                 495     


Arg Met Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser 
            500                 505                 510         


Gln Asp Asp Asp Cys Leu Pro Leu Leu Ala Thr Pro Ala Ala Val Ser 
        515                 520                 525             


Gly Arg Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile 
    530                 535                 540                 


Pro Pro Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser 
545                 550                 555                 560 


Ser Thr Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala 
                565                 570                 575     


Arg Arg Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Ala Met Gly Ala 
            580                 585                 590         


Arg Thr Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro 
        595                 600                 605             


Pro Thr Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser 
    610                 615                 620                 


Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu 
625                 630                 635                 640 


Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His 
                645                 650                 655     


Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys 
            660                 665                 670         


Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu 
        675                 680                 685             


Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln 
    690                 695                 700                 


Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro Gln Pro Gly Pro 
705                 710                 715                 720 


Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln 
                725                 730                 735     


Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr 
            740                 745                 750         


Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Cys Pro Gly Ala 
        755                 760                 765             


Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg Ser Leu Pro Asp 
    770                 775                 780                 


Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys 
785                 790                 795                 800 


Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met 
                805                 810                 815     


Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys 
            820                 825                 830         


Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val 
        835                 840                 845             


Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp Pro Thr Ala Phe 
    850                 855                 860                 


Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln 
865                 870                 875                 880 


Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu 
                885                 890                 895     


Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val 
            900                 905                 910         


Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg Gly Val Pro Val 
        915                 920                 925             


Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg 
    930                 935                 940                 


Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser 
945                 950                 955                 960 


Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln 
                965                 970                 975     


Thr Arg Leu 
            


<210>  631

<211>  2940

<212>  DNA

<213>  Homo sapiens



<400>  631
atgaggggtt accatggcga ccgaggcagc catccccgcc cagcccgctt tgctgaccaa     60

cagcatatgg acgtgggccc tgctgccagg gccccatacc tgctgggctc cagggaggcc    120

ttctccaccg agccccgctt ctgtgccccg agagctggcc tgggacacat ttctcctgaa    180

gggcccctga gcctgagtga ggggccgtcg gtaggccctg agggagggcc agcgggggcc    240

ggggttgggg ggggtagcag caccttcccc aggatgtacc ctggccaggg ccccttcgac    300

acctgtgaag actgtgtggg ccacccacag ggcaagggtg ccccccgcct gcctcctaca    360

ctcctggatc agtttgaaaa gcagttgcca gttcaacaag atggcttcca cacactacca    420

taccagcgag ggccagcagg ggcagggccc gggccagcgc cagggacggg cactgcccca    480

gagccccgca gtgagagccc tagccgcatc cggcacctgg ttcattctgt gcagaagctc    540

tttgccaagt cccactctct ggaggcgccg gggaagcggg actataatgg gcccaaggct    600

gagggaagag gtggctctgg aggagacagc taccccggcc cgggctctgg aggcccccac    660

acctcccatc accaccatca ccaccaccat caccaccacc accagtcccg gcacggcaag    720

aggagcaaga gcaaggaccg caagggggat gggcggcacc aggccaagtc cacaggctgg    780

tggagttccg atgacaactt ggacagtgat agcggcttcc tggcgggtgg gaggccccct    840

ggggagcctg gtggtccctt ctgcctggag ggtccagatg ggtcctaccg ggacttgagc    900

ttcaaggggc gctcgggcgg gtcggaaggc cgctgccttg cctgcactgg catgtccatg    960

tcactggatg gacagtcggt caagcgaagt gcctggcata ccatgatggt cagccagggc   1020

cgggatggat acccgggggc cgggccaggc aaggggctcc tgggtccgga gaccaaggcc   1080

aaagccagga cttatcacta tctgcaggtg ccgcaagatg actggggggg ttaccccacc   1140

ggtggcaagg atggggagat cccctgccgc aggatgcgga gcggcagcta catcaaagcc   1200

atgggggatg aggagagcgg agactcagac ggcagcccca agacatctcc caaagcagtc   1260

gcccgacgct tcaccacccg tcgctcctcc agcgtggacc aggccaggat cagctgctgt   1320

gtcccacccc ggatccaccc ccggagctcc atccctggct acagccgttc cctcaccact   1380

ggacagctca gcgatgagtt gaaccagcag ctggaggccg tgtgcgggtc ggtgtttggg   1440

gagctggagt cccaggccgt ggacgccctg gacctgcccg gctgtttccg catgcggagc   1500

cacagctacc tccgggccat ccaggccggc tgctctcaag acgacgactg cctgcccctc   1560

ctcgctaccc ctgccgctgt ctcagggagg cccggctcct ccttcaactt cagaaaggcc   1620

ccgcccccca tcccgccggg aagccaggcc ccgccccgca tctccatcac cgcccagagc   1680

agcaccgact ccgcgcacga gagcttcacg gcggccgagg gccccgcccg gcgctgcagc   1740

tccgccgacg ggctggacgg ccccgccatg ggtgcgcgca cactggagtt ggcgccggtg   1800

ccgccccggg ccagccccaa gccccccaca ctcatcatca agaccatccc tggcagggag   1860

gagctgcgga gcctggcgcg gcagcggaag tggcggccgt ccattggggt gcaggtggag   1920

acgatctcag attcggacac cgagaacagg agccggaggg agttccactc tattggcgtg   1980

caggtggaag aggacaagag gcgagcaagg ttcaagcgct ccaatagtgt gacggctggc   2040

gtgcaggcag acctggagct ggagggcctg gcaggcctgg ccacggtggc cacagaagac   2100

aaggccctgc agtttggacg ctccttccag aggcacgcct ctgagcccca gcctgggccc   2160

cgggccccca cctactcagt cttccgcacg gtccacacgc agggccagtg ggcctaccgc   2220

gagggctacc cactgccgta cgagccgccg gccaccgatg ggtcgcccgg ccctgccccc   2280

gcccccaccc cctgccctgg ggccggccgc cgtgactcct ggatagagcg cggttcacgt   2340

agcctccccg actcaggccg cgcatccccc tgcccacgcg acggcgagtg gttcatcaag   2400

atgctgcggg cagaggtgga gaagctggag cactggtgcc agcagatgga gcgtgaggcg   2460

gaggactatg agctacccga ggagatcctg gagaagatcc gcagtgctgt gggcagcaca   2520

caacttctcc tgtcccagaa ggttcagcag ttcttccggc tgtgtcagca aagcatggat   2580

cccactgcgt tccctgtgcc caccttccag gacctggcgg gtttctggga cctcctacag   2640

ctctccatcg aggatgtgac cctcaagttc ctggagctac agcaactcaa ggccaacagc   2700

tggaaactcc tggagcctaa ggaggagaag aaggtccctc cgccgatacc aaagaagccc   2760

ctgcggggcc ggggcgtgcc ggtgaaggag cgctccctgg actccgtgga ccggcagcgg   2820

caggaagcgc gcaagcggct cctggcggcc aagcgcgccg cttccttccg ccacagctcg   2880

gccaccgaga gcgccgacag catcgagatt tacatccccg aggcccagac caggctgtga   2940


<210>  632

<211>  359

<212>  PRT

<213>  Homo sapiens



<400>  632

Glu Leu Arg Ser Leu Ala Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly 
1               5                   10                  15      


Val Gln Val Glu Thr Ile Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg 
            20                  25                  30          


Arg Glu Phe His Ser Ile Gly Val Gln Val Glu Glu Asp Lys Arg Arg 
        35                  40                  45              


Ala Arg Phe Lys Arg Ser Asn Ser Val Thr Ala Gly Val Gln Ala Asp 
    50                  55                  60                  


Leu Glu Leu Glu Gly Leu Ala Gly Leu Ala Thr Val Ala Thr Glu Asp 
65                  70                  75                  80  


Lys Ala Leu Gln Phe Gly Arg Ser Phe Gln Arg His Ala Ser Glu Pro 
                85                  90                  95      


Gln Pro Gly Pro Arg Ala Pro Thr Tyr Ser Val Phe Arg Thr Val His 
            100                 105                 110         


Thr Gln Gly Gln Trp Ala Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu 
        115                 120                 125             


Pro Pro Ala Thr Asp Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro 
    130                 135                 140                 


Cys Pro Gly Ala Gly Arg Arg Asp Ser Trp Ile Glu Arg Gly Ser Arg 
145                 150                 155                 160 


Ser Leu Pro Asp Ser Gly Arg Ala Ser Pro Cys Pro Arg Asp Gly Glu 
                165                 170                 175     


Trp Phe Ile Lys Met Leu Arg Ala Glu Val Glu Lys Leu Glu His Trp 
            180                 185                 190         


Cys Gln Gln Met Glu Arg Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu 
        195                 200                 205             


Ile Leu Glu Lys Ile Arg Ser Ala Val Gly Ser Thr Gln Leu Leu Leu 
    210                 215                 220                 


Ser Gln Lys Val Gln Gln Phe Phe Arg Leu Cys Gln Gln Ser Met Asp 
225                 230                 235                 240 


Pro Thr Ala Phe Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp 
                245                 250                 255     


Asp Leu Leu Gln Leu Ser Ile Glu Asp Val Thr Leu Lys Phe Leu Glu 
            260                 265                 270         


Leu Gln Gln Leu Lys Ala Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu 
        275                 280                 285             


Glu Lys Lys Val Pro Pro Pro Ile Pro Lys Lys Pro Leu Arg Gly Arg 
    290                 295                 300                 


Gly Val Pro Val Lys Glu Arg Ser Leu Asp Ser Val Asp Arg Gln Arg 
305                 310                 315                 320 


Gln Glu Ala Arg Lys Arg Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe 
                325                 330                 335     


Arg His Ser Ser Ala Thr Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile 
            340                 345                 350         


Pro Glu Ala Gln Thr Arg Leu 
        355                 


<210>  633

<211>  977

<212>  PRT

<213>  Rattus norvegicus



<400>  633

Met Arg Gly Tyr His Gly Asp Arg Gly Ser His Pro Arg Pro Ala Arg 
1               5                   10                  15      


Phe Ala Asp Gln Gln His Met Asp Val Gly Pro Ala Ala Arg Ala Pro 
            20                  25                  30          


Tyr Leu Leu Gly Ser Arg Glu Ala Phe Ser Thr Glu Pro Arg Phe Cys 
        35                  40                  45              


Ala Pro Arg Ala Gly Leu Gly His Leu Ser Pro Glu Gly Pro Leu Ser 
    50                  55                  60                  


Leu Ser Glu Gly Pro Ser Ser Val Gly Pro Glu Gly Ser Pro Gly Gly 
65                  70                  75                  80  


Val Gly Ala Gly Gly Ser Ser Ser Thr Phe Pro Arg Met Tyr Pro Gly 
                85                  90                  95      


Gln Gly Pro Phe Asp Thr Cys Glu Asp Cys Val Gly His Pro Gln Gly 
            100                 105                 110         


Lys Gly Ala Thr Arg Leu Leu Pro Thr Phe Leu Asp Gln Phe Glu Lys 
        115                 120                 125             


Gln Leu Pro Val Gln Gln Asp Gly Phe His Thr Leu Pro Tyr Gln Arg 
    130                 135                 140                 


Gly Pro Ala Gly Pro Gly Pro Gly Pro Gly Ser Gly Ala Ala Pro Glu 
145                 150                 155                 160 


Ala Arg Ser Glu Ser Pro Ser Arg Ile Arg His Leu Val His Ser Val 
                165                 170                 175     


Gln Lys Leu Phe Ala Lys Ser His Ser Leu Glu Ala Pro Gly Lys Arg 
            180                 185                 190         


Asp Tyr Asn Gly Pro Lys Ala Glu Gly Arg Ser Ser Ser Gly Gly Asp 
        195                 200                 205             


Ser Tyr Ser Gly Pro Gly Ser Gly Gly Pro Pro Thr Ser His His His 
    210                 215                 220                 


His His His His His His His His His Gln Ser Arg His Gly Lys Arg 
225                 230                 235                 240 


Ser Lys Ser Lys Asp Arg Lys Gly Asp Gly Arg His Gln Thr Lys Ala 
                245                 250                 255     


Thr Gly Trp Trp Ser Ser Asp Asp Asn Leu Asp Ser Asp Ser Gly Phe 
            260                 265                 270         


Leu Gly Gly Arg Pro Pro Gly Glu Pro Gly Gly Pro Phe Cys Leu Asp 
        275                 280                 285             


Ala Pro Asp Gly Ser Tyr Arg Asp Leu Ser Phe Lys Gly Arg Ser Gly 
    290                 295                 300                 


Gly Ser Glu Gly Arg Cys Leu Ala Cys Thr Gly Met Ser Met Ser Leu 
305                 310                 315                 320 


Asp Gly Gln Ser Val Lys Arg Ser Ala Trp His Thr Met Met Val Ser 
                325                 330                 335     


Gln Gly Arg Asp Gly Tyr Pro Gly Ala Gly Pro Gly Lys Gly Leu Leu 
            340                 345                 350         


Gly Pro Glu Thr Lys Ala Lys Ala Arg Thr Tyr His Tyr Leu Gln Val 
        355                 360                 365             


Pro Gln Asp Asp Trp Gly Gly Tyr Pro Thr Gly Gly Lys Asp Gly Glu 
    370                 375                 380                 


Ile Pro Cys Arg Arg Met Arg Ser Gly Ser Tyr Ile Lys Ala Met Gly 
385                 390                 395                 400 


Asp Glu Glu Ser Gly Asp Ser Asp Gly Ser Pro Lys Thr Ser Pro Lys 
                405                 410                 415     


Ala Leu Ala Arg Arg Phe Ala Ser Arg Arg Ser Ser Ser Val Asp Thr 
            420                 425                 430         


Ala Arg Ile Asn Cys Cys Val Pro Pro Arg Ile His Pro Arg Ser Ser 
        435                 440                 445             


Ile Pro Gly Tyr Ser Arg Ser Leu Thr Thr Gly Gln Leu Ser Glu Glu 
    450                 455                 460                 


Phe Asn Gln Gln Leu Glu Ala Val Cys Gly Ser Val Phe Gly Glu Leu 
465                 470                 475                 480 


Glu Ser Gln Ala Val Asp Ala Leu Asp Leu Pro Gly Cys Phe Arg Met 
                485                 490                 495     


Arg Ser His Ser Tyr Leu Arg Ala Ile Gln Ala Gly Cys Ser Gln Asp 
            500                 505                 510         


Asp Asp Cys Leu Pro Leu Leu Ala Ala Pro Ala Ser Val Ser Gly Arg 
        515                 520                 525             


Pro Gly Ser Ser Phe Asn Phe Arg Lys Ala Pro Pro Pro Ile Pro Pro 
    530                 535                 540                 


Gly Ser Gln Ala Pro Pro Arg Ile Ser Ile Thr Ala Gln Ser Ser Thr 
545                 550                 555                 560 


Asp Ser Ala His Glu Ser Phe Thr Ala Ala Glu Gly Pro Ala Arg Arg 
                565                 570                 575     


Cys Ser Ser Ala Asp Gly Leu Asp Gly Pro Thr Met Gly Ala Arg Thr 
            580                 585                 590         


Leu Glu Leu Ala Pro Val Pro Pro Arg Ala Ser Pro Lys Pro Pro Thr 
        595                 600                 605             


Leu Ile Ile Lys Thr Ile Pro Gly Arg Glu Glu Leu Arg Ser Leu Ala 
    610                 615                 620                 


Arg Gln Arg Lys Trp Arg Pro Ser Ile Gly Val Gln Val Glu Thr Ile 
625                 630                 635                 640 


Ser Asp Ser Asp Thr Glu Asn Arg Ser Arg Arg Glu Phe His Ser Ile 
                645                 650                 655     


Gly Val Gln Val Glu Glu Asp Lys Arg Arg Ala Arg Phe Lys Arg Ser 
            660                 665                 670         


Asn Ser Val Thr Ala Gly Val Gln Ala Asp Leu Glu Leu Glu Gly Leu 
        675                 680                 685             


Ala Gly Leu Ala Thr Val Ala Thr Glu Asp Lys Ala Leu Gln Phe Gly 
    690                 695                 700                 


Arg Pro Phe Gln Arg Gln Ala Ser Glu Pro Gln Pro Gly Pro Arg Ala 
705                 710                 715                 720 


Pro Thr Tyr Ser Val Phe Arg Thr Val His Thr Gln Gly Gln Trp Ala 
                725                 730                 735     


Tyr Arg Glu Gly Tyr Pro Leu Pro Tyr Glu Pro Pro Ala Thr Asp Gly 
            740                 745                 750         


Ser Pro Gly Pro Pro Pro Val Pro Ala Pro Gly Pro Gly Ser Gly Arg 
        755                 760                 765             


Arg Asp Ser Trp Met Glu Arg Gly Ser Arg Ser Leu Pro Asp Ser Gly 
    770                 775                 780                 


Arg Thr Ser Pro Cys Pro Arg Asp Gly Glu Trp Phe Ile Lys Met Leu 
785                 790                 795                 800 


Arg Ala Glu Val Glu Lys Leu Glu His Trp Cys Gln Gln Met Glu Arg 
                805                 810                 815     


Glu Ala Glu Asp Tyr Glu Leu Pro Glu Glu Ile Leu Glu Lys Ile Arg 
            820                 825                 830         


Ser Ala Val Gly Ser Thr Gln Leu Leu Leu Ser Gln Lys Val Gln Gln 
        835                 840                 845             


Phe Phe Arg Leu Cys Gln Gln Ser Leu Asp Pro Thr Ala Phe Pro Val 
    850                 855                 860                 


Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp Leu Leu Gln Leu Ser 
865                 870                 875                 880 


Ile Glu Asp Val Thr Leu Lys Phe Leu Glu Leu Gln Gln Leu Lys Ala 
                885                 890                 895     


Asn Ser Trp Lys Leu Leu Glu Pro Lys Glu Glu Lys Lys Val Pro Pro 
            900                 905                 910         


Pro Ile Pro Lys Lys Pro Ser Arg Gly Arg Gly Val Pro Val Lys Glu 
        915                 920                 925             


Arg Ser Leu Asp Ser Val Asp Arg Gln Arg Gln Glu Ala Arg Lys Arg 
    930                 935                 940                 


Leu Leu Ala Ala Lys Arg Ala Ala Ser Phe Arg His Ser Ser Ala Thr 
945                 950                 955                 960 


Glu Ser Ala Asp Ser Ile Glu Ile Tyr Ile Pro Glu Ala Gln Thr Arg 
                965                 970                 975     


Leu 
    


<210>  634

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  634

Thr Ser His His His His His His His His His His His 
1               5                   10              


<210>  635

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  635

Gly Pro His Thr Ser His His His His His His His His 
1               5                   10              


<210>  636

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  636

Pro His Thr Ser His His His His His His His His His 
1               5                   10              


<210>  637

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  637

His Thr Ser His His His His His His His His His His 
1               5                   10              


<210>  638

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  638

Ser His His His His His His His His His His His His 
1               5                   10              


<210>  639

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  639

Gly Gly Pro His Thr Ser His His His His His His His 
1               5                   10              


<210>  640

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  640

His His His His His His His His His His 
1               5                   10  


<210>  641

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  641

His His His His His His His His His His 
1               5                   10  


<210>  642

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  642

His His His His His His His His His His 
1               5                   10  


<210>  643

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  643

His His His His His His His His His His 
1               5                   10  


<210>  644

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  644

His His His His His His His Gln Ser Arg 
1               5                   10  


<210>  645

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  645

His His His His His His His His Gln Ser 
1               5                   10  


<210>  646

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  646

Gly Ser Pro Gly Pro Ala Pro Ala Pro Thr Pro Cys Pro Gly Ala 
1               5                   10                  15  


<210>  647

<211>  24

<212>  PRT

<213>  Homo sapiens



<400>  647

Gly Gly Pro His Thr Ser His His His His His His His His His His 
1               5                   10                  15      


His His Gln Ser Arg His Gly Lys 
            20                  


<210>  648

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  648

His His His His His His His His His His His His Gln 
1               5                   10              


<210>  649

<211>  34

<212>  PRT

<213>  Homo sapiens



<400>  649

Arg Phe Cys Ala Pro Arg Ala Gly Leu Gly His Ile Ser Pro Glu Gly 
1               5                   10                  15      


Pro Leu Ser Leu Ser Glu Gly Pro Ser Val Gly Pro Glu Gly Gly Pro 
            20                  25                  30          


Ala Gly 
        


<210>  650

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  650

Gly Pro His Thr Ser His His His His His 
1               5                   10  


<210>  651

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  651

Gly Pro Lys Ala Glu Gly Arg Gly Gly Ser Gly Gly Asp 
1               5                   10              


<210>  652

<211>  23

<212>  PRT

<213>  Homo sapiens



<400>  652

His Thr Ser His His His His His His His His His His His His Gln 
1               5                   10                  15      


Ser Arg His Gly Lys Arg Ser 
            20              


<210>  653

<211>  17

<212>  PRT

<213>  Homo sapiens



<400>  653

Thr Ala Phe Pro Val Pro Thr Phe Gln Asp Leu Ala Gly Phe Trp Asp 
1               5                   10                  15      


Leu 
    


